Basel Life Science Week最新文献

{"title":"Remote Digital Biomarker Monitoring Bringing a smartphonebased diagnostic test for Parkinson's Disease progression into an interventional trial","authors":"C. Gossens","doi":"10.5281/ZENODO.31310","DOIUrl":"https://doi.org/10.5281/ZENODO.31310","url":null,"abstract":"","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134451326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Patient Recruitment - Become a Partner in the Patient Journey Using Digital Media","authors":"C. Gossens","doi":"10.5281/zenodo.31311","DOIUrl":"https://doi.org/10.5281/zenodo.31311","url":null,"abstract":"","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"154 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125890682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High throughput screen for developmental neurotoxicity using human induced pluripotent stem cell-derived neurons","authors":"O. Sirenko, E. Cromwell, K. Ryan, R. Tice, M. Behl, C. Holtz, F. Parham","doi":"10.5281/zenodo.31168","DOIUrl":"https://doi.org/10.5281/zenodo.31168","url":null,"abstract":"","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126939832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified polyamidoamine based nanoparticles for tumor cell gene delivery","authors":"Samira Hossaini Alhashemi","doi":"10.5281/ZENODO.31179","DOIUrl":"https://doi.org/10.5281/ZENODO.31179","url":null,"abstract":"Polyamidoamine is a cationic dendrimer with the ability to condense plasmid DNA into nanometric particles suitable for gene transfer applications. Toxicity is one of the obstacles in wide range usage of this dendrimer in cancer gene therapy. The toxicity is mainly associated with high density of positive charge on its surface which leads to cell membrane disruption. Therefore, modification of the dendrimer backbone to reduce the positive charge might be useful in order to decrease the dendrimer cytotoxicity. To achieve this goal, a series of hydrophobic derivatives of PAMAM was prepared by reacting with ethyl, butyl, hexyl and lauryl acrylates. By these modifications the surface positive charge was modulated and the hydrophobic balance of the dendrimer was improved.","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130783303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic Sequence Analysis of Mycobacterium tuberculosis H37Rv and M. tuberculosis DR-689 Subjected to Continuous Subculturing","authors":"L. Vera-Cabrera, R. Ortíz-López, R. Walls, G. Guerrero-Ramírez, Carmen Molina-Torres, J. Ocampo-Candiani, J. Castro-Garza","doi":"10.5281/zenodo.31184","DOIUrl":"https://doi.org/10.5281/zenodo.31184","url":null,"abstract":"","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124789911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased production of antioxidants in the presence of cadmium by Promicromonospora sp. UTMC2243","authors":"M. Mirjalili","doi":"10.5281/zenodo.31275","DOIUrl":"https://doi.org/10.5281/zenodo.31275","url":null,"abstract":"","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129206759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in silico chemoproteomic prediction-scan for the generation of a tyrosinase aa95-104FMGFNCGNCK antigenic patternLFA-3/IgG fusion polypeptide IleAlaArgArgPheLeuOH (Kinetensin) mimetic pharmacophore on conserved Vitiligo post-trancripts domains.","authors":"I. Grigoriadis","doi":"10.5281/zenodo.31284","DOIUrl":"https://doi.org/10.5281/zenodo.31284","url":null,"abstract":"ABSTRACT: Vitiligo is a skin disorder characterized by selective melanocyte destruction and concomitant appearance of depigmented macules that over time enlarge, coalesce, and form patches. It has been suggested that vitiligo is, at least in part, caused by autoimmune responses mediated by cytotoxic T cells against melanocytes, causing depigmentation Immune responses contribute to the pathogenesis of vitiligo and target melanoma sometimes associated with vitiligo-like depigmentation in some melanoma patients. It has been perviously reported that the tyrosinase autoantigen was immunorecognized with the same molecular pattern by sera from vitiligo and melanoma patients. Five autoantigen peptides was found to compose the immunodominant antityrosinase response: aa95-104FMGFNCGNCK; aa175-182 LFVWMHYY; aa176-190FVWMHYYVSMDALLG; aa222-236IQKLTGDENFTIPYW, and aa233-247IPYWDWRDAEKCDIC. Synergistic therapies for the treatment of vitiligo are provided. The major therapies for the treatment of vitiligo a pigmentary disorder characterized by patchy depigmentation of skin are Psoralens plus UV-A, steroids, basic fibroblast growth factor (bFGF) peptide location or surgical procedures. Psoralens plus UV-A is effective in about 50% of cases, steroids are limitedly effective only in fast spreading cases of vitiligo and often reoccurs on stoppage of treatment. Surgical treatment is the last resort for vitiligo therapy, when all other therapies failed. It is limitedly effective. Basic fibroblast growth factor peptide(s) location was developed as a new mode therapy for the treatment of vitiligo. Therefore, SEQ ID NO: 01 VPHIPPN, SEQ ID NO: 02 MPPTQVS, SEQ ID NO: 03 QMHPWPP, SEQ ID NO: 1 1 LPLTPLP, SEQ ID NO: 12 QLNVNHQARADQ, SEQ ID NO: 13 TSASTRPELHYP, SEQ ID NO: 14 TFLPHQMHPWPP peptides, modified peptides and antibody or antibody fragments inhibiting the activity of MIA and can be used for treating vitiligo by inducing re-pigmentation. Fragment-based lead discovery is a method used for finding lead compounds as part of the drug discovery process. In this science project we perfomed an in silico ChemoProteomic Prediction-Scan for the generation of Antigenic PatternLFA-3/IgG fusion polypeptide aa95-104FMGFNCGNCK; aa175-182 LFVWMHYY; aa176-190FVWMHYYVSMDALLG; aa222-236IQKLTGDENFTIPYW, and aa233247IPYWDWRDAEKCDICmimetic pharmacophore on conserved Vitiligo post-trancripts domains.","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123082141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affinity Measurement of Antibodies in Allergy Diagnosis","authors":"G. Lain","doi":"10.5281/ZENODO.31285","DOIUrl":"https://doi.org/10.5281/ZENODO.31285","url":null,"abstract":"u SPRi allows a multiplex monitoring of the complex antibody response to the major allergens of an allergenic source u SPRi monitoring is faster, label-free and more informative than ELISA, but less sensitive u The avidity of the antibody response may be evaluated and this evaluation is reproducible Conclusion The biological diagnosis of type I hypersensitivity reactions is based on the quantification of specific IgEs. However, the IgE titer is not always strongly related to the clinical symptoms or predictive of the evolution of the disease. The specificity and affinity of antibodies of other isotypes may contribute to the allergic status of the patients. The aim of this work was to develop a method that simultaneously detects the complex antibody response to various allergens and measures the avidity of the antibodies directed to each allergen (Cf Journal of immunological Methods, Volume 405, March 2014, Pages 23–28). We developed a tool to detect and measure the avidity of the various antibodies recognizing the major allergens of an allergenic source. Surface Plasmon Resonance imaging (SPRi) is a sensitive label-free method to detect and visualize biomolecular interactions. Our configuration allows the use of a pattern of various immobilized molecules and simultaneously follows up the kinetic curves of each spotted molecule. Introduction","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"256 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134282187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomics and Clinical Benchmarking with Low Coverage Oxford Nanopore Data","authors":"Noah Alexander","doi":"10.5281/zenodo.31274","DOIUrl":"https://doi.org/10.5281/zenodo.31274","url":null,"abstract":"","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128141768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jayce Technology to decipher receptor biology and pharmacology","authors":"Manon Kiry","doi":"10.5281/ZENODO.31265","DOIUrl":"https://doi.org/10.5281/ZENODO.31265","url":null,"abstract":"Manon Kiry, Serge Brand, Alexandre Peter, Urs Luthi and Xavier Leroy* Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, CH-4123 Allschwil, Switzerland *Corresponding author: xavier.leroy@actelion.com Introduction G-Protein Coupled Receptor Pharmacology was following classical models assuming that agonists at a particular receptor elicit effects through a single mechanism of activation, implying a single activated conformation of the agonist-occupied receptor. This assumption led to the standard nomenclature of GPCR modulators based on affinity and efficacy, and to their classification as full agonist, partial agonist, neutral antagonist, or inverse agonist. However a receptor can engage a variety of biochemical responses and different agonists can elicit different patterns of these responses. Ligands should therefore be classified on the basis of their individual effects in the cell, instead of being either an agonist or an antagonist. The current challenge in the GPCR drug discovery field is based on the development and the implementation of assays that would lead to the discovery of biased or pathways selective agonists in a pro-active and prospective manner. For this achievement, we have developed assays aiming at the characterization of GPCR signaling pathways. Actelion’s JAYCE platform was developed to generate biological information delineating beneficial and adverse signaling pathways at specific receptors and identifies ligands that activate only the pathways associated with therapeutic benefit.","PeriodicalId":315352,"journal":{"name":"Basel Life Science Week","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114854932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}