{"title":"Using the photonic toolbox to study chromosomes: 50 years in search of an answer!","authors":"M. Berns","doi":"10.1117/12.2603700","DOIUrl":"https://doi.org/10.1117/12.2603700","url":null,"abstract":"Little did I know that when I published our first laser microbeam paper on chromosome surgery in 1969, that 50 years later I would still be doing that—trying to explain the inexplicable result we saw back then. The path to an answer of why cells with partially photon-ablated chromosomes could reproduce and maintain the photon-induced deletion in the clonal population of cells, was a path that was solely possible by the parallel development of additional tools in the photonic toolbox. Development of digital-based imaging technologies, GFP-based molecular fluorescent probes, and an evolution of optical manipulation tools (photonic scissors and tweezers) have been combined to provide a tantalizing answer to the question of why cells can divide and form clones following removal of a segment of their DNA.","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125279481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self-Organizing Optical Matter Machines and Many-Body Forces","authors":"N. Scherer","doi":"10.1117/12.2595310","DOIUrl":"https://doi.org/10.1117/12.2595310","url":null,"abstract":"Optical Matter systems, particularly those created with nanoparticles, allow studying new optical physics phenomena, non-reciprocal forces and even many-body effects. This talk will introduce self-assembling nanoparticle-based optical matter machines and the inter particle electrodynamic interactions that give rise to structures that can do work. It will also introduce a new many-body mechanism for spin-to-orbital angular momentum conversion as studied by experimental measurements, electrodynamics-Langevin dynamics simulations and theory.","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124563398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramon Gao, M. Kelzenberg, Yonghwi Kim, Adrien Merkt, O. Ilic, H. Atwater
{"title":"Restoring optical forces and torques for passive stabilization of microscopic lightsails","authors":"Ramon Gao, M. Kelzenberg, Yonghwi Kim, Adrien Merkt, O. Ilic, H. Atwater","doi":"10.1117/12.2594383","DOIUrl":"https://doi.org/10.1117/12.2594383","url":null,"abstract":"Directed propulsion of lightsails to relativistic speeds by laser radiation pressure demands for passive stabilization, which can be achieved with subwavelength metasurface elements. Our tailored nanophotonic design based on silicon nitride is predicted to give rise to restoring forces and torques upon small perturbations in its dynamics. By measuring the angles and intensities of the diffracted orders, we infer the light-induced pressures on our lightsail prototype. Using Michelson interferometry and laser deflection spectroscopy, we can directly observe the dynamical stability of spring-supported suspended membrane designs. Our results pave the way for lab-scale experiments on optical manipulation of microscopic lightsails.","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117322329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danika R. Luntz-Martin, R. G. Felsted, S. Dadras, P. Pauzauskie, A. N. Vamivakas
{"title":"Temperature control of levitated nanoparticles in an optical trap","authors":"Danika R. Luntz-Martin, R. G. Felsted, S. Dadras, P. Pauzauskie, A. N. Vamivakas","doi":"10.1117/12.2595583","DOIUrl":"https://doi.org/10.1117/12.2595583","url":null,"abstract":"Optically levitated nanoparticles provide excellent systems to sense minute forces and explore quantum effects in a large system. However, optically levitated nanoparticles are prone to heating and require cooling and temperature stabilization to reach sensitivities necessary to study small forces and quantum effects. This problem can be solved by trapping nanocrystals doped with rare-earth ions that can be anti-Stokes cooled by tens of degrees. The efficiency of the anti-Stokes depends on gas pressure and can counter heating due to optical absorption. Cooling nanocrystals allows for thermally stabilizing nanocrystal systems to measure minute forces and quantum effects.","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115005441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dalziel J. Wilson, J. Manley, Swati Singh, Mitul Dey Chowdhury, D. Grin, Aman R. Agrawal
{"title":"Optomechanical dark matter detection","authors":"Dalziel J. Wilson, J. Manley, Swati Singh, Mitul Dey Chowdhury, D. Grin, Aman R. Agrawal","doi":"10.1117/12.2595608","DOIUrl":"https://doi.org/10.1117/12.2595608","url":null,"abstract":"Recently it has been proposed to search for dark matter using mechanical sensors, exploiting the fact that all dark matter candidates couple to the size or position of atoms. While focus has been directed towards analyzing signal from gravitational wave detectors and equivalence principle tests, a unique opportunity has emerged to develop compact detectors based on cavity optomechanical systems, which have recently achieved force measurements at the quantum limit. I'll discuss this concept from an experimentalist's perspective, highlighting systems based on levitated dielectrics, silicon nitride membranes, and bulk acoustic wave resonators which are beginning to play an early role. In this context, our lab is developing a new generation of ultra-sensitive optomechanical accelerometers based on centimeter-scale silicon nitride membranes.\u0000\u0000References:\u0000[1] Manley et. al., PRL 126(6), 061301(2021)\u0000[2] Carney et. al., QST 6(2), 024002 (2021)\u0000[3] Manley et. al., PRL 124(15), 151301 (2020)","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121256670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical positioning and linking for nanoscale assembly","authors":"J. Melzer, E. Mcleod","doi":"10.1117/12.2594734","DOIUrl":"https://doi.org/10.1117/12.2594734","url":null,"abstract":"Three-dimensional (3D) structures with nanoscale building blocks often benefit from light-matter interaction at the nanometer size scale. The most popular existing technologies for the 3D fabrication of these small structures (e.g. direct laser writing) typically encounter significant restrictions. Here we demonstrate our optical positioning and linking (OPAL) platform for the assembly of multi-material 3D devices consisting of nanoscale components. OPAL integrates an optical trapping setup with a computer-controlled motion platform, microfluidic building block delivery apparatus, and imaging feedback system, overcoming the limitations of many traditional nanofabrication approaches, and establishing a versatile tool for the fabrication of complex 3D nanophotonic structures.","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127972511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacob Kher-Alden, T. Carmon, M. Douvidzon, L. Deych
{"title":"Microspheres with atomic-scale tolerances generate hyper-degeneracy","authors":"Jacob Kher-Alden, T. Carmon, M. Douvidzon, L. Deych","doi":"10.1117/12.2595201","DOIUrl":"https://doi.org/10.1117/12.2595201","url":null,"abstract":"Highly symmetrical objects are important to a manifold of applications such as precise measurements and sensing. However, creating a perfect sphere proves to be experimentally extremely difficult, as gravity and the support deform the sphere from its perfect shape. \u0000In this work, we optically levitate a micro oil droplet and activate it as whispering gallery mode optical resonator. Our contactless resonator displays a sphericity of less than one Angstrom for a 10 µm radius droplet and is therefore one of the roundest objects there is. Additionally, we demonstrate an unprecedented resonance enhancement defined by “optical quality” over “mode volume” and lastly, benefitting from the high sphericity, we lift degeneracies of order higher than 200.","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134331145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First search for new long rage forces at the micron scale using optically levitated microspheres","authors":"G. Gratta, N. Priel","doi":"10.1117/12.2594895","DOIUrl":"https://doi.org/10.1117/12.2594895","url":null,"abstract":"First search for new long rage forces at the micron scale using optically levitated microspheres","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117078030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Jagiełło, Qingda Hu, Ulysses Castillo, E. Botvinick
{"title":"Using light to establish and measure stiffness gradients in three-dimensional engineered tissues","authors":"A. Jagiełło, Qingda Hu, Ulysses Castillo, E. Botvinick","doi":"10.1117/12.2595590","DOIUrl":"https://doi.org/10.1117/12.2595590","url":null,"abstract":"Studies of cell-extracellular matrix (ECM) interactions within fibrous systems such as collagen or fibrin are challenging, particularly if peri-cellular stiffness cannot be monitored. Here we present our light-based method for non-invasive patterning of molecular crosslinking combined with multi-axes optical tweezers active microrheology to map ECM stiffness landscapes. This method allows us to generate prescribed stiffness gradients and associated anisotropies, which model stiffness of the natural peri-cellular ECM. Patterned crosslinking induces strain hardening and measured stiffness gradients are in agreement with predicted strain fields. Migratory cells respond to these gradients as assessed by change in F-actin distribution and morphological properties.","PeriodicalId":311295,"journal":{"name":"Optical Trapping and Optical Micromanipulation XVIII","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134378059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}