Infarma Pharmaceutical Sciences最新文献

{"title":"Pharmaceutical properties of sour tea (Hibiscus sabdariffa), Toward an ideal treatment for Hypertension","authors":"Seyyed Mohammad Bagher Fazljou, Raha Kamyab, H. Namdar, M. Torbati, Mostafa Araj-khodaei, M. Ghojazadeh","doi":"10.34172/ps.2021.68","DOIUrl":"https://doi.org/10.34172/ps.2021.68","url":null,"abstract":"High blood pressure is the main risk factor for cardiovascular disease and should be controlled primarily by changes in lifestyle, such as regular exercise, a low-salt diet, and weight loss in overweight or obesity. If lifestyle changes are not enough, many types of medications can be used to control high blood pressure; however, side effects constitute one of the most critical limitations of conventional medicines associated with high blood pressure. For this reason, the use of traditional and herbal medicines has been welcomed by the public for many years. Sour tea (Hibiscus sabdariffa) is one of the most suitable herbal medicines for hypertension. According to research results, sour tea has the same effect as conventional medicines without serious side effects. The present study introduces sour tea as a suitable herbal medicine for high blood pressure to provide readers of this article with a comprehensive understanding of the medicinal properties of sour tea for the treatment of hypertension and its effects on several other common diseases, including cancer.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77132728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Terbium Metal–Organic Framework Platform for Determination of Lamotrigine in Exhaled Breath Condensate","authors":"Parisa Eydi, E. Rahimpour, M. Khoubnasabjafari, V. Jouyban-Gharamaleki, A. Jouyban","doi":"10.34172/ps.2021.67","DOIUrl":"https://doi.org/10.34172/ps.2021.67","url":null,"abstract":"Background: Lamotrigine is widely used in the management of partial epilepsy, generalized tonic-clonic epilepsy and Lenox-Gastut syndrome and an add-on therapy in the treatment of complex and simple partial seizures and secondarily generalized tonic-clonic seizures resistant to multiple drug therapy. Methods: In the current study, a fluorometric nanoprobe based on metal–organic frameworks (MOF) was designed for the determination of lamotrigine in exhaled breath condensate (EBC). The MOF nanoprobe consisted of Tb3+ ions as metal part and dimethylformamide (DMF) and 1,10-phenanthroline (Phen) as organic parts of nanoprobe. Results: The used probe shows a week fluorescence in alkaline media owing to an energy transfer from nitrogen groups of DMF and Phen on carbonyl group of DMF as an antenna for Tb3+ luminescence. However, its fluorescence is enhanced in acidic conditions by protonation of DMF nitrogen atoms and Phen and deactivation of energy transfer pathways of nitrogen groups to carbonyl group. Lamotrigine addition to this fluorescent system leads to quenching in the fluorescence intensity due to reactivation of the above mentioned energy transfer pathways resulting in competitive interaction with H+ ions. Moreover, the inner filter effect (IFE) of lamotrigine on DMF–Tb–Phen MOF NPs is considered as another reason for the observed quenching in the fluorescence of DMF–Tb–Phen MOF NPs. The intensity of the fluorescence was recorded at λem = 545 nm and the difference between fluorescence signal in the absence and presence of lamotrigine was the analytical response. The factors affected on experimental conditions were optimized utilizing a multivariate optimization technique. The validation of nanoprobe response to lamotrigine gives a linear relationship in the range of 0.05 to 2.0 µg⋅mL‒1 with a detection limit of 11.0 ng⋅mL‒1 for lamotrigine. Conclusion: The developed method reveals good repeatability and selectivity for lamotrigine in real samples.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87180410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and in vivo toxicity study of allantoin incorporated hyaluronic acid-L-cysteine oral solution: A future treatment for mucositis","authors":"Zainab Ahmadian, Ali Reza Dargahi, Kiyan Musaie, M. Eskandari","doi":"10.34172/ps.2021.65","DOIUrl":"https://doi.org/10.34172/ps.2021.65","url":null,"abstract":"Background: Thiolated hyaluronic acid (HA) with interesting properties, such as muco-adhesiveness, enzyme inhibitory, permeation enhancing, and release controlling properties can be applied for drug delivery in various diseases like mucositis. The purpose of this study was to evaluate the stability and toxicity of thiol modified HA by the aid of L-cysteine ethyl ester hydrochloride (Cys) named (HA-Cys) and allantoin (Alla) incorporated HA-Cys (HA-Cys-Alla) to reveal their potential for the future treatment of mucositis. Methods: The HA modification and drug incorporation were investigated using FTIR spectroscopy. The evaluation of in vitro cytotoxicity on Caco-2 cell line by means of MTT assay and in vivo toxicity by measuring the hematological and biochemical parameters in rats were performed. The appearance stability of HA-Cys and HA-Cys-Alla was evaluated at room and refrigerator temperatures over time. In addition, the stability of HA-Cys and HA-Cys-Alla subjected to heating and cooling, freeze-thaw, centrifugal forces, as well as the pH stability under the above-mentioned conditions were also investigated. Results: The results indicated that the synthesized HA-Cys and HA-Cys-Alla with pseudo-plastic rheological behavior demonstrated excellent stability at refrigerator temperature. Although HA-Cys showed good stability, the HA-Cys-Alla revealed color change at room temperature. Moreover, despite no much resistance of HA-Cys and HA-Cys-Alla against the heating-cooling test, the samples exhibited good resistance against freeze-thaw and centrifugal forces. Also, convenient pH stability and high in vitro and in vivo biocompatibility were observed. Conclusions: The low in vitro and in vivo toxicity and convenient stability of HA-Cys-Alla has introduced it as a proper candidate for future clinical applications.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76822270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review","authors":"K. Shahsavarinia, M. Ghojazadeh, S. Sanaie, L. Vahedi, Mahta Ahmadpour, A. Mahmoodpoor, H. Soleimanpour","doi":"10.34172/ps.2021.66","DOIUrl":"https://doi.org/10.34172/ps.2021.66","url":null,"abstract":"Background Many of the known coronaviruses cause a wide range of respiratory infections in humans, and the novel coronavirus is no exception to this rule. Although no drug has yet been discovered to prevent or treat this disease, chloroquine (CQ) and hydroxychloroquine (HCQ) have been widely used in studies showing different results. Methods The present study is an umbrella study. The search was conducted for the articles published from January 2020 to November 2020 using the keywords (\"COVID-19\" OR \"SARS-CoV-2\" AND \"Hydroxychloroquine\" OR \"Chloroquine\" AND \"Systematic Review\" OR \"Metanalysis\"). This study was limited to human samples and systematic reviews with or without meta-analysis. The quality of the articles was also evaluated independently by two researchers. Results To evaluate the clinical efficacy of HCQ and CQ, a total of 176 papers and 643569 cases ranging from patients with mild pneumonia to intubated critically ill patients were evaluated. Finally, 8 studies were included. Conclusion There are conflicting results regarding HCQ or CQ efficacy and safety in the systematic reviews. More evidence is needed to confirm whether these drugs are useful in COVID-19 infection, and their usage as the standard care cannot be recommended based on the majority of the studies included in this umbrella review.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87138068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression, purification and characterization of anti-FGF7 domain antibody identified using phage display technique","authors":"Aliakbar Alizadeh, Mona Roshani, Omid Jamshidi Kandjani, Milad Soltani-Saif, S. Dastmalchi","doi":"10.34172/ps.2021.64","DOIUrl":"https://doi.org/10.34172/ps.2021.64","url":null,"abstract":"Background: Fibroblast growth factors (FGFs) are involved in angiogenesis, wound healing and embryonic development. However, one of the causes of cancer cell growth in fibroblast-dependent cancers is FGF7 secreted by fibroblasts. Therefore, antibodies against FGF7 can be used for treatment of these types of cancers. Methods: In previous studies, a phage displaying single domain antibody, D53, against human FGF7 has been identified using the phage display technique. In the present study, D53 was produced and purified in its isolated form. ELISA experiment was performed to evaluate the binding of D53 to FGF7. The mode of interaction of D53-FGF7 was explored using docking study and molecular dynamics (MD) simulations. Results: The expression and purification processes were verified using western blotting and SDS-PAGE analyses. ELISA experiment showed that D53 is able to recognize and bind FGF7. Docking study and MD simulations indicated that compared to dummy VH, D53 has more affinity towards FGF7. Conclusion: The findings in the current study can be useful for generation and development of FGF7 inhibitors with potential use in fibroblast-dependent cancers.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86115302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Chitosan–Tripolyphosphate Nanoparticles as Glycopeptide Antibiotic Reservoirs and Ex vivo Evaluation for Their Potential to Enhance the Corneal Permeation in Ocular Drug Delivery","authors":"F. Safari, S. Mirzaeei, G. Mohammadi","doi":"10.34172/ps.2021.62","DOIUrl":"https://doi.org/10.34172/ps.2021.62","url":null,"abstract":"Purpose: The present investigation aimed to prepare Vancomycin-loaded nanoparticles (VAN-NPs) using chitosan (CS) and tripolyphosphate (TPP) besides exploring the effects of changing CS/TPP ratio on the physicochemical properties, corneal permeation, and ocular delivery of the prepared NPs. Methods: Different pre-formulations were prepared using the modified ionic gelation process, then were characterized in terms of size distribution. Optimized formulations were furtherly evaluated by some characteristic tools such as Fourier-transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). The in vitro antimicrobial efficacy and drug release amounts along with the Ex-vivo corneal permeation of NPs through the sheep cornea were investigated. Quantification was performed using High-Performance Liquid Chromatography. Results: Spherical and uniformly distributed NPs were developed with a mean particle size varied between 215–290 nm. FTIR spectroscopy confirmed that the CS/TPP cross-linking has taken place without affecting the pharmacologically active moiety of the drug. The obtained zeta potential values were in the range of +34 to +37 mV, which could ensure the stability of formulations. TGA analysis indicated enhanced thermal stability for the encapsulated drug compared to the plain drug. Formulations indicated suitable antimicrobial efficacy while releasing more than 90% of the drug during 24 h. NPs offered a 10-fold enhancement in corneal permeation compared to the drug solution. Conclusions: Although further in vivo evaluation is still required to completely confirm the efficacy of the formulations, the enhanced release and corneal permeation of the drug suggest that the prepared NPs are suitable for ocular delivery of VAN.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72730344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol prevents lipopolysaccharide-induced cognitive impairment in rats through regulation of hippocampal GluA1-containing AMPA receptors","authors":"Mohammadmehdi Hassanzadeh-Taheri, Somayeh Hayati, M. Mohammadifard, Mehran Hosseini","doi":"10.34172/ps.2021.61","DOIUrl":"https://doi.org/10.34172/ps.2021.61","url":null,"abstract":"Background: Evidence suggests that dysregulation in AMPA-type glutamate receptors (AMPA-Rs) has been associated with the pathogenesis of Alzheimer's disease (AD), especially during its early phase. Hence, the present study was performed to elucidate the impact of resveratrol (RV) on hippocampal expression of AMPA-Rs in a rat model of AD. Methods: A rat model of cognitive deficits was developed by a stereotactic intracerebroventricular infusion of lipopolysaccharide (LPS) in male Wistar rats (n=24). The LPS+RV30 group (n=12) received intraperitoneal injections of RV (30 mg/kg) at 30 min, 12 h, and 24 h before LPS injection. Meanwhile, the model (LPS) and sham (SO) groups only were treated with the vehicle solution (normal saline containing 1% ethanol). One day after the LPS infusion, the mRNA expressions of AMPA-Rs subunits (Gria1-4) were evaluated by RT–PCR. In addition, hippocampal levels of lipid peroxidation, superoxide dismutase, and nitric oxide were assessed. Seven days after the LPS challenge, the remaining animals (n=6 each group) were subjected to the Y-maze task, and the expression and localization of GluA1-containing AMPA-Rs in their hippocampi were investigated immunohistochemically. Results: Pretreatment with RV prevented LPS-induced cognitive dysfunction in rats and enhanced their working memory performance. Moreover, RV could moderately prevent oxidant-antioxidant imbalance in rats' hippocampi. RT-PCR results revealed that the hippocampal mRNA expression of the Gria1 was significantly reduced, while the expressions of Gria2 and Gria3 were increased in LPS-challenged rats. RV significantly modulated the alteration in the Gria1 mRNA expression; however, it could not influence the Gria2 and Gria3 mRNA expressions. The immunohistochemical assessment showed a significantly reduced immunoreactivity for GluA1-containing AMPA-Rs in all hippocampal subfields of the LPS group, and RV could effectively ameliorate the alteration. Conclusion: This study is the first to report that RV could modulate GluA1-containing AMPA-Rs dysregulation in a rat AD model.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80166874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metronidazole induced anaphylactic shock: a case report","authors":"Mahsa Panahishokouh, N. Alizadeh, Mehrnoush Dianatkhah, M. Borran, B. Behnoush","doi":"10.34172/ps.2021.60","DOIUrl":"https://doi.org/10.34172/ps.2021.60","url":null,"abstract":"Metronidazole induced anaphylactic shock is an extremely rare drug reaction. We reported a 39-year-old man with severe anaphylactic shock caused by Metronidazole. He denied history of food or drugs allergy. Severe cardiovascular collapse suddenly occurred after receiving intravenous Metronidazole. The patient was successfully managed as a case of anaphylactic shock and finally discharge.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87892229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Two Equations for Estimation of Kidney Function (Cockcroft-gault and Glomerular Filtration Rate Assessment in Liver Disease) for Vancomycin Dosing in Adult Liver Transplant Recipients: a Pilot, Randomized Clinical Trial","authors":"Yasaman Saee, S. Dashti-Khavidaki, Z. Ahmadinejad, F. Ghiasvand","doi":"10.21203/rs.3.rs-744829/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-744829/v1","url":null,"abstract":"\u0000 Background: In the setting of impaired liver function, estimation of glomerular filtration rate (GFR) using common creatinine based equations is inaccurate. Recently, Glomerular Filtration Rate Assessment in Liver Disease (GRAIL) model has been introduced for estimating GFR in liver transplantation. This study was conducted to compare vancomycin dose adjustment in liver transplant patients using Cockcroft-Gault (C-G) versus GRAIL method.Methods: In this pilot, randomized clinical trial, adult liver transplant recipients who were candidate to receive intravenous vancomycin were enrolled. GFR and creatinine clearance were estimated using GRAIL model and C-G equation in the intervention and control arms, respectively and vancomycin maintenance doses were adjusted accordingly. At the steady state , peak and trough serum concentrations of vancomycin were collected for pharmacokinetic comparisons.Results: Fifteen patients were enrolled in each arm of the study. Mean daily dose of vancomycin was estimated insignificantly lower for individuals in GRAIL arm than C-G group (1500.00±544.45 versus 1750.00± 389.60mg). The rate of patients who achieved the target vancomycin trough concentration was similar between the two study arms (20%). Compared with C-G group, higher rate of patients in GRAIL arm experienced below-target vancomycin trough concentrations (40% versus 13.3%) and lower rate showed above target trough concentration (40% versus 66.7%), although these differences did not reach statistical significance. Higher rates of patients with at target and above target vancomycin AUC/MIC were seen in the C-G group compared with GRAIL group (40% versus 26.7% and 53.3% versus 26.7%, respectively), while individuals in the GRAIL arm represented significantly higher rate of below target vancomycin AUC/MIC than C-G arm (46.7% versus 6.7%) (P=0.049). No differences in clinical outcomes were observed between the two groups.Conclusion: Using GRAIL model for vancomycin dose selection may result in less percent of patients with at target AUC/MIC exposure compared to C-G method and expose more percent of patients at risk of vancomycin under dosing.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74956564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broad-spectrum Cannabis oil alleviates behavioral symptoms associated with stress-related anxiety and depression in mice","authors":"Pollyana Mendonça de Assis, E. G. Ferrarini, Gabriela M Baldasso, Rodrigo S Paes, Murilo Chaves Gouvêa, Carlos Espínola Neto Segundo, F. Borrelli, M. Brandão, Raffaelle Capasso, R. C. Dutra, N. Raposo","doi":"10.34172/ps.2021.59","DOIUrl":"https://doi.org/10.34172/ps.2021.59","url":null,"abstract":"Background: Posttraumatic stress disorder (PTSD) is a psychiatric condition that manifests through a broad range of symptoms and shares several phenotypes with anxiety and depression. Refractory PTSD affects 10 – 30% of the patients and highlights the need for alternative pharmacotherapy. The suggested involvement of the endocannabinoid system (ECS) with the emotional processes has enlightened the use of Cannabis sp. Then, this study aimed to evaluate the therapeutic effects of a broad-spectrum Cannabis oil on anxiety- and depressive-like behaviors triggered by stressors from combined nature. In addition, this study investigated the effect of the oil on central cannabinoid receptor 1 and serum levels of cytokines, chemokines, and growth factors. Methods: Mice were randomized into five groups (vehicle; Cannabis oil; fluoxetine; single oral dose) and submitted to acute restraint and chronic unpredictable stress. Then, they were behaviorally assessed in the elevated plus-maze test (EPMT), forced swimming test (FST), splash test (ST), and open field test (OFT). The tetrad cannabinoid assay evaluated the central effect of the oil. Serum biomarkers levels were measured by a multiplex bead-based assay. Results: Cannabis oil (0.1 mg/kg, p.o.) significantly reduced the anxiety-like behavior in EPMT in the acute restraint stress model (p < 0.05) as compared to vehicle. Moreover, compared to the vehicle, Cannabis oil significantly reverted the despair and anhedonic-like behaviors in FST (p < 0.05) and ST (p < 0.05), respectively, in chronically stressed mice. Yet, compared to vehicle, therapy with Cannabis oil did not induce cannabinoid-tetrad (p < 0.0001); downregulated granulocyte-macrophage colony-stimulating factor (GM-CSF; p < 0.01) and advanced glycation end-products (RAGE; p < 0.0001); and upregulated vascular endothelial growth factor (VEGF; p < 0.01) serum levels. Conclusion: Altogether, our data suggest the potential of the broad-spectrum Cannabis oil to improve symptoms related to anxiety and depression caused by traumatic events.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86153629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}