Journal of Oncological Sciences最新文献_第8页

Benefits of Neoadjuvant Chemotherapy for Luminal Breast Cancer with Respect to Tumor Response 新辅助化疗对腔内乳腺癌肿瘤反应的益处

Journal of Oncological Sciences Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-75852

Bala Başak Öven, S. Çelik, G. Gürleyik, F. Vardar, E. Çoban, M. Seker, I. Okten, A. Aktekin

引用次数: 0

Subclinical Hypothyroidism in Patients with Newly Diagnosed Breast Cancer 新诊断乳腺癌患者的亚临床甲状腺功能减退

Journal of Oncological Sciences Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-79561

M. Kara, Oyku Beyaz, E. Koç, O. Sonmez

{"title":"Subclinical Hypothyroidism in Patients with Newly Diagnosed Breast Cancer","authors":"M. Kara, Oyku Beyaz, E. Koç, O. Sonmez","doi":"10.37047/JOS.2020-79561","DOIUrl":"https://doi.org/10.37047/JOS.2020-79561","url":null,"abstract":"become the most common malignant disease, with two million new cases and more than 600,000 deaths in 2018, making it vital to identify the associated risk factors.1,2 Many earlier studies have attempted to assess an association between thyroid disease and breast cancer, but it is difficult to distinguish a cause-and-effect relationship between the two conditions despite their high prevalence in women.3 The relation between hypothyroidism and the risk of breast cancer was first published in 1976 by Kapdi and Wolfe, who observed a higher breast cancer incidence rate among patients undergoing thyroid supplement treatment.4 Since then, four metaanalyses have studied thyroid dysfunction and the risk of breast cancer.5-8 Angelousi et al. examined 12 studies and found no association between hypothyroidism and increased risk of breast cancer, five and further suggested that thyroid hormone replacement therapy did not reduce the prevalence of breast cancer. In a later metaanalysis, Fang et al. reported no relationship between thyroid dysfunction and risk of breast cancer, while Wang et al. found a reduced risk of breast cancer due to hypothyroidism in the European population.7,8","PeriodicalId":31838,"journal":{"name":"Journal of Oncological Sciences","volume":"7 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69819770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pericatheter Fibrin Sheath Calcification Mimicking Retained Catheter Fragment 导管周围纤维蛋白鞘钙化模拟保留导管碎片

Journal of Oncological Sciences Pub Date : 2021-01-01 DOI: 10.37047/jos.2020-80449

F. Çay, G. Eldem, B. Peynircioğlu

引用次数: 0

Evaluation of Smoking Status of Cancer Patients Admitted to the Nuclear Medicine Department According to the Demographic Characteristics and Cancer Type 根据人口学特征和肿瘤类型对核医学住院肿瘤患者吸烟状况的评价

Journal of Oncological Sciences Pub Date : 2021-01-01 DOI: 10.37047/jos.2021-84128

S. Göksel, D. Karadoğan

引用次数: 0

Sleep Quality of Cancer Patients Receiving Systemic Treatment: A Cross-Sectional Study 接受系统治疗的癌症患者睡眠质量:一项横断面研究

Journal of Oncological Sciences Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-71898

N. Sanlier, M. Şahin, A. Demirkazık, Asiye Özkan, F. Senler

引用次数: 5

Deciphering the Role of Combination Therapy of Cobimetinib, Vemurafenib, and Antidepressant Drugs in QTc Prolongation and Torsade De Pointes (TDP) in Malignant Melanoma 解读Cobimetinib, Vemurafenib和抗抑郁药物联合治疗在恶性黑色素瘤QTc延长和TDP中的作用

Journal of Oncological Sciences Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-73730

A. Paudel, O. Mammadov, Özlem Sönmez

{"title":"Deciphering the Role of Combination Therapy of Cobimetinib, Vemurafenib, and Antidepressant Drugs in QTc Prolongation and Torsade De Pointes (TDP) in Malignant Melanoma","authors":"A. Paudel, O. Mammadov, Özlem Sönmez","doi":"10.37047/jos.2020-73730","DOIUrl":"https://doi.org/10.37047/jos.2020-73730","url":null,"abstract":"combination of MEK inhibitors (cobimetinib and trametinib), and BRAF inhibitors (vemurafenib and dabrafenib) is now considered as the first-line treatment of patients with BRAF V600-mutated metastatic melanoma. The common side-effects of BRAF inhibitors are cutaneous toxicity, nephrotoxicity, and cardiotoxicity.1 In a previous clinical study, the combined administration of vemurafenib and cobimetinib has been associated with cardiotoxicity (heart failure) and QTc prolongation, that persisted after the discontinuation of therapy but returned to normal after six months. The patient was discharged with an implantable intracardiac defibrillator (ICD) for safety.2 Most TKIs significantly increase the QT interval, while the incidence of arrhythmias was noted highest in vemurafenib.3 Additionally, vemurafenib might induce severe acute renal failure, including persistent renal injury.4 Though, the result from the previous clinical study which was based on 38 patients, showed that the adjunction of MEK inhibitor to vemurafenib in the treatment of metastatic melanoma reduces the incidence and severity of nephrotoxicity compared to monotherapy in a study of 38 patients, while a phase IB dose-escalation study of the cobimetinib and duligotuzumab showed that the 26% of the patients experienced hypokalemia, further indicating cobimetinib which might have some adverse effects on the renal tubular system.5,6 J Oncol Sci.2020;6(2):123-6","PeriodicalId":31838,"journal":{"name":"Journal of Oncological Sciences","volume":"6 1","pages":"123-126"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69817535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Turkish Medical Oncology Society COVID-19 Pandemic Advisory Board Recommendations for Cancer Patients and Medical Oncologist 土耳其医学肿瘤学会COVID-19大流行咨询委员会对癌症患者和医学肿瘤学家的建议

Journal of Oncological Sciences Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-75364

A. Sümbül, Ş. Yalçın, A. Özet, S. Ünal, O. Dizdar, H. Akbulut, A. Karaoglu, N. Karadurmuş, M. Şendur, E. Çılbır, F. Yıldız, G. Tufan, O. Sonmez, N. Turhal

引用次数: 4

Optimal Cytoreduction is an Independent Prognostic Factor in Ovarian Carcinosarcoma: A Turkish Gynecologic Oncology Group Study 最佳细胞减少是卵巢癌肉瘤的独立预后因素:土耳其妇科肿瘤组研究

Journal of Oncological Sciences Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-73073

A. Ayhan, I. Çiçin, A. Gökyer, M. Sarı, A. Turan, S. Taşkın, K. Gungorduk, O. Akbayir, P. Saip, H. Şahin, G. Çoban, S. Topuz, I. Selcuk, G. Tulunay, M. Meydanlı

引用次数: 0

Epidemiology of Lung Cancer in Women: A Hospital-Based Descriptive Study 女性肺癌流行病学:一项基于医院的描述性研究

Journal of Oncological Sciences Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-73409

Ö. Er, Didem Saka, Elif Özuğuz

引用次数: 0

The Impact of Loneliness and Cancer Diagnosis on Cognitive Impairment in Geriatric Patients 孤独感与癌症诊断对老年患者认知功能障碍的影响

Journal of Oncological Sciences Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-71889

A. Alkan, H. S. Öztorun, E. Karci, Y. Urun, G. Tuncay, A. Yaşar, E. Çınar, S. Aras, M. Varlı, G. Utkan, A. Demirkazık, H. Akbulut, F. Senler

{"title":"The Impact of Loneliness and Cancer Diagnosis on Cognitive Impairment in Geriatric Patients","authors":"A. Alkan, H. S. Öztorun, E. Karci, Y. Urun, G. Tuncay, A. Yaşar, E. Çınar, S. Aras, M. Varlı, G. Utkan, A. Demirkazık, H. Akbulut, F. Senler","doi":"10.37047/jos.2019-71889","DOIUrl":"https://doi.org/10.37047/jos.2019-71889","url":null,"abstract":"experience or feeling that results from inadequacies in personal or social requirements. It principally originates from differences between the desired and actual social relations.1 Its prevalence increases linearly with age, and thus, is found in up to 50% of geriatric patients.2 Geriatric patients are more exposed to loneliness; hence, this subject has been studied more extensively in the geriatric patient group. Female geriatric patients have been documented to be at higher risk of loneliness due to factors such as being single/widowed, older age, low educational status, low household income, living alone, decreased quality of social interactions, poor health, and decreased functional status.3 In addition, the presence of depression has been associated with increased loneliness.4,5 Studies on the clinical effects of loneliness on geriatric patients have shown that loneliness is associated with mental health issues, reduced sleep quality, decreased quality of life, increased hospitalizations, and increased mortality.6-9 In addition, loneliness has been associated with cognitive dysfunction and Alzheimer’s disease.10-13 J Oncol Sci.2020;6(2):65-70","PeriodicalId":31838,"journal":{"name":"Journal of Oncological Sciences","volume":"6 1","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69817464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0