Journal of V N Karazin Kharkiv National University Series Medicine最新文献

{"title":"TO THE PROBLEM OF COMORBIDITY AND SYNTHROPY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE","authors":"T. Ospanova, Z. Semidotskaya, I. Chernyakova, O. Avdeyeva, O. Pionova, N. Tryfonova","doi":"10.26565/2313-6693-2018-35-07","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-35-07","url":null,"abstract":"The study objective is to establish the relationships features between lipid profile and other parameters of homeostasis in case of chronic obstructive pulmonary disease in framework comorbidity with coronary artery disease and arterial hypertension. Materials and methods: the lipid profile, CRP, IgE, НbА1С, FEV1, Tiffno’s index and SpO2 in 35 patients with chronic obstructive pulmonary disease (groups B, C, D), that were studied by standard methods. Results: A large quantity of correlations between different indicators that increased in relation to disease progression and presence of comorbidity was found. Cluster analysis confirmed the affinity between these indicators. Conclusion: A large quantity of correlation links between lipids and other indices of homeostasis and the results of cluster analysis indicate the development of adaptation and disadaptation processes under such circumstances as elevation of hypoxia in chronic obstructive pulmonary disease and these might be evaluated as synthropy of comorbidity with coronary artery disease and arterial hypertension.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"1 1","pages":"46-56"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76178802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical case of Crohn’s disease","authors":"N. Y. Bohun, I. Kushnir, A. Chernyak, S. Belal","doi":"10.26565/2313-6693-2018-35-13","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-35-13","url":null,"abstract":"The article demonstrates a clinical case of Crohn’s disease. The clinical manifestation of the disease, a diagnostic approach based on laboratory and instrumental methods with discussion of obtained results, and the up-to-date methods of investigation based on the literature data are shown. The significance of lifestyle modification, optimal drug treatment and regular check-ups for improvement of prognosis is emphasized. \u0000TreatmentGeneral approach includes smoking cessation; lactose-free diet in case of secondary lactose intolerance which is present in approximately one third of cases; in the case of malabsorption syndrome appropriate replacement of vitamins, calories, protein, zinc, calcium and other nutrients is considered. Treatment bile acid diarrhea includes administration of ion-exchange resins to bind bile acids (e.g., cholestyramine).During acute episodes recommendations to avoid dietary fibers should be given and parenteral nutrition can be prescribed.Our patient received drug therapy: reosorbilact solution 200,0ml during four The goal of treatment of CD is thus to slow the progression of the disease, avoid recurrence of inflammatory episodes and prevent complications which are extremely common in the absence of optimal treatment. Life expectancy is normal and quality of life may be satisfactory with aggressive evidence-based treatment. Majority of patients (approximately 70%) requires surgical operations due to complications within 15years of their onset.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"37 1","pages":"78-83"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84908267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical case of general somatic complaints in 47 Y. O. female","authors":"G. Reng, O. Kanishcheva, N. V. Zhuravka, M. Yabluchansky","doi":"10.26565/2313-6693-2018-35-22","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-35-22","url":null,"abstract":"A clinical case of general somatic complaints in 47 y.o. female, presenting for several years has described. Patient F., presents with uncertain complaints of general character – tiredness, general weakness, loss of energy. During the biennium was examined and treated by gynecologist, endocrinologist, cardiologist, gastroenterologist with no benefit. Anamnesis vita is significant for uterine fibroid. After thorough interviewing was found that patient was done ECG, EchoCG, gastroscopy, thyroid tests but no CBC, urinalysis, general biochemical panel during this two years. The CBC results were stunning and gave answers to all questions.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"52 1","pages":"129-131"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83797633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Failed prehospital fibrinolysis in patient with percutaneous coronary intervention in ST-elevation myocardial infarction","authors":"O. Makharynska, I. Oktiabrova, H. Y. Kartvelishviliy, O. O. Okhryamkina","doi":"10.26565/2313-6693-2018-35-19","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-35-19","url":null,"abstract":"On the example of the clinical case of newly diagnosed ST-elevation myocardial infarction combination of different reperfution strategies and their benefit was discussed. Recommendations on lifestyle modification and medicament treatment tactics are described. From one hand, in spite of side-effects of treatment as an increased risk of stroke and hemorrhagic stroke, prehospital FL is associated with a decreased risk of cardiogenic shock and its effectiveness depends on the time from symptom onset to reperfusion. From other hand, despite the fact that PPCI is the recommended default reperfusion strategy, its effectiveness depends also on time limits and absence of the majority of PPCI-facilated hospitals worldwide. Combination of prehospital single-bolus FL following after 3–24h early routine angiography and PCIcan improve post-STEMI survival and help to avoid hyperreactivity and thrombin-induced platelet activation after FL, which can be a key to success in effective treatment and rehabilitationafter STEMI in patients without high risk factors of potential bleeding or stroke.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"57 1","pages":"113-117"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74456675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral consumption of caffeinated energy drinks affects the morphofunctional state of stress-associated endocrine glands","authors":"M. Tkachenko, G. I. Gubina-Vakylyuk, T. Gorbach, S. A. Denysenko, A. Tkachenko, A. Onishchenko, E. P. Zhurba","doi":"10.26565/2313-6693-2018-35-01","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-35-01","url":null,"abstract":"The aim of the research was to study the features of the morphofunctional state of the pineal gland, neurohypophysis and adrenal medulla, as well as the сontent of serotonin and catecholamine in the blood serum of rats against the background of energy drink administration during two weeks. In animals that consumed energy drinks during two weeks at a dose of 6 ml per kg of body weight, serum serotonin and catecholamine levels were determined. Histological, including morphometric, studies of the epiphysis, posterior pituitary and adrenal medulla were performed. Against the background of energy drink administration, an increase in the content of blood serum serotonin, norepinephrine and epinephrine was detected. The morphofunctional state of the endocrine glands investigated in the present study is strongly stimulated. Indirect signs of apoptosis of parenchymal cells in the pineal gland, neurohypophysis and adrenal medulla were established. The studied stress-associated endocrine glands in animals against the background of the two-week intake of energy drinks have signs of a sharp stimulation of hormone production (serotonin, norepinephrine, epinephrine, and vasopressin). \u0000Oral consumption of energy drinks during two weeks by experimental animals led to morphological changes in the pineal gland (prevalence of indolamine-producing pinealocytes), an increased load on these cells and probably their faster and frequent apoptosis. The number of pinealocytes in the pineal gland decreases and their morpho-functional load increases.2. Short-term administration (14 days) of caffeinated energy drinks affects the morphofunctional state of posterior pituitary, which can be highly likely interpreted as a result of overproduction of vasopressin.3. Overproduction of serotonin by pynea-locytes and catecholamine by adrenal glands is confirmed by their higher levels in blood serum of animals after the two-week-long intake of energy drinks compared to the control group.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"3 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82625336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIOVASCULAR PATIENT WITH PERMANENT PACEMAKER DUE TO COMPLETE ATRIOVENTRICULAR BLOCK","authors":"D. Oladipo, J. Swanzy-Krah, M. V. Pochinska","doi":"10.26565/2313-6693-2018-35-20","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-35-20","url":null,"abstract":"Permanent pacemaker implantation and medical therapy due to complete atrioventricular block and comorbid cardiac pathology are considered at an example of clinical case. Permanent pacemaker solved the problem of AV-block, however, drug therapy due to arterial hypertension, heart failure and dyslipidemia is not canceled and requires modification. \u0000Permanent pacemaker solved the problem of AV-block, however, drug therapy due to arterial hypertension, heart failure and dyslipidemia is not canceled and requires modification.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"89 1","pages":"118-121"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77205525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CANDIDA ALBICANS AND STAPHYLOCOCCUS AUREUS CO-INFECTION IN MICE AFTER ANTIBIOTIC-INDUCED DYSBIOSIS","authors":"S. A. Muradova, S. Gurbanova, Suruya Hadjieva, Mehman Aliyev","doi":"10.26565/2313-6693-2018-36-03","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-03","url":null,"abstract":"Microbial interactions in Staphylococcus aureus–Candida albicans dual-species biofilms is a relevant research topic given the significant contribution of these microorganisms to hospital-acquired infections. Therefore, the purpose of our investigation was to study the interaction of opportunistic C. albicans and S. aureus in vivo and in vitro, both with the participation of normal microflora and in mice with antibacterial dysbiosis. The study of mentioned interactions was carried out on 100 white male mice weighing approximately 18 grams in vivo and using smears prepared from the grown mixed cultures of C. albicans and S. aureus and the Japan JEM 1400 transmission electron microscope for the purpose of electron microscopic study of microorganisms in vitro. Healthy mice forming control groups and mice with antibiotic-induced dysbiosis (after introduction of vancomycin, gentamicin, ampicillin) were divided into groups to create a mono- and associative infection: Ι group was given 1×107 CFU of C. albicans, II group – 1×108 CFU of S. aureus, and III group – a mixture of specified concentrations of C. albicans and S. aureus in the same proportion. Microorganisms causing monoinfection were being isolated from the body of animals treated with antibiotics till the end of the experiments in large quantities unlike in case of the healthy mice. Co-inoculation of these microbes in the same dose to animals (co-infection), which were injected with antibiotics, turned out to be fatal for them, whereas an adhesive bond was seen between the cells of C. albicans vs. S. aureus in vitro. As can be seen, such bacterial-fungal co-infection reduce substantially the effectiveness of antibiotic therapy and the likelihood of successful treatment and can not be ignored when choosing the appropriate treatment","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"67 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74733795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANGINA PECTORIS AND MYOCARDIAL ISCHEMIA IN THE ABSENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE: CLINICAL CASE","authors":"M. Karavanova, N. Lisova, M. Shevchuk","doi":"10.26565/2313-6693-2018-36-09","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-09","url":null,"abstract":"Our clinical case shows patient with worsening clinical signs of angina without obstructive lesions of coronary artery which requires further control. Recommendations for lifestyle modification as well as further treatment tactics are described. This case is іnterestіng іn the development of decompensatіon (oedema of the lower extremities, reduced tolerance to stress) in a patient with cardiac syndrome X. Management of patents with angina and evidence of myocardial schema on stress testing without obstructive coronary artery disease by angiography (previously referred to as cardiac syndrome X, or CSX) is a challenge. Key points for the clіnіcіan include recognition of schema and deployment of guideline-endorsed therapy for angina and reduction of cardiac risk factors. Systemic hypertension is often associated with mіcrovascular angіna. Several pathogenic mechanisms have been іdentіfіed which represent suitable targets for treatment. Mіcrovascular dysfunction needs to be іnvestіgated (and treated if present) іn patents with systemic hypertension, angina and angіographically normal coronary arteries.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"191 1","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76852161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABDOMINAL COMPARTMENT SYNDROME IN BURN PATIENTS","authors":"I. Belozorov, A. Lytovchenko, G. Oliynyk, Olena Lytovchenko, M. Matvieienko","doi":"10.26565/2313-6693-2018-36-10","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-10","url":null,"abstract":"Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are consistently associated with morbidity and mortality among the critically ill or injured. Thus, avoiding or potentially treating these conditions may improve patient outcomes. Despite a large number of special publications devoted to this problem, very little attention is paid to the ACS in patients with severe burn injuries. Severe burns have been shown to be a risk factor for developing IAH. Fluid resuscitation practices used in burns management further predispose patients to increase intra-abdominal pressure. The incidence of intraabdominal hypertension in patients with severe thermal injury is, according to different authors, 57.8–82.6 %. The mortality associated with IAH in severe burns is very high once organ dysfunction occurs. The purpose of this work is to collect and analyze the problem of abdominal hypertension in burn patients, as well as to draw conclusions on the prevention of this condition and improve the results of treatment of patients with severe burn injury. Intra-abdominal hypertension is a frequent complication in severe burn patients requiring massive fluid resuscitation. Development of ACS in burn patients is associated with high mortality. Prevention, early detection and proper management may avoid this usually fatal complication. Fluid resuscitation volume is directly responsible for the development of ACS in severe burned patients. Thus, optimal fluid resuscitation can be the best prevention of IAH and ACS.","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"116 1","pages":"63-71"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87723986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LONG-TERM RESULTS FOR THE TREATMENT OF PATIENTS WITH THE APPLICATION OF ORGAN-PRESERVING OPERATIONS IN PAPILARY THYROID CANCER","authors":"A. Korkelia","doi":"10.26565/2313-6693-2018-36-01","DOIUrl":"https://doi.org/10.26565/2313-6693-2018-36-01","url":null,"abstract":"Іn order to analyse the changes in the structural and functional state of the thyroid gland, a group of 185 patients (67.8 %) were examined after the surgical treatment of papillary thyroid cancer. Of these, 94 patients belonged to the first group – the comparison group where thyroidectomy was performed, and 91 to the second – the main group where, mainly, organ-preserving operations were performed. The average follow-up was 6.5 ± 5.1 years (varied from 2 to 11 years. Hypoparathyroidism in patients receiving replacement therapy was observed in 20 (16.4 %) patients after thyroidectomy and only in 4 (6.3 %) patients after organ-preserving techniques (the differences are significant, p 0.05). The use of organ-preserving approaches in the main group allowed improving functional results by reducing the frequency of hypothyroidism and side effects of replacement therapy, due to the preservation of thyroid secretion and its regulation, without worsening the results of relapse-free survival","PeriodicalId":31685,"journal":{"name":"Journal of V N Karazin Kharkiv National University Series Medicine","volume":"41 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88171100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}