International Journal of Travel Medicine and Global Health最新文献

{"title":"Ambulance Use by International Travelers in Japan: A Retrospective Descriptive Study","authors":"Y. Oshita, Koki Tsuchiya, K. Ishikawa, K. Hirabayashi, T. Nemoto","doi":"10.34172/ijtmgh.2020.02","DOIUrl":"https://doi.org/10.34172/ijtmgh.2020.02","url":null,"abstract":"Introduction: Reports indicate that 22%–64% of travelers experience some illness when in a foreign country. To date, no prior study has reported the use of ambulances by travelers or the epidemiology of travel-related injury. Methods: In this retrospective study, we aimed to describe ambulance use by international travelers, including the rates of travel-related injury and illness. To do so, ambulance dispatch data from January 1, 2010 to December 31, 2018 was used. Results: Overall, of the 43 201 cases of ambulance use during the study period, 524 (1.2%) were international travelers. Ambulance use by international travelers increased from 0.35% in 2010 (15/4311) to 2.54% in 2018 (125/4913), an average annual increase of 0.27%. Of the international travelers, 392 (74.8%) had minor complaints, 110 cases (21.0%) had moderate complaints, 280 (53.4%) had internal disease, and 223 cases (42.6%) had suffered trauma. Regarding location, 253 (48.3%) were from a hotel/lodge, 83 (15.8%) were from a road/parking, and 30 (5.7%) were in the forest/mountain. Conclusion: Most international travelers use ambulances for minor complaints, typically internal disease or trauma, and approximately half access the service from a hotel or lodge.","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2020-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49065961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Coronavirus (2019-nCoV): An Insight Toward Preventive Actions and Natural Medicine","authors":"L. Khedmat","doi":"10.34172/ijtmgh.2020.07","DOIUrl":"https://doi.org/10.34172/ijtmgh.2020.07","url":null,"abstract":"Today, one of the most critical health issues is the wide outbreak of novel coronavirus infection, which is so far affected 115 countries and territories all around the world. Presenting the possible risks and appropriate health preventive measures, as well as finding some bio-pharma strategies may open a bright horizon to alleviate the number of patients and the rate of disease transmission until discovering the vaccines and definitive treatments. In December 2019, novel coronavirus was initially recognized in Wuhan State, Hubei Province, China. This virus and its disease were called “SARS-CoV-2” and “coronavirus disease 2019 or COVID-19”, respectively. The COVID-19 was quickly spread in other Far East Asian countries and then to the Middle East and Europe.1 Similar to severe acute respiratory syndrome (SARS; 2002-2003) and the Middle East respiratory syndrome (MERS; 2012-ongoing), SARS-CoV-2 is the beta-coronavirus that originated from bats, causing fever, dry cough, and severe acute respiratory (SAR, e.g., breath shortness).2 Other common symptoms of this viral disease are fatigue, sputum production, myalgia or arthralgia, sore throat, headache, chills, nausea or vomiting, nasal congestion, diarrhea, and hemoptysis, and conjunctival congestion.2,3 In general, undesirable clinical outcomes are correlated to older adults and travelers with underlying health issues. Although the clinical diagnosis of COVID-19 in people can be resulted according to their signs, exposures, and chest imaging, nucleic acid testing of respiratory tract samples (eg, throat swabs) can be considered as a “gold standard” to confirm the viral infection.4,5 The COVID-19 outbreak not only can occur under the individual’s close contact with people carrying this virus but also being in areas where ongoing community spread of the virus. Due to the relatively high prevalence rate, many continuing efforts have been made to design guidelines to reduce outbreaks and encourage accurate and timely clinical reporting. From an epidemiologic viewpoint, the assessment of transmission modes, reproduction interval, and clinical spectrum of COVID-19 may have a vital role to prevent or control, and stop its incidence in communities. In this short time, no vaccine or efficient clinical treatment to fight COVID-19 infection has been yet explored. Therefore, the implementation of some preventive health measures as well as experiences of using medicinal herbs with excellent antiviral activities in controlling primary complications in patients will be important. The first step to prevent the spread of COVID-19 is the reduction or abolition of social gathering in areas with an elevated risk of exposure to the virus. A priority to reduce the disease rate is the quarantine of healthy individuals without symptoms at home, while suspected COVID-19 patients should be under quarantine at the assigned hospital and healthcare centers. The next step is the compliance of elementary cleanliness strategies ba","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 1","pages":"44-45"},"PeriodicalIF":0.0,"publicationDate":"2020-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48797828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of the Factors Affecting the Growth of Medical Tourism in Iran","authors":"M. Gholami, A. K. H. Abadi, Shima Miladi, Marjan Gholami","doi":"10.34172/ijtmgh.2020.01","DOIUrl":"https://doi.org/10.34172/ijtmgh.2020.01","url":null,"abstract":"Introduction: Planning in the field of medical tourism is of particular importance. The main objective of this research was to identify and analyze the factors affecting the growth of medical tourism in Iran. It could be a small step toward promoting entrepreneurship and increasing non-oil revenues in the country. Methods: Studies published in the Persian and English language during the years 2006-2019 in Science Direct, ProQuest, Springer, Medline, Scopus, Ovid, and SID databases were reviewed, and the findings were then compared. Results: A total of 75 articles out of 2631 unique publications were included in this study. Most articles reported studies performed for all patients, including the whole country (Iran) (n=22, 30%), Shiraz only (n=11, 15%), Tehran only (n=11, 15%), Mashhad only (n=6, 8%), Isfahan only (n=5, 6%), and Ardabil only (n=4, 5%). Conclusion: Given the history of Iranian hospitals in attracting foreign patients and the analysis of their status, there are many limitations in achieving a proper standing in the medical tourism industry. Strategies offered by various managers and authorities in tourism can lead to increased attraction of medical tourists to public and private hospitals in Shiraz, relying on the capabilities and potential of Shiraz and its health sectors, including climate and nature, cultural and historical attractions, renowned practitioners, advanced equipment, facilities, and methods, and thereby generating more foreign exchange earnings and employment.","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48821324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Risk of Type 2 Diabetes Among Adults of Banepa Municipality, Nepal: Community Based Cross-Sectional Study","authors":"S. Thapa, Pratigya Kayastha, D. Mishra","doi":"10.34172/ijtmgh.2020.05","DOIUrl":"https://doi.org/10.34172/ijtmgh.2020.05","url":null,"abstract":"Introduction: The prevalence of type 2 diabetes has been escalating worldwide, including low- and middle-income countries such as Nepal. Early detection of individuals at risk is of the utmost importance to prevent the escalating condition. This study used a simple, cost-effective screening tool known as the Indian Diabetes Risk Score (IDRS) in order to assess the proportion of risk groups and factors associated with it among the residents of Banepa municipality, a semi-urban area of central Nepal. Methods: A community-based cross-sectional study was conducted among 245 adults of Banepa municipality. Face to face interviews were conducted to collect the information through a pretested, semi-structured questionnaire. IDRS was used to identify the risk group for developing type 2 diabetes. Data were entered in Microsoft Excel 2010 and exported to SPSS v.11.5 for further analysis. Results: The proportion of people with high risk, moderate risk and low risk was 31%, 51.4% and 17.6%, respectively for developing type 2 diabetes. The analysis showed age (P < 0.01), education (P = 0.05), marital status (P = 0.01), body mass index (BMI) (P < 0.01), waist circumference (P < 0.01), physical activities (P < 0.01) and family history of diabetes (P < 0.04) were significantly associated with risk of type 2 diabetes. Conclusion: Nearly one-third of the study participants were in high-risk group and half of them were at moderate risk. This increasing trend of risk requires an urgent application of preventive measures through lifestyle modification.","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43988523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude and Practices Regarding Extreme Environments and Cold Adaptation at Extreme Altitudes on the Himalayan Ranges","authors":"Inam Danish Khan","doi":"10.34172/ijtmgh.2020.03","DOIUrl":"https://doi.org/10.34172/ijtmgh.2020.03","url":null,"abstract":"Introduction: Extreme-altitudes (5500 m/18045 ft and higher) pose environmental, psychophysiological, infrastructural, logistic, and ergonomic challenges that question explorer’s adaptability and mission-efficiency due to isolation, monotony, intimidating environment and terse health conditions. The assessment of an explorer’s comprehensive adaptability in extreme-altitudes is of paramount importance in ensuring mission-preparedness. Knowledge, attitude, and practices (KAP) of explorers staying on extreme-altitudes was assessed through personal interview technique. Methods: 125 healthy, acclimatized, mountain-trained explorers staying above 4570 m/15 000 ft in winter-season for at least 30 days on extreme-altitudes were assessed by a single cross-sectional study through personal interviews on KAP related to extreme-altitude and cold-adaptation. Results: Mean duration of stay on extreme-altitude was 55.7 days. All explorers knew about difficulties and health-problems at extreme-altitude. All explorers felt that mountain-training and acclimatization were beneficial. 92% felt that mission tenure of 90 days on the extreme-altitude was adequate. 92.8% felt they were adequately trained for the extreme-altitude; however, only 52% felt confident about health-training. 66.4% did preventive rewarming of extremities. 66.4% regularly smoked/chewed tobacco. 57.6% had sleep problems and 64% had altered appetite. 26.4% felt difficulties related to living conditions, infrastructure, and logistics. Conclusion: Explorers at extreme-altitude exhibited adequate knowledge and performed activities with progressive attitude and healthy practices. Explorers endured altered psychophysiology at extreme-altitude and regarded the utility of training and acclimatization programs. Knowledge-practice gap existed towards tobacco consumption. There was a felt need for the improvement of living conditions, infrastructure, logistics, and health-related training.","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 1","pages":"18-21"},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44311933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education Level and Self-rated Health in the United States: Immigrants' Diminished Returns.","authors":"Shervin Assari,&nbsp;Maryver U Perez,&nbsp;Nay'Air Johnson,&nbsp;Nikesha R Williams,&nbsp;Esmeralda Carrillo,&nbsp;Leslye Garcia,&nbsp;Xiaxiang T Hollis","doi":"10.34172/ijtmgh.2020.20","DOIUrl":"https://doi.org/10.34172/ijtmgh.2020.20","url":null,"abstract":"<p><strong>Introduction: </strong>Although education is among the major socioeconomic status (SES) resources that influence populations' and individuals' health, social marginalization may reduce the health gain that follows access to SES indicators such as education, a pattern called marginalization-related diminished return (MDR). The literature on MDRs, however, has been mainly derived from studies that have defined marginalization based on race, ethnicity, and sexual orientation. Thus, more research is needed on MDRs that may follow as a result of immigration. To extend what is known on immigration status related MDRs, this study compared a national sample of immigrants and non-immigrants for the effect of education on the poor self-rated health (SRH) of adults in the United States.</p><p><strong>Methods: </strong>With a cross-sectional design, this study employed data from the 2015 National Health Interview Survey (NHIS), a survey that had enrolled 33,654 adults who were either immigrants (n = 6225; 18.5%) or non-immigrants (n = 27 429; 81.5%). The independent variable was education level, treated as a categorical variable. The dependent variable was SRH treated as a dichotomous variable. Race, ethnicity, age, gender, marital status, and region were the confounders. Immigration (nativity) was the moderator. Logistic regression was used for data analysis.</p><p><strong>Results: </strong>Higher education credentials were associated with better SRH in the pooled sample; however, immigration showed a significant statistical interaction with education level (college graduation) on the outcome. This interaction was indicative of a smaller protective effect of college graduation on poor SRH among immigrants than non-immigrant adults.</p><p><strong>Conclusion: </strong>In line with the MDRs framework, the effect of education on SRH is weaker for immigrants than for non-immigrant adults. There is a need to help highly educated immigrants to mobilize their human capital to secure their best health outcomes, similar to non-immigrants. Such strategies may require bold and innovative policy solutions to reduce discrimination against immigrants, so they can more effectively translate their education and human capital into tangible outcomes such as health.</p>","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 3","pages":"116-123"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38359614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household Income and Children's Depressive Symptoms: Immigrants' Diminished Returns.","authors":"Shervin Assari","doi":"10.34172/IJTMGH.2020.27","DOIUrl":"https://doi.org/10.34172/IJTMGH.2020.27","url":null,"abstract":"<p><strong>Introduction: </strong>Relative to socially privileged groups, socially marginalized people experience weaker health effects of household income and other economic resources, a pattern known as Minorities' Diminished Returns (MDRs). These MDRs are frequently seen in racial and ethnic minorities, but less is known about the relevance of such MDRs in immigrant families. To investigate the MDRs of household income on children's depression as a function of immigration, we compared non-immigrant and immigrant children for the effect of household income on children's depressive symptoms.</p><p><strong>Methods: </strong>This cross-sectional study was conducted across multiple cities in the United States. Baseline data from the Adolescent Brain Cognitive Development (ABCD) study collected in 2018 was used. A total of 6,412 children between the ages of 9-10-year-old were included. The predictor variable was household income. The primary outcome was children's depression measured by the Child Behavior Checklist (CBCL). Race, ethnicity, age, sex, parental marital status, parental employment, and financial difficulties were the covariates. Immigration status was the effect modifier.</p><p><strong>Results: </strong>Overall, high household income was associated with lower children's depressive symptoms. Immigration status showed a statistically significant interaction with household income on children's depression. This interaction term suggested that high household income has a smaller protective effect against depression for immigrant children than non-immigrant children.</p><p><strong>Conclusion: </strong>The protective effect of household income against children's depression is diminished for immigrant than non-immigrant children.</p>","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 4","pages":"157-164"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39019223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Status and Current Cigarette Smoking Status: Immigrants' Diminished Returns.","authors":"Shervin Assari","doi":"10.34172/IJTMGH.2020.11","DOIUrl":"https://doi.org/10.34172/IJTMGH.2020.11","url":null,"abstract":"<p><strong>Introduction: </strong>Although socioeconomic status (SES) resources influence population and individual health behaviors, socially marginalized groups gain significantly less health from their SES indicators, such as education and income, compared to the socially privileged groups. This pattern is called marginalization-related diminished returns (MDRs). However, most of the MDRs literature is derived from studies that have defined marginalization based on race and ethnicity. As a result, more research is needed on MDRs due to immigration. To extend what is known about MDRs due to immigration, the current study compared a national sample of immigrants and non-immigrants for the effects of education and income on current cigarette smoking of adults in the United States.</p><p><strong>Methods: </strong>This is a cross-sectional study. The 2015 National Health Interview Survey (NHIS) enrolled 14,149 individuals who were either immigrants (n=1977; 14.0%) or non-immigrants (n=12,166; 86.0%). The independent variables (IV) were education and income that were treated as categorical variables. The dependent variable was current cigarette smoking. Age, gender, race, ethnicity, marital status, employment, and region were confounders. Immigration was the moderator. Logistic regression was used for data analysis.</p><p><strong>Results: </strong>High education and income were associated with lower odds of current cigarette smoking. However, immigration showed significant statistical interactions with both education and income. These interactions were suggestive of smaller protective effects of high education and income on current cigarette smoking for immigrant than non-immigrant adults.</p><p><strong>Conclusion: </strong>In line with the MDRs, the effects of education and income on tobacco use is weaker for immigrant than non-immigrant adults.</p>","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 2","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38145032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Income and Mental Well-Being of Middle-Aged and Older Americans: Immigrants' Diminished Returns.","authors":"Shervin Assari","doi":"10.34172/ijtmgh.2020.06","DOIUrl":"https://doi.org/10.34172/ijtmgh.2020.06","url":null,"abstract":"<p><strong>Introduction: </strong>Although income is among the major social determinants of mental health of middle-aged and older individuals, socially marginalized groups gain less health from their income and other socioeconomic status (SES) resources compared to socially privileged groups. This pattern is called marginalization-related diminished returns (MDRs). Most of the existing knowledge on MDRs, however, has been derived from studies that have defined marginalization based on race, ethnicity, or sexual orientation. As a result, very limited information exists on whether similar MDRs can be observed for middle-aged and older immigrants or not. Building on the MDRs framework, this study compared a national sample of immigrants and non-immigrants for the effects of income on the mental well-being of middle-aged and older adults in the United States.</p><p><strong>Methods: </strong>This is a cross-sectional study. The 2015 National Health Interview Survey (NHIS) enrolled 14 149 middle-aged and older individuals who were either immigrants (n=1977; 14.0%) or non-immigrants (n=12 166; 86.0%). The independent variable (IV) was income that was treated as a continuous variable. The dependent variable was mental well-being, also treated as a continuous variable. Age, gender, race, ethnicity, education, marital status, employment, self-rated health, obesity, and region were confounders. Immigration (nativity status) was the moderator. Logistic regression was applied for data analysis.</p><p><strong>Results: </strong>High income was associated with higher odds of good mental well-being in middle-aged and older adults. However, immigration showed a significant statistical interaction with income, which was suggestive of a smaller protective effect of high income on mental well-being for immigrant than non-immigrant middle-aged and older adults.</p><p><strong>Conclusion: </strong>In line with MDRs, the association between income and mental well-being is weaker for immigrant than non-immigrant middle-aged and older adults. There is a need to help high income immigrants secure health outcomes similar to those of non-immigrants. Such changes may require bold and innovative economic, public, and social policies that help immigrants more effectively translate their income and socioeconomic resources into tangible outcomes such as mental well-being.</p>","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"8 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37813492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halogenation as a Strategy to Improve Antiplasmodial Activity: A Report of New 3-Alkylpyridine Marine Alkaloid Analogs","authors":"Camila S Barbosa, Daniel Silqueira Martins Guimarães, Juliana Da Costa Alves, C. F. Brito, R. Ribeiro-Viana, F. Varotti, G. H. R. Viana","doi":"10.15171/ijtmgh.2019.27","DOIUrl":"https://doi.org/10.15171/ijtmgh.2019.27","url":null,"abstract":"Introduction: Due to the emergence of resistance to antimalarial drugs as well as the lack of vaccination for malaria, there is an urgent demand for the development of new antimalarial alternatives. Recently, our research group developed a new set of 3-alkylpyridine marine alkaloid analogs, of which a compound known as compound 5 was found to be inactive against Plasmodium falciparum. Methods: Herein, we report a successful halogenation strategy to improve the antiplasmodial activity of compound 5 through the replacement of a hydroxyl group by chlorine (compound 6) and fluorine (compound 7) atoms. Results: Compounds 6 and 7 showed improved antiplasmodial activities (IC50 = 7.2 and 8.3 μM, respectively) 20 times higher than that of their precursor, compound 5 (IC50 = 210.7 μM). Ultraviolet-visible titration experiments demonstrated that halogenation of compound 5 did not alter its ability to bind its target, hematin. Conclusion: Halogenation can enhance the antiplasmodial activity of a compound without altering its mechanism of action.","PeriodicalId":32539,"journal":{"name":"International Journal of Travel Medicine and Global Health","volume":"7 1","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48438346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}