Infarma Pharmaceutical Sciences最新文献_第3页

Application of 3D Printing in Pharmaceutical Sciences, and Evaluation of Administration Routes for Drug-Loaded Composites 3D打印在制药科学中的应用，以及载药复合材料给药途径的评价

Infarma Pharmaceutical Sciences Pub Date : 2022-12-09 DOI: 10.34172/ps.2022.49

M. Khatami, A. Doniavi, S. Allahyari, Mahsa Feizollahi, A. Abazari, M. Fotouhi

{"title":"Application of 3D Printing in Pharmaceutical Sciences, and Evaluation of Administration Routes for Drug-Loaded Composites","authors":"M. Khatami, A. Doniavi, S. Allahyari, Mahsa Feizollahi, A. Abazari, M. Fotouhi","doi":"10.34172/ps.2022.49","DOIUrl":"https://doi.org/10.34172/ps.2022.49","url":null,"abstract":"3D printing is novel approach in pharmaceutical field, but its usage has not yet fully established. This method can promote drug therapy and overcome some traditional treatment challenges in different ways that are discussed at this paper. \"One-size-fits-all\", Large-scale production, and less patient and physician acceptability are some limitations that we will encounter in traditional therapy. Three-dimensional printing of pharmaceutical products, is a versatile technology that needs specific attention. droplet-based, extrusion-based, and laser-assisted 3D printers are three main techniques that can be used in this field. The limitations and advantages of this method are also discussed, highlighting potential innovative pathways towards the possibility of drug carriers’ usage in ink formulas. The administration pathway of drug-loaded composites is another important issue in drug treatment strategies that has been discussed here. Oral drug delivery as a convenient method of systemic drug administration with great patient preference, is introduced as a most prevalent pathway that has been studies about 3D printed medicines. Finally, essential ethics and future directions of 3D printing in the pharmaceutical and healthcare industries are outlined.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85467660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigation of the apoptotic effects of mesenchymal stem cells on KG-1 leukemic cell line 间充质干细胞对KG-1白血病细胞系凋亡作用的研究

Infarma Pharmaceutical Sciences Pub Date : 2022-12-04 DOI: 10.34172/ps.2022.48

E. Fathi, Behnaz Valipour, Z. Sanaat, Ali Akbar Movassaghpour-Akbari, R. Farahzadi, S. Montazersaheb

{"title":"Investigation of the apoptotic effects of mesenchymal stem cells on KG-1 leukemic cell line","authors":"E. Fathi, Behnaz Valipour, Z. Sanaat, Ali Akbar Movassaghpour-Akbari, R. Farahzadi, S. Montazersaheb","doi":"10.34172/ps.2022.48","DOIUrl":"https://doi.org/10.34172/ps.2022.48","url":null,"abstract":"Background: Mesenchymal stem cells (MSCs) are undifferentiated cells with the ability of multi-potency, pluripotency, and self-renewal. MSCs show great promise in cancer therapy due to their unique features. MSC secrete various cytokines with multifunctional properties, although their roles are unclear. Methods: We have investigated the influence of secreted cytokines from MSCs on KG-1 cells as a cell model of acute myeloid leukemia (AML). For this purpose, following the culture and characterization of MSCs, a trans-well system was used for co-culturing MSCs and KG-1. To determine apoptosis induction Ki/Caspase-3 assay was conducted for cultured KG-1 alone and in co-culture with MSCs (10:1) on day 7. In the following step, the protein was isolated from both groups (control and experimental) and western blotting was done for investigating the BAX and BCL-2 proteins expression. Results: It was found that MSCs significantly enhanced caspase-3 activity in KG-1 cells (*P<0.05). Besides, A significant increase in protein expression of BAX was detected, while BCL-2 displayed a dramatic reduction (*P<0.01). Conclusion: As a concluding remark, MSCs have a contributory role in the apoptosis of KG-1 cells that is mediated by Caspase-3, BAX, and BCL2 expression.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82104257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minoxidil and dexamethasone eluting nanofiber dressing for cutaneous wound healing in rat 米诺地尔和地塞米松洗脱纳米纤维敷料对大鼠皮肤创面愈合的影响

Infarma Pharmaceutical Sciences Pub Date : 2022-12-02 DOI: 10.34172/ps.2022.47

Saber Khosan, Behsa Salehian, Fatemeh Montaghimi, Y. Sharifi, Anahita Fathi Azarbayjani

{"title":"Minoxidil and dexamethasone eluting nanofiber dressing for cutaneous wound healing in rat","authors":"Saber Khosan, Behsa Salehian, Fatemeh Montaghimi, Y. Sharifi, Anahita Fathi Azarbayjani","doi":"10.34172/ps.2022.47","DOIUrl":"https://doi.org/10.34172/ps.2022.47","url":null,"abstract":"Background: Minoxidil is an antihypertensive agent and vasodilator which may help to promote local blood flow thus hastening the closure of excisional skin wounds. Corticosteroids may down-regulate wound healing. This work aims to develop and characterize nanofiber eluting dexamethasone and minoxidil and investigate their effect on wound healing in a rat model. Method: Minoxidil and dexamethasone-loaded wound dressing were developed and characterized with SEM and FT-IR. In vitro, drug release studies were performed for 12 days. To model the wound healing activity of the developed formulations, excisional wounds were created on the dorsal section of male rats. Results: Histological results of Hematoxylin & Eosin and Masson’s trichrome staining indicate wound healing suppression in the dexamethasone-treated group and good healing activity in the minoxidil-treated group. Here we identified that the application of topical minoxidil can be effective for wound healing probably driven by the anagen hair growth while dexamethasone suppresses collagen production and prevents scar formation. Conclusion: The findings suggest that this minoxidil and dexamethasone wound dressing can potentially be developed as a new treatment modality in the clinic to accelerate wound healing while preventing scar formation.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78425683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological effects of melatonin on telomere length in breast cancer: a review article 褪黑素对乳腺癌端粒长度的生物学效应综述

Infarma Pharmaceutical Sciences Pub Date : 2022-11-28 DOI: 10.34172/ps.2022.46

Elmira Barari, Golnoosh Azarsina, G. Ferns, S. Pirouzpanah

{"title":"Biological effects of melatonin on telomere length in breast cancer: a review article","authors":"Elmira Barari, Golnoosh Azarsina, G. Ferns, S. Pirouzpanah","doi":"10.34172/ps.2022.46","DOIUrl":"https://doi.org/10.34172/ps.2022.46","url":null,"abstract":"There has been increasing interest in studying the effects of dietary factors on telomere length. The telomere is a noncoding DNA sequence including \"TTAGGG\" at the ends of chromosomes of vertebrates. The stability of telomere length is an important factor as a survival signal for cells and cancer prevention. Telomerase is a multi-subunit DNA polymerase that plays a crucial role in maintaining the telomere length, which is critical for the age-related pathogenesis of breast neoplasm. Some regulatory factors interfere with telomerase activity and therefore promote breast tumorigenesis. High telomerase activity and restoring telomere lengths are determined as key factors in progressing tumors to advanced stages of malignancies, which are highly estrogen-dependent in breast carcinogenesis. Melatonin is a hormone-like substance secreted by the pineal gland and has been reported to downregulate telomerase. It may therefore control telomere length in cancer cells. Certain malignancy-related biological pathways have recently been linked to telomere length, and this review provides new insights regarding the effects of melatonin on telomere length by reviewing the anticarcinogenic mechanisms underlying melatonin in relation to telomerase activity in breast carcinogenesis. Experimental insights presenting the effects of melatonin alone or in combination with drugs on enhancing therapeutic protocols were also reviewed, which could assist our understanding of this hormone-like substance and telomeres as prognostic and therapeutic biomarkers in breast cancer.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83846794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promotion of antioxidant and anti-inflammatory activity by Nrf2 amplifier is a potential technique in diabetic wound healing — a review Nrf2放大器促进抗氧化和抗炎活性是一种潜在的糖尿病伤口愈合技术

Infarma Pharmaceutical Sciences Pub Date : 2022-11-24 DOI: 10.34172/ps.2022.45

Tharani Mohanasundaram, V. Ramachandran, Rymbai Emdormi Rymbai, Rinu Mary Xavier, Bhargav Bhongiri, Narasimha Rao Gaddam, Chintha Narendar

{"title":"The promotion of antioxidant and anti-inflammatory activity by Nrf2 amplifier is a potential technique in diabetic wound healing — a review","authors":"Tharani Mohanasundaram, V. Ramachandran, Rymbai Emdormi Rymbai, Rinu Mary Xavier, Bhargav Bhongiri, Narasimha Rao Gaddam, Chintha Narendar","doi":"10.34172/ps.2022.45","DOIUrl":"https://doi.org/10.34172/ps.2022.45","url":null,"abstract":"Wound healing is a complicated organised process that includes numerous phases that connect diverse cellular events and activate several intracellular molecular pathways in injured cells and tissues. Delay in wound healing owing to high levels of oxidative stress is a major difficulty in various metabolic illnesses, including diabetes mellitus. Several therapeutic wound dressing materials and methods, such as hyperbaric oxygen treatment and negative pressure wound therapy, have been developed to speed up wound healing and restore cellular homeostasis. A significant advance has been made in locating transcriptional regulators involved in wound healing. The redox sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is the major regulator of antioxidant defense regulation, inducing the expression of cyto-protective genes and increasing the generation of antioxidants that scavenge free radicals.Activators of Nrf2 have been shown to reduce oxidative stress and improve wound healing in a variety of pathophysiological situations, including diabetes and its consequences such as diabetic foot ulcers, chronic kidney disease, and diabetic nephropathy. Several therapeutic chemicals have been discovered to alleviate oxidative stress and consequently increase cell proliferation. Angiogenesis results in tissue healing through activating the transcription factor Nrf2. This review focuses on role of Nrf2 mediated antioxidant gene expression for diabetic wound healing.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82099674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fucoxanthin inhibits the proliferation of ABCC2-over expressing cisplatin-resistance ovarian cancer cells via inducing apoptosis 岩藻黄素通过诱导凋亡抑制abcc2过表达顺铂耐药卵巢癌细胞的增殖

Infarma Pharmaceutical Sciences Pub Date : 2022-11-23 DOI: 10.34172/ps.2022.44

Fatemeh Valinezhad Sani, Safa Kamalian, Hakim H Abdi, Shiva Ghofrani, Arad Boustan, F. Mosaffa

{"title":"Fucoxanthin inhibits the proliferation of ABCC2-over expressing cisplatin-resistance ovarian cancer cells via inducing apoptosis","authors":"Fatemeh Valinezhad Sani, Safa Kamalian, Hakim H Abdi, Shiva Ghofrani, Arad Boustan, F. Mosaffa","doi":"10.34172/ps.2022.44","DOIUrl":"https://doi.org/10.34172/ps.2022.44","url":null,"abstract":"Background: The development of multidrug resistance (MDR) is a major barrier to achieving effective chemotherapy in cancer. Studies have shown that epithelial ovarian cancer initially responds to platinum-based therapy, however, the recurrent type is often resistant to treatment and is associated with high mortality. Fucoxanthin, a natural component found in marine algae, possesses various pharmacologic properties. This study evaluated the cytotoxicity and resistance reversal activity of fucoxanthin on multidrug resistance-associated protein 2 (MRP2)-overexpressing, cisplatin-resistant ovarian cancer cells (A2780RCIS) and their parental cells (A2780). Methods: Cell viability was evaluated in the presence of different concentrations of fucoxanthin or cisplatin or fucoxanthin/cisplatin combination using the MTT assay. Propidium iodide staining and sub-G1 analysis were used to evaluate fucoxanthin potential for cell cycle modification and apoptosis induction in cancer cell lines. Results: The results showed that fucoxanthin was able to cause similar cell toxicity in both cell lines via apoptosis induction. Co-treatment of cells with cisplatin (3.125 to 100 µM) and nontoxic concentrations of fucoxanthin (1 and 2.5 µM) did not reverse resistance to cisplatin in A2780RCIS cells. Conclusion: Although fucoxanthin was not able to modify cisplatin-resistance in ovarian cancer cells, it was equally effective in inducing apoptosis and death in both A2780 and A2780RCIS cells indicating it is not an MRP2 substrate.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85938257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Crystal Structure and Antibacterial Activity of Cu(II) Complex with Nitrogen Donor Pyrazolyl Borate Derivatives 氮供体吡唑基硼酸盐衍生物Cu(II)配合物的合成、晶体结构及抗菌活性

Infarma Pharmaceutical Sciences Pub Date : 2022-11-18 DOI: 10.34172/ps.2022.43

Behzad Soltani, Monireh Ghorbanpour, Saeide Bagheri, Mostafa Ebadi-Nahari, Christopher J. Ziegler

{"title":"Synthesis, Crystal Structure and Antibacterial Activity of Cu(II) Complex with Nitrogen Donor Pyrazolyl Borate Derivatives","authors":"Behzad Soltani, Monireh Ghorbanpour, Saeide Bagheri, Mostafa Ebadi-Nahari, Christopher J. Ziegler","doi":"10.34172/ps.2022.43","DOIUrl":"https://doi.org/10.34172/ps.2022.43","url":null,"abstract":"Background: Pyrazolyl borate derivatives are versatile ligands that can be coordinated with transition metals and formated a variety of different coordination modes. Copper complexes are highly active in biological applications and have high bioactivity. Because of the above description and applications, in the present work, synthesis and characterization of pyrazolyl borate derivative ligands and their Cu(II) complex were reported. The structure of the synthesized complex was determined by X-ray crystallography. In addition, the antimicrobial activity of the synthesized compounds along with the molecular docking of them was investigated. Methods: N-donor pyrazolyl borate derivative ligands abbreviated as K[HB(PzMe2)3] and K[H2B(PzMe2)2] and their Cu(II) complex were synthesized and characterized. The synthesized ligands and complex were evaluated for antibacterial activities against the gram-positive (B. subtilis) and the gram-negative (S. enterica) bacteria. Also, their molecular docking with B. subtilis SMC head domain (PDB ID: 5H67) as the possible targets was investigated. Results: The in vitro and in silico results showed, among the investigated compounds, complex [Cu(H2B(PzMe2)2)(HB(PzMe2)3)] indicated the highest antibacterial activity. Also, the Statistical analysis showed that the difference between the obtained data was significant. Conclusion: We have synthesized N-donor pyrazolyl borate derivatives and their copper (II) complex. Single X-ray results indicated the Cu(II) complex adopted an N5 environment around the metal center with a distorted square pyramidal geometry. The obtained binding energy of molecular docking studies is in direct correlation with the in vitro antibacterial studies. Briefly, the reported Cu(II) complex may be considered as a potential antibacterial candidate.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"131 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90921092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hansen Solubility Parameters: A Tool for Solvent Selection in Drugs 汉森溶解度参数:药物溶剂选择的工具

Infarma Pharmaceutical Sciences Pub Date : 2022-11-17 DOI: 10.34172/ps.2022.42

M. Peña, Fleming Martínez

引用次数: 1

Clinical Evaluation of a Topical Dosage Form of Alkanna orientalis Root Extract in the Management of Pressure Lesions: A Pilot Cross-sectional Study 一种局部剂型东方alkan根提取物在压性病变治疗中的临床评价:一项试点横断面研究

Infarma Pharmaceutical Sciences Pub Date : 2022-11-13 DOI: 10.34172/ps.2022.41

Elham Lazarzareh, B. Davami, H. Valizadeh, K. Shahsavarinia, H. Nazemiyeh, L. Khodaie, A. Gharekhani

{"title":"Clinical Evaluation of a Topical Dosage Form of Alkanna orientalis Root Extract in the Management of Pressure Lesions: A Pilot Cross-sectional Study","authors":"Elham Lazarzareh, B. Davami, H. Valizadeh, K. Shahsavarinia, H. Nazemiyeh, L. Khodaie, A. Gharekhani","doi":"10.34172/ps.2022.41","DOIUrl":"https://doi.org/10.34172/ps.2022.41","url":null,"abstract":"Background: Pressure lesions are chronic wounds causing the development of infection and inflammation into deeper structures and finally necrosis. In Persian medicine, Alkanna orientalis (Boraginaceae) has been used for centuries as a naturally derived remedy for managing lesions. A cross-sectional pilot clinical trial was conducted to assess the wound healing effect of an ointment made of chloroform extract of roots of A. orientalis (CERAO). Methods: Sixty patients (36 men and 24 women) diagnosed with bedsore staging 1-2 entered the study for one year. They were divided into two groups of control and treatment with equal proportions. The control group received conventional treatment from the hospital, including irrigation serum, mupirocin, phenytoin ointments, and gauze dressing. After rinsing and cleansing with normal saline, in the intervention group, patients received a thin layer of CERAO once daily for four weeks. Clinical outcomes were measured at weeks 2 and 4. Results: Recovery assessment was carried out by measuring wound area, days of epithelia formation, and complete wound closure. The difference between the two groups was statistically significant (P-value <0.05) in terms of the mentioned criteria. The recovery percentage was 26.7% and 60% for the control and treatment groups, respectively. In the control group, 16.7% of the study population experienced the development of wounds, while in the intervention group, wound progression was not observed. Conclusion: The results of this pilot study indicated that the clinical efficacy of CERAO could be promising and a replacement for conventional treatment of pressure ulcers.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75205171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of β-alanine supplementation on recovery biomarkers in adults: A systematic review and meta-analysis 补充β-丙氨酸对成人恢复生物标志物的影响:系统回顾和荟萃分析

Infarma Pharmaceutical Sciences Pub Date : 2022-10-18 DOI: 10.34172/ps.2022.40

M. Mahmoudinezhad, Meysam Zarezadeh, Fatemeh Pourteymour Fard Tabrizi, Parsa Jamilian, Parmida Jamilian, A. Ostadrahimi

{"title":"The influence of β-alanine supplementation on recovery biomarkers in adults: A systematic review and meta-analysis","authors":"M. Mahmoudinezhad, Meysam Zarezadeh, Fatemeh Pourteymour Fard Tabrizi, Parsa Jamilian, Parmida Jamilian, A. Ostadrahimi","doi":"10.34172/ps.2022.40","DOIUrl":"https://doi.org/10.34172/ps.2022.40","url":null,"abstract":"Background: Clinical studies, investigating the effect of β-Alanine (BA) supplementation on recovery biomarkers in physically active individuals, have generated inconsistent results. This systematic review and meta-analysis study aimed to clarify the clinically relevant dietary effects of BA supplementation. Methods: A comprehensive search was done in the electronic databases of Scopus, PubMed, ISI Web of Science and Embase from inception to 2020. Meta-analysis was done using the random-effects model. Pooled effect size was evaluated using standard mean difference (SMD) and 95% confidence intervals (CI). Heterogeneity of between-study was evaluated according to Cochran’s Q test and I2. Subgroup analysis was conducted to identify the potential sources of heterogeneity. Results: Overall, 32 studies were included in the current study. The results suggested that BA supplementation increases carnosine level significantly (SMD: 0.22mmol/L, 95%CI: -0.17,0.61, P=0.27) but no effect was shown about lactate, fatigue, VO2, PH and bicarbonate (HCO3-) (P>0.05). Subgroup analysis revealed a significant association of VO2, carnosine and fatigue with supplementation dosage, gender and duration of administration respectively. Conclusion: BA supplementation emerged its beneficial effects on enhancing carnosine level which highlights its ergogenic effects. In contrast, no significant effects had been shown in term of fatigue delay and blood levels of lactate, HCO3-, PH, and VO2 value. These results warrant more investigation in a prospective design to clarify the exact mechanism in this way.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89443066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0