Cervical Cancer - A Global Public Health Treatise [Working Title]最新文献

The Importance of the Extracellular Matrix in HPV-Associated Diseases 细胞外基质在hpv相关疾病中的重要性

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-09-28 DOI: 10.5772/intechopen.99907

J. Sampaio, J. Ferreira, Ana Carolina Santos, M. Bicho, M. Clara Bicho

引用次数: 4

Cervical Cancer Elimination by 2030: The “SMASH” Strategy of Raj © A Global Public Health Treatise 到2030年消除宫颈癌:拉吉的“SMASH”战略©全球公共卫生专著

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-09-05 DOI: 10.5772/intechopen.99949

R. Rajkumar

{"title":"Cervical Cancer Elimination by 2030: The “SMASH” Strategy of Raj © A Global Public Health Treatise","authors":"R. Rajkumar","doi":"10.5772/intechopen.99949","DOIUrl":"https://doi.org/10.5772/intechopen.99949","url":null,"abstract":"Cervical cancer is a leading cancer among women, being the second most gynecological cancers in the developing countries, accounting for about 6 million new cases every year and 3.5 million deaths. The Cervical cancer is easily detectable by simple screening tests, like visual inspection methods, pap smear examination, and the recent HPV DNA test methods. If the precancer conditions are diagnosed, treatment can be done by ablation or excisional methods. The women can be followed by periodic cervical biopsy examinations, ideally once in 6 months for 3 years. If, at the end of 3 years, there is no evidence of cervical precancer, then the women will not develop invasive cancer stages. The HPV vaccination of adult and adolescent girls, offer more than 90% protection against Cervical Cancer. Thus, Cervical cancers are early detectable, effectively treatable and successfully preventable. The author, having been the Principal Investigator for one of the largest Cervical Cancer Screening programs in India, atAmbillikai, Tamil Nadu, India, during 2000–2007, which was in collaboration with the International Agency for Research on Cancer – IARC / WHO. The program was successful in reducing the Incidence Rate of Cervical Cancer by 25% and Mortality Rate due to Cervical Cancer, by 35% in a span of 5 years. From the experiences of this “Proof of Concept” project, the author has advocated, “SMASH” strategy of Raj©, for Cervical Cancer Elimination by 2030, which is deliberated in detail, i n this chapter. Hope that, this will serve as a Global Public Health Treatise, for the health care planners and providers in particular and the community at large, worldwide.","PeriodicalId":321318,"journal":{"name":"Cervical Cancer - A Global Public Health Treatise [Working Title]","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132706634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Cancer Prevention and Control 子宫颈癌预防及控制

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-09-01 DOI: 10.5772/intechopen.99620

Tariku Laelago Ersado

引用次数: 0

Insights of Cisplatin Resistance in Cervical Cancer: A Decision Making for Cellular Survival 宫颈癌顺铂耐药的见解:细胞生存的决策

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-08-03 DOI: 10.5772/intechopen.98489

Elizabeth Mahapatra, Salini Das, Souvick Biswas, Archismaan Ghosh, D. Sengupta, M. Roy, S. Mukherjee

引用次数: 2

Human Papillomavirus and Cervical Cancer 人乳头瘤病毒和子宫颈癌

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-07-29 DOI: 10.5772/intechopen.98490

Saliha Sağnıç

{"title":"Human Papillomavirus and Cervical Cancer","authors":"Saliha Sağnıç","doi":"10.5772/intechopen.98490","DOIUrl":"https://doi.org/10.5772/intechopen.98490","url":null,"abstract":"Cervical cancer is one of the leading female cancers especially in developing countries and a common cause of death among middle-aged women. The main role of Human Papillomavirus (HPV) in both cervical cancer and pre-invasive lesions of the cervix has been proven in studies. Reducing the incidence of the disease can be achieved by the regular cervical screening of women and vaccination of appropriate age groups. The disease can be better controlled by better elucidating the details of HPV carcinogenesis, the interaction between the host and the virus, and determinants of the systemic and cellular immune response to the viral infection. HPV causes oropharyngeal and anogenital diseases in both men and women and is usually sexually transmitted. Most infections are transient and could be cleared spontaneously by the host immune system. After the first encounter with HPV infection, it takes years to progress to cervical cancer, which gives clinicians a long period to follow these patients in terms of precancerous lesions and to investigate the pathogenesis of the disease. HPV plays a major role in the development of cervical cancer, but histological types have different relationships with HPV genotypes. HPV can remain latent for a long time and the most important thing determining the persistence is the type of HPV. HPV vaccination provides a direct benefit to both men and women by providing safe protection against cancers that may result from persistent HPV infection.","PeriodicalId":321318,"journal":{"name":"Cervical Cancer - A Global Public Health Treatise [Working Title]","volume":"264 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123017538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Presence of HPV in Dental Calculus: It’s Role in Pathogenesis of Oral and Cervical Cancer HPV在牙结石中的存在:它在口腔癌和宫颈癌发病中的作用

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-06-18 DOI: 10.5772/intechopen.98347

Sunardhi Widyaputra, Natallia Pranata, Ignatius Setiawan, Jamas Ari Anggraini

{"title":"The Presence of HPV in Dental Calculus: It’s Role in Pathogenesis of Oral and Cervical Cancer","authors":"Sunardhi Widyaputra, Natallia Pranata, Ignatius Setiawan, Jamas Ari Anggraini","doi":"10.5772/intechopen.98347","DOIUrl":"https://doi.org/10.5772/intechopen.98347","url":null,"abstract":"Human papillomavirus (HPV) infection accounts for approximately 5.2% of the worldwide human cancer burden. Molecular epidemiologic evidence clearly indicates that certain types of HPV are the principal cause of both cervical and oral cancers. Major oncoproteins E6 and E7 can inactivate p53 and pRB proteins because it happened genome instability and dysregulation host cell cycles. This virus is an epithelial tropism, vulnerable area mainly at the basal layer and epithelial stem cell, because it still has a high proliferation capacity, so it can support the replication of the virus. Virions bind initially to the glycosaminoglycan (GAG) chains of heparan sulphate proteoglycan (HSPG). More than 99% cervical cancer arise at the cervical transformation zone. In oral cavity, exposed areas of the basal layer will be very susceptible to HPV infection. The HPV presence in the oral area is considered as one of the etiologics of oral cancer in those who do not have bad habits such as smoking, betel chewing, or poor oral hygiene. Our study successfully identified HPV type 58 in dental calculus. Dental calculus, calcified oral plaque biofilm, has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, including bacteria, archaea, eukaryote, and viruses. During biomineral maturation process, several biological contents around the oral region should be trapped, including the exfoliated virus contained cells. Dental calculus is a promising source of HPV and carcinogens molecules in the oral cavity and could be used as a biomarker for early detection.","PeriodicalId":321318,"journal":{"name":"Cervical Cancer - A Global Public Health Treatise [Working Title]","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124101366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventing Human Papilloma Virus through Community Education and Vaccination 通过社区教育和疫苗接种预防人类乳头瘤病毒

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-05-31 DOI: 10.5772/INTECHOPEN.98350

C. Baldwin, Lisa Rinke

{"title":"Preventing Human Papilloma Virus through Community Education and Vaccination","authors":"C. Baldwin, Lisa Rinke","doi":"10.5772/INTECHOPEN.98350","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.98350","url":null,"abstract":"Human Papilloma Virus (HPV) affects many members of the community. To better educate the community in a participatory manner, engaging those outside of the health care arena is necessary. To prevent the spread of the disease in the United States, reaching the parents of children at the vulnerable age of 9–11 years of age is critical. The barriers to education of parents and children around the spread of a sexually transmitted disease are vast and difficult to overcome. However, the use of proven vaccinations give healthcare providers and community advocates the main tool for prevention of the spread of the disease. It is often taboo to discuss anything related to sexual promiscuity or sexual activity in the United States in the public schools. The biggest myth includes the fear parents and grandparents have is that if HPV is talked about, then the child may become sexually active sooner. This myth needs to be challenged with science and reality including taking on the those vehemently opposed to vaccines, known as “Anti-Vaxers” that obstruct vaccine education. The strategies utilized in public health outreach to the community should be reviewed and uniquely developed for each diverse community to overcome the challenges in the prevention of HPV.","PeriodicalId":321318,"journal":{"name":"Cervical Cancer - A Global Public Health Treatise [Working Title]","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114608508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of AI in Cervical Cancer Screening 人工智能在子宫颈癌筛查中的作用

Cervical Cancer - A Global Public Health Treatise [Working Title] Pub Date : 2021-05-29 DOI: 10.5772/intechopen.98348

B. Turic, Sun Xiaorong, Wang Jian, Baochang Pang

引用次数: 2