National Journal of Laboratory Medicine最新文献

{"title":"Association of ABO Blood Group Status in Patients with Breast Lesions and Emphasis on Invasive Breast Carcinoma","authors":"Shahanaz Shaik, B. Kumarguru, Ashutosh Ramaswamy, R. Anegundi, P. Janakiraman","doi":"10.7860/njlm/2022/51863.2647","DOIUrl":"https://doi.org/10.7860/njlm/2022/51863.2647","url":null,"abstract":"Introduction: The ABO blood group antigens are expressed on the erythrocyte membrane and on the surface of other normal and pathological cells. Recently, there has been an increasing research interest in the association between ABO blood group antigens and certain type of human cancers. Aim: To determine the association of ABO blood group and Rh blood type in patients with breast lesions. Materials and Methods: It was a retrospective observational study done at a rural tertiary care referral institute, PES Institute of Medical Sciences and Research (PESIMSR), Kuppam, Andhra Pradesh, India, from January 2015 to December 2018. Apparently healthy female voluntary blood donors constituted the control group (n=222). Patients with breast lesions constituted the study group (n=125). The association of the breast lesions with ABO blood group and Rh blood type was analysed. Frequencies, Chi‑square test and crosstabs were the statistical tools used for data analysis. All the statistical calculations were performed through Statistical Software for Data Science (STATA) version 14.1. Results: Total 125 cases of breast lesions were analysed. Neoplastic lesions 113 (90.4%) were more common than the non neoplastic lesions 12 (9.6%). Blood group “O” was the most common blood group in malignant neoplasms and was statistically significant (p=0.045). Blood group B was the most common blood group in grade II invasive breast carcinoma and was statistically just significant (p=0.05). Conclusion: A definite change in the pattern of distribution of ABO blood group was observed in grade II malignant neoplasms. It may be hypothesised that knowing the blood group of breast cancer patients may be beneficial in order to triage the patients for the purpose of efficient management.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71270277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological and Immunohistochemical Features of Nasal and Paranasal Sinus Neoplastic Lesions- A Cross-sectional Study","authors":"C. Anushree, S. S. Maharana, Bhavya Nair, Y. Manjunatha","doi":"10.7860/njlm/2022/53594.2611","DOIUrl":"https://doi.org/10.7860/njlm/2022/53594.2611","url":null,"abstract":"Introduction: Majority of nasal and paranasal sinus lesions clinically present as polypoidal lesions, complicating the diagnosis for the physician which inturn hampers the patient prognosis and in few cases survival of patient, so histopathology is imperative to arrive at the diagnosis. Carcinoma of the paranasal sinus cavity is rare representing 3-4% of head and neck tumours and less than 1% of all malignancies. Aim: To examine the histopathological patterns of neoplastic nasal and paranasal sinus lesions, to categorise neoplastic lesions into benign and malignant types, to find the relation of these lesions with age and sex and also to find the utility of Immunohistochemistry (IHC) in differentiating morphologically suspicious lesions. Materials and Methods: The present cross-sectional study was carried out between January 2020-January 2021. A total of 22 cases were taken for the study, which were received as nasal and paranasal sinus lesions in histopathology. All the lesions received were processed according to standard protocol and diagnosed histopathologically and confirmed by relevant special stains and immunohistochemical analysis (CD99, CD56 etc.). Results: Out of 22 cases, 16 were benign and six were malignant. The lesions were commonly detected between fourth to sixth decades. Male to female ratio was 1.4:1. The ratio of benign to malignant lesion was 2.67:1. The most common benign lesion encountered was capillary haemangioma (seven cases) and malignant lesion seen was squamous cell carcinoma (three cases), comparable to other similar studies. The IHC was done in malignant lesions for accurate diagnosis. Conclusion: In the present study, the cases are divided into benign and malignant lesions with the help of histopathological examination. Cases showing features of malignancy were further subjected to immunohistochemical examination as to diagnose the cases precisely and thus help in patient treatment and prognosis.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71270634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Plasma Glucose Estimations as Reliable Economical Surrogate for HbA1c in Monitoring Glycaemic Status of T2DM Patients: A Retrospective Study","authors":"K. M. Mathi, M. Chowdary","doi":"10.7860/njlm/2022/53060.2658","DOIUrl":"https://doi.org/10.7860/njlm/2022/53060.2658","url":null,"abstract":"Introduction: In Low and Middle Income Countries (LMIC) like India, either Fasting Plasma Glucose or Postprandial Plasma Glucose (FPG/PPG) estimations were adopted as surrogate alternative to Glycated Haemoglobin (HbA1c) in Type 2 Diabetes Mellitus (T2DM). However, the reliability of this correlation remains ambiguous due to lack of consensus among the previous studies. Aim: To determine the correlation of FPG and PPG as well as their calculated mean with HbA1c in T2DM subjects for monitoring glycaemic status. Materials and Methods: A single centre, retrospective, cross- sectional data survey was carried out for a sampling frame of 13 months (August 2017 to August 2018) encompassing 1268 T2DM subjects. The data was collected during September 2018 to March 2019 and subsequently analysed during April 2019 to August 2019. The analysis was carried out in two approaches. In the first approach: the data was segregated into two major groups and six subgroups to understand relative concordance and discordance percentage; sensitivity, specificity and accuracy; and absolute and percentage difference recruiting relevant statistical tools. In the second approach, Area Under Curve (AUC) of Receiver Operating Characteristic (ROC) curves were employed to understand changes in FPG/PPG/calculated mean with increasing severity of T2DM. Results: With increasing severity of T2DM (HbA1c), not only gradual exacerbation of underestimation in FPG and overestimation in PPG but also declination of sensitivity in either of them was apparent. Though calculated mean of FPG and PPG measurements appended with intermittent features yet mimics PPG. AUC of ROC analysis revealed relatively high PPG levels at lower HbA1c levels and its replacement with FPG with increasing HbA1c levels. Conclusion: An integrated utility of both FPG and PPG as tuning tools of treatment modalities to achieve desired HbA1c levels in T2DM could be a promising approach.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71270787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Analytic Error Which Can Mimic as a Preanalytical Error","authors":"M. Shankar, Anjali Sharma, Mumta Singh, .. Sugandha","doi":"10.7860/njlm/2022/52303.2636","DOIUrl":"https://doi.org/10.7860/njlm/2022/52303.2636","url":null,"abstract":"","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71270994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Transfusion Transmitted Diseases in a Tertiary Care Hospital of Northern India: A Five Year Retrospective Study","authors":"H. Sharma, Meghana Bansal, Ritu Sharma, Nikhilesh Kumar, Deepak Munjal","doi":"10.7860/njlm/2022/53686.2621","DOIUrl":"https://doi.org/10.7860/njlm/2022/53686.2621","url":null,"abstract":"Introduction: Although transfusion of blood and its components is life saving but it may also pose a threat to life as with every unit of blood there is 1% chance of transfusion associated problems which include the transfusion of transmitted diseases as well. The Ministry of Health and Family Welfare (Government of India) under The Drug and Cosmetic Act, 1945 (amended from time to time) mandates the screening of blood donations against five major infections- Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Syphilis and Malaria. Aim: To estimate the prevalence of Transfusion Transmitted Infections (TTIs) among blood donors in a tertiary care hospital. Materials and Methods: This is a retrospective five year study from February 2016 to January 2021. The study was undertaken at TS Misra Medical College and Hospital, Lucknow, Uttar Pradesh, India. The sample size included 5420 blood donors. The data concerning type of donors, gender and results of screening tests were obtained from blood bank register/records. Donor selection was based on history of present and past illness and also included a pre-donation questionnaire. Serum samples were screened for Hepatitis B Surface Antigen (HBsAg), antibodies to HIV Type 1 and 2 and antibodies to HCV using Microwell Enzyme Linked Immuno Sorbent Assay (ELISA) Test. For syphilis and malaria detection, membrane based immunoassay and sandwich immunoassay techniques were used respectively. Results: Out of a total of 5420 blood donations over a period of five years, there were 5298 male donors and 122 female donors. There were 5368 replacement donors and 52 voluntary donors. The prevalence of HIV, HBsAg, HCV, syphilis and malaria was 0.16%, 0.77%, 0.11%, 0.53% and 0%, respectively. Conclusion: Voluntary blood donations, stringent screening measures, advanced screening techniques, strict donor selection are essential features for decreasing the prevalence further and also would ensure blood safety.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71271033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocytic Thyroiditis- Association between Cytology and Biochemical Findings","authors":"Priya P Kartha, Aysha Ali, K. Jayasree, B. Sreeram","doi":"10.7860/njlm/2022/54808.2619","DOIUrl":"https://doi.org/10.7860/njlm/2022/54808.2619","url":null,"abstract":"Introduction: Hashimoto’s thyroiditis otherwise called as chronic lymphocytic thyroiditis is the most common cause of hypothyroidism and one of the most common thyroid lesions in Fine Needle Aspiration Cytology (FNAC). Diagnosis depends on clinical findings, ultrasonographic findings, thyroid profile and antithyroid antibody levels along with the FNAC findings. Not much studies are there which have assessed the association of the clinical and biochemical parameters with the cytological findings. Aim: To grade the cytological features of lymphocytic thyroiditis and to study the association of the grades with Thyroid Function Test (TFT) and antithyroid antibody levels. Materials and Methods: A prospective time bound analytical observational study of one year was carried out in the Department of Pathology at Government Medical College, Palakkad, Kerala, India after obtaining approval from the Institutional Ethics Committee (IEC). Out of the total of 462 cases of thyroid lesions who underwent Fine Needle Aspiration (FNA), 147 cases were lymphocytic thyroiditis as per cytology. Of these, 40 cases had Thyroid Stimulating Hormone (TSH), Antithyroglobulin Antibody (ATG) and Antithyroid Peroxidase Antibody (ATPO) levels known which were included in the study. Cytological grading of those were done and the association of the same with the above mentioned parameters was studied. Data was analysed using Statistical Package for the Social Sciences (SPSS) software. Descriptive statistics were calculated and presented as percentages, mean and Standard Deviation (SD). Chi-square test was used to find the association between the categorical variables. The p-value <0.05 was taken as statistically significant. Results: Cytomorphology was diagnostic of thyroiditis in all the cases. Out of the 40 cases, 32 were females.The most common age group affected was 31-40 years, though it ranged from 18-68 years. Most common clinical presentation was diffusely enlarged thyroid, though a few presented as nodular disease. Most of the patients had grade 1 thyroiditis (23 cases) followed by grade 2 (13 cases). Elevated antithyroid antibody levels - ATPO elevated in 32 cases and ATG in 20 cases. TSH was seen elevated in 28 cases of thyroiditis. No association was observed with the antithyroid antibody levels and the cytological grade. Conclusion: Lymphocytic infiltration into the follicles is the diagnostic cytological feature of chronic lymphocytic thyroiditis. TSH elevation and positive ATPO levels strongly suggest Hashimoto’s thyroiditis. No association was found between the cytological grade and TSH and antibody levels.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71271086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Cytological and Histomorphological Findings in Breast Tumours- A Study from a Tertiary Care Hospital in Southern India","authors":"Subhashini Ramamoorthy, S. Sinhasan, Basavanandaswami C Harthimath","doi":"10.7860/njlm/2022/53673.2626","DOIUrl":"https://doi.org/10.7860/njlm/2022/53673.2626","url":null,"abstract":"Introduction: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in females. There is increasing awareness and the associated anxiety and stress among women, who perceive every symptom in breast as carcinoma, compels the patients to seek medical advice. Fine Needle Aspiration Cytology (FNAC) is a relatively simple, reliable, atraumatic, economical and complication free technique for the evaluation of mass lesions. Aim: To study the varied spectrum of breast tumours and to evaluate the diagnostic utility of cytological findings by comparing it with histopathological findings in breast tumours. Materials and Methods: The present study was a hospital- based cross-sectional study conducted in the Department of Pathology, Indira Gandhi Medical College and Research Institute, Pondicherry, India, from November 2017-October 2019. All cases of breast tumours, sent by surgeon, as out-patient or in- patient, who underwent FNAC followed by surgical biopsy, were included in this study. A total of 150 cases were studied. FNAC smears were stained using Haematoxylin and Eosin (H&E) and Papanicolaou (Pap) stains and air-dried smears were stained using May Grunwald Giemsa (MGG) stain. The excised specimen after surgery was subjected to detailed histopathological examination. Representative bits were taken from appropriate sites and stained using H&E stains, special stains and Immunohistochemistry (IHC) were carried out wherever necessary. Results: Majority of cases were in the age group of 21-30 years. There were 149 cases of female patients and only one case of male patient with breast carcinoma during the study period. Cytology showed 117 cases of benign tumours and 33 cases were malignant. Histopathology revealed 116 cases of benign tumours and 34 cases of malignant. One case was given as Atypical Ductal Hyperplasia (ADH) in cytology, found to be malignant Infiltrating Ductal Carcinoma (IDC) on histopathological examination. Five cases on cytology which were given as suspicious of carcinoma (C4 category) were found to be IDC on excision biopsy. Benign lesions were common in right breast, whereas malignant lesions were common in left breast. The diagnostic value of FNAC was assessed and showed sensitivity: 97.06%, specificity: 100%, Positive Predictive Value (PPV): 100%, Negative Predictive Value (NPV): 99.15% Accuracy of 99.33%. Conclusion: The present study was an attempt to compare cytological and histomorphological findings in breast tumours to know the diagnostic accuracy of FNAC and also studying the spectrum of breast lesions. The high specificity and negative predictive value showed high accuracy of FNAC in diagnosing the malignancy. It is an established method to determine the nature of breast lesions. In the present study, fibroadenoma was the commonest benign tumour and IDC- Not Otherwise Specified (NOS) type was the commonest malignant tumour.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71271432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device Associated Hospital Acquired Infections in a Tertiary Care Hospital in Western Odisha","authors":"A. Behera, Swetalina Jena, R. Sethi","doi":"10.7860/njlm/2022/50353.2562","DOIUrl":"https://doi.org/10.7860/njlm/2022/50353.2562","url":null,"abstract":"Introduction: Hospital Acquired Infection (HAI) is defined as infection that is acquired after 48 hours of admission in hospital for a reason other than that infection and the infection was neither present nor incubating at the time of admission. Device Associated Hospital Acquired Infections (DAHAIs) mainly Central Line Associated Blood Stream Infection (CLABSI), Ventilator Associated Pneumonia (VAP) and Catheter Associated Urinary Tract Infection (CAUTI) pose significant threat to patients associated with prolonged hospital stays, greater healthcare costs and increased mortality. Surveillance of Device Associated Infections (DAI) can reduce the incidence of Nosocomial Infections (NI) by as much as 32% and lead to reduced healthcare costs. Aim: To determine the microbiological profile of device associated HAI and to find the antimicrobial susceptibility pattern of the isolated organisms. Materials and Methods: This was a hospital based crosssectional study conducted in the Department of Microbiology, from November 2015 to October 2017. The study was targeted at three common DAHAIs: CAUTI, CLABSI and VAP. Patients admitted to clinical wards with 48 hours of indwelling devices like urinary catheter, central line and with endotracheal intubation developing signs and symptoms of DAI were included in the study. Specimen was collected with all aseptic precautions. Samples were processed by standard bacteriological methods. Isolates obtained were characterised by biochemical methods. Antibiotic susceptibility tests were done by Kirby Bauer discdiffusion method. Total of 425 samples were included in the study of which 152 (35.76%) showed positive growth and in 273 (64.24%) samples culture was sterile. The samples were collected from Intensive Care Unit (ICU) and various wards. The results were expressed in terms of mean, percentage and rate. Results: A CAUTI was the most common 53.28%, followed by VAP 37.51% and then CLABSI 9.21%. Escherichia coli was most commonly isolated organism 38 (23.45%) followed by Staphylococcus aureus 30 (18.51%). In CAUTI Escherichia coli (38.27%) was most commonly isolated and Acinetobacter baumannii (32.25%) was most commonly seen in VAP and in CLABSI Candida spp. (31.57%) was predominantly isolated. Conclusion: This study gave an insight into the incidence and prevalence of DAHAIs and helps in instituting various interventional strategies to prevent these infections.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71270033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of CO-RADS Score with Inflammatory Markers in COVID-19 Patients: A Retrospective Analysis at a Designated COVID Centre of Kolhapur, India","authors":"Sapna S Deshpande, Namrata B Mestri, C. Patil","doi":"10.7860/njlm/2022/51293.2598","DOIUrl":"https://doi.org/10.7860/njlm/2022/51293.2598","url":null,"abstract":"Introduction: Coronavirus Disease-2019 (COVID-19) Reporting and Data System (CO-RADS) score in Computed Tomography (CT) scan of the chest is a priority investigation in early identification of the disease. Although, a CT scan gives a clear parenchymal picture of the condition, it has its disadvantages of the cost and specificity in the prognosis of COVID-19. In addition, clinical studies have revealed its decreased utility in assessing the severity of the disease. Aim: To understand the correlation of the CO-RADS score with various inflammatory markers and explore the changes in CO- RADS score with the severity of COVID-19 infection. Materials and Methods: The present study is a retrospective observational study in a designated COVID-19 centre in Kolhapur, India. The radiological and pathological records of 64 cases for two months (September to October 2020) were reviewed and charted. The present study included all the cases over 18 years. The authors excluded pregnant women, patients with tuberculosis, interstitial lung disease, and pulmonary malignancy with a view of interference with the radiological presentation of COVID- 19. Along with demographics, biomarkers like Total Leucocyte Count (TLC), C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), D-Dimer, Interleukin-6 (IL-6), Procalcitonin (PCT), and serum ferritin were retrospectively reviewed and documented. The CO-RADS score, as reported by an expert radiologist, was noted down. Pearson’s correlation coefficient was used to correlate the CO-RADS score with various inflammatory markers. Results: The authors found significant high positive correlation of CT score with LDH (r=0.754; p-value <0.001), moderate positive correlation with IL-6 (r=0.503; p-value <0.001), low positive correlation with CRP (r=0.477; p-value <0.001) and PCT (r=0.461; p-value <0.001). The correlation between the CT score with serum ferritin (r=0.284; p-value=0.023), total leukocyte count (r=0.260; p-value=0.038) and D-dimer (r=0.242; p-value 0.050) was negligible. Conclusion: The CO-RADS CT score is associated with the severity of COVID-19 disease and with mortality. The CO-RADS score showed a high positive correlation with LDH values of the present study. The LDH seems to be a promising marker and has to be further evaluated in assessing early COVID-19 infection with a multi-centric and more extensive sample size approach.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71270491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histomorphological Study of Ovarian Lesions with Emphasis on Rare Entities- A Descriptive Study","authors":"S. Surapaneni, Vandana Gangadharan, Harika Pentakota, Krishna Kumari Sala","doi":"10.7860/njlm/2022/53606.2657","DOIUrl":"https://doi.org/10.7860/njlm/2022/53606.2657","url":null,"abstract":"Introduction: The ovaries are bilateral organs on either side of the uterus. Non neoplastic and neoplastic lesions occur in all age groups and can present with similar clinical and radiological features. Histopathology remains the gold standard for diagnosing and categorising these lesions. Aim: To study the prevalence of ovarian lesions in relation to age and clinical findings. Neoplastic lesions will be histologically classified as per World Health Organisation guidelines. Findings in this study will be compared with that in other studies. Materials and Methods: This is an observational study of all ovarian lesions undertaken in the Department of pathology in NRI Institute of Medical Sciences, Sangivalasa, Vishakhapatnam, Andhra Pradesh, India, from June 2018 to November 2021. Specimens were received as ovarian masses alone, or in combination with hysterectomy with either unilateral or bilateral salpingo- oophorectomy. Relevant clinical information was obtained from the records. The tissues were processed by using an automatic tissue processor, paraffin blocks were made and sections cut were stained with Haematoxylin and Eosin(H&E) and examined under the microscope. The lesions were categorised as non neoplastic and neoplastic. The neoplastic lesions were classified according to the latest 2020 World Health Organisation (WHO) guidelines. Incidence of various lesions was expressed in percentage. Results: A total of 119 specimens were studied. Some of the specimens had bilateral ovaries and the second ovary had a different nonneoplastic lesion in 18 cases. 80 (60.60%) were nonneoplastic lesions and 52 (39.39%) were neoplastic lesions. 5 cases of torsion could not be classified into neoplastic or non-neoplastic due to lack of viable histological features. Non neoplastic lesions were more common in the 31-50 years age group. Benign neoplasms were common in 41-50 years age group. Malignant tumours were more common in the perimenopausal and postmenopausal age group. The most common non neoplastic lesion were 39 cases (48.75%) of follicular cyst followed by 26 cases (32.5%) of corpus luteal cyst, 13 cases (16.25%) of cystic follicles and 2 cases (2.5%) of endometriotic lesions. Of the neoplastic lesions, 47 cases (90.38%) were benign, 2 cases (3.84%) were borderline and 3 cases (5.76%) were malignant tumours. Surface epithelial tumours were 42 cases (80.76%), followed by 6 cases (11.53%) of germ cell tumours and 4 cases (7.69%) of sex cord stromal tumours. Conclusion: Non neoplastic lesions and neoplastic lesions present with similar clinical and radiologic picture and must be differentiated histopathologically. Non neoplastic lesions were more common in the present study. Among the neoplasms, benign tumours were more common and surface epithelial tumours were more common than any other category. Torsion ovary, Seromucinous cystadenoma, atypical endometrioid tumor and granulosa cell tumor were some rare entities that were encountered in the study. Cla","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71270696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}