低剂量关节内 S（+）氯胺酮对大鼠骨关节炎的影响：一项实验研究

IF 1.7 4区医学 Q2 ANESTHESIOLOGY

Brazilian Journal of Anesthesiology Pub Date : 2024-04-09 DOI:10.1016/j.bjane.2024.844502

Eugênio dos Santos Neto , Pedro Paulo de Alcantara Pedro , Maria do Socorro de Sousa Cartágenes , José Osvaldo Barbosa Neto , João Batista Santos Garcia

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引用次数: 0

摘要

背景本研究旨在探讨S(+)-氯胺酮对骨关节炎（OA）模型中疼痛行为和滑膜炎症的镇痛作用：OA-盐水组（n = 24）和OA-氯胺酮组（n = 24），通过关节内单碘乙酸钠（MIA）诱导OA；非OA组（n = 24）作为对照。OA诱导后第7天，动物接受生理盐水或S（+）-氯胺酮（0.5 mg.kg-1）治疗。结果S（+）-氯胺酮减轻了第7天至第28天的异痛感，减轻了第10天至第28天的高痛感。从第10天到研究结束，它明显减轻了体重分布障碍。经 S（+）-氯胺酮处理的大鼠在第 14 天行走能力明显改善。从第 14 天开始，OA 组大鼠的握力出现下降，而 S（+）-氯胺酮在第 21 天起到了抑制作用。结论低剂量的S（+）-氯胺酮能减轻MIA诱发的OA疼痛，但不能逆转滑膜组织病理学变化。

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The effect of low dose intra-articular S(+) ketamine on osteoarthritis in rats: an experimental study

Background

This study aimed to investigate the analgesic impact of S(+)-ketamine on pain behavior and synovial inflammation in an osteoarthritis (OA) model.

Methods

Animals were grouped as follows: OA-Saline (n = 24) and OA-Ketamine (n = 24), OA induced via intra-articular sodium monoiodoacetate (MIA); a Non-OA group (n = 24) served as the control. On the 7^th day post OA induction, animals received either saline or S(+)-ketamine (0.5 mg.kg⁻¹). Behavioral and histopathological assessments were conducted up to day 28.

Results

S(+)-ketamine reduced allodynia from day 7 to 28 and hyperalgesia from day 10 to 28. It notably alleviated weight distribution deficits from day 10 until the end of the study. Significant walking improvement was observed on day 14 in S(+)-ketamine-treated rats. Starting on day 14, OA groups showed grip force decline, which was countered by S(+)-ketamine on day 21. However, S(+)-ketamine did not diminish synovial inflammation.