Journal of V N Karazin Kharkiv National University Series Medicine最新文献

{"title":"MODERN FEATURES OF CHICKEN POX COURSE IN ADULTS","authors":"O. Volobuieva, T. Liadova, T. Sevastianova, D. Volobuiev","doi":"10.26565/2313-6693-2018-36-07","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-07","url":null,"abstract":"The article presents the epidemiological and clinical data of the modern course of chickenpox. A high incidence among adults with a bright manifestation of the clinical picture was shown. Recurrent episodes of chicken pox were marked. The modern course of varicella in Ukraine is characterized by an increase in the incidence among the adult population. Infection is manifested by a long prodromal period, a pronounced intoxication syndrome, lymphadenopathy, and an abundant polymorphic rash. At the same time, the rash had a pustular character in 54.3 % of patients; exanthema was observed with scleritis and conjunctivitis in 45 % of cases. There are repeated cases of chickenpox, the interval between these episodes ranged from 5 to 12 years. Taking into account the epidemiological situation in the country it remains relevant to study main features of the course of chickenpox in individuals against the background of pulmonary tuberculosis, depending on the age and duration of the underlying disease.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"38 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78363622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FUNCTIONAL CLASSES AND CLINICAL CHARACTERISTICS OF CHRONIC HEART FAILURE IN PATIENTS WITH ATRIAL FIBRILLATION AND/OR FLUTTER AFTER RADIOFREQUENCY ABLATION","authors":"T. Zolotarova, M. Brynza, M. I. Yabluchanskiy","doi":"10.26565/2313-6693-2018-35-11","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-35-11","url":null,"abstract":"The combination of atrial fibrillation and/or flutter and chronic heart failure is a frequent problem for many patients. Radiofrequency ablation is effective in the strategy for controlling the rhythm of patients with atrial fibrillation and/or flutter, but always requires concomitant therapeutic support. The study involved 70 patients with atrial fibrillation and/or flutter after radiofrequency ablation which were divided into groups according to the functional class of chronic heart failure. Gender and age of patients; types of ischemic heart disease; stages of chronic heart failure; degrees of arterial hypertension; the form of atrial fibrillation and flutter; class EHRA; the presence of diabetes mellitus type 1 or 2 we evaluated. The female sex prevailed in the group of II functional class of chronic heart failure than in I functional class or III functional class. Ischemic heart disease, first of all angina of effort, in patients with III functional class of chronic heart failure was significantly more frequent. In group of III functional class of chronic heart failure there were significantly more patients with 3 degrees of arterial hypertension. Male patients, regardless of functional class of chronic heart failure, more often than females are conducted invasive methods of treatment for atrial fibrillation/flutter. With increasing of functional class of angina the functional class of chronic heart failure is increasing. Among patients II and III functional class of chronic heart failure prevails the arterial hypertension III degree, which may be a predictor of adverse prognosis.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"8 1","pages":"72-77"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82112553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIAGNOSTICS OF INFLAMMATORY INSIDE THE PLEURAL COMPLICATIONS OF THORACIC INJURY","authors":"E. V. Kosov, O. Rozhkova, Victor Veklych, Nikita Barsukov","doi":"10.26565/2313-6693-2018-36-02","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-02","url":null,"abstract":"The non-specificity of the clinical signs of posttraumatic purulent thoracic complications indicates the importance of instrumental diagnostic methods. There is no generally accepted algorithm for examining an injured person with a chest injury that would allow timely recognition of purulent complications in the posttraumatic period. The results of the examination of patients with intra-pleural complications of thoracic injury using the spiral computed tomography method, which in dynamics allows objectively documenting the dynamics of the pathological process, evaluating the effectiveness of treatment, timely diagnose secondary complications, are presented. Тhe analysis of the results of the study indicates the need for a comprehensive examination of suspected post-traumatic intra pleural thoracic complications. In the presence of any manifestations of systemic inflammatory response in the posttraumatic period in patients with chest lesions, regardless of the results of the X-ray examination, ultrasound examination and computed tomography of the chest should be performed, which allows to detect the accumulation of pathological contents in the pleural and pericardial cavity, to assess the nature changes in the pulmonary tissue, mediastinum, thoracic wall and decide on the drainage of lesions fester. At the same time, for the correct interpretation of some changes in spiral computed tomography, including the lung abscess that developed in the background of pulmonary hemorrhages and mediastinitis against the background of hemorrhages in the mediastinum and pneumomediastinum, it is necessary to compare them with the baseline data. This testifies to the necessity of performing an early spiral computed tomographic examination in patients with chest lesions in the presence of any focal changes on the review X-ray. Spiral computer tomography of the chest in dynamics allows to objectively document the dynamics of the pathological process, evaluate the effectiveness of treatment, timely diagnose secondary complications. The application of this algorithm allows to diagnose the entire spectrum of intra-pleural complications in the early stages and to avoid diagnostic errors","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"7 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74489434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AUTOLOGOUS PLATELET‐RICH PLASMA: A REVIEW OF SCIENTIFIC ARTICLES ON THE STUDY OF EFFICIENCY IN TREATMENT OF ANDROGENETIC ALOPECIA IN MEN AND WOMEN","authors":"Julia V. Ovcharenko, Olena Salenkova","doi":"10.26565/2313-6693-2018-36-11","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-11","url":null,"abstract":"This article is an analysis of scientific publications that reflect the experience of using autologous plateletrich plasma in patients with androgenic alopecia (AGA), a multifactorial genetically predisposed disease caused by the influence of exogenous or endogenous triggers responsible for the clinical manifestations of pathology. Attention to this topic is due to the significant prevalence of AGA, as well as unsatisfactory results in achieving a positive therapeutic effect. Positive results were obtained during the 12 clinical studies among the conducted ones, no positive dynamics were observed in the end of other 2 studies. It can be noted that different methods and parameters of centrifugation were used to perform these experiments: PRP used differ or PRP activators were not used at all, variations were observed in methods for evaluating the obtained results, the multiplicity of procedures and intervals between them, the procedure technique (using a mezoroller, anesthetics, injections, etc.). Studies with a negative result were characterized by the smallest number of procedures performed (1 or 2 procedures), and methods for evaluating the results cannot be called sufficiently reliable (a magnifying glass). It is obvious that the use of PRP has a positive effect on the state of AGA and can be used with approved methods of this disease treatment. However, the published results of only a small number of clinical trials on the effectiveness of PRP for hair growth cannot be considered objective. In addition, there is no published agreed protocol for the standard use of PRP, and the use of growth factors and stimulants in the expression of their genes still requires comparative evaluation with preparations approved for the treatment of hair. Thus, the method of PRP using can be considered as a method of treating AGA, however, it is necessary to continue research for further study and standardization of this technique.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"71 1","pages":"72-79"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76416683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS","authors":"M. Shustval, T. Liadova, O. Volobuieva, K. Pavlikova, A. Gamilovska","doi":"10.26565/2313-6693-2018-36-05","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-05","url":null,"abstract":"The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes. Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood. The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis. The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"6 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88886381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PATTERN-RECOGNIZING RECEPTORS AND THE INNATE IMMUNE RESPONSE TO VIRAL INFECTION","authors":"Ksenia Veklich","doi":"10.26565/2313-6693-2018-36-13","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-13","url":null,"abstract":"The innate immune response to viral pathogens is crucial in mobilizing defensive reactions of an organism during the development of an acute viral infection. Cells of the innate immunity system detect viral antigens due to genetically programmed pattern-recognition receptors (PRRs), which are located either on the cell surface or inside the certain intracellular components. These image-recognizing receptors include Toll-like receptors (TLRs), retinoic acid-inducible gene I-like receptors (RIG-I-like receptors), nucleotide oligomerization domain-like receptors (NOD-like receptors), also known as NACHT, LRR and PYD domains of the protein, and cytosolic DNA sensors. The trigger mechanisms for these receptors are viral proteins, and nucleic acids serve as activators. The presence of PRRs that are responsible for the determination of viral antigens in cellular components allows the cells of innate immunity to recognize a wide range of viral agents that replicate in various cellular structures, and develop an immune response to them. This article summarizes the disparate data presented in modern English literature on the role of PRRs and the associated signaling pathways. Understanding the recognition of viral pathogens required triggering a cascade of cytokine and interferon production provides insights into how viruses activate the signal paths of PRRs and the effect of the interaction of viral antigens and these receptors on the formation of the antiviral immune response.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"208 1","pages":"96-103"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76047373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOGENOUS RETROVIRUSES AS GENETIC MODULES THAT SHAPE THE GENOME REGULATORY NETWORKS DURING EVOLUTION","authors":"Mikola Popov, T. Kolotova, M. Davidenko","doi":"10.26565/2313-6693-2018-36-12","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-12","url":null,"abstract":"Endogenous retroviruses (ERV) are the descendants of exogenous retroviruses that integrated into the germ cells genome, fixed and became inheritable. ERVs have evolved transcriptional enhancers and promoters that allow their replication in a wide range of tissue. Because ERVs comprise the regulatory elements it could be assume that ERVs capable to shape and reshape genomic regulatory networks by inserting their promoters and enhancers in new genomic loci upon retrotransposition. Thus retroransposition events can build new regulatory regions and lead to a new pattern of gene activation in the cell. In this review we summarize evidence which revealed that ERVs provide a plethora of novel gene regulatory elements, including tissue specific promoters and enhancers for protein-coding genes or long noncoding RNAs in a wide range of cell types. The accumulated findings support the hypothesis that the ERVs have rewired the gene regulatory networks and act as a major source of genomic regulatory innovation during evolution.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"132 1","pages":"80-95"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79636796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARAMETERS OF THE HEMODYNAMIC AFTER ABLATION ATRIAL FIBRILLATION AND/OR FLUTTER DEPENDING ON THE FUNCTIONAL CLASS OF CHRONIC HEART FAILURE","authors":"T. Zolotarova, O. Bilchenko","doi":"10.26565/2313-6693-2018-36-08","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-08","url":null,"abstract":"Evaluated parameters of the hemodynamic before and after ablation atrial fibrillation and/or flutter depending on the functional class of chronic heart failure in 74 patients. It was found that patients with the I functional class of chronic heart failure have significantly lower left atrium size compared to III functional class, which is associated with the better efficiency of the radiofrequency ablation in the remote period. Patients with the I and III functional class of chronic heart failure are having increasement of QTc duration in acute period of radiofrequency ablation that could be used as an independent predictor of arrhythmia recurrence. Patients with the I functional class chronic heart failure who failed drug therapy for atrial fibrillation and/or flutter alternative treatment in the form of the radiofrequency ablation should be considered as choice therapy. The levels of heart rate and pulse decreases in I and III functional class of the chronic heart failure in the acute period radiofrequency ablation; systolic and diastolic blood pressure, QRS, left ventricle end-diastolic and left ventricle end-systolic diameter do not change after radiofrequency ablation. Patient I and III functional class of the chronic heart failure are having increasement of QTc duration in acute period of radiofrequency ablation that could be used as an independent predictor of arrhythmia recurrence. Patients with I functional class of the chronic heart failure have significantly lower left atrium size compared to III functional class of the chronic heart failure, which is associated with the best outcome of effectiveness of radiofrequency ablation in the late period.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"33 1","pages":"52-57"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78681068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UNIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA AS A POTENTIAL PREDICTOR OF ARTERIAL HYPERTENSION DEVELOPMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS","authors":"L. Sherstyuk, Y. Nikolenko","doi":"10.26565/2313-6693-2018-36-04","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-04","url":null,"abstract":"The article presents the results of studies of markers of connective tissue dysplasia and the content of the main fibroblast growth factor in blood plasma in patients with type 2 diabetes. The presence of significant correlations between the studied parameters with the occurrence and progression of hypertension in patients with type 2 diabetes is established. A regression model for predicting the development of arterial hypertension is proposed in patients with diabetes mellitus. The development of hypertension in patients with DM type 2 in combination with UCTD occurs earlier, is almost independent of the duration of diabetes, more pronounced hypertension is observed in patients with visceral and skeletal symptoms of UCTD. This is evidence of the role of UCTD in the pathogenesis of hypertension in patients with type 2 diabetes. Essential role in the emergence and progression of hypertension in patients with DM type 2 is played by metabolic disorders of the connective tissue that manifests as clinical signs of UCTD. FGF2, which content is increased in patients with visceral and/or skeletal symptoms of UCTD, is involved in its pathogenesis. The regression model of the prediction of hypertension in patients with DM type 2 with an assessment of the presence of UCTD signs and the duration of diabetes has a high prognosticity, specificity and sensitivity, which makes it possible to apply this method in clinical practice to determine patients with high risk of development of hypertension.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"8 3 1","pages":"23-32"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86533987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}