发布求助
文献互助 智能选刊 最新文献

Proceedings of the 4th International Conference on Statistics: Theory and Applications最新文献

筛选
英文 中文
Understanding the Population Structure Correction Regression 理解人口结构修正回归
Proceedings of the 4th International Conference on Statistics: Theory and Applications Pub Date : 2021-08-12 DOI: 10.11159/icsta22.114
T. T. Mai, Pierre Alquier
{"title":"Understanding the Population Structure Correction Regression","authors":"T. T. Mai, Pierre Alquier","doi":"10.11159/icsta22.114","DOIUrl":"https://doi.org/10.11159/icsta22.114","url":null,"abstract":"Although genome-wide association studies (GWAS) on complex traits have achieved great successes, the current leading GWAS approaches simply perform to test each genotype-phenotype association separately for each genetic variant. Curiously, the statistical properties for using these approaches is not known when a joint model for the whole genetic variants is considered. Here we advance in GWAS in understanding the statistical properties of the\"population structure correction\"(PSC) approach, a standard univariate approach in GWAS. We further propose and analyse a correction to the PSC approach, termed as\"corrected population correction\"(CPC). Together with the theoretical results, numerical simulations show that CPC is always comparable or better than PSC, with a dramatic improvement in some special cases.","PeriodicalId":325859,"journal":{"name":"Proceedings of the 4th International Conference on Statistics: Theory and Applications","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125594768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信