Pakistan Armed Forces Medical Journal最新文献

Open Access Original Article The Best Imaging Modality for Axillary Lymph Node Status in Breast Cancer 乳腺癌腋窝淋巴结状态的最佳成像方式

Pakistan Armed Forces Medical Journal Pub Date : 2025-06-30 DOI: 10.51253/pafmj.v75i3.11374

Shandana Gul, Zaini Azam, Maria Mir Jan, Maham Tariq, Aqsa Saleema, Syeda Rifaat Qamar Naqvi

{"title":"Open Access Original Article The Best Imaging Modality for Axillary Lymph Node Status in Breast Cancer","authors":"Shandana Gul, Zaini Azam, Maria Mir Jan, Maham Tariq, Aqsa Saleema, Syeda Rifaat Qamar Naqvi","doi":"10.51253/pafmj.v75i3.11374","DOIUrl":"https://doi.org/10.51253/pafmj.v75i3.11374","url":null,"abstract":"Objectives: To explore the diagnostic accuracy of different imaging modalities including Axillary Ultrasound (AUS), CT Scan and Contrast Enhanced Magnetic Resonance Imaging (MRI) breast in determining the axillary lymph node status in breast cancer keeping histopathology as reference standard. Study Design: Retrospective Comparative Study. Place and Duration of Study: The Breast Clinic, Combined Military Hospital, Rawalpindi Pakistan, from Jul 2022 to Jun 2023. Methodology: A retrospective comparative study was conducted at a dedicated breast cancer center with 90 early breast cancer patients. Diagnostic accuracy of Axillary Ultrasound, contrast-enhanced CT, and MRI was evaluated for axillary nodal staging. Final histopathology served as the reference standard. Imaging interpretations were performed by experienced radiologists, and data were analyzed using SPSS 22.0. The following metrics were determined: accuracy, specificity, negative predictive value, sensitivity, and specificity. Results: In total, 90 female patients mean age of 53.5±21.2 years were evaluated. N Staging displayed differences between patients who tested positive and negative for nodes. We found that MRI had the highest sensitivity of the three imaging modalities (93.34%: 95% CI, 84.34% - 98.82%) whereas CT scan had the lowest sensitivity (71.70%; 95% CI, 57.65% - 82.21). AUS had sensitivity (84.91%; 95% CI: 72.41% - 93.25) Similarly MRI had the highest Specificity of the three imaging modalities (78.38%: 95% CI, 61.79% - 90.17%) whereas CT scan had the lowest Specificity (62.96%; 95% CI, 42.37% -80.60%) and AUS had Specificity (67.57%; 95% CI: 50.21% - 1.99%). Conclusion: MRI scan is more effective; Axillary Ultrasound shows better outcomes than..","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"75 3","pages":"573-577"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pafmj.org/PAFMJ/article/download/11374/7016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The molecular pathology at Work: Metformin and Variability in Glycemic Control 分子病理学的作用：二甲双胍和血糖控制的可变性

Pakistan Armed Forces Medical Journal Pub Date : 2024-04-29 DOI: 10.51253/pafmj.v74i2.12070

Sikandar Hayat Khan, Muhammad Qaiser Alam Khan, Asma Hayat, Asif Ali, Sajida Shaheen, Muhammad Younis, Muhammad Naveed Anwar, Eijaz Ghani

{"title":"The molecular pathology at Work: Metformin and Variability in Glycemic Control","authors":"Sikandar Hayat Khan, Muhammad Qaiser Alam Khan, Asma Hayat, Asif Ali, Sajida Shaheen, Muhammad Younis, Muhammad Naveed Anwar, Eijaz Ghani","doi":"10.51253/pafmj.v74i2.12070","DOIUrl":"https://doi.org/10.51253/pafmj.v74i2.12070","url":null,"abstract":"Optimized management of type-2 diabetes mellitus (T2DM) remains a challenge not just because micro and microangiopathies’, chronic kidney disease, and infections related to poor cellular immunity. Methodology to manage T2DM remains in need for evolution to curb disease and help manage economy of diabetes care. Metformin remains the frontline soldier against T2DM. However, optimized and evidence-based use of metform for managing T2DM in clinics needs better molecular analytics to micro-precise medical management. We evaluated 353 manuscripts to finally shortlisted 45 reviews and RCTs using PRISMA guidelines from Google Scholar, PubMed and Cochrane Reviews. This systematic review attempted to identify the role of pharmacokinetic, pharmacogenomic, epigenetic and mitochondrial factors which can lead to sub-optimal diabetes management, metformin resistance and mutations which could lead to poor to no response to medicine. The most common mutations and polymorphisms in solute channels were observed to reduce the therapeutic efficacy/resistance","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"74 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.pafmj.org/PAFMJ/article/download/12070/6166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Impact of Subcutaneous Neurokinin B Administration on Epididymal Proliferation in Adult New Zealand White Rabbits: A Dose-Dependent Study 皮下注射神经激肽 B 对成年新西兰白兔附睾增殖的不同影响：剂量依赖性研究

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.11435

F. Ramzan, Ramsha Zahra, Muhammad Haris Ramzan

{"title":"Differential Impact of Subcutaneous Neurokinin B Administration on Epididymal Proliferation in Adult New Zealand White Rabbits: A Dose-Dependent Study","authors":"F. Ramzan, Ramsha Zahra, Muhammad Haris Ramzan","doi":"10.51253/pafmj.v74i1.11435","DOIUrl":"https://doi.org/10.51253/pafmj.v74i1.11435","url":null,"abstract":"Objective: To investigate the potential of variable doses of Neurokinin B on histomorphology of epididymis in adult rabbits.\u0000Study Design: Laboratory-based experimental study.\u0000Place and Duration of Study: Gomal Centre of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan, from Jun 2019 to Jun 2020.\u0000Methodology: Adult male New Zealand White rabbits with an average weight of 1.5–2 Kg were randomly assigned to three groups. Study animals were administered subcutaneously with Neurokinin B in two variable doses: 1 µg and one ηg. Control rabbits were injected with distilled water in parallel. After 12 days of continuous peptide treatment, animals (n=06) in each group were sacrificed. Epididymis were dissected and processed for light microscopy and sperm count.\u0000Results: Mean epididymis weight (mg) increased significantly (p<0.001) with the treatment of Neurokinin B 1 ηg and Neurokinin B 1 µg as compared to control. With the increase in doses of Neurokinin B (1 ηg, 1 μg), the lumen of caput, corpus and cauda of the epididymis got significantly (p<0.001) dilated dose-dependently in Neurokinin B treated animals. Sperm count increased significantly (p<0.001) in the Neurokinin B-treated rabbits compared to the control. Light microscopy revealed increased luminal diameter compared to control in all Neurokinin B treated groups as compared to control.\u0000Conclusion: Continuous administration of Neurokinin B could benefit the epididymis, as shown by increased luminal diameter and sperm count.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern Of Maxillofacial Fractures In Combined Military Hospital, Peshawar 白沙瓦联合部队医院颌面部骨折的模式

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.10325

Faisal Nawaz Khan, Zainab Akbar, Sanya Javaid, Muhammad Afzal, Muhammad Ramzan Adeel, Sabeen Saeed

{"title":"Pattern Of Maxillofacial Fractures In Combined Military Hospital, Peshawar","authors":"Faisal Nawaz Khan, Zainab Akbar, Sanya Javaid, Muhammad Afzal, Muhammad Ramzan Adeel, Sabeen Saeed","doi":"10.51253/pafmj.v74i1.10325","DOIUrl":"https://doi.org/10.51253/pafmj.v74i1.10325","url":null,"abstract":"Objectives: To determine the various patterns of maxillofacial fractures in patients presenting at CMH, Peshawar\u0000Study Design: Cross-sectional study\u0000Place and Duration of Study: 30-Military Dental Center, CMH, Peshawar Pakistan, from Sep 2021 to Mar 2022.\u0000Methodology: A total of 207 patients from all age groups, both genders, presenting with any features of maxillofacial fracture due to accidental injuries were included. A thorough history and clinical and radiographic examination were carried out, along with a diagnosis of suspected facial fractures per clinical presentation and radiographic assessment.\u0000Results: The different accidental injuries found in this study were as follows; 127(61.35%) road traffic accidents, 45(21.74%) falls, 13(6.28%) assaults, 16(7.73%) sports injuries and 6(2.90%) gunshot wounds. The different bones involved were 38(18.36%) injuries of the frontal bone, 48(23.19%) in the maxilla, 42(20.29%) in nasal, (14.01%) in NOE, 110(53.14%) in zygoma and 122(58.94%) injuries included mandible bone.\u0000Conclusion: Roadside accidents are the most common aetiology of maxillofacial fracture, and the mandible is the most commonly involved bone in such fracture.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence of Primary Caregiver To Post Stroke Dysphagia Recommendations In Pakistan 巴基斯坦初级护理人员对卒中后吞咽困难建议的遵守情况

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.5981

Rimsha Shakeel, Nazia Mumtaz, G. Saqulain, Maryam Shakeel, Nadeem Ahmad

{"title":"Adherence of Primary Caregiver To Post Stroke Dysphagia Recommendations In Pakistan","authors":"Rimsha Shakeel, Nazia Mumtaz, G. Saqulain, Maryam Shakeel, Nadeem Ahmad","doi":"10.51253/pafmj.v74i1.5981","DOIUrl":"https://doi.org/10.51253/pafmj.v74i1.5981","url":null,"abstract":"Objective: To find the adherence of primary caregivers to post-stroke dysphagia recommendations in Pakistan.\u0000Study Design: Cross-sectional study\u0000Place and Duration of Study: Armed Forces Institute of Rehabilitation Medicine, Rawalpindi Pakistan, from Jun 2019 to April 2020.\u0000Methodology: We recruited 92 primary caregivers of either gender aged ≥ 18 years, assisting stroke patients with dysphagia in feeding and activities of daily living. Caregivers of cases with multiple disabilities, those not aware of dysphagia recommendations and those not involved in the implementation of dysphagia recommendations were excluded. Caregiver Mealtime and Dysphagia Questionnaire (CMDQ) were used for data collection. \u0000Results: Out of 92 Caregivers 17(18.48%) were non-compliant while 75(82%) reported significant compliance to dysphagia recommendations with mean scores of 3.11±0.48 and 1.98±0.51, respectively. In addition, the significant difference between scores of compliant and non-compliant groups was noted for the domains of Quality, Avoidance and Disagreement (p<0.001).\u0000Conclusion: Most primary caregivers were compliant and adhered to the dysphagia recommendation of stroke in Pakistan","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"43 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Tumour Budding With Histological Type And Grade, Pathological Stage And Lymph Node Metastasis In Colorectal Carcinoma 肿瘤萌发与结直肠癌组织学类型和分级、病理分期及淋巴结转移的关系

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.10290

Wajahat Ahmed Khan, Bushra Parveen, Muhammad Asif, Muhammad Usman Rathore, Farhat Rashid, Hassan Tariq, Naveed Khan

{"title":"Association of Tumour Budding With Histological Type And Grade, Pathological Stage And Lymph Node Metastasis In Colorectal Carcinoma","authors":"Wajahat Ahmed Khan, Bushra Parveen, Muhammad Asif, Muhammad Usman Rathore, Farhat Rashid, Hassan Tariq, Naveed Khan","doi":"10.51253/pafmj.v74i1.10290","DOIUrl":"https://doi.org/10.51253/pafmj.v74i1.10290","url":null,"abstract":"Objective: To investigate the association between the tumour budding of colorectal carcinoma and its histological type, grade, lymph node metastasis, and pathological stage.\u0000Study Design: Cross-sectional study\u0000Place and Duration of Study: Histopathology Department, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Dec 2021 to Mar 2023.\u0000Methodology: One hundred and twenty colorectal carcinoma patients were examined for existence and severity using Hematoxylin and Eosin-stained sections. According to the number of tumour buds, cases were categorised as low grade (<10/200X), intermediate grade (10-19/200X), and high grade (>20/200X). These categories were related to lymph node involvement, histological type and grade, and pathological staging. In challenging cases, pan-cytokeratin immunohistochemistry labelling was conducted to confirm tumour budding.\u0000Results: The mean age of presentation was 55.78±12.47 years. The most common site of involvement was the ascending colon 66(55%), followed by the recto-sigmoid colon 29(24.2%). Most cases were conventional adenocarcinoma 80(67%), followed by mucinous carcinoma 31(26%). Most cases were moderately differentiated 62(52%) and were stage III 79(66%). Forty-two (35%) had low-grade, and thirty-four (28.3%) had intermediate-grade and high-grade tumour budding. Tumour budding significantly correlates with tumour size, histological grade, invasion extent, and lympho-vascular invasion (p-value <0.05).\u0000Conclusion: Tumour budding is strongly associated with nodal metastasis and a high grade of colorectal carcinoma; thus, it must be considered an important independent adverse prognostic indicator for colorectal carcinoma.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Audit on the Quality of Pre-Anaesthesia Assessment based on Predefined Pre-anaesthesia Assessment Form 基于预定义麻醉前评估表的麻醉前评估质量临床审计

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.8681

Khalid Mahmood, Muhammad Ali Abbas, Bilal Yasin, Muhammad Saeed, Mohsin Saleem, Saleha Sarfraz

{"title":"Clinical Audit on the Quality of Pre-Anaesthesia Assessment based on Predefined Pre-anaesthesia Assessment Form","authors":"Khalid Mahmood, Muhammad Ali Abbas, Bilal Yasin, Muhammad Saeed, Mohsin Saleem, Saleha Sarfraz","doi":"10.51253/pafmj.v74i1.8681","DOIUrl":"https://doi.org/10.51253/pafmj.v74i1.8681","url":null,"abstract":"Objective: To determine the percentage completion of individual GQI indicators and the overall percentage of completed predefined Pre-anaesthesia assessment forms and identify any areas for improvement in the documentation of pre-anaesthesia assessment.\u0000Study Design: Cross-sectional study.\u0000Place and Duration of Study: Department of Anaesthesiology, Combined Military Hospital, Sialkot Pakistan, from Mar to Sep 2021.\u0000Methodology: Patients who reported to the operation theatre during the study period for elective surgery after having undergone formal pre-anaesthesia assessment preoperatively based on predefined Pre-anaesthesia assessment form (PAAF) were included. The quality of Pre-anaesthesia assessments from completion was assessed using a modified Global Quality Index with twenty-seven components.\u0000Results: The overall completion rate for all pre-anaesthesia assessment form components was 77.10±30.26%. The lowest completed items were local examination (0.00%), airway assessment, neck mobility, mouth opening, thyromental distance (24,10.61%), weight (25, 11.36%), GIT (86, 38.64%) and CNS/GCS (108, 48.48%) assessment, pre-operative vitals (121, 54.55%) and family history (129, 58.33%).\u0000Conclusion: We need to improve the quality of pre-anaesthesia assessment forms at our institution by ensuring that all relevant information is collected and documented.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"248 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Mullarian Hormone As A Diagnostic Marker of Polycystic Ovary Syndrome 作为多囊卵巢综合征诊断标志物的抗卵巢激素

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.9166

S. Abbas, Asma Hayat, Rabiya Shabir, Muhammad Mujahid Sharif, Asma Iqbal, Rehana Abbas

{"title":"Anti-Mullarian Hormone As A Diagnostic Marker of Polycystic Ovary Syndrome","authors":"S. Abbas, Asma Hayat, Rabiya Shabir, Muhammad Mujahid Sharif, Asma Iqbal, Rehana Abbas","doi":"10.51253/pafmj.v74i1.9166","DOIUrl":"https://doi.org/10.51253/pafmj.v74i1.9166","url":null,"abstract":"Objective: To determine the utility of Anti-mullerian hormone (AMH) as a diagnostic marker of Polycystic ovarian syndrome (PCOS).\u0000Study Design: Comparative cross-sectional study\u0000Place and Duration of the Study: Department of Chemical Pathology and Endocrinology, Army Medical College Rawalpindi, Pakistan in collaboration with the Department of Gynaecology and Obstetrics, Pak-Emirates Military Hospital, Rawalpindi Pakistan from Jan 2019 to Jan 2020.\u0000Methodology: The study recruited 30 cases of PCOS and 30 age-matched Controls using Rotterdam criteria. Anti-mullerian hormone (AMH) and testosterone were measured for both the study groups. \u0000Results: Receiver operator curve (ROC) analysis confirmed the utility of anti-mullerian hormone in diagnosing patients with PCOS. The AUC was 0.754 with 95% CI (0.629-0.880). The optimal cut-off point was 3.22ng/mL (Sensitivity 80%, Specificity 66.7%).\u0000Conclusion: The AMH is appraised as an independent screening marker for PCOS patients. Using this single parameter can decrease the patient's inconvenience and financial burden on the health care system and the patient.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Haller Index Values Calculated with Chest Radiographs versus Computed Tomography for Pectus Excavatum Evaluation 胸片与计算机断层扫描计算的霍勒指数值在胸大肌评估中的比较

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.7465

A. Kiani, Sara Haider, Sana Sharif, K. Kubra, Khushbu Fatima, Nadia Murtaza

引用次数: 0

Comparison of Interferon-Inducible Patient-10 and Chemokine Ligand-2 Expression in COVID-19 Patients COVID-19 患者干扰素诱导型患者-10 和趋化因子配体-2 的表达比较

Pakistan Armed Forces Medical Journal Pub Date : 2024-02-28 DOI: 10.51253/pafmj.v74i1.11796

Nayab Khalid, Mehwish Qamar, Sadia Syed, Ibrahim Liaqat, Muhammad Irfan ul Akbar Yousufzai, Summyah Niazi

{"title":"Comparison of Interferon-Inducible Patient-10 and Chemokine Ligand-2 Expression in COVID-19 Patients","authors":"Nayab Khalid, Mehwish Qamar, Sadia Syed, Ibrahim Liaqat, Muhammad Irfan ul Akbar Yousufzai, Summyah Niazi","doi":"10.51253/pafmj.v74i1.11796","DOIUrl":"https://doi.org/10.51253/pafmj.v74i1.11796","url":null,"abstract":"Objective: To compare interferon-inducible patient-10 and chemokine lisgand-2 expression in COVID-19 Patients. \u0000Study Design: Cross-sectional study. \u0000Place and Duration of Study: University of Lahore Teaching Hospital, Lahore Pakistan, from Dec 2020 to Mar 2021. \u0000Methodology: We assessed the level of cytokines in forty-five COVID-19 patients and compared it with the 45 healthy individuals. The pro-inflammatory cytokines IP-10 and CCL-2 levels were evaluated in patients and healthy people via ELISA kits. \u0000Results: The study included ninety (n=90) patients. Our data suggested that the serum levels of IP-10 and CCL-2 were increased (8.5±1.5 ng/ml and 11.89±4.55 pg/ml) significantly in patients with COVID-19 as compared to healthy Controls (4±0.5ng/ml and 6.15±1.91 pg/ml). A significant increase was recorded in INR, PT (sec) and APTT (sec) levels in COVID-19 patients. Whereas the platelets count (109/ml) was decreased significantly in COVID-19 patients (220±42) as compared to healthy individuals (419±69). Significant elevation of D-Dimer (ng/ml) was recorded in patients with COVID-19. \u0000Conclusion: Our data suggested a significantly increased level of IP-10 and CCL-2 in COVID-19-associated patients, which may be of essential diagnostic and prognostic significance for these biomarkers.","PeriodicalId":31059,"journal":{"name":"Pakistan Armed Forces Medical Journal","volume":"135 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0