TP75. TP075 PEDIATRIC LUNG INFECTION最新文献

{"title":"Platelet Protein Role as Biomarkers in Early Sepsis Diagnostics in Pediatric Emergency Settings","authors":"L. Jankauskaite, A. Pociute, G. Laucaityte, A. Dagys","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3411","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3411","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122362896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Life Antibiotic Treatment Results in Both Transient and Persistent Changes to the Microbiome","authors":"N. Siegel, M. Ralston, T. Westmont, A. Rindy, H. Deshmukh, L. Miller","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3409","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3409","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124668945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not in Our Neck of the Woods: An Atypical Presentation of Lemierre’s Syndrome","authors":"V.E. Saurman, P. Kharayat, C. Browning, A. Butler","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3412","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3412","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130654686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More Than COVID19","authors":"L. Lee, C. Okorie","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3416","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3416","url":null,"abstract":"Introduction: COVID19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with widely varying severity of disease, with pediatric patients experiencing milder disease than adults. Most children requiring mechanical ventilation had underlying comorbidities, most commonly cardiovascular abnormality or obesity. We report an adolescent with severe obesity with COVID19 pneumonia, requiring mechanical ventilation, incidentally, found to have a Morgagni hernia. Case: A 15-year-old male, with severe obesity (BMI 67) presented with acute hypoxemic respiratory failure secondary to SARS-CoV-2 infection leading to severe COVID19 pneumonia. Chest X-ray on admission was significant for bilateral reticulonodular opacities consistent with COVID19. His respiratory failure rapidly progressed despite high-flow nasal oxygen, leading to intubation for high pressure mechanical ventilation and adjunct inhaled nitric oxide to improve oxygenation. He was treated with Remdesivir and dexamethasone. He developed pulmonary edema, which was managed with aggressive diuresis and fluid restriction. He developed right axillary and basilic occlusive thrombi associated with hypercoagulability and was treated with subcutaneous enoxaparin sodium. Subsequent chest X-ray showed significant left hemidiaphragm elevation, concerning for diaphragmatic eventration. After 15 days of intubation, he was extubated to continuous non-invasive ventilation (NIV) before weaning to room air when awake and empiric nocturnal NIV with supplemental oxygen due to hypoxemia attributed to previously undiagnosed severe obstructive sleep apnea and atelectasis secondary to his illness and deconditioning. CT Chest demonstrated a massive Morgagni hernia containing mesenteric fat and multiple loops of bowel, with associated left lung compression and displacement of the heart and mediastinum into the right hemithorax. Lung parenchyma had scattered areas of air trapping and small airway obstruction. Gated cardiac CT showed low to normal systolic function without pulmonary hypertension. The patient was discharged with nocturnal NIV with supplemental oxygen with plans for outpatient polysomnography and titration. Surgical correction of the diaphragmatic defect was deferred as patient had no gastrointestinal symptoms and follow up CT Chest at discharge showed no evidence of obstruction or strangulation. Discussion: Limited data exists regarding risk factors for severe COVID19 disease in pediatric patients, but describes chronic cardiac conditions, respiratory disease and obesity as prominent risk factors, similarly described in adult populations. Despite severity of presentation, a high proportion of adolescents recover without sequelae thus far. We present a case of severe COVID19 in an adolescent with multiple comorbidities, incidentally, found to have a Morgagni hernia. This case represents a favorable outcome despite multiple risk factors and severe presentation requiring mechanical v","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124539715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 in Pediatric Patients with Pulmonary Disorders: A Single Center Experience","authors":"B. Johnson, A. Bhandari, P. Planet, P. C. Cheng","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3406","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3406","url":null,"abstract":"IMPORTANCE: In December 2019, an infectious disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) emerged. There remains limited information regarding the epidemiology and clinical features of pediatric patients affected by COVID-19, particularly in the pulmonary sub-population. OBJECTIVE: Describe the clinical course of pediatric pulmonary patients with COVID-19 throughout the initial wave of infection at a single pediatric center. METHODS: Retrospective chart review was conducted on 1,350 patients, ≤ 35 years who tested positive for SARS-CoV-2 infection between March 1 and August 31, 2020. Patients followed by our pulmonary group, and evaluated at least once in the three years preceding study completion, were identified for additional chart review. Demographics, pulmonary diagnoses, co-morbidities, presenting symptoms, clinical course and management were collected for analysis. RESULTS: 70 pulmonary patients (mean age 8.3 years, range 8 months to 23 years;45% male;44% Black of African American;29% Hispanic or Latino) were identified from 1,350 patients who tested positive for COVID-19 via nasopharyngeal PCR testing through our hospital system. Most frequently reported symptoms were fever (49%), cough (49%), and nasal congestion (29%). Thirteen patients (19%, mean age 9.2 years, range 12 months to 18 years) required inpatient treatment for symptoms related to SARS-CoV-2 infection, one asymptomatic patient tested positive while admitted. Most common pulmonary diagnoses of those requiring admission were asthma (57%), prematurity (29%), sleepdisordered breathing (29%), and respiratory disorders with positive pressure requirement (29%). For those requiring inpatient care, extra-pulmonary co-morbidities included chronic neurological disorders (71%), gastrointestinal disease (43%), and allergic rhinitis (36%). Disease severity was defined as asymptomatic (17%), mild (67%), moderate (6%), severe (6%), or critical (3%). Mild disease was defined as cases managed outpatient or those admitted for observation and supportive care;moderate as those admitted for medical intervention or respiratory support via supplemental oxygen or high-flow nasal cannula;severe as those who received noninvasive ventilation or an increase in baseline respiratory support;critical were patients who received mechanical ventilation. Inpatient complications associated with SARS-CoV-2 included superinfection, thrombosis, refractory hypoxemia and tracheostomy placement. Seven experienced complications and required intensive care unit services;two required tracheostomy. No deaths were reported. CONCLUSIONS: Patients followed by our pediatric pulmonary group presented with similar symptoms compared to the general pediatric population. The majority of our patients were managed outpatient, however the rate of hospitalization was higher than those of the general pediatric population in existing studies. Of those admitted, few required invasive mechanical ventilation","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132977318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Children Little Adults? Perspective into Management of Necrotizing MSSA Pneumonia in a 3-Year-Old Girl","authors":"J. Rickert, B. Desai, R. Puttagunta, F. Lodeserto","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3417","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3417","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129719430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Syncytial Virus Infection Leads to Enhanced Cell Layer Accumulation of Hyaluronan and Increased Leukocyte Retention by Airway Epithelial Cells","authors":"S. R. Reeves, K. Barrow, L. M. Rich, M. White, E. Vanderwall, J. Debley","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3407","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3407","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114428401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Antibiotic Stewardship in Hospitalized Children in a Developing Nation","authors":"R. Green, F. Mustafa, L. Koekemoer, A. Turner, P. Becker, I. van Biljon","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3400","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3400","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133195872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Hemoptysis","authors":"K. Garagozlo, R. Kochhar, S. Worgall, E. Fiorino, J.-Y. Han","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3395","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3395","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130728019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life-Threatening Acute Tracheal Compression Due to Histoplasmosis-Related Necrotizing Mediastinal Lymphadenitis in a Healthy Toddler","authors":"S. Saxena, K. W. Malloy, R. Brown, M. Fazili","doi":"10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3396","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3396","url":null,"abstract":"","PeriodicalId":310689,"journal":{"name":"TP75. TP075 PEDIATRIC LUNG INFECTION","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127505850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}