Journal of Basic and Applied Zoology最新文献_第6页

Effect of traditional plant medicines (Cinnamomum zeylanicum and Syzygium cumini) on oxidative stress and insulin resistance in streptozotocin-induced diabetic rats 传统植物药(肉桂和茴香)对链脲佐菌素诱导的糖尿病大鼠氧化应激和胰岛素抵抗的影响

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-11-23 DOI: 10.1016/j.jobaz.2015.09.002

Khaled Sharafeldin , Moattar Raza Rizvi

{"title":"Effect of traditional plant medicines (Cinnamomum zeylanicum and Syzygium cumini) on oxidative stress and insulin resistance in streptozotocin-induced diabetic rats","authors":"Khaled Sharafeldin , Moattar Raza Rizvi","doi":"10.1016/j.jobaz.2015.09.002","DOIUrl":"10.1016/j.jobaz.2015.09.002","url":null,"abstract":"<div>Many traditional plants have been used to fight life-threatening diseases such as diabetes. These plants have been shown to possess antioxidant activities, improving the diabetes inconveniences. Wister albino rats became diabetic by streptozotocin (STZ) induction. The effect of 200mg/kg ethanolic extracts of either Cinnamomum zeylanicum bark (CZ) or Syzygium cumini seeds (SC) was investigated on STZ-induced diabetic rats. The impact of CZ or SC administration was observed. Blood glucose, insulin level, hemoglobin content, lipid profile, liver and kidney functions, and antioxidant enzymes in plasma were evaluated. Diabetic rats exhibited an increase in the levels of blood glucose, total cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-cholesterol). In contrast, the levels of insulin and high density lipoprotein cholesterol (HDL-cholesterol) were diminished.The oral administration of CZ and SC showed a decrease in glucose level, total cholesterol, triglycerides, and LDL-cholesterol, whereas an increase in insulin level and HDL-cholesterol were recorded. What’s more, the antioxidant enzymes in diabetic control rats showed significantly abnormal activities of low superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (GPx) activities and reduced glutathione (GSH) compared to treated diabetic rats. Also, in the extent of lipid peroxidation (LPO).Both CZ and SC possessed antioxidant activity as shown by elevated SOD and GPx activities and reduction in LPO. CZ and SC are functioning to improve the level of insulin, hyperglycemia, hyperlipidemia, oxidative stress and kidney and liver dysfunctions in STZ-induced diabetic rats.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 126-134"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89005474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Hematological and biochemical characters of monosex tilapia (Oreochromis niloticus, Linnaeus, 1758) cultivated using methyltestosterone 甲基睾酮培养单性罗非鱼(Oreochromis niloticus, Linnaeus, 1758)的血液学和生化特性

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-04-23 DOI: 10.1016/j.jobaz.2015.03.002

Alaa El-Din H. Sayed, Rehab H. Moneeb

{"title":"Hematological and biochemical characters of monosex tilapia (Oreochromis niloticus, Linnaeus, 1758) cultivated using methyltestosterone","authors":"Alaa El-Din H. Sayed, Rehab H. Moneeb","doi":"10.1016/j.jobaz.2015.03.002","DOIUrl":"10.1016/j.jobaz.2015.03.002","url":null,"abstract":"<div>The use of steroid-treated feeds as 17 α-methyltestosterone for the production of all-male populations is widespread in tilapia aquaculture. The aim of the present study was to investigate the misuse effects of methyltestosterone on monosex farmed Nile tilapia, Oreochromis niloticus by evaluation of hematological and biochemical values. The fishes were obtained from four localities (Assiut as a control, Beheira, Alexandria and Kafr el-Sheikh: three farms from each governorate as farmed monosex produced using methyltestosterone). The total erythrocyte count, hemoglobin rate, hematocrit percentage, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), white blood cell count, blood platelets, lymphocyte, monocyte, neutrophils and basophils were determined. The results showed that there were changes in the erythrocytic series and in the defense white blood cells. Activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), glucose, cholesterol, total protein, uric acid and creatinine were determined for biochemical study. These alterations are considered an indication for performance and health of fish in the monosex culture medium indicating the side effects of overdose induction of MT.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 36-42"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79774462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Lipid profile and levels of homocysteine and total antioxidant capacity in plasma of rats with experimental thyroid disorders 实验性甲状腺疾病大鼠血浆脂质特征、同型半胱氨酸水平及总抗氧化能力

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-01-31 DOI: 10.1016/j.jobaz.2015.01.001

Afaf Abbass Sayed Saleh

{"title":"Lipid profile and levels of homocysteine and total antioxidant capacity in plasma of rats with experimental thyroid disorders","authors":"Afaf Abbass Sayed Saleh","doi":"10.1016/j.jobaz.2015.01.001","DOIUrl":"10.1016/j.jobaz.2015.01.001","url":null,"abstract":"<div>This study focuses on the relationship between serum levels of cholesterol and homocysteine with that of total antioxidant capacity in rats with thyroid dysfunction.Adult male Wistar rats were divided into three groups, a control (euthyroid), hypothyroidism and hyperthyroidism, each of them containing ten rats. Hypothyroidism was induced by administration of 0.1% aminotriazole in drinking water for 3weeks. Hyperthyroidism was induced by chronic subcutaneous injection of l-thyroxine (100μg/day, dissolved in 200μL saline solution/100g body weight) for 3weeks. The control and hypothyroid groups were injected subcutaneously with the same volume of saline solution.Results showed that hyperthyroidism is characterized by reduced serum thyroid stimulating hormone (TSH) levels despite increased free thyroxine (FT4) and free triiodothyronine (FT3) levels.Significant (p  <0.05) elevation in serum levels of lipid profile (cholesterol, triglyceride and LDL) in hypothyroidism. Significant (p  <!-->0.05) reduction occurred in the levels of cholesterol and triglyceride in hyperthyroidism. The association of hyperhomocysteinemia and lipid abnormalities occurring in hypothyroidism may represent a dynamic atherogenic state.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 173-178"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79546931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Immunoenhancing properties of the anti-tumor effects of adoptively transferred T cells with chemotherapeutic cyclophosphamide by co-administration of bone marrow cells 骨髓细胞与化疗环磷酰胺过继转移T细胞抗肿瘤作用的免疫增强特性

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-07-06 DOI: 10.1016/j.jobaz.2015.05.005

Mohamed L. Salem , Soha G.R. Abdel Salam , Mohamed Nassef , Said Hammad , Rania El Adl

{"title":"Immunoenhancing properties of the anti-tumor effects of adoptively transferred T cells with chemotherapeutic cyclophosphamide by co-administration of bone marrow cells","authors":"Mohamed L. Salem , Soha G.R. Abdel Salam , Mohamed Nassef , Said Hammad , Rania El Adl","doi":"10.1016/j.jobaz.2015.05.005","DOIUrl":"10.1016/j.jobaz.2015.05.005","url":null,"abstract":"<div>In this study we aimed to determine the anti-tumor efficacy of co-treatment of adoptively transferred T cells with bone marrow either harvested from naïve mice or G-CSF activated after treatment with the anti-cancer drug cyclophosphamide (CTX) as a source enriched in stem cells. CTX-treated Swiss Albino (CD-1) mice were injected with 2×105 Ehrlich ascetic carcinoma (EAC) cell line and then adoptively transferred with in vitro co-activated T cells with or without bone marrow one day post CTX treatment. All mice were vaccinated with tumor lysate and Hiltonol®. The results showed that co-transfer of activated T cells with bone marrow provided the highest antitumor effect and induced marked increase in numbers of splenocytes, leucocytes and bone marrow cells. Interestingly, T cells derived from EAC tumor-bearing host induced higher effects than those from normal mice. In sum, our data suggest that combination of CTX and activated transferred T cells with bone marrow induces proliferation and expansion of immune cells, which are functional and can be exploited in vivo to foster more effective antitumor adoptive immunotherapy strategies.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 96-103"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.05.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84248057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Role of Matricaria recutita L. and Asparagus officinalis L. against the neurotoxicity of diazinon in rats 苦参和芦笋对重嗪嗪大鼠神经毒性的作用

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-04-17 DOI: 10.1016/j.jobaz.2015.02.002

Fahmy G. Elsaid , Ali A. Shati , Mohammad A. Sarhan

{"title":"Role of Matricaria recutita L. and Asparagus officinalis L. against the neurotoxicity of diazinon in rats","authors":"Fahmy G. Elsaid , Ali A. Shati , Mohammad A. Sarhan","doi":"10.1016/j.jobaz.2015.02.002","DOIUrl":"10.1016/j.jobaz.2015.02.002","url":null,"abstract":"<div>Diazinon (DZN) is an organophosphorus insecticide widely used in agriculture. It has a variety of harmful effects on humans. Asparagus and chamomile have antioxidant properties and are used as antidotes of DZN in this study. Thirty-five adult male Sprague Dawley rats were divided into: control group; DZN group: subdivided into two subgroups which received ¼ LD50 and ½ LD50 dose of DZN for 30days; DZN and asparagus extract group: subdivided into two subgroups which received ¼ LD50 and ½ LD50 dose of DZN respectively and treated with asparagus extract (300mg/kg b. wt.) after 15min of DZN administration; DZN and chamomile extract group: subdivided into two subgroups receiving DZN respectively and treated with chamomile extract (300mg/kg b. wt.). The results herein showed that the antioxidant enzyme changes associated with the exposure to DZN are dose dependant in cerebrum, cerebellum and spinal cord tissues. The tumorigenicity of DZN was represented by the significant increase of arginase and the alpha-l-fucosidase in sera of all DZN groups. In addition, the molecular changes were investigated by the changes in Cu/Zn-dependent superoxide dismutase, glutathione-S-transferase and glutathione peroxidase enzymes that were altered after administration of DZN to rats. Present findings suggest that oral administration of aqueous extracts of asparagus or chamomile is able to restore the total antioxidant capacity, as demonstrated by the increase of superoxide dismutase activity, glutathione content and their relative enzymes in the investigated tissues. Due to their antioxidant activities, asparagus and chamomile are potential candidates as anti-neurotoxic agents.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 26-35"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73031182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Evaluation of the neuroprotective effect of taurine and green tea extract against oxidative stress induced by pilocarpine during status epilepticus 评价牛磺酸和绿茶提取物对匹罗卡品诱导的癫痫持续状态氧化应激的神经保护作用

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-03-14 DOI: 10.1016/j.jobaz.2015.02.001

Neveen A. Noor , Haitham S. Mohammed , Yasser A. Khadrawy , Heba S. Aboul Ezz , Nasr M. Radwan

{"title":"Evaluation of the neuroprotective effect of taurine and green tea extract against oxidative stress induced by pilocarpine during status epilepticus","authors":"Neveen A. Noor , Haitham S. Mohammed , Yasser A. Khadrawy , Heba S. Aboul Ezz , Nasr M. Radwan","doi":"10.1016/j.jobaz.2015.02.001","DOIUrl":"https://doi.org/10.1016/j.jobaz.2015.02.001","url":null,"abstract":"<div>Status epilepticus (SE) has functional and structural consequences resulting in brain damage. The present study aims to investigate the role of taurine and green tea extract in the neuroprotection against oxidative stress and changes in acetylcholinesterase (AChE) and Na+,K+-ATPase activities during SE induced by pilocarpine in the hippocampus of adult male rats. Animals received an oral administration of either taurine (100mg/kg) or green tea extract containing 100mg/kg epigallocatechin gallate for 3days before the induction of SE with pilocarpine (380mg/kg, i.p.) and were sacrificed 1h after pilocarpine injection. Data indicated that a state of oxidative stress has evolved during SE as evident from the significant increase in lipid peroxidation level and significant decrease in reduced glutathione (GSH) level. Significant decreases in AChE and Na+,K+-ATPase activities were also recorded. Pretreatment of rats with taurine exaggerated the increase in lipid peroxidation and failed to prevent the decrease in Na+,K+-ATPase activity resulting from pilocarpine. However, taurine pretreatment prevented the reduced activity of hippocampal AChE induced by pilocarpine during SE. Pretreatment of rats with green tea extract prevented the increase in lipid peroxidation occurring during SE. However, it failed to inhibit the decrease in Na+,K+-ATPase activity. In conclusion, taurine pretreatment failed to reduce the oxidative stress induced during SE. In contrast, pretreatment of rats with green tea extract ameliorated the oxidative stress induced by pilocarpine and this may assist in reducing the insults of hyperexcitability and excitotoxicity that occur during SE and thereby reduce neuronal damage.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 8-15"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138266775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

How to map the bridges between zoology and pharmacology? 如何绘制动物学和药理学之间的桥梁

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2016-02-03 DOI: 10.1016/S2090-9896(16)00021-7

Abdelaziz Ghanemi

引用次数: 5

Acute and sublethal intoxication of deltamethrin in an Indian major carp, Labeo rohita: Hormonal and enzymological responses 溴氰菊酯在印度鲤鱼中的急性和亚致死中毒:激素和酶学反应

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-05-16 DOI: 10.1016/j.jobaz.2015.04.005

Lenin Suvetha , Manoharan Saravanan , Jang-Hyun Hur , Mathan Ramesh , Kalliappan Krishnapriya

{"title":"Acute and sublethal intoxication of deltamethrin in an Indian major carp, Labeo rohita: Hormonal and enzymological responses","authors":"Lenin Suvetha , Manoharan Saravanan , Jang-Hyun Hur , Mathan Ramesh , Kalliappan Krishnapriya","doi":"10.1016/j.jobaz.2015.04.005","DOIUrl":"10.1016/j.jobaz.2015.04.005","url":null,"abstract":"<div>This study aimed to evaluate the median lethal concentration (LC50), acute (24 and 96h) and sublethal (35d) effects of deltamethrin, a synthetic pyrethroid pesticide on hormonal and enzymological responses in an Indian major carp, Labeo rohita. In this study, the LC50 values of deltamethrin for 24 and 96h were found to be 0.438 and 0.38mgL—1, respectively. During acute (0.438mgL−1) and sublethal (1/10th of 24h LC50 value, 0.0438mgL−1) studies, plasma cortisol and prolactin levels were significantly increased (p   <0.05) increase in alkaline phosphatase (ALP) activity was observed in liver and kidney of fish treated with deltamethrin. However, a significant decrease in the activity of acid phosphatase (ACP) was observed in liver and kidney of deltamethrin exposed fish. In addition, cholinesterase (ChE) activity was significantly (p <!-->0.05) decreased in the plasma of fish exposed to both acute and sublethal concentrations of deltamethrin. These results suggest that the tested concentrations of deltamethrin could have significant adverse effects on the hormonal and enzymological parameters of fish L. rohita. The alterations of these parameters can be effectively used to monitor the impact of deltamethrin in aquatic ecosystem.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 58-65"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89837387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

How can pharmacology benefit from the concepts of evolutionary principles and adaptational mechanisms? 药理学如何从进化原理和适应机制的概念中获益

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-11-23 DOI: 10.1016/j.jobaz.2015.09.001

Abdelaziz Ghanemi

引用次数: 1

Anti-neuroinflammatory and antioxidant effects of N-acetyl cysteine in long-term consumption of artificial sweetener aspartame in the rat cerebral cortex n -乙酰半胱氨酸对长期食用人工甜味剂阿斯巴甜大鼠大脑皮层的抗神经炎和抗氧化作用

Journal of Basic and Applied Zoology Pub Date : 2015-10-01 Epub Date: 2015-05-20 DOI: 10.1016/j.jobaz.2015.05.001

Afaf Abbass Sayed Saleh

{"title":"Anti-neuroinflammatory and antioxidant effects of N-acetyl cysteine in long-term consumption of artificial sweetener aspartame in the rat cerebral cortex","authors":"Afaf Abbass Sayed Saleh","doi":"10.1016/j.jobaz.2015.05.001","DOIUrl":"10.1016/j.jobaz.2015.05.001","url":null,"abstract":"<div>This study specifically focuses to investigate whether N-acetyl cysteine (NAC) has potential ameliorative effects against aspartame-induced brain pathophysiology in rats. Thirty adult male Wistar rats weighing 200–220g were randomly divided into three groups as follows: the first group was administered with distilled water and served as the control group; the second group was given aspartame at a dose of 75mg/kgb.wt. and the third group was given both aspartame and N-acetyl cysteine at dose of 75mg/kgb.wt. and 600mg/kgb.wt. respectively. Oral administration was done in the morning daily for 90days.Long term consumption of the artificial sweetener aspartame (ASP) induced large increments in cortical inflammation and oxidative stress. Daily oral NAC administration can significantly reverse brain-derived neurotrophic factor (BDNF) levels, blocked the cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) production with selective attenuation in expression of proinflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the rat cerebral cortex. Also, NAC can significantly replenish and correct intracellular glutathione (GSH) levels, modulate the elevated levels of total nitric oxide (TNO) and lipid peroxidation (LPO). Conclusions: The present results amply support the concept that the brain oxidative stress and inflammation coexist in experimental animals chronically treated with aspartame and they represent two distinct therapeutic targets in ASP toxicity. The present data propose that NAC attenuated ASP neurotoxicity and improved neurological functions, suppressed brain inflammation, and oxidative stress responses and may be a useful strategy for treating ASP-induced neurotoxicity.</div>","PeriodicalId":31288,"journal":{"name":"Journal of Basic and Applied Zoology","volume":"72 ","pages":"Pages 73-80"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jobaz.2015.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74065227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18