Pakistan Armed Forces Medical Journal最新文献_第8页

Dose of Protamine for Heparin Reversal in CABG Surgery 在 CABG 手术中逆转肝素的原胺剂量

Pakistan Armed Forces Medical Journal Pub Date : 2023-12-21 DOI: 10.51253/pafmj.v73isuppl-3.10671

Syed Ali Raza Ali Shah, S. S. Naqvi, Syed Muzaffar Hasan Kirmani, Syed Aqeel Hussain, Imran Bashir Malik, Muhammad Umar Farooq

{"title":"Dose of Protamine for Heparin Reversal in CABG Surgery","authors":"Syed Ali Raza Ali Shah, S. S. Naqvi, Syed Muzaffar Hasan Kirmani, Syed Aqeel Hussain, Imran Bashir Malik, Muhammad Umar Farooq","doi":"10.51253/pafmj.v73isuppl-3.10671","DOIUrl":"https://doi.org/10.51253/pafmj.v73isuppl-3.10671","url":null,"abstract":"Objective: To determine the dose of Protamine required for reversal of Heparin effect in Coronary Artery Bypass Grafting (CABG).\u0000Study Design: Quasi-experimental study. \u0000Place and Duration of Study: Adult Cardiac Surgery Unit, Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi Pakistan, from May to Dec 2022.\u0000Methodology: Total 382 patients were included in this study through consecutive sampling and were divided into two groups (n=191 participants in each group). After induction of anesthesia, baseline Activated Clotting Time (ACT) was measured. About 300units/kg of unfractionated Heparin was given non-randomly before establishing Cardiopulmonary Bypass (CPB). After termination of CPB, Protamine was administered in doses of 1 mg/kg and 1.5 mg/kg to Group-A and Group-B respectively. Protamine was diluted in 20ml of saline, and administered at a rate of 100ml/hr. Once Protamine was administered, blood sample was taken after 5min for ACT measurement. If this ACT was within 10% of baseline, it was taken as sign for reversal of Heparin effect. Student t-test and Chi-square test were applied to compare the groups and level of significance taken was p<0.05.\u0000Results: Majority cases were males 287(75.1%), whereas 95(24.9%) were females. Statistically significant mean differences were noted between Cardiopulmonary Bypass (CPB) time, ACT after Protamine administration, and requirement for extra Protamine administration between two groups (p<0.05). However, no significant differences were noted between age, weight and ACT before Heparin administration .... \u0000Conclusion: Classical doses of 3mg/kg of Protamine in CABG patients may actually be exposing patients to higher than required ..........","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"15 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ondansetron in the Prevention of Post Cardiotomy Delirium after Coronary Artery Bypass Grafting Surgery 昂丹司琼在预防冠状动脉旁路移植术后谵妄中的作用

Pakistan Armed Forces Medical Journal Pub Date : 2023-12-21 DOI: 10.51253/pafmj.v73isuppl-3.10514

Daniyal Ahmad Kamal, Muhammad Afsheen Iqbal, Sana Sarfraz, Atif Nawaz, Nasir Ali, Rehan Masroor, Fahad Ur Rehman, Ayesha Sana

{"title":"Ondansetron in the Prevention of Post Cardiotomy Delirium after Coronary Artery Bypass Grafting Surgery","authors":"Daniyal Ahmad Kamal, Muhammad Afsheen Iqbal, Sana Sarfraz, Atif Nawaz, Nasir Ali, Rehan Masroor, Fahad Ur Rehman, Ayesha Sana","doi":"10.51253/pafmj.v73isuppl-3.10514","DOIUrl":"https://doi.org/10.51253/pafmj.v73isuppl-3.10514","url":null,"abstract":"Objective: To determine the efficacy of Ondansetron as a prophylctic agent in patients undergoing Coronary Artery Bypass Grafting.\u0000Study Design: Quasi-experimental study.\u0000Place and Duration of study: Adult Cardiac Surgery Department, AFIC/NIHD Rawalpindi Pakistan, from Nov 2022 to Feb 2023.\u0000Methodology: A total of 156 patients undergoing Coronary Artery Bypass Grafting Surgery irrespective of age and gender were included in the study via nonprobability consecutive sampling. Patients who had a previous history of psychiatric illness, and those in whom delirium could not be reliably tested were excluded from the study. The study population was divided into two groups (group A and group B). Those in the group A received 8mg Ondansetron intravenously on zero, first and second post-operative day. Group B did not receive any intervention. Descriptive statistics were used to measure percentages, frequencies and Mean±SD. Comparison between variables was made by Chi-square test for categorical variables and t-test for continuous variables. p<0.05 was considered statistically significant.\u0000Results: Total 156 patients were included in the study and mean age of the patients was 59.47±10.98 years. A total of 3(14.3%) patients who had been given Ondansetron compared to 18(85.7%) patients who were not given Ondansetron developed delirium (p<0.001). Other factors significantly associated with post cardiotomy delirium were age (p<0.001), hypertension (p<0.001), and diabetes (p=0.03).\u0000Conclusion: Our study revealed that Ondansetron can be used effectively to reduce the incidence of post cardiotomy delirium in patients of coronary artery bypass grafting.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Post-operative Outcomes of Single versus Multiple Arterial Grafts in Coronary Artery Bypass Grafting; A Comparative Analysis 冠状动脉旁路移植术中单根动脉移植物与多根动脉移植物术后早期疗效的比较分析

Pakistan Armed Forces Medical Journal Pub Date : 2023-12-21 DOI: 10.51253/pafmj.v73isuppl-3.10968

Imtiaz Ahmed Chaudhry, Nasir Ali, Sidra Afzal, Imran Bashir

{"title":"Early Post-operative Outcomes of Single versus Multiple Arterial Grafts in Coronary Artery Bypass Grafting; A Comparative Analysis","authors":"Imtiaz Ahmed Chaudhry, Nasir Ali, Sidra Afzal, Imran Bashir","doi":"10.51253/pafmj.v73isuppl-3.10968","DOIUrl":"https://doi.org/10.51253/pafmj.v73isuppl-3.10968","url":null,"abstract":"Objective: To compare early post-operative outcomes of Single versus Multiple Arterial grafts in Coronary Artery Bypass Grafting (CABG) surgery.\u0000Study Design: Analytical Cross-sectional study.\u0000Place and Duration of Study: Adult Cardiac Surgery, Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi Pakistan, from Jul 2022 to May 2023.\u0000Methodology: One hundred and forty nine patients planned for elective isolated CABG (with two or more grafts) were enrolled in study using consecutive sampling. They were allocated into two groups, group A (Multiple Arterial CABG group) and group B (Conventional CABG group). Data was collected on early post-op outcomes i.e. ICU stay, ventilation time, inotropic duration, chest drainage, rhythm complications including Supraventricular Tachycardia (SVT) and mortality using a structured proforma. Chi-square and t-test were applied to make comparison between both groups. p<0.05 was considered statistically significant.\u0000Results: Out of one hundred and forty nine patients, who underwent elective CABG, majority were males 124(83.2%). Mean age of the patients was 59.18±9.28 years. Seventy four (49.7%) patients underwent Multiple Arterial CABG while 75(50.3%) had conventional CABG. Mean ICU stay duration was 56.74±48.30 hours in group A while it was 67.25±73.42 hours in group B; p=0.30. Mean Chest Drainage was 622.05±505.69 ml in group A while it was 846.13±799.67 ml in group B; p=0.04. Mean ventilation time was 10.28 ± 19.88 hours..................\u0000Conclusion: The use of the Radial Artery (RA) in CABG surgery was associated with better early ...............","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"58 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138950960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Total Ischemia Time with No-Reflow Phenomenon in Patients Presenting with ST Elevation Myocardial Infarction, Undergoing Primary Percutaneous Coronary Interven 接受原发性经皮冠状动脉介入治疗的 ST 段抬高心肌梗死患者的总缺血时间与无回流现象的关系

Pakistan Armed Forces Medical Journal Pub Date : 2023-12-20 DOI: 10.51253/pafmj.v73isuppl-3.10500

Waheed Ashraf, S. Kiani, Muhammad Nadir Khan, Asif Nadeem, Bakht Umar, Ayesha Sana, Javeria Kamran, Muhammad Yaseen

{"title":"Association of Total Ischemia Time with No-Reflow Phenomenon in Patients Presenting with ST Elevation Myocardial Infarction, Undergoing Primary Percutaneous Coronary Interven","authors":"Waheed Ashraf, S. Kiani, Muhammad Nadir Khan, Asif Nadeem, Bakht Umar, Ayesha Sana, Javeria Kamran, Muhammad Yaseen","doi":"10.51253/pafmj.v73isuppl-3.10500","DOIUrl":"https://doi.org/10.51253/pafmj.v73isuppl-3.10500","url":null,"abstract":"Objective: To find out the association of total ischemic time with no-reflow phenomenon, in terms of Thrombolysis in Myocardial Infarction (TIMI) flow grade, in patients presenting with ST-Elevation Myocardial Infarction and undergoing Primary Percutaneous Coronary Intervention(PPCI). \u0000Study Design: Analytical Cross-Sectional study.\u0000Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi Pakistan, from Nov, 2022 to Jan, 2023. \u0000Methodology: This analytical cross-sectional study was conducted on n=184 patients, recruited through consecutive sampling technique to collect data prospectively. Patients were divided into no-reflow and normal flow group. Patients’ total ischemic time was documented and pre & post-procedural TIMI flow was noted. SPSS version-24:00 was used to enter and analyze data. Chi-square, Fisher exact test and t-test were applied and p-value≤0.05 was taken as statistically significant. \u0000Results: Out of 184 study participants, 17(9.2%) were females as compared to 167(90.8%) males. The mean age was 60.23±10.28 years. No-reflow phenomenon was observed in 20(10.9%) patients. The mean age was higher in the no-reflow group than that of the normal flow group (62.65±11.61 vs 59.94±10.12 years). Total ischemic time, pre & post-procedural TIMI flow were found to be significantly associated with no-reflow phenomenon (p<0.05). \u0000Conclusion: There exists a strong association between total ischemic time and the occurrence of no-reflow phenomenon. Patients with delayed reperfusion present with greater frequency of no-reflow and low TIMI grade and vice versa.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of CHADVASC Score in Predicting In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary PCI CHADVASC 评分与预测接受初级 PCI 治疗的 ST 段抬高型心肌梗死患者院内死亡率的关系

Pakistan Armed Forces Medical Journal Pub Date : 2023-12-19 DOI: 10.51253/pafmj.v73isuppl-3.10647

Zohair Aziz, S. Shahzad, Fahd Ur Rehman, Ismail Ahmed Khan, Asma Zafar Khawaja, H. M. Shafique, Sehrish Mumtaz, Abdul Hameed Siddiqui

{"title":"Association of CHADVASC Score in Predicting In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary PCI","authors":"Zohair Aziz, S. Shahzad, Fahd Ur Rehman, Ismail Ahmed Khan, Asma Zafar Khawaja, H. M. Shafique, Sehrish Mumtaz, Abdul Hameed Siddiqui","doi":"10.51253/pafmj.v73isuppl-3.10647","DOIUrl":"https://doi.org/10.51253/pafmj.v73isuppl-3.10647","url":null,"abstract":"Objective: To assess CHADVASC score in predicting in-hospital mortality in patients presenting to the hospital with ST segment Elevation Myocardial Infarction undergoing primary PCI.\u0000Study Design: Analytical Cross-sectional study.\u0000Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi,Pakistan, from Mar 2023 to Apr 2023.\u0000Methodology: A total of 198 patients were enrolled. Their CHADVASC scores were recorded and were divided into Group-A (score of 0-1), B (score 2-3) and C (score 4 and above). Sampling was done by using non-probability consecutive sampling. A brief clinical history including duration of symptoms, comorbid, duration of hospital stay and survivability status were recorded. Chi-square and Independent sample t-test were applied to find the association between In-hospital mortality and CHADVASC score, duration of hospital stay as well as comorbids. p-value <0.05 was taken as significant \u0000Results: Among study participants, majority were males 133(67.2%). Mean age of patients was 60.86±9.02 years. In-hospital mortality was noted in 13(6.56%) patients. There was a significant association between CHADVASC score and mortality (p<0.001). It was also noted that mortality increased with prolonged duration of stay in hospital (p=0.03). Another observation noted was that males presented at an earlier age (59.45±9.79 years) than females (63.63±6.54 years).Conclusion: CHADVASC score like the TIMI score and GRACE score can be used to stratify risk in patients presenting with Acute Coronary Syndrome (ACS). It is a fairly easy to use test at bed side and can help clinicians decide further treatment strategies and how .............","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":" 705","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of GRACE Score and SYNTAX Score in Predicting Complexity of Coronary Artery Disease in Patients with NST-ACS GRACE 评分与 SYNTAX 评分在预测 NST-ACS 患者冠状动脉疾病复杂性方面的比较

Pakistan Armed Forces Medical Journal Pub Date : 2023-12-19 DOI: 10.51253/pafmj.v73isuppl-3.10664

Asma Zafar Khawaja, S. Shahzad, Muhammad Khalil, Zohair Aziz, Mazhar Ahmed, S. Kiani, Javeria Kamran, N. Samore

{"title":"Comparison of GRACE Score and SYNTAX Score in Predicting Complexity of Coronary Artery Disease in Patients with NST-ACS","authors":"Asma Zafar Khawaja, S. Shahzad, Muhammad Khalil, Zohair Aziz, Mazhar Ahmed, S. Kiani, Javeria Kamran, N. Samore","doi":"10.51253/pafmj.v73isuppl-3.10664","DOIUrl":"https://doi.org/10.51253/pafmj.v73isuppl-3.10664","url":null,"abstract":"Objective: To compare the GRACE score and SYNTAX score in predicting Coronary Artery Disease (CAD) severity and the variation of GRACE score with respect to SYNTAX score to assess severity of CAD.\u0000Study Design: Analytical, Cross-sectional study.\u0000Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi Pakistan, from Jan 2023 to Jun 2023.\u0000Methodology: Data was gathered from n=139 participants by using consecutive sampling technique on a data collection tool.Study variables such as demographics, comorbids, clinical characteristics and SYNTAX and GRACE score were noted to asses their role in determining CAD severity. An experienced cardiologist was assigned to analyze the coronary angiogram findings, performed by using conventional techniques through radial artery, ulnar or femoral artery access. SPSS version-24.00 was used for data management and analysis. Chi square test and Pearson correlation was applied to find the association and correlation respectively.\u0000Results: Mean age of study participants was 62.09±9.74 years and males were more in number 114(82.0%). Ninety three (66.9%) patients had NSTEMI. Gender (p=0.011,0.007), was significantly associated with SYNTAX score as well as GRACE score respectively and diabetic status (p=0.003) with GRACE score. There was a strong and positive correlation between GRACE score and SYNTAX score (r=0.64; p<0.001). Both scores showed significant association with CAD severity (p<0.05). \u0000Conclusion: There exists a statistically significant and positive correlation between GRACE score and SYNTAX score in non-ACS (NSTEMI and UA) patients who had confirmed diagnosis of CAD on coroangiogram. The greater the GRACE score, the greater was........","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":" 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Red Cell Distribution Width with Thrombus Burden in Patients of ST Elevation Myocardial Infarction Undergoing Primary PCI 接受初级 PCI 治疗的 ST 期抬高型心肌梗死患者的红细胞分布宽度与血栓负担的关系

Pakistan Armed Forces Medical Journal Pub Date : 2023-12-19 DOI: 10.51253/pafmj.v73isuppl-3.10497

Ismail Ahmed, S. Shahzad, Fahd Ur-Rehman, A. Chaudhry, Zohair Aziz, Ali Farahe, Sheharbano Ahmed Khan, Javeria Kamran

{"title":"Association of Red Cell Distribution Width with Thrombus Burden in Patients of ST Elevation Myocardial Infarction Undergoing Primary PCI","authors":"Ismail Ahmed, S. Shahzad, Fahd Ur-Rehman, A. Chaudhry, Zohair Aziz, Ali Farahe, Sheharbano Ahmed Khan, Javeria Kamran","doi":"10.51253/pafmj.v73isuppl-3.10497","DOIUrl":"https://doi.org/10.51253/pafmj.v73isuppl-3.10497","url":null,"abstract":"Objective: To study the association of Red Cell Distribution Width (RDW) with thrombus burden in patients of ST Elevation Myocardial Infarction (STEMI) undergoing Primary Percutaneous Coronary Intervention (PPCI).\u0000Study Design: Analytical Cross-sectional study.\u0000Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi, Pakistan, from Aug 2022 to Dec 2022.\u0000Methodology: Using non-probability consecutive sampling, three hundred and sixty-nine (n=369) patients were included in the study. RDW values were obtained from complete blood count sent at presentation in emergency department. Thrombolysis in Myocardial Infarction (TIMI) thrombus grading was used to determine the angiographic thrombus burden. For quantitative variables, means and standard deviations were calculated, while frequencies and percentages were calculated for qualitative variables. Receiver Operating Characteristic (ROC) curve for RDW values for predicting thrombus burden was plotted. Correlation between RDW with thrombus burden was established. Eta, Chi-square and independent samples t-test was used to determine p-value.\u0000Results: The study included 369 STEMI patients, out of which 287(77.8%) were males and 82(22.2%) were females. 203(55.0%)patients had high thrombus burden while 166(45.0%) patients had low thrombus burden. Patients in the high RDW groupmore frequently had ventricular arrhythmias, and heart blocks. Mean RDW was 13.57±0.71 in low thrombus burden groupwhile it was 14.67±1.21 in high thrombus burden group. Area under the curve derived from ROC curve for RDW forpredicting high thrombus burden was 0.79(CI=0.74-0.83, p<0.001)\u0000Conclusion: The study demonstrates that high RDW is a sensitive and specific predictor of high angiographic thrombus bur..........","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138963097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Per-Operative Angiogram and Doppler Ultrasound as an Adjunct to Assess the Cerebral Vessels Following Aneurysmal Brain Surgery 应用术前血管造影和多普勒超声辅助评估脑动脉瘤术后脑血管状况

Pakistan Armed Forces Medical Journal Pub Date : 2023-10-30 DOI: 10.51253/pafmj.v73i5.8979

Awais Ali Khan, None Habib Ullah Khan, None Khurshid Ali Bangash, None Shahzad Ahmed Qasmi, None Syed Adeel Ahmed, None Asif Hashmat, None Babar Shamim

{"title":"Use of Per-Operative Angiogram and Doppler Ultrasound as an Adjunct to Assess the Cerebral Vessels Following Aneurysmal Brain Surgery","authors":"Awais Ali Khan, None Habib Ullah Khan, None Khurshid Ali Bangash, None Shahzad Ahmed Qasmi, None Syed Adeel Ahmed, None Asif Hashmat, None Babar Shamim","doi":"10.51253/pafmj.v73i5.8979","DOIUrl":"https://doi.org/10.51253/pafmj.v73i5.8979","url":null,"abstract":"Objective: To study the efficacy of per-operative angiogram and Doppler ultrasound as an adjunct to assess the cerebral vessels during intracranial aneurysm clipping surgery. Study Design: Cross-sectional study Place and Duration of Study: Department of Neurosurgery, Combined Military Hospital, Rawalpindi Pakistan, from Jan 2020 to Dec 2021. Methodology: Forty-eight diagnosed cases of subarachnoid haemorrhage secondary to ruptured aneurysm were included. All the patients who were not coiled-able (broad-based, multi-lobed, complex) were operated on (craniotomy and clipping of aneurysm). Intraoperative angiogram and Doppler ultrasound of cerebral vasculature were done in all cases to see the patency of vessels and the position of clips. Results: Mean age of the patients was 43.97±8.23 years. 24(50.00%) patients had anterior communicating artery aneurysms, 18(37.50%) had middle cerebral artery aneurysms, whereas 6(12.50%) were of an anterior cerebral artery. Craniotomy and clipping of aneurysm were done in all the cases; among them, 15(31.25%) were operated on early (between 48-96 hrs), whereas 33(68.75%) were operated on after 10-14 days. Per-operatively, cerebral angiogram and Doppler ultrasound were used to assess the cerebral vasculature and position of the clip. About of 5(10.00%) required clip readjustment, 4(8.33%) had parent vessel occlusion, 10(20.83%) required vasodilator therapy due to vasospasm, and 4(8.33%) had residual aneurysm neck. All these were rectified during the same procedure. Conclusion: Per-operative angiography and Doppler ultrasound are useful adjuncts in aneurysmal brain surgery to prevent complications like cerebral ischemia, recurrence, residual aneurysm and re-bleed.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136133025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Immunohistochemistry in Metastatic Bone Diseases 免疫组织化学在转移性骨病中的作用

Pakistan Armed Forces Medical Journal Pub Date : 2023-10-30 DOI: 10.51253/pafmj.v73i5.6426

None Farukh Mir Muhammad, None Farhan Akhtar, None Nighat Jamal, None Rabia Ahmed, None Muhammad Asif, None Fatima Wagan

{"title":"Role of Immunohistochemistry in Metastatic Bone Diseases","authors":"None Farukh Mir Muhammad, None Farhan Akhtar, None Nighat Jamal, None Rabia Ahmed, None Muhammad Asif, None Fatima Wagan","doi":"10.51253/pafmj.v73i5.6426","DOIUrl":"https://doi.org/10.51253/pafmj.v73i5.6426","url":null,"abstract":"Objectives: To identify the role of immunohistochemistry in correctly identifying metastasis of bone disorders. Study Design: Cross-sectional study Place and Duration of Study: Department of Histopathology Pakistan Naval Ship, Shifa Hospital, Karachi Pakistan, from Jun 2019 to Jun 2020. Methodology: Patients aged 18-75 years, of either gender, already diagnosed case of the primary tumour, and now diagnosed with bone metastasis on biopsy were included. Various imaging techniques were used to locate the site of metastases. The histopathological reports of all the intra-operative specimens of bone metastases were reviewed. Results: The mean age of 60 patients was 59.5±28.8 years and mean weight was 67.4±13.5 kg. The period of presentation from diagnosis of the primary tumour was 34±15.4 months, and the period from onset of symptoms was 8.2±5.8 months. The most common site of the primary tumour was the breast in 18(30%) of patients, followed by the kidney in 14(23.3%) of patients. The most common site of metastasis was the femur in 30(50 %) of patients, followed by the spine in 15 patients. Conclusion: The most common site of primary tumour identified by immunohistochemistry was the breast, followed by the lungs. The femur was the most common site of metastasis, followed by the spine.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"260 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Cytomegalovirus in Post Hematopoietic Stem Cells Transplant Recipients by Real-Time PCR 实时荧光定量PCR检测造血干细胞移植后受者巨细胞病毒

Pakistan Armed Forces Medical Journal Pub Date : 2023-10-30 DOI: 10.51253/pafmj.v73i5.8812

Saifullah Khan Niazi, Nadia Gulzar, Eijaz Ghani, Faraz Ahmed, Noman Shakoor, Hina Hammad

{"title":"Detection of Cytomegalovirus in Post Hematopoietic Stem Cells Transplant Recipients by Real-Time PCR","authors":"Saifullah Khan Niazi, Nadia Gulzar, Eijaz Ghani, Faraz Ahmed, Noman Shakoor, Hina Hammad","doi":"10.51253/pafmj.v73i5.8812","DOIUrl":"https://doi.org/10.51253/pafmj.v73i5.8812","url":null,"abstract":"Objective: To evaluate the frequency of Cytomegalovirus in Post Hematopoietic Stem Cell Transplant Recipients by molecular method. Study Design: Cross-sectional study. Place and Duration of Study: Virology Department, Armed Forces Institute of Pathology, Rawalpindi Pakistan Jan to Dec2021. Methodology: One hundred and twenty-six hematopoietic stem cell transplant (HSCT) recipients were included in this study and were separated into various age groups. All included patients were CMV IgG positive. Real-time polymerase chain reaction (PCR) was performed on post-HSCT recipients to detect CMV. Results: Out of 126 post-HSCT recipients, CMV was detected in 80(63%) patients and was not found in 46(36%) patients. Among positive patients, 60(75%) were males, and 20(15%) were female. Maximum cases of CMV detection in post-HSCT were found in 23 patients aged 1-10 years. Conclusion: A high frequency of CMV in post-HSCT recipients was observed in this study. CMV cause major complications in immunocompromised patients, such as in transplant recipients. Prevention of CMV infection is a main part of post-transplant monitoring and management.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"62 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136105887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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