TP75. TP075 PEDIATRIC LUNG INFECTION最新文献_第3页

Anterior Mediastinal Mass in an Infant Revealing Rare Diagnosis 婴儿前纵隔肿块的罕见诊断

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3402

Y. Fireizen, I. Randhawa, D. Vasquez, C. Shahriary, B. Ovunc

引用次数: 0

Long-Term Pulmonary Sequalae in Children After Severe Viral Lower Respiratory Tract Infections Treated with Mechanical Ventilation 机械通气治疗严重病毒性下呼吸道感染患儿的长期肺部后遗症

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3414

E. D. de Sonnaville, H. Knoester, S. Terheggen-Lagro, M. Königs, J. Oosterlaan, J. V. van Woensel

引用次数: 0

The Effects of Early-Life Rhinovirus Infection on Airway Remodeling Factors in Term and Premature Infants 早期鼻病毒感染对足月和早产儿气道重塑因子的影响

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3413

X. Xu Chen, J. Weinstock, M.A. Arroyo Morr, K. Salka, E. Chorvinsky, K. Abutaleb, H. Aguilar, R. Kahanowitch, C. E. Rodriguez Martinez, G. Perez, M. Gutierrez, G. Nino

引用次数: 0

Respiratory Findings in Children Post-COVID-19 Infection covid -19感染后儿童的呼吸道症状

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3404

S. L. Leftin Dobkin

{"title":"Respiratory Findings in Children Post-COVID-19 Infection","authors":"S. L. Leftin Dobkin","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3404","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3404","url":null,"abstract":"The COVID-19 disease pandemic has resulted in millions of patients infected globally. Data have emerged that some patients continue to experience long-term adverse outcomes related to COVID-19 after the acute phase of infection;and chronic symptoms following other coronaviruses, specifically Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), have been well documented. There is currently scarce literature describing post-acute symptoms in pediatric patients with COVID-19. Here we describe respiratory findings following acute COVID-19 infection in a cohort of pediatric patients aged 10-to 20-years-old (average age 14-years-old) presenting for pulmonary evaluation. Data were evaluated by retrospective chart review. The majority of patients had pre-existing lung disease (86%). The most common comorbidity was asthma (71%) followed by allergies (29%) and obesity (14%). Most asthmatic patients had mild intermittent asthma (80%) followed by moderate persistent asthma (20%). All patients engaged in regular physical activity prior to COVID-19 infection. Patients were assessed a mean 92 days after SARS-CoV-2 positive PCR. Most common acute COVID-19 symptoms were fever (71%), cough (57%), fatigue (42%), dyspnea (29%) and anosmia (29%). None of the patients required hospitalization, supplemental oxygen, or noninvasive or invasive ventilation. All of the patients experienced dyspnea for at least two months at the time of this abstract following acute COVID-19 infection. The other most common reported chronic symptoms were decreased exercise tolerance (71%), cough (43%) and chest pain (43%). No patients had fevers at time of follow up, and all patients had normal oxyhemoglobin saturations. All patients had normal chest radiographs at the time of follow up. Pulmonary function testing was normal in the majority of cases and average percent predicted spirometry results included FEV1 104.5%, FVC 110%, FEV1/FVC 84% and FEF25-75% 84%. Reduced FEF25-75% was observed in a small number of patients (29%). Exercise intolerance on a six-minute walk test was observed in one patient, with significant tachycardia for age and baseline fitness level, after two minutes. The burden of caring for COVID-19 survivors is expected to be tremendous, and future medical and social interventions must consider the late sequelae of SARS-CoV-2 infection. There is currently limited information about the chronic adverse outcomes of COVID-19 particularly in children, and it is important for healthcare providers and policy makers to understand the long-term impact of COVID-19 on survivors. This information will likely have important implications for public health surveillance, health resource allocation, clinical research, and future treatments.","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124545422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Early Life Antibiotic Treatment Results in Sex-Dependent Alterations in Lung Development 早期抗生素治疗导致肺部发育的性别依赖性改变

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3401

T. Westmont, C. M. Royer, A. Rindy, N. Siegel, H. Deshmukh, L. A. Miller

引用次数: 0

Between a Rock and a Hard Place: A Newborn with Thrombosis of the Patent Ductus Arteriosus

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3415

M. Nguyen, V. Soetanto, C. Peshkovsky

{"title":"Between a Rock and a Hard Place: A Newborn with Thrombosis of the Patent Ductus Arteriosus","authors":"M. Nguyen, V. Soetanto, C. Peshkovsky","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3415","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3415","url":null,"abstract":"Introduction: Thromboembolic events (TE) in neonates are rare, with even more infrequent occurrence of thrombosis of the patent ductus arteriosus (PDA). Whereas previously estimated to be 2.4 in 1000 live births, new developments in screening and diagnostic modalities have added to the incidence of TE. Further, incidence of TE has increased in those affected by coronavirus-19 (COVID-19). We present a case of a neonate born to a mother diagnosed with COVID-19, found to have thrombosis of the ductus arteriosus. Case: The patient is a full-term male neonate (3.2 kg), born to a healthy mother with mild gestational hypertension who was diagnosed for COVID-19 infection at 21 weeks gestation which had resolved perinatally. A routine fetal echocardiogram performed at 21 weeks showed a serpiginous PDA with mildly elevated velocity (2.3 m/s) and normal fetal cardiac anatomy. At birth, although he was initially stable with mild sinus bradycardia, he quickly developed respiratory distress with significant hypoxia. Four hours after birth, he was given oxygen supplementation and was evaluated for transient tachypnea of the newborn or persistent pulmonary hypertension. The transthoracic echocardiogram showed pulmonary hypertension with systemic right ventricular systolic pressure and bidirectional shunting at the foramen ovale. Additionally, he was noted to have a large thrombus (5 mm) occluding the proximal end of his large PDA (Figure 1). Due to concern for potential dislodgement of the thrombus and subsequent pulmonary or systemic embolism, anticoagulation therapy (enoxaparin) was initiated and supplemental oxygen was continued. A brain ultrasound and clotting factor assessment was also done, with serial echocardiograms. The thrombus disappeared by the eighth day. Enoxaparin was continued for a total of six weeks. Discussion: In a neonate with TE, several risk factors should be considered including congenital cardiac anomalies and hypercoagulability state. In this case, the neonate had a serpiginous ductus arteriosus. He also had umbilical catheters, which are considered risk factors for thrombosis, but these were not placed until after the thrombus was already identified. In addition, his birth history was significant for a mother who was diagnosed with COVID-19, but data on vertical transmission of COVID-19 and subsequent risk for TE has not been fully reported. With increased incidence of COVID-19 in the general population, further studies on its effects on fetal health should be explored.","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130746865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of COVID-19 Symptom Severity in NYC Children: A Prospective Cohort Study 纽约市儿童COVID-19症状严重程度的预测因素:一项前瞻性队列研究

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3419

I. Gourari, S. Worgall, P. Permaul

{"title":"Predictors of COVID-19 Symptom Severity in NYC Children: A Prospective Cohort Study","authors":"I. Gourari, S. Worgall, P. Permaul","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3419","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3419","url":null,"abstract":"Rationale: There is an urgent need to better understand the factors associated with symptomatic COVID-19 illness in the general pediatric population, and specifically, children with asthma. Children can contract the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) but most are asymptomatic. Little is known, however, about the subset of children at risk for symptomatic illness. We sought to identify the sociodemographic and clinical characteristics associated with symptomatic COVID-19 disease in children, with and without asthma, exposed to SARS-CoV-2 during the pandemic in New York City (NYC). Methods: Data from an ongoing prospective observational cohort of 103 children, aged 2-20 years, enrolled from New York-Presbyterian/Weill Cornell Medicine outpatient clinics across the epicenter of the COVID-19 pandemic in NYC were included in this analysis. Participants had baseline determination of body mass index percentile. A comprehensive survey was administered. COVID-19 illness was ascertained by positive SARS-CoV-2-specific serologies and/or the presence of symptoms with known positive contact. Symptom severity was assessed using a novel COVID-19 symptom grading system. Descriptive analysis was used for comparisons across symptom severity categories. Results: Of 103 children enrolled to date, 24 (23.4%) had COVID-19 illness. Of these, 11 were asymptomatic, 8 mild, 4 moderate, and 1 had severe symptoms. Those with greater symptoms tended to be older. All children with moderate-severe symptoms were female. A higher percentage of Hispanic children were seen in all categories: no symptoms (64%), mild (62.5%), moderate (75%), severe (100%). SARS-CoV-2 household exposure was present in 100% of positive symptom categories (N=13) but in only 55% of the asymptomatic category (N=6). A higher percentage of obese children were seen in all symptom categories: no symptoms(73%), mild(62.5%), moderate(50%), severe(100%). Thirteen (54%) children with COVID-19 illness had asthma. There were no demonstrable COVID-19 symptom differences appreciated between asthma severity classifications. However, of those treated with inhaled corticosteroids (ICS) (N=6), 50% were asymptomatic. Other atopic conditions (food allergy, allergic rhinitis, eczema) were present in all symptom severity categories. Conclusion: Older age, female gender, and positive household exposure were higher in those with more symptomatic COVID-19 disease. The majority of children with COVID-19 illness were Hispanic and/or obese. At least half of our cohort had asthma;moderate-severe persistent asthmatics did not endorse greater COVID-19 symptoms but higher ICS use seemed to be protective against severe COVID-19 illness. Other atopy was prevalent among all symptom categories. A larger sample size is needed to further assess the significance of these initial trends.","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117280103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ABPA Complicated by Severe Mucus Plugging and Resultant Complicated Actinomyces Pneumonia ABPA合并严重粘液堵塞及并发放线菌性肺炎

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3420

N. Stephenson, S. Abu-Nasser, W. Gower

引用次数: 0

Staphylococcus Aureus Infection Presenting as an Endobronchial Mass 金黄色葡萄球菌感染表现为支气管内肿块

TP75. TP075 PEDIATRIC LUNG INFECTION Pub Date : 1900-01-01 DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3391

S. Lee, N. Eid, M. Fallat, R. Dȩbski, S. Bickel

引用次数: 0