T. Ćebović, J. Vladić, Aleksandra Gavarić, Z. Zeković, S. Vidovic
{"title":"Assessment of antioxidant and hepatoprotective potential of Satureja montana extracts against CCl4 induced liver damage","authors":"T. Ćebović, J. Vladić, Aleksandra Gavarić, Z. Zeković, S. Vidovic","doi":"10.5937/LEKSIR1939005C","DOIUrl":"https://doi.org/10.5937/LEKSIR1939005C","url":null,"abstract":"The influence of Satureja montana extracts on several liver biochemical parameters in mice administered with carbon tetrachloride was estimated. In vivo investigation of antioxidant properties of S. montana extracts encompassed monitoring of biochemical parameters (derived from liver homogenate and blood hydrolyzate) and examination of potential hepatoprotective effect after intoxication with carbon tetrachloride. Biochemical tests included determination of activity of several antioxidant enzymes: xanthine oxidase, catalase, peroxidase, glutathione peroxidase, amount of reduced glutathione and intensity of lipid peroxidation. In order to obtain data about the potent hepatoprotective effect of examined extracts, the following parameters were determined: aspartate aminotransferase, alanine aminotransferase, bilirubin, hepatic DNA and hydroxyprolin. Results of this study demonstrate that S. montana extracts inhibited the hepatotoxicity produced by carbon tetrachloride administration most probably through activation of physiological common defense mechanisms.","PeriodicalId":31829,"journal":{"name":"Lekovite Sirovine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43160106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Aćimović, M. Todosijević, A. Varga, Biljana Kiprovski, V. Tešević, I. Čabarkapa, V. Sikora
{"title":"Bioactivity of essential oils from cultivated winter savory, sage and hyssop","authors":"M. Aćimović, M. Todosijević, A. Varga, Biljana Kiprovski, V. Tešević, I. Čabarkapa, V. Sikora","doi":"10.5937/leksir1939011a","DOIUrl":"https://doi.org/10.5937/leksir1939011a","url":null,"abstract":"Species of the Lamiaceae family have enjoyed a rich tradition of use for flavoring, food preservation, and medicinal purposes, due to their curative and preventive properties. Cultivated winter savory ( Satureja montana L.), sage ( Salvia officinalis L.) and hyssop ( Hyssopus officinalis L.) are produced for seed, herb, and essential oil. Dominant compounds in S. montana essential oil were carvacrol (43.2%) and thymol (28.4%), while cis -thujone (27.1%) and camphor (19.3%), followed by trans -thujone and 1,8-cineole were the major compounds in S. officinalis essential oil. As for H. officinalis essential oil, cis - and trans -pinocamphone (41.1% and 20.5%, respectively) were the most abundant compounds, followed by β-pinene. The highest antimicrobial properties, as well as antioxidant capacity, showed S. montana essential oil compared to other tested essential oils. Furthermore, H. officinalis essential oils showed higher antioxidant activity than that of S. officinalis . The aim of this investigation was to determine the composition and bioactivity of essential oils of mentioned varieties. Presented results show that S. montana essential oil could be proposed as a valuable source of natural preservatives.","PeriodicalId":31829,"journal":{"name":"Lekovite Sirovine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41751739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}