Comparison of Interferon-Inducible Patient-10 and Chemokine Ligand-2 Expression in COVID-19 Patients

Abstract

Objective: To compare interferon-inducible patient-10 and chemokine lisgand-2 expression in COVID-19 Patients. Study Design: Cross-sectional study. Place and Duration of Study: University of Lahore Teaching Hospital, Lahore Pakistan, from Dec 2020 to Mar 2021. Methodology: We assessed the level of cytokines in forty-five COVID-19 patients and compared it with the 45 healthy individuals. The pro-inflammatory cytokines IP-10 and CCL-2 levels were evaluated in patients and healthy people via ELISA kits. Results: The study included ninety (n=90) patients. Our data suggested that the serum levels of IP-10 and CCL-2 were increased (8.5±1.5 ng/ml and 11.89±4.55 pg/ml) significantly in patients with COVID-19 as compared to healthy Controls (4±0.5ng/ml and 6.15±1.91 pg/ml). A significant increase was recorded in INR, PT (sec) and APTT (sec) levels in COVID-19 patients. Whereas the platelets count (109/ml) was decreased significantly in COVID-19 patients (220±42) as compared to healthy individuals (419±69). Significant elevation of D-Dimer (ng/ml) was recorded in patients with COVID-19. Conclusion: Our data suggested a significantly increased level of IP-10 and CCL-2 in COVID-19-associated patients, which may be of essential diagnostic and prognostic significance for these biomarkers.