Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya最新文献_第3页

The spiritual and mental health assessment of social workers working for Internally Displaced Persons during Covid-19 in Myanmar 缅甸国内流离失所者社会工作者在2019冠状病毒病期间的精神和心理健康评估

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.16809

Saw Ye Win Thu, Hsiu-Ching Chen

{"title":"The spiritual and mental health assessment of social workers working for Internally Displaced Persons during Covid-19 in Myanmar","authors":"Saw Ye Win Thu, Hsiu-Ching Chen","doi":"10.30651/jqm.v7i1.16809","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.16809","url":null,"abstract":"This study applies the spiritual assessment viewpoint toanalyze the responses of participants who are working for InternallyDisplaced Persons (IDPs) in Kachin and Northern Shan State,Myanmar. It was an online survey of workers' work experience in April2022. The analysis applies a quantitative research method to explorethe spirituality of social workers who are working in conflict-affectedareas where works are stressful, and the guarantee of security isuncertain. To analyze participants’ spirituality, in quantitative method,the form of the Spirituality Assessment of Worker Working for IDPs(SASSIDPs) is designed as three dimensions of SASSIDPs: Healthyself-awareness (HSA), healthy relationship (HR), and healthy feeling(HF). The results are conducted with the Social Science StatisticsSoftware (SPSS) 22.0 for the statistical analysis. Most of theparticipants are female (66%) and 34% are male. The results of in threedimensions of the SASSIDPs are different from their socialcharacteristics: in gender, males and females are significantly differentin HF of SASSIDPs (t=-3.21**), female is higher than male; in termsof religion/faith, group of “Christianity” is significantly different fromthe group of “non-Christian” in HF(t=-2.833**), and “non-Christianity”group gets higher agree than “Christianity” group; in term of workingyears, people who have been working below 2 years has significantlydifferent from 3 years above in HSA (t=2.918**); in term of age, thereis no difference among the different age groups.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75291420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of common bile duct exploration with biliary drainage in choledocholithiasis during pregnancy 妊娠期胆总管探查与胆道引流在胆总管结石中的作用

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.10816

Gadang Ryan Dewantoro, Putra Gelar Parlindungan

{"title":"The role of common bile duct exploration with biliary drainage in choledocholithiasis during pregnancy","authors":"Gadang Ryan Dewantoro, Putra Gelar Parlindungan","doi":"10.30651/jqm.v7i1.10816","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.10816","url":null,"abstract":"Pregnancy is a risk factor for gallstone disease and may evolve into symptomatic choledocholithiasis/ common bile duct (CBD) stone; however, the treatment of choice is controversial and may not apply to all gestational ages. Standard therapy with endoscopic retrograde cholangiopancreatography (ERCP) exposes the patient and fetus to ionizing radiation; hence other strategies are needed to address this problem. We report a case of 29 years old female presented with biliary pain and jaundice. The patient was pregnant at 14 weeks gestation age. Laboratory data showed biliary obstruction, and abdominal ultrasound showed multiple bile duct stones with significant dilatation in the CBD. CBD exploration with external biliary drainage was performed to treat obstructive jaundice while avoiding ionizing radiation exposure to the fetus and patient. After the procedure, the patient showed clinical improvement. CBD exploration with external biliary drainage avoids ionizing radiation in choledocholithiasis management. This method may be applied as a temporary emergent treatment of obstructive jaundice in pregnant patients with gestational age sensitive to ionizing radiation.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86380697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of the quality of Tuberculosis services with adherence to taking Anti-tuberculosis drugs 坚持服用抗结核药物对结核病服务质量的影响

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.15582

Ridhona Fajar Sari, M. Martini, M. Raharjo

{"title":"The influence of the quality of Tuberculosis services with adherence to taking Anti-tuberculosis drugs","authors":"Ridhona Fajar Sari, M. Martini, M. Raharjo","doi":"10.30651/jqm.v7i1.15582","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.15582","url":null,"abstract":"Indonesia was the second world's highest TB case in 2021. Tuberculosis therapy that takes a long time can cause patients to drop out of treatment. Hospitals conduct quality evaluations regularly and improve the quality of health service personnel to realize excellent health services. This literature review aims to determine the effect of the quality of tuberculosis services on patient compliance with anti-tuberculosis drugs. This literature review was written using a systematic approach. The databases used were Google Scholar, Science Direct, Proquest, and Scopus. The total number of articles obtained was 8 out of 64 based on inclusion criteria. The things that affect the regularity of taking medication based on the eight journal articles above are as follows: 1) the assurance dimension is 50%, 2) the dimensions of empathy and reliability amounted to 37.5%, 3) the responsiveness dimension is 25%, 4) patient satisfaction, direct evidence and service quality amounted to 12.5%. Adherence to taking medication is influenced by: 1) the presence of supporters of taking medication, 2) difficulty taking the medication regularly, (3) perceived benefits of taking anti-tuberculosis drugs, and 4) self-perception related to healing. The dimensions of assurance, empathy, and reliability have the most influence on the regularity of taking anti-tuberculosis drugs.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85429670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The differences of parasitemia in Plasmodium berghei infected mice treated with extract of mango parasite leaves with Artemisinin combination 芒果寄生叶提取物与青蒿素联合治疗伯氏疟原虫感染小鼠的寄生虫血症差异

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.13882

Muhammad Zulkifly Tasman, H. Arwati, Nurina Hasanatuludhhiyah, Puspa Wardhani

{"title":"The differences of parasitemia in Plasmodium berghei infected mice treated with extract of mango parasite leaves with Artemisinin combination","authors":"Muhammad Zulkifly Tasman, H. Arwati, Nurina Hasanatuludhhiyah, Puspa Wardhani","doi":"10.30651/jqm.v7i1.13882","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.13882","url":null,"abstract":"Malaria is a disease transmitted through the bite of a female Anopheles mosquito caused by the Plasmodium parasite. Plasmodium has been reported to become resistant to artemisinin. Thus, the study on the ethanol extract of mango parasite leaves/Dendrophthoe pentandra (MP) on P. berghei-infected BALB/c mice with and without artemisinin combination (MP+A) was conducted. This study is experimental laboratory research with a post-test only design. The percent parasitemia in mice treated with ethanol extract of MP and MP+A leaves decreased. There was no difference in the spleen index in mice given ethanol extract of MP, and MP+A leaves with p = 0.203 and the spleen weight of mice with p = 0.134 (significance: p <0.005). Pearson Correlation test showed a correlation between spleen index with parasitemia and spleen weight with parasitemia; however, there was no correlation between body weight and parasitemia. The ethanol extracts of MP and MP+A leaves had significant antimalarial activity, and the difference in the percent parasitemia between groups was significant but not so far. The spleen index value was not affected by the ethanol extract of MP and MP+A leaves, but the percent parasitemia was affected.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74331172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the degree of Osteoarthritis and pain level of patients at Baptist Hospital, Batu City 巴图市浸信会医院骨关节炎程度与患者疼痛程度的关系

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.13483

Panji Sananta, Ha M Hansel, D. Widasmara, Eka Noviya Fuzianingsih

{"title":"Association between the degree of Osteoarthritis and pain level of patients at Baptist Hospital, Batu City","authors":"Panji Sananta, Ha M Hansel, D. Widasmara, Eka Noviya Fuzianingsih","doi":"10.30651/jqm.v7i1.13483","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.13483","url":null,"abstract":"Osteoarthritis is a chronic disease characterized by the destruction of cartilage in the joints, causing stiffness, pain, and impaired movement. The condition most commonly affects the joints of the knees, hands, feet, spine, and often the shoulders and hips. Knee osteoarthritis is a major public health problem that causes chronic pain and reduces physical function and quality of life. This study determined the relationship between the degree of Osteoarthritis and the pain level in patients at Baptist Hospital, Batu City. This research used a cross-sectional study with 31 respondents. Data collection was conducted directly using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) questionnaire, modified in Indonesian. To determine the grade of Osteoarthritis using the Kellgren-Lawrence system. The results showed that out of 31 respondents, there were nine patients (29%) who had grade 1 osteoarthritis, 12 patients (38.7%) had grade 2, and 10 patients (32.3%) had grade 3. There were 22 patients (71%) who had a mild pain level, four patients (13%) had a moderate level, and five patients (16%) had a severe pain level. The Spearman correlation test showed no significant relationship (p>0.05) between the degree of Osteoarthritis and the level of pain in patients. This study concludes that there was no relationship between the increasing degree of Osteoarthritis and the level of pain.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"147 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86095558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A successfully treated Basal Cell Carcinoma using elliptical excision surgery 一个成功治疗基底细胞癌的椭圆切除手术

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.15384

I. Citrashanty, Hamidah Luthfidyaningrum, Evy Ervianti, B. H. Kusumaputra, Maylita Sari, M. Listiawan, Yoana Fransiska Wahyuning Christi

{"title":"A successfully treated Basal Cell Carcinoma using elliptical excision surgery","authors":"I. Citrashanty, Hamidah Luthfidyaningrum, Evy Ervianti, B. H. Kusumaputra, Maylita Sari, M. Listiawan, Yoana Fransiska Wahyuning Christi","doi":"10.30651/jqm.v7i1.15384","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.15384","url":null,"abstract":" Basal cell carcinoma (BCC) is a non-keratinization cell-derived neoplasm. Surgical excision is the most common way to remove a tumor. The excision depends on the tumor type, size, and location. This paper reported a 44- years-old woman presented with the chief complaint of a single bump that bleeds easily in the facial region that began one year ago. Dermatology examination revealed hyperpigmented plaque with an ulcer in central, solitary, oval, 2 cm x 1 cm in size, covered with blackish crust on top. A Dermoscopy examination showed blue dots and globules, arborizing vessels, and ulceration. Histopathology examination findings were in concordance with BCC. The patient was treated with elliptical surgical excision. The lesion was successfully removed and showed good results with minimal scarring. BCC occurs in 75% of all skin cancers. Elliptical surgical excision on the left cheek was performed after considering the location anatomy, defect size, age, and general condition patient and postoperative cosmetic estimates. The minimal scar that occurs is planned to be performed with a fractional laser. The prognosis is generally good. There is no recurrence until one year later. In conclusion, elliptical surgical excision is an effective standard treatment if performed with a safe margin. In this case, we used 5 mm safe outer margin.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79125001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of mid-parental height, Calcium intake, and intensity of physical activity with body height growth of high school students in Malang 父母中等身高、钙摄入量、体育活动强度与马郎高中生身高增长的关系

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.13979

Arif Kusuma Firdaus, Anung Putri Illahika, Annisa Hanifwati, Hanna Cakrawati

{"title":"Relationship of mid-parental height, Calcium intake, and intensity of physical activity with body height growth of high school students in Malang","authors":"Arif Kusuma Firdaus, Anung Putri Illahika, Annisa Hanifwati, Hanna Cakrawati","doi":"10.30651/jqm.v7i1.13979","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.13979","url":null,"abstract":"Abstract Stunting is one of Indonesia's problems, as portrayed in RISKESDAS 2018. This means the growth of Indonesian children was not optimal. Some factors that might affect body height growth were genetic factors, represented by mid-parental height, nutritional factors, especially calcium, and physical activity, which could activate pathways to stimulate growth. These factors were known to have a huge role in body height growth, especially if these factors were optimized in adolescence, as in high school students. This research aimed to explain the relationship between body height growth and the factors that might affect it: mid-parental height, calcium intake, and the intensity of physical activity. This research was observational analytic, using purposive sampling as the sampling method and collecting data using a cross-sectional questionnaire. Statistical analysis between variables shows that mid-parental height was positively related (p<0.05, r: 0,356), while calcium supplementation was not associated (p<0.05, r: -0.165), and intensity of physical activity was not related (p=0.059, r: 0.089) with the body height growth of the students. In conclusion, among the factors that were analyzed, mid-parental height was the only one that had a relationship with body height growth.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85534856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid-term functional outcome after distal Achilles tendon rupture anchoring screw repair in elderly osteopenia as a reliable technique: A case report 远端跟腱断裂后锚定螺钉修复作为可靠技术治疗老年骨质减少的中期功能结果:1例报告

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.15604

Teddy Heri Wardhana, Mukhlis Aziz

{"title":"Mid-term functional outcome after distal Achilles tendon rupture anchoring screw repair in elderly osteopenia as a reliable technique: A case report","authors":"Teddy Heri Wardhana, Mukhlis Aziz","doi":"10.30651/jqm.v7i1.15604","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.15604","url":null,"abstract":"The management of distal Achilles tendon rupture is still controversial, especially in elderly patients, due to poor bone quality and tendon stump integrity. One of the proposed repair techniques is by using an anchoring screw. Here we report the mid-term follow-up of two patients with distal Achilles tendon rupture treated with an anchoring screw. Two elderly males in their sixties came to the outpatient clinic with similar complaints of intermittent pain, reddening, and ankle swelling after falling. Both patients were diagnosed with distal Achilles tendon rupture and were treated with open repair using a Krakow suture and anchoring screws. Functional outcome evaluation postoperatively found a good outcome. Previous studies have shown that repair with the anchoring technique is better biomechanically than with ordinary sutures. Repairs with this technique can withstand greater forces and loads before they fail. An anchoring screw repair technique for total distal Achilles tendon rupture repair provides good results in elderly with osteopenia.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84630956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Android-based health media applications as promotional media in improving COVID-19 preventive behavior in the community 开发基于android的健康媒体应用，作为促进社区COVID-19预防行为的宣传媒体

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.12828

I. Purnamasari, Ferry Effendy, Lailatun Ni’mah, Dede Nasrullah

{"title":"Development of Android-based health media applications as promotional media in improving COVID-19 preventive behavior in the community","authors":"I. Purnamasari, Ferry Effendy, Lailatun Ni’mah, Dede Nasrullah","doi":"10.30651/jqm.v7i1.12828","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.12828","url":null,"abstract":"Corona Virus Disease 2019 (COVID-19) caused by SARS-CoV-2 became a worldwide pandemic. The spread of wrong information causes people to misperceive the information. The massive spread of the virus shows the lack of public knowledge about preventing the transmission of COVID-19. Intrapersonal factors, namely changes in individual behavior, are the main focus of breaking the chain of the spread of COVID-19. This study aims to develop an Android-based health education application for COVID-19 prevention behavior in the community. This research method used an exploratory design with an R&D approach which consists of 2 stages. The first stage was making a prototype application through 1) Evaluation of public knowledge and attitudes about COVID-19 prevention with a questionnaire in the form of a google form to find strategic issues; 2) Development and mapping of prototype content through Focus Group Discussions with nurses and expert consultations. The evaluation used a simple random sampling technique on 193 respondents. The second stage was socialization and application feasibility testing on 193 respondents. The results of the first stage were an overview of the implementation of health education that had not been maximized due to the risk of transmission, sufficient knowledge (52.8%), and negative attitudes (63.2%) toward the prevention of COVID-19, as well as a prototype system of health education in applications that include prevention COVID-19 prevention. It was followed by the second stage of socialization and application feasibility testing for users. This study concludes that the development of an android-based application supports effective health promotion efforts in conveying information to increase knowledge and attitudes toward COVID-19 prevention.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89646528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin increase sciatic nerve damage and degeneration in adolescent rats 亚慢性暴露于毒死蜱、氟虫胺和氯氰菊酯会增加青春期大鼠坐骨神经损伤和变性

Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya Pub Date : 2023-01-30 DOI: 10.30651/jqm.v7i1.13666

Muhammad Ihwan Narwanto, Muhammad Haikal Supriyadi, Desie Dwi Wisudanti

{"title":"Subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin increase sciatic nerve damage and degeneration in adolescent rats","authors":"Muhammad Ihwan Narwanto, Muhammad Haikal Supriyadi, Desie Dwi Wisudanti","doi":"10.30651/jqm.v7i1.13666","DOIUrl":"https://doi.org/10.30651/jqm.v7i1.13666","url":null,"abstract":"Several types of pesticides that are often used are chlorpyrifos (organophosphate), carbofuran (carbamate), and cypermethrin (pyrethroid). Pesticides can kill pests but also can cause toxic effects on humans when exposed. One of the adverse effects of pesticide exposure is a disturbance in the peripheral nervous system. Age is an essential factor in peripheral nerve damage. Nerve injury is one of the most common injuries in children and adolescents and is estimated at 10% to 15% of all exceptional unit cases. However, the outcome of peripheral nerve injury is known better in subjects who sustain the injury at a younger age. This study aims to determine the subchronic exposure effect of chlorpyrifos, carbofuran, and cypermethrin to sciatic nerve histopathology in juvenile rats. This study used 30 male Wistar rats (Rattus norvegicus) which were divided into 5 groups, normal group (N), control group (K), chlorpyrifos group (P1), carbofuran group (P2) and cypermethrin group (P3). Subcutaneous injection of pesticides was carried out for 21 days. Rats were sacrificed using the cervical dislocation method, and the right sciatic nerve was taken for histopathological observation. Assessment of the degree of ischiatic nerve histopathological damage is using the Jensen et al., (2018) method. Data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney test. This study showed a significantly increased degree of histopathological damage in the chlorpyrifos group, carbofuran group, and cypermethrin group compared to the control group and the normal group (p<0.05). It can be concluded that exposure to chlorpyrifos, carbofuran, and cypermethrin pesticides increased damage and degeneration of the ischiadicus nerve in juvenile rats.","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89436930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0