{"title":"Incorporation of Extracellular Matrix-Binding Peptides into Hydrogel Network: A Strategy to Mimic the Stem Cells Microenvironment in 3D Conditions","authors":"Hadi Hezaveh","doi":"10.37191/mapsci-2582-385x-4(5)-120","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(5)-120","url":null,"abstract":"The advancement of science and medicine in recent decades has improved human health care resulting in increased quality and length of life. The progress of regenerative medicine has opened new venues for therapeutic techniques to treat cancer and traumatic injuries. The development of three-dimensional materials that can closely mimic the conditions cells are presented with in vivo is a great challenge in biomaterials development for regenerative medicine applications. Synthesised scaffolds should be tuneable in terms of their mechanical properties to be suited for regenerative applications. In addition, these materials should provide cells with a platform such that they can survive, differentiate, and proliferate. The incorporation of ECM proteins binding peptides into the polymeric network can be an effective strategy to provide cell-supporting biomaterials with the additional benefit of supporting cells to generate their in vivo-like microenvironment within hydrogels.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130894277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Clinical Trial Between Conventional Treatment and Treatment with Rich Plasma Implants in Platelets (PRP) in Patients with Pseudarthrosis in the Tibia","authors":"Valéria Botelho","doi":"10.37191/mapsci-2582-385x-4(4)-118","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(4)-118","url":null,"abstract":"The objective of this work was to carry out a comparative clinical study of the cost between the Conventional Treatment and the Treatment with Platelet Rich Plasma (PRP) in patients with Pseudarthrosis in the Tibia. At human bone fractures, mainly at arising in accidents in traffic and others and your complications, represent one important condition what has jeopardized health and quality of life, in addition to crescents for the Unified Health System (SUS), so much in the treatment primary, how much of us care with their grievances. One there, the Pseudarthrosis, entity gives Orthopedics already quite known, it is one complication of fractures Where o bone no it presents features in consolidation and regeneration. This is mainly due to poor vascularization at the fracture site, inadequate or late treatment and follow-up of the fracture, or the presence of a gap between the bone fragments. Surgical treatment is the most common for Pseudoarthrosis and it may be necessary for the patient to have a vascularized bone graft in the affected region. Against in a scenery, in what if observe o increase in costs hospital at the treatment surgical of fractures, so as pension expenses at the costing in pensions and retirements, resulting in loss gives activity work and loss of Health and Quality of Life with great repercussion at economy of country, was performed a study with essay Clinical Cats Comparison of Treatment Surgical Conventional for Pseudarthrosis gives Tibia, with o use in new technologies like the injection in Plasma Rich in Platelets (PRP) at the focus gives referred lesion, in patients attended fur System single of Health (SUS). The results obtained demonstrate that treatment with Platelet Rich Plasma (PRP) is less expensive, less traumatic, effective and allows for a shorter hospital stay, in addition to improving the Quality of Life.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132377390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Neurophysiology in the Prognostic and Diagnostic Evaluation of Disorders of Consciousness","authors":"Berenika Maciejewicz","doi":"10.37191/mapsci-2582-385x-4(4)-117","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(4)-117","url":null,"abstract":"According to its neurophysiological function, a disorder of consciousness (DOC) is a long-lasting change in the consciousness state of a patient that can be categorized as a coma, vegetative state, locked-in syndrome, or minimally conscious state. Although recent advances in neuroimaging and electroencephalography may help us better understand the brain networks involved in states of awareness and consciousness, the pathophysiology of DOC remains poorly understood. The main objectives of DOC rehabilitation programs are to maintain live support, to reduce the likelihood of a comatose patient developing new medical conditions, and to provide the affected families with the relevant information to make informed choices as to whether to continue the live-supporting programs. Therapeutic interventions can include both pharmacologic and nonpharmacologic therapies although at present there are no definite medical treatments for people with DOC. This research investigates and recommends numerous diagnostic methods and treatments that can be used to identify cognitive and neurobiological impaired states of consciousness, including coma, persistent vegetative state (PVS), also referred to as \"unresponsive wakefulness syndrome\" and other severe forms of awareness impairments, often brought on by acute brain injury but also other toxic or metabolic causes.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128614087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of Stem Cells: Why Do We Age?","authors":"G. Slater","doi":"10.37191/mapsci-2582-385x-4(4)-116","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(4)-116","url":null,"abstract":"The answer to “why we age and how we stop it” is one of the most sought-after explanations of all time. The key to stopping, or at least slowing, the process of mammalian ageing begins by understanding the mechanisms behind it. The aim of this review is to shed light on the inner workings of stem cell ageing and extrapolate possibilities for health span extension. Understanding ageing (and not just as the process that brings us closer to death, but as a declining quality of life) at a deeper level not only allows for breakthroughs in slowing ageing, but also permits practitioners to recommend and personalize the best course of treatment for any disease or disability based on a patient’s level of stem cell activity. The findings, in summary, indicate that stem cells themselves can be either the cause or the victim of ageing and there are multiple factors which determine the outcome. Whilst many stem cell types don’t diminish in number over time, their function does decline. An ultimately, cell senescence is the most prominent key to understanding stem-cell associated ageing.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121734044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gelatin Methacryloyl Bioscaffolds: A Viable Option for Alveolar Bone Tissue Engineering?","authors":"Kirthanashri S. Vasanthan","doi":"10.37191/mapsci-2582-385x-4(3)-115","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(3)-115","url":null,"abstract":"The concept of tissue engineering involves the deposition of cells on bioscaffolds in a particular location that ultimately leads to regeneration of tissues. The combinatorial effect of cells, bioscaffolds and molecular signaling factors, works conjunctly to provide exact microenvironment mimicking the native in vivo system. Alveolar bone regeneration due to its location, poses certain challenges where appropriate mechanical loading and microbial flora need addressing during construction of the scaffold [1]. Three dimensional (3D) bioprinting has unfolded vast possibilities for bone regeneration through fabrication of 3D constructs that support adhesion and proliferation of pleuripotent stem cells in desired location. 3D printing allows individual-specific construction of scaffolds of a certain shape and size that allow regeneration of bone through cellular proliferation, differentiation, and molecular-signalling pathways in a guided fashion.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114964921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Senescence and its Effect on Aging and Dementia","authors":"Farihah Khaliq","doi":"10.37191/mapsci-2582-385x-4(3)-114","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(3)-114","url":null,"abstract":"The term senescence was first proposed by Hayflick and Moorhead in 1960. They defined it as an interchangeable term with aging, which is an additional response by proliferating cells that adopt permanent arrest of cell cycles. Cellular senescence is considered a hallmark of aging termed ‘antagonistic pleiotropy’ that describes the deterioration causing tissue dysfunction in brain cells. Mainly senescent cell inhibits the growth of DNA in the G1 phase. Since aging is the main risk factor for causing neurodegenerative diseases, senescence plays a crucial role in causing Alzheimer’s disease leading to dementia. Besides, senolytic therapies are in development to prevent neuronal loss and restrict disease progression.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125358862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio, Novel Biomarkers and Applications in Urology: An Update","authors":"T. Q. Ngo","doi":"10.37191/mapsci-2582-385x-4(3)-110","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(3)-110","url":null,"abstract":"Blood cells play a vital role in homeostasis that can interact with numerous conditions such as inflammation, immune responses, hemostasis, and oncogenesis. The complete blood count test is an inexpensive and regular tool that provides a lot of informative markers revealing shifts in the different blood cell types in case of acute inflammation and prothrombotic phase. Among them, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are emerging biomarkers as the indicators and predictors for varied inflammatory responses and oncologic diseases. These markers were extensively studied in cardiovascular diseases, rheumatic diseases, colorectal, gastric lung, and ovarian cancer, as well as other diseases. In Urology field, higher NLR and PLR could be utilized for predicting prognosis and diagnosis of urinary tract infection states as well as urologic cancer diseases, such as prostate cancer, bladder cancer, and upper tract urothelial carcinoma. Also, in comparison to individuals without kidney stones, forbearing along with the kidney stones had greater NLR and PLR rates. This article aims to review some scientific evidence for the applications of NLR and PLR in Urology.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126645323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glycadelin in Obstetrical Practice: Past, Present, Practice","authors":"Fazilova Makhshura Olimjanovna","doi":"10.37191/mapsci-2582-385x-4(3)-112","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(3)-112","url":null,"abstract":"The article presents a review of the literature on one of the main proteins of the human reproductive system-glycodelin. The issues of the discovery of glycodelin, the features of synthesis, different names of the protein, its functions are covered. Depending on the place of origin, the same protein skeleton is glycosylated differently, giving rise to glycodelin isoforms with different biological effects. Glycodelin A (endometrial) and F (follicular fluid) inhibit the binding of spermatozoa and zona pellucida, thereby exhibiting contraceptive properties. In contrast, glycodelin C (cumulus) stimulates the binding of spermatozoa to the zona pellucida. Glycodelin S of seminal vesicles does not have a contraceptive effect, it affects the stability of the spermatozoa membrane, controls capacitation. The pronounced immunosuppressive activity of glycodelin A contributes to successful implantation and placentation, glycodelin S promotes the formation of antisperm immunity. The role of glycodelin in human reproductive function, the pathogenesis of reproductive losses (miscarriage, ectopic pregnancy, stillbirth), assessment of the functional state of the ovaries, fallopian tubes and endometrium, the maternal part of the placenta, and sperm fertility are shown. The review reflects both fundamental scientific data and the results of clinical studies of glycodelin content in menstrual blood, peripheral venous blood in women and semen in men, which made it possible to develop methods for diagnosing and predicting disorders of reproductive health and reproductive function in a married couple.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115948313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperbaric Oxygen Therapy: An Overview","authors":"G. Slater","doi":"10.37191/mapsci-2582-385x-4(3)-111","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(3)-111","url":null,"abstract":"Hyperbaric Oxygen Therapy (HBOT) has been a recognised treatment for a multitude of injuries for decades and presents significant opportunities for the improvement of wound healing, blood vessel restoration, reduction in recovery time after surgery, treatment of neurological and neurodegenerative disorders, improvement of memory and cognition, sports injury rehabilitation, cartilage regeneration, and overall quality of life. This paper aims to investigate HBOT and its indications for use, both as an adjuvant with other established treatments and independently, in order to provide an overview of treatment avenues with immense possibilities and versatility.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124395789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Idiopathic Symptomatic Planovalgus Foot- Current Concepts in Minimally Invasive Correction","authors":"G. Slater","doi":"10.37191/mapsci-2582-385x-4(2)-109","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-4(2)-109","url":null,"abstract":"This paper presents a literature review and the author’s current recommended surgical treatment for idiopathic symptomatic planovalgus foot. This condition has gained recognition as a diagnosis entity over the past several years. There have only been brief case reports prior to this paper. The authors aim to describe the anatomical and morphological features indicative of idiopathic pes planovalgus (ISP). This also includes the distinct features of the flat medial arch and how the medial rotation of the talus affects the different types of ISP.ISP, in essence, is a diagnosis of exclusion. It is distinct from conditions such as tibilias posterior failure and as such, the approach to management is different.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131980917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}