Journal of Cancer Research and Practice最新文献_第7页

Pleural effusion as the initial presentation of synchronous small lymphocytic lymphoma and non-small cell lung cancer 胸膜积液作为同步小淋巴细胞淋巴瘤和非小细胞肺癌的初始表现

Journal of Cancer Research and Practice Pub Date : 2021-10-01 DOI: 10.4103/jcrp.jcrp_20_21

Chao-Hung Wei, Yih-Leong Chang, H. Hou

引用次数: 0

Success is not final, failure is not fatal: The changing landscape of systemic therapy for advanced hepatocellular carcinoma 成功不是最终的，失败不是致命的：晚期肝细胞癌系统治疗的变化

Journal of Cancer Research and Practice Pub Date : 2021-10-01 DOI: 10.4103/jcrp.jcrp_21_21

Chiun Hsu

引用次数: 1

Aldosterone-producing adrenocortical carcinoma with unusual initial presentations: A rare disease and case report 产生醛固酮的肾上腺皮质癌具有不寻常的初始表现:一个罕见的疾病和病例报告

Journal of Cancer Research and Practice Pub Date : 2021-10-01 DOI: 10.4103/jcrp.jcrp_23_21

Jen-Hwa Chen, T. Wei, C. Pan, Yen-Hua Chang, William V. Huang

引用次数: 0

Laparoscopic resection of an adrenaline secreting para-aortic paraganglioma 一例分泌肾上腺素的主动脉旁副神经节瘤的腹腔镜切除术

Journal of Cancer Research and Practice Pub Date : 2021-10-01 DOI: 10.4103/jcrp.jcrp_18_21

Basil Badruddin, S. Gupta

引用次数: 0

Using interim positron emission tomography as a predictor for relapse-free survival in hodgkin lymphoma: Experience from a single Institution 使用中期正电子发射断层扫描作为霍奇金淋巴瘤无复发生存的预测指标:来自单一机构的经验

Journal of Cancer Research and Practice Pub Date : 2021-10-01 DOI: 10.4103/jcrp.jcrp_14_21

H. Liu, M. Wang, C. Kuo, M. Ma, Chun- Liao

{"title":"Using interim positron emission tomography as a predictor for relapse-free survival in hodgkin lymphoma: Experience from a single Institution","authors":"H. Liu, M. Wang, C. Kuo, M. Ma, Chun- Liao","doi":"10.4103/jcrp.jcrp_14_21","DOIUrl":"https://doi.org/10.4103/jcrp.jcrp_14_21","url":null,"abstract":"Background: Since the emergence of 18F-fluoro-2-deoxyglucose positron emission tomography (PET), PET has been widely implemented for the initial staging and evaluation of treatment response of classical Hodgkin lymphoma (cHL). Interim PET after two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) has been proven to be a reliable tool to predict clinical outcomes in patients with cHL, and response-adapted therapies based on interim PET results have become the standard method of treatment. The aim of this study was to report our experience of using interim PET in our institution and determine whether it is a predictive marker for cHL. In addition, we also analyze associations between other patient characteristics and interim PET results at initial diagnosis. Materials and Methods: This retrospective study enrolled patients verified to have newly diagnosed cHL and who received ABVD as frontline treatment between 2008 and 2019 in our hospital. Interim PET was arranged after 2-3 cycles of ABVD, and we used Deauville 5-point score to evaluate the response. Subgroup analysis was performed to assess correlations between interim PET and patient characteristics. Results: Sixty patients underwent interim PET examinations. The age ranged from 14 to 74 years with a medium follow-up of 18.3 months (range: 4–113 months). The patients who had negative interim PET results (n = 36, 60%) had significantly longer relapse-free survival than those with positive results (P < 0.001). Patients with bulky disease, B-symptoms, or neutrophil to lymphocyte ratio (NLR) >6 were more likely to have positive interim PET-computed tomography results (P < 0.001, 0.023, and 0.037, respectively). Conclusion: Interim PET plays an important role in predicting relapse free survival for patients with Hodgkin lymphoma at our institution. A high NLR was correlated with interim PET results in this study.","PeriodicalId":31219,"journal":{"name":"Journal of Cancer Research and Practice","volume":"8 1","pages":"134 - 138"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43907595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Histologic characteristics of invasive oral carcinoma and the role of epithelial-mesenchymal transition in cancer progression 侵袭性口腔癌的组织学特征及上皮-间质转化在肿瘤进展中的作用

Journal of Cancer Research and Practice Pub Date : 2021-10-01 DOI: 10.4103/jcrp.jcrp_25_21

S. Jetley, Beenish Sultan, S. Rana, S. Khetrapal, Arun Sharma, K. Naseeruddin, Z. Jairajpuri

{"title":"Histologic characteristics of invasive oral carcinoma and the role of epithelial-mesenchymal transition in cancer progression","authors":"S. Jetley, Beenish Sultan, S. Rana, S. Khetrapal, Arun Sharma, K. Naseeruddin, Z. Jairajpuri","doi":"10.4103/jcrp.jcrp_25_21","DOIUrl":"https://doi.org/10.4103/jcrp.jcrp_25_21","url":null,"abstract":"Background: To find the association of tumor budding, depth of invasion (DOI), and epithelial-to-mesenchymal transition (EMT) markers (E-cadherin and smooth muscle actin [SMA] expression) with prognostic factors of oral squamous cell carcinoma (OSCC). Materials and Methods: A cross-sectional study conducted on 50 cases of histologically proven OSCC were selected for the assessment of TNM staging, tumor budding, DOI, and EMT markers (E-cadherin and SMA expression). Associations were evaluated between established clinical prognostic factors and histological parameters. Statistical analysis was performed using SPSS version 21.0. (IBM, Chicago, Illinois, USA) and P < 0.05 was considered statistically significant. Results: In the study, the median age of distribution was 48.5 years with 86% of males. Tobacco consumption was seen among 90% of patients. A significant association of pathological TNM staging with tumor budding and DOI (P < 0.05). There was a loss of E-cadherin expression with loss of tumor differentiation, progressive TNM stage, increasing DOI and more tumor budding (P < 0.05). On the contrary, α-SMA (% stained cells) expression showed an increase with increasing pathological T stage, N stage, tumor budding, and DOI (P < 0.0001). However, the tumor differentiation showed no significant association with SMA expression (P = 0.44). Conclusion: It can be concluded that EMT has a strong association with OSCC demonstrated by loss of E-cadherin and increased expression of α-SMA at the invasive front in higher grade carcinomas, in tumors with increased DOI, high-risk tumor budding, and increased pathological T and cases showing lymph node metastasis. Hence, SMA can be used in conjunction with loss of E-cadherin expression for determining the aggressive nature of OSCC and predicting the survival rates of the patients.","PeriodicalId":31219,"journal":{"name":"Journal of Cancer Research and Practice","volume":"8 1","pages":"139 - 147"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44264792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indocyanine green fluorescence imaging-guided resection of colorectal liver metastasis 吲哚菁绿荧光成像引导下大肠癌肝转移灶切除术

Journal of Cancer Research and Practice Pub Date : 2021-07-01 DOI: 10.4103/jcrp.jcrp_30_20

C. Kang, I. Chen

引用次数: 0

Decreased visual acuity after chemotherapy in a case with diffuse large B cell lymphoma 一例弥漫性大B细胞淋巴瘤化疗后视力下降

Journal of Cancer Research and Practice Pub Date : 2021-07-01 DOI: 10.4103/jcrp.jcrp_16_21

Cheng-chih Tsai, Chai Chen, T. Chao, Y. Hsieh

{"title":"Decreased visual acuity after chemotherapy in a case with diffuse large B cell lymphoma","authors":"Cheng-chih Tsai, Chai Chen, T. Chao, Y. Hsieh","doi":"10.4103/jcrp.jcrp_16_21","DOIUrl":"https://doi.org/10.4103/jcrp.jcrp_16_21","url":null,"abstract":"A 53-year-old male with no past medical history presented with abdominal pain for 2 days, accompanied with fever and poor appetite. Leukoerythroblastosis along with elevated lactate dehydrogenase and a bone marrow exam led to the diagnosis of diffuse large B-cell lymphoma, germinal center B-cell (GCB) type. After the 5th cycle of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone, progressively decreased visual acuity along with left ptosis occurred. Drug-related optic neuropathy was suspected, and initial magnetic resonance imaging (MRI) and cerebral spinal fluid (CSF) studies revealed negative results. However, meningeal lymphomatosis with bilateral optic nerve infiltration was finally diagnosed by subsequent MRI and CSF studies after 1 month. This rare case highlights the pitfalls of CSF studies. Based on previous studies, an adequate sample (>10.5 ml), rapid processing within 1 h, and serial testing at least twice can improve the rate of positive results while reducing the false-negative rate. We hope that this case can remind clinicians of the possible diagnosis of lymphomatous optic nerve infiltration from systemic lymphoma, and that properly conducted CSF studies can help to avoid missing this diagnosis.","PeriodicalId":31219,"journal":{"name":"Journal of Cancer Research and Practice","volume":"8 1","pages":"123 - 125"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46243177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of expression of p53 and Ki-67 in Benign, premalignant, and malignant lesions of the gallbladder p53和Ki-67在胆囊良恶性病变中的表达研究

Journal of Cancer Research and Practice Pub Date : 2021-07-01 DOI: 10.4103/jcrp.jcrp_7_21

Ranjeet Kumar, S. Yadav, Garima Singh, Ruchika Gupta, Sompal Singh

{"title":"Study of expression of p53 and Ki-67 in Benign, premalignant, and malignant lesions of the gallbladder","authors":"Ranjeet Kumar, S. Yadav, Garima Singh, Ruchika Gupta, Sompal Singh","doi":"10.4103/jcrp.jcrp_7_21","DOIUrl":"https://doi.org/10.4103/jcrp.jcrp_7_21","url":null,"abstract":"Background: Gallbladder cancer (GBC) has a distinctly higher incidence in certain demographic groups and areas. Chronic cholecystitis and epithelial changes such as metaplasia/dysplasia are associated with a higher incidence of gallbladder carcinoma. Progression from chronic cholecystitis to metaplasia/dysplasia to carcinoma is multifactorial. Ki-67 and p53 are involved at various stages of the cell cycle, and altered expressions of Ki-67 and p53 have been implicated in the carcinogenesis of various malignant tumors. Materials and Methods: Eighty gallbladder specimens were included in the study. Cases were grouped as chronic cholecystitis (Group 1), metaplasia-dysplasia (Group 2), and GBC (Group 3). P53 and Ki-67 immunoexpressions were determined and results were compared between groups. Results: The p53 expression score was highest in Group 3 (4.35 ± 1.72) and lowest in Group 1 (0.73 ± 0.98). The difference in the mean level of p53 expression was significantly (P = 0.0001) different among the groups. Ki-67 index was highest in Group 3 (47.85 ± 17.46) and lowest in Group 1 (6.50 ± 3.88). The mean Ki-67 index was significantly higher in Group 3 compared to Groups 1 and 2. P53 overexpression and Ki-67 expression were significantly associated with the presence of GBC (P = 0.0001). There was a positive correlation (r2 = 0.37, P = 0.001) between the expressions of p53 and Ki-67. Conclusion: P53 overexpression and Ki-67 index were significantly higher in the patients with GBC compared to those with chronic cholecystitis. This supports the theory of progression from chronic cholecystitis to metaplasia/dysplasia to carcinoma in the gallbladder. The expressions of p53 and Ki-67 in the metaplasia and dysplasia group were between the GBC and chronic cholecystitis groups.","PeriodicalId":31219,"journal":{"name":"Journal of Cancer Research and Practice","volume":"8 1","pages":"87 - 92"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44743396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impact of an intrahospital awareness strategy on attendance to the cervical cancer screening unit of the Yaoundé university teaching hospital cameroon 医院内部意识战略对喀麦隆雅温得大学教学医院癌症子宫颈筛查室就诊的影响

Journal of Cancer Research and Practice Pub Date : 2021-07-01 DOI: 10.4103/jcrp.jcrp_8_21

J. Antaon, Leuwe Eli, Robertine Mamche, Y. Mawamba, P. Tebeu

{"title":"Impact of an intrahospital awareness strategy on attendance to the cervical cancer screening unit of the Yaoundé university teaching hospital cameroon","authors":"J. Antaon, Leuwe Eli, Robertine Mamche, Y. Mawamba, P. Tebeu","doi":"10.4103/jcrp.jcrp_8_21","DOIUrl":"https://doi.org/10.4103/jcrp.jcrp_8_21","url":null,"abstract":"Background: Approximately 1500 women in Cameroon die annually from cervical cancer, but only 8% of women at risk have undergone cervical cancer screening. The objective of this study was to analyze the impact of an intrahospital awareness strategy on the frequency of cervical cancer screening at Yaoundé University Teaching Hospital(YUTH). Materials and Methods: This quasi-experimental study (before/after) was conducted at the Yaoundé UTH. It involved women who received an awareness of cervical cancer intervention at the Yaoundé CHU (intervention group) and those who did not (without intervention group) for 4 months (March to June) of 2 consecutive years (2016 and 2017). Proportions, central tendency parameters (mean or median), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Results: A total of 1,313 women participated in screening for cervical cancer, of whom 40.60% were in the without intervention group and 59.40% were in the intervention group. The level of education and marital status were heterogeneously distributed in the two groups (P < 0.05). Women with a higher education level and who were married were more likely to participate in cervical cancer screening after intrahospital sensitization (OR [95% CI] = 5.64 [4.41–7.20] and OR [95% CI] = 1.48 [1.19–1.85], respectively). Conclusion: An intrahospital awareness intervention increased the number of participants in screening for cervical cancer. There is a need to implement this strategy in other hospitals and place particular emphasis on sensitizing less educated and single women.","PeriodicalId":31219,"journal":{"name":"Journal of Cancer Research and Practice","volume":"8 1","pages":"93 - 97"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49422894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0