Pulmonary and Respiratory Medicine International Journal最新文献

{"title":"Curcumin improves step 4 asthma treatment: placebo-controlled, single blind study","authors":"E. Jusufovic, M. Košnik, N. Arifhodzic, J. Nurkić, M. Al‐Ahmad, Azra Jusufovic, Dženan Halilović, R. Sejdinović","doi":"10.30881/PRMIJ.00010","DOIUrl":"https://doi.org/10.30881/PRMIJ.00010","url":null,"abstract":"Background: Despite multistep efforts, many asthma patients remain symptomatic. Anti-inflammatory activities of curcumin are shown. Aim of the study was to analyse the impact of curcumin add-on therapy on inflammatory parameters, lung function, disease control and quality of life in asthma patients. Subjects and methods: Three-months lasting study was done on 150 non-smokers with asthma, that were treated with stable, moderate dose of inhaled glucocorticoids (IGK) and divided into three groups (n=50 each): curcumin group (receiving curcumin 500 mg per os twice daily), placebo group (receiving placebo tablets) and control (non-intervention) group. Sputum eosinophils (sEo), blood eosinophils (bEo), high sensitive C-reactive protein (hsCRP), predicted forced expiratory volume in first second (FEV1%), Asthma Control Test (ACT) and mini Asthma Quality of Life Questionnaire (mAQLQ) were compared before and after study, as well as between groups. Results: Before study, all followed parameters were similar between groups. After study, FEV1%, ACT and AQLQ were improved in all groups, but these improvements were more prominent in curcumin group than in placebo and control. Additionally curcumin group only showed improvement in sEo, bEo and hsCRP. Furthermore, curcumin group showed more frequent clinically significant improvement in ACT score (change>3) and in mAQLQ score (change≥0.5) when compared to placebo and control. On the other side, after study FEV1%, ACT, mAQLQ, hsCRP, sEo and bEo were similarly distributed among placebo and control group. Conclusion: This is the first placebo controlled and single-blind study to suggest that add-on therapy with curcumin could improve lung function, disease control and quality of life in moderate partially controlled asthma. Future studies may benefit from a larger sample size, longer study duration, double blind design, different dose of curcumin and/or improvements in oral bioavailability.","PeriodicalId":326257,"journal":{"name":"Pulmonary and Respiratory Medicine International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128599190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary spindle cell carcinoma: case report and literature review","authors":"Alexis Eduardo Higareda Basilio, Cecilio Omar Ceballos Zuñiga, Federico Isaac Hernandez Rocha, S. Ham","doi":"10.30881/PRMIJ.00009","DOIUrl":"https://doi.org/10.30881/PRMIJ.00009","url":null,"abstract":"Spindle cell carcinoma is a rare and malignant variety of squamous cell carcinoma. It is a tumor that is constituted by a double cell proliferation: a carcinomatous sarcomatous epithelial cells of spindle cells and another sarcomatous of spindle cells. It can affect any part of the body; however, it is more commonly found in upper airway and digestive tract. It affects men more frequently between the sixth and seventh decade of life. It has an aggressive behavior with a tendency of recurrence. Alcohol and tobacco have been identified as the most important risk factors. The histopathological diagnosis is complicated and it is often necessary to resort to immunohistochemical techniques and the use of the electron microscope. Given the infrequent strain, it is considered important to publish the information collected from a case in our environment to compare it with what is currently described in the literature. Pulmonary and Respiratory Medicine International Journal Submit your Article | www.ologypress.com/submit-article Ology Press Citation: Basilio AEH, Zuñiga COC, Rocha FIH, et al. Pulmonary spindle cell carcinoma: case report and literature review. Pulm Resp Med Int J. (2019);2(1):1-3. DOI: 10.30881/prmij.00009 2 of 18,340 uL, with neutrophils of 17,550 uL (95.7%), lymphocytes 460 uL (2.5%) monocytes 290 uL ( 1.6%), eosinophils of 0%, and basophils of 40 uL (0.2%). This is why third-generation cephalosporin and macrolide are initiated for suspected community-acquired pneumonia with pleural effusion. The following approach was to perform a contrast computed tomography of the thorax, which reported a tumor with central necrosis in the right hemithorax of 3.5 inches x 4.3 inches, infiltrating the right pulmonary bronchus from its origin in the main carina, with peripheral enhancement, practically collapsing the right hemithorax in its entirety, with left hemithorax without evident alterations, and mediastinum with retraction towards affected hemithorax as well as infiltration to fat, presence of adenopathies reporting 1.1 inches as the largest diameter located sub-carinal. The esophagus showed a loss of fat separation interface in the middle third, which is why it is considered infiltration of the same. Bone tissues showed only degenerative changes and soft tissues with hypotrophy. The department of diagnostic radiology suggested the diagnosis of bronchogenic cancer, possibly of large cells, thus requiring histopathological confirmation. Macrolide was suspended and clindamycin was initiated for probable post obstructive pneumonia. During his hospital stay prior to his bronchoscopy, the patient was found to have a transcutaneous oxygen measurement of 89% without supplementary oxygen, which improved with the administration of supplementary oxygen by nasal tips at 0.5 L/min. Continuing with the same symptomatology, the patient was stable. A bronchoscopy was performed with diagnostic cryobiopsy, showing extrinsic compression of the middle third of th","PeriodicalId":326257,"journal":{"name":"Pulmonary and Respiratory Medicine International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129430390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal Tuberculosis- Review of Literature and Few case reports","authors":"Dr. C. Sumalata, Dr. Arundhathi","doi":"10.30881/PRMIJ.00008","DOIUrl":"https://doi.org/10.30881/PRMIJ.00008","url":null,"abstract":"Extrapulmonary tuberculosis forms 15% of total tuberculosis in India. Skeletal tuberculosis which constitutes bone and joint tuberculosis, results from haematogenous spread from a pulmonary or other visceral or lymph node focus. Tuberculosis osteomyelitis was described by Nelatoo (1837); histologic morphology was given by Rokitansky (1884); tuberculosis nodule in a joint was seen by Koster (1869); and synovial tuberculosis by Volkmann (1879). Case No. 1: A case of Shoulder joint Tuberculosis which was relatively rare, was diagnosed in a middle aged farmer after taking proper history of pain and inability to move. He was investigated appropriately with radiological images and the case eventually responded to the anti-tuberculosis treatment. Case No. 2: A case of rib osteomyelitis was diagnosed when the young lady had only a complaint of pain in lower chest right side. The diagnosis of TB was reached after she had empyema and the same pus was tested for TB DNA. The decrease in pain and relieve of symptoms noticed after the initiation of treatment with Anti tuberculous treatment. She had surgical intervention for the same. Case No. 3 A young lady complained of pain and swelling in left wrist for a long duration. MRI showed bone marrow oedema in distal row of carpal bones with loss of articular cartilage and small erosion noted in trapezoid, base of metacarpal and capitates and base of third metacarpal joint. The diagnosis of tuberculosis was supported with Immunoglobulin Releasing Assay (IGRA) which was positive. Anti tuberculous drugs were given, and she responded well. Case No. 4 A middle aged man who was suffering from low back ache from 3 years had been diagnosed as Potts spine at L5 –S1 with the help of MRI spine. He was started with Anti tuberculosis drugs and he responded well. All the cases were also worked up for primary pulmonary involvement.","PeriodicalId":326257,"journal":{"name":"Pulmonary and Respiratory Medicine International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132539331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Bronchial Asthma in the era of biological treatments","authors":"Eleni Manoloudi, P. Steiropoulos","doi":"10.30881/PRMIJ.00007","DOIUrl":"https://doi.org/10.30881/PRMIJ.00007","url":null,"abstract":"Severe bronchial asthma is a chronic heterogeneous disease that requires a combination of therapies in order to be sufficiently controlled. A significant number of patients, however, do not achieve adequate control, leading to frequent exacerbations, impaired quality of life and increased health care costs. In recent years, several biological agents for severe asthma treatment have been introduced in the market or are under development. Although, biological treatment regimens for severe asthma are increasing our perspective about future asthma approach for specific asthma phenotypes and endotypes, still certain issues are raised concerning their appropriate use in line with everyday clinical practice. Pulmonary and Respiratory Medicine International Journal Submit your Article | www.ologypress.com/submit-article Ology Press Citation: Manoloudi E, Steiropoulos P. Severe Bronchial Asthma in the era of biological treatments. Pulm Resp Med Int J. (2018);1(1):6-9. 7 Anti-immunoglobulin E More than 50% of patients with poorly controlled asthma have allergic immunoglobulin E (IgE)-mediated asthma.10 IgE has a crucial upstream role in the inflammatory cascade of allergy and allergic asthma.6 Omalizumab is the only biological anti-IgE agent currently approved for humans.10 It was approved by the FDA in 2003 and by the European Union in 2005 as add-on treatment for patients aged >12 years with severe persistent allergic asthma who have serum total IgE levels 30-700 IU/mL.10 It is a recombinant DNA derived humanized IgG1 monoclonal antibody, which was originally constructed as a murine antibody selectively binding to human IgE.11 It has two main mechanisms of action: 1) it binds exclusively to circulating IgE in the blood and interstitial space and promotes its depletion and 2) it inhibits IgE binding to high-affinity (FcoRI) or low-affinity receptors (FcoRII) on basophils, mast cells and dendritic cells.10 As a result, it hinders the release of inflammatory mediators from mast cells reducing the recruitment of inflammatory cells, especially eosinophils, into the airways.11 As reported in clinical trials, omalizumab contributes to reduction in exacerbation rates, fewer emergency department visits and asthma related hospitalizations, better asthma symptom control, reduction in ICS or oral CS dose and improvement in asthma-related quality of life (QoL).6","PeriodicalId":326257,"journal":{"name":"Pulmonary and Respiratory Medicine International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125666138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video-Assisted Thoracoscopic Surgery versus open approach for systematic mediastinal lymph node dissection as surgical staging in major pulmonary resections for lung cancer","authors":"J. L. Fernández, R. M. Balsalobre, H. Goicoechea, I. C. Vázquez, Paloma Rofso Raboso, A. D. L. Fuente","doi":"10.30881/PRMIJ.00006","DOIUrl":"https://doi.org/10.30881/PRMIJ.00006","url":null,"abstract":"Introduction Oncological pulmonary resection should include ipsilateral hilar and mediastinal systematic lymphatic dissection allowing adequate pathological staging. Video-Assisted Thoracoscopic Surgery (VATS) has been proposed as an appropriate surgical procedure for treatment of early-stage lung cancer patients. This study aims to compare VATS versus Thoracotomy lymph node dissection in patients who underwent pulmonary resection for lung cancer. Methods This is a retrospective analysis of prospectively collected data from 585 patients operated at La Princesa University Hospital in Madrid (Spain) from December 2007 to January 2018. All included patients underwent complete major pulmonary resection, lobectomy or bilobectomy, and mediastinal lymph node dissection. Patients were divided in two groups, VATS group with 290 patients and thoracotomy group (TT) with 295 patients. Results The number of lymph nodes resected in each group did not present significant differences. VATS-group was 13.4 and TT-group was 14.1. We did not appreciate any significant difference regarding the identification of positive hilar lymphadenopathies in VATS-group versus TT-group, 36 and 41 patients respectively. However, we observed differences in patients with mediastinal lymph node metastasis (N2 disease). 34 cases (11.7%) in VATS-group and 28 cases (9.5%) in the TT-group. Lymphadenectomy 2R and 4R stations was equivalent in both groups and did not show any statistically significant difference. In the same way, there was no difference in the number of lymph nodes for levels 7R and 8R. Hilar lymphadenectomy (10R and 11R) was performed in both procedures in an equivalent manner obtaining 3.4 lymphadenopathies in VATS-group and 3.3 lymphadenopathies in TT-group. Regarding lymphadenectomy on the left side, we did not observe any difference between both groups at 5L or 6L levels. Otherwise, subcarinal lymphadenectomy on the left side showed differences when this was performed by VATS in comparison to open surgery. 3.2 lymph nodes in the VATS-group versus 4.9 lymph nodes in TT-group. This difference was statistically significant (p < 0.01). There was no difference in at the level of 8L and 9L stations. Hilar lymphadenectomy at 10L and 11L levels was superior in VATS-group, 4.4 lymphadenopathies, respect to TT-group, 3.1 lymph nodes. This difference was statistically significant (p <0. 01). Conclusions VATS seems to be at least equivalent to thoracotomy for pulmonary major resections in terms of oncological and staging criteria.","PeriodicalId":326257,"journal":{"name":"Pulmonary and Respiratory Medicine International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122081897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It is a bile!","authors":"A. Fayed, Mona Hassan","doi":"10.30881/PRMIJ.00005","DOIUrl":"https://doi.org/10.30881/PRMIJ.00005","url":null,"abstract":"Bilothorax is a rare reported complication of hepatobiliary tree manipulation and can cause a great threat for life. We reported in this case a benign course of this problem without detection of obvious communication between peritoneal and pleural spaces and without peritonitis.","PeriodicalId":326257,"journal":{"name":"Pulmonary and Respiratory Medicine International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125731599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gorham-Stout disease with thoracic, vertebral and pleural involvement: case report and literature review","authors":"F. H. Hernández Rocha, Alexis Eduardo Higareda Basilio, Cecilio Omar Ceballos Zuñiga","doi":"10.30881/prmij.00011","DOIUrl":"https://doi.org/10.30881/prmij.00011","url":null,"abstract":"Gorham-Stout disease, pathology with vascular proliferation, angiomatosis and bone lymphangiomatosis that causes progressive osteolysis and loss of bone mass. Thoracic, pulmonary or pleural affection leads to a compromised respiratory function that can lead to a fatal outcome. The mandibular involvement may lead to the development of obstructive sleep apnea. The etiopathogenesis is currently unknown and occurs sporadically. Since the description of the pathology in 1838, there have been documented more than 200 cases in the literature being 50 of these in pediatric population. We report the case of a 13-year-old patient with Gorham-Stout disease with thoracic, vertebral and pleural involvement.","PeriodicalId":326257,"journal":{"name":"Pulmonary and Respiratory Medicine International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122902710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}