The Orthopedic clinics of North America最新文献_第3页

Symposium on metabolic bone disease. 代谢性骨病研讨会。

The Orthopedic clinics of North America Pub Date : 1983-10-01 DOI: 10.1177/003693308302800419

G. Beastall, M. A. Bell, J. Fyffe, M. D. Gardner, V. A. Moss

{"title":"Symposium on metabolic bone disease.","authors":"G. Beastall, M. A. Bell, J. Fyffe, M. D. Gardner, V. A. Moss","doi":"10.1177/003693308302800419","DOIUrl":"https://doi.org/10.1177/003693308302800419","url":null,"abstract":"of Short Papers INVESTIGATION OF BONE MINERALISATION USING TECHNIQUES FOR ELEMENTAL MICROANALYSIS AND IMAGE ANALYSIS WITH TIlE ELECfRON MICROSCOPE. D. W. Dempster, H. Y. Elder, V. A. Moss, W. A. P. Nicholson, D. A. Smith, Departments of Physiology, Natural Philosophy and Medicine (Western Infirmary), University ofGlasgow. Advances in solid state physics have permitted the combination of x-ray elemental analysis with the high special resolution of transmission electron microscopy. Ultra-rapid cooling techniques and anhydrous preparation routes can preserve fiffusible substances including electrolytes in their in vivo locations. Fully quantitative analyses can be obtained from ultrathin sections of mineralized tissue using the Hall continuum normalization method. We have shown that mineralization failure in the osteoid of osteomalacic rats is caused not by a failure to accumulate adequate Ca or P but probably by a failure of mineral release (1). Simple and rapid methods are now also available for preparation of relatively large areas of bone mineral surface for scanning electron microscopy and a number of forming and eroding mineral surface types have been characterised. Using image analysis, quantitative ·discrimination between normal and pathological mineral surfaces is possible (2) and automated computer texture recognition is now being developed. References 1 Dempster DW, Elder HY, Nicholson WAP, Smith DA. Microprobe analysis of calcium and phosphorus levels in rachitic rate osteoid. J PhysioI1980; 300:67. 2 Dempster DW, Elder HY, Smith DA. Scanning electron microscopy of rachitic rate bone. Scan Electron Microsc. 1979;2:513-520. CLINICAL EXPERIENCE OF OSTEOMALACIA IN GLASGOW. L. M. Matheson, J. Henderson, W. B. McIntosh, M. G. Dunnigan, Department of Medicine, Stobhill General Hospital, Glasgow. The present study had two parts: a) a review of eighteen Asian female patients admitted to Glasgow hospitals between 1973-83. b) a biochemical screening of 220 randomly selected Asian women aged 21 to 60 years. Twentv seven women had evidence of osteomalacia: nine ~ith biochemical evidence only were found on screening. Eight Hindu/Sikh women had severe disease with positive aetiology; seven were lactovegetarians. No severe bone disease was found in Moslems. An assessment of sunlight exposure showed no significant difference between religious groups and no correlation was made with the occurrence of osteomalacia. A seven day weighed dietary survey of 100 women showed a correlation between osteomalacia and lactovegetarianism; the chapatti content of the diets was uniform. Although osteomalacia has a multifactorial aetiology, our conclusion is that, in the adult Asian female population in Glasgow, severe disease is found in lactovegetarians i.e. Hindu/Sikh women. We hypothesise that there may be as yet undetected vitamin D in animal products exerting a protective effect against osteomalacia. STUDIES WITII BONE-SEEKING ISOTOPES. D. A. S. Smith and M. Forwe","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126199947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}