Francisco Jos.. Chiaradia Davolos, Norma S. Modolo, Leandro G. Braz, Paulo do Nascimento Junior
{"title":"Palonosetron versus ondansetron for prophylaxis of postoperative nausea and vomiting in laparoscopic cholecystectomy: a non-inferiority randomized controlled trial","authors":"Francisco Jos.. Chiaradia Davolos, Norma S. Modolo, Leandro G. Braz, Paulo do Nascimento Junior","doi":"10.1016/j.bjane.2021.06.020","DOIUrl":"10.1016/j.bjane.2021.06.020","url":null,"abstract":"<div><h3>Background</h3><p>We tested the hypothesis that, within the margin of 15% of risk difference, palonosetron is not inferior to ondansetron in reducing the incidence of postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomy.</p></div><div><h3>Methods</h3><p>We conducted a double-blind, non-inferiority, randomized, controlled trial of 212 patients aged 18 to 65 years undergoing laparoscopic cholecystectomy under general anesthesia in two secondary care hospitals. Patients were randomly assigned to receive either palonosetron (0.075.ßmg) or ondansetron (8.ßmg) intravenously at induction of anesthesia. Ondansetron (8.ßmg) was also administered 8 and 16.ßhours postoperatively. All anesthetic and surgical procedures were standardized. Patients were evaluated for 24.ßhours postoperatively for the occurrence of PONV.</p></div><div><h3>Results</h3><p>A high incidence of PONV was observed at 2...6.ßhours postoperatively, with a rate of 36.8% (95% confidence interval [CI] 28.2...46.3) in the palonosetron group, as compared to 43.4% (95% CI 34.4...52.9) in the ondansetron group. The risk difference (95% CI) between palonosetron and ondansetron for PONV was 0 (-10.9 to 10.9) at 0...2.ßhours, -6.6 (-19.4 to 6.5) at 2...6.ßhours, -0.9 (-11.0 to 9.2) at 6...12.ßhours, and -2.8 (-9.6 to 3.6) at 12...24.ßhours. There was no statistically significant difference between the palonosetron and ondansetron groups in the use of rescue medication (dimenhydrinate). There were no adverse events associated with the medications under study.</p></div><div><h3>Conclusion</h3><p>Palonosetron is not inferior to ondansetron in patients at risk of PONV undergoing laparoscopic cholecystectomy, providing a good option for PONV prophylaxis, as it can be administered in a single dose.</p></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"74 1","pages":"Article 744216"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0104001421002761/pdfft?md5=c2516a80cab48c5ed2f369e28bc8dafe&pid=1-s2.0-S0104001421002761-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39199035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of palonosetron and ondansetron in preventing postoperative nausea and vomiting in renal transplantation recipients: a randomized clinical trial","authors":"Tanvi Bhargava , Sandeep Sahu , Tapas Kumar Singh , Divya Srivastava , Abhishek Kumar , Danish Mohammad , Aneesh Srivastava","doi":"10.1016/j.bjane.2021.07.027","DOIUrl":"10.1016/j.bjane.2021.07.027","url":null,"abstract":"<div><h3>Background</h3><p>End-stage renal diseases patients have a high risk of postoperative nausea and vomiting (PONV), which is multifactorial and need acute attention after renal transplantation for a successful outcome in term of an uneventful postoperative period. The study was done to compare the efficacy of palonosetron and ondansetron in preventing early and late-onset PONV in live donor renal transplantation recipients (LDRT).</p></div><div><h3>Methods</h3><p>The prospective randomized double-blinded study was done on 112 consecutive patients planned for live donor renal transplantation. Patients of both sexes in the age group of 18...60 years were randomly divided into two groups: Group O (Ondansetron) and Group P (Palonosetron) with 56 patients in each group by computer-generated randomization. The study drug was administered intravenously (IV) slowly over 30.ßseconds, one hour before extubation. Postoperatively, the patients were accessed for PONV at 6, 24, and 72.ßhours using the Visual Analogue Scale (VAS) nausea score and PONV intensity scale.</p></div><div><h3>Results</h3><p>The incidence of PONV in the study was found to be 30.35%. There was significant difference in incidence of PONV between Group P and Group O at 6.ßhours (12.5% vs. 32.1%, <em>p</em>.ß=.ß0.013) and 72.ßhours (1.8% vs. 33.9%, <em>p</em>.ß<.ß0.001), but insignificant difference at 24.ßhours (1.8% vs. 10.7%, <em>p</em>.ß=.ß0.113). VAS-nausea score was significantly lower in Group P as compared to Group O at a time point of 24.ßhours (45.54.ß...ß12.64 vs. 51.96.ß...ß14.70, <em>p</em>.ß=.ß0.015) and 72.ßhours (39.11.ß...ß10.32 vs. 45.7.ß...ß15.12, <em>p</em>.ß=.ß0.015).</p></div><div><h3>Conclusion</h3><p>Palonosetron is clinically superior to ondansetron in preventing early and delayed onset postoperative nausea and vomiting in live-related renal transplant recipients.</p></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"74 1","pages":"Article 744251"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S010400142100316X/pdfft?md5=72426e87a387fa71affb8ae7637010e0&pid=1-s2.0-S010400142100316X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39327064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcio V. Pimenta, Amanda T. Nakamura, Hazem A. Ashmawi, Joaquim E. Vieira, Hermann dos Santos Fernandes
{"title":"Ultrasound-guided pericapsular nerve group and obturator nerve phenol neurolysis for refractory inpatient hip cancer metastasis pain: a case report","authors":"Marcio V. Pimenta, Amanda T. Nakamura, Hazem A. Ashmawi, Joaquim E. Vieira, Hermann dos Santos Fernandes","doi":"10.1016/j.bjane.2021.02.037","DOIUrl":"10.1016/j.bjane.2021.02.037","url":null,"abstract":"<div><h3>Introduction</h3><p>Bone cancer metastasis may produce severe and refractory pain. It is often difficult to manage with systemic analgesics. Chemical neurolysis may be an effective alternative in terminally ill patients.</p></div><div><h3>Case report</h3><p>Female terminally ill patient with hip metastasis of gastric cancer in severe pain. Neurolytic ultrasound-guided blocks of the pericapsular nerve group and obturator nerve were performed with 5% phenol. This led to satisfactory pain relief for 10 days, until the patient's death.</p></div><div><h3>Discussion</h3><p>This approach may be effective and safe as an analgesic option for refractory hip pain due to metastasis or pathologic fracture in terminally ill patients.</p></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"74 1","pages":"Article 744089"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0104001421001056/pdfft?md5=252a5f98567c462f4fa2d0ca7360180a&pid=1-s2.0-S0104001421001056-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25517020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expert recommendations for managing difficult airways in adults and children: insights from the Brazilian Society of Anesthesiology (SBA)","authors":"André P. Schmidt","doi":"10.1016/j.bjane.2024.844479","DOIUrl":"10.1016/j.bjane.2024.844479","url":null,"abstract":"","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"74 1","pages":"Article 844479"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0104001424000010/pdfft?md5=35151d51856a17f4b1bf9f67b1f17f2a&pid=1-s2.0-S0104001424000010-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula A. Vullo , Mar.ía I. Real Navacerrada , Ricardo Navarro Suay
{"title":"Hemodynamic impact of increasing time between fentanyl and propofol administration during anesthesia induction: a randomised, clinical trial","authors":"Paula A. Vullo , Mar.ía I. Real Navacerrada , Ricardo Navarro Suay","doi":"10.1016/j.bjane.2021.07.009","DOIUrl":"10.1016/j.bjane.2021.07.009","url":null,"abstract":"<div><h3>Background and objective</h3><p>Anesthesia induction can produce severe propofol dose-dependent hypotension. Fentanyl coadministration reduces the catecholaminergic response to orotracheal intubation allowing propofol dose reduction. The aim of this study is to determine whether the hemodynamic response is improved by increasing the time between fentanyl and propofol administration and reducing the dose of the latter without increasing the time to achieve optimal hypnosis.</p></div><div><h3>Methods</h3><p>After approval by the Research Ethics Committee, patients undergoing non-cardiac surgery with endotracheal intubation were randomized by a computer-generated table into six time-dose groups (1 or 2...minutes/1, 1.5, or 2...mg.kg<sup>-1</sup> of propofol). Patients with high bronchoaspiration risk, a difficult airway, hemodynamic instability, or anesthetic allergies were excluded. After giving intravenous fentanyl (2.....g.kg<sup>-1</sup>), each group received different doses of propofol after 1 or 2...minutes. Noninvasive blood pressure (BP) and heart rate (HR) were measured at pre-induction, pre-intubation, and post-intubation. Time to hypnosis (bispectral index < 60) was also recorded.</p></div><div><h3>Results</h3><p>Of the 192 recruited patients, 186 completed the study (1...min group n...=...94; 2...min group n...=...92). It was observed that HR and BP decreased after propofol administration and increased after intubation in all groups (<em>p</em>...<...0.0001). In patients over 55 years, the 2 min ... 2 mg.kg<sup>-1</sup> group showed the greatest systolic BP reduction (36........12%) at pre-intubation, while the 1...min.........1.5...mg.kg<sup>-1</sup> group showed the least hemodynamic alteration between pre- and post-intubation (-4........13%). No significant differences were found in younger patients or in the time to reach hypnosis between the six groups. While no cases of severe bradycardia were recorded, 5,4% of the sample required vasopressors.</p></div><div><h3>Conclusion</h3><p>Increasing the time between the administration of fentanyl and propofol by up to two minutes results in greater hypotension in patients over 55 years.</p></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"74 1","pages":"Article 744230"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0104001421002906/pdfft?md5=523dde509da1dcd16541dba5f6ce572f&pid=1-s2.0-S0104001421002906-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39258339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M..rcio Cardoso Krambek , Jo.·o Luiz Vitorino-Araujo , Renan Maximilian Lovato , Jos.. Carlos Esteves Veiga
{"title":"Awake craniotomy for eloquent pial arteriovenous fistula: anesthetic and surgical consideration of a rare case","authors":"M..rcio Cardoso Krambek , Jo.·o Luiz Vitorino-Araujo , Renan Maximilian Lovato , Jos.. Carlos Esteves Veiga","doi":"10.1016/j.bjane.2021.03.009","DOIUrl":"10.1016/j.bjane.2021.03.009","url":null,"abstract":"<div><p>Intracranial pial Arteriovenous Fistulas (AVFs) are rare cerebral vascular lesions composed of one or more arterial connections to a single venous channel. We report a 50-year-old patient with a ruptured pial AVF located in an eloquent area. Microsurgery for pial AVF occlusion was proposed with awake craniotomy for motor function and neurological evaluation. Awake craniotomy is a technique that is especially useful for cerebral vascular lesions in eloquent areas, where an occlusion often compromises or suppresses the blood supply, culminating in ischemia with consequent transient or definitive deficits in neurological function.</p></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"74 1","pages":"Article 744115"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0104001421001391/pdfft?md5=18b86d01f4b5e87de474c3176acc2eff&pid=1-s2.0-S0104001421001391-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38902896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helder Pereira , Maria Vaz Antunes , Daniel Teles , Luís Guimarães Pereira , Fernando Abelha
{"title":"Association between intraoperative ketamine and the incidence of emergence delirium in laparoscopic surgeries: an observational study","authors":"Helder Pereira , Maria Vaz Antunes , Daniel Teles , Luís Guimarães Pereira , Fernando Abelha","doi":"10.1016/j.bjane.2022.10.002","DOIUrl":"10.1016/j.bjane.2022.10.002","url":null,"abstract":"<div><h3>Background</h3><p>Emergence <em>Delirium</em> (ED) is an essential condition in the immediate postoperative period. Systematic review and meta-analysis of randomized controlled trials have concluded that the effect of ketamine on postoperative delirium remains unclear. The present study sought to evaluate if the intraoperative use of ketamine for postoperative analgesia is associated with postoperative ED in laparoscopic surgeries.</p></div><div><h3>Methods</h3><p>A prospective observational study was performed in the PostAnesthetic Care Unit (PACU) to evaluate patients who had undergone laparoscopic surgery under a rigid intraoperative anesthesia protocol from July 2018 to January 2019. Patients submitted to laparoscopic surgery for cholecystectomy, oophorectomy, or salpingectomy with a score ≥1 on the Richmond Assessment Sedation Scale (RASS) or ≥2 on the Nursing Delirium Screening Scale (Nu-DESC) were considered to have ED. <em>t</em>-test, Chi-Square test or Fisher's exact tests were used for comparison.</p></div><div><h3>Results</h3><p>One hundred and fifteen patients were studied after laparoscopic surgery. Seventeen patients (14.8%) developed ED, and the incidence of ED in patients who received ketamine was not different from that of other patients (18.3% vs. 10.6%, <em>p =</em> 0.262). Patients with ED had more postoperative pain and morphine requirement at the PACU (<em>p</em> = 0.005 and <em>p</em> = 0.025, respectively). Type of surgery (general surgery, OR = 6.4, 95% CI 1.2‒35.2) and postoperative pain (OR = 3.7, 95% CI 1.2‒11.4) were risk factors for ED.</p></div><div><h3>Conclusion</h3><p>In this study, no association was found between ED and intraoperative administration of ketamine in laparoscopic surgeries. Type of surgery and postoperative pain were risk factors for ED.</p></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"74 1","pages":"Article 744414"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0104001422001348/pdfft?md5=72dd50a1aa4d1357ff194505d4411d66&pid=1-s2.0-S0104001422001348-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40585683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}