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The Oxford Handbook of Developmental Neural Plasticity最新文献

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Developmental Cortical Plasticity in the Central Auditory System 中枢听觉系统发育的皮质可塑性
The Oxford Handbook of Developmental Neural Plasticity Pub Date : 2017-05-10 DOI: 10.1093/OXFORDHB/9780190635374.013.1
Michele N. Insanally, R. Froemke
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引用次数: 0
Environmental Enrichment and Neuronal Plasticity 环境富集与神经元可塑性
The Oxford Handbook of Developmental Neural Plasticity Pub Date : 2017-05-10 DOI: 10.1093/OXFORDHB/9780190635374.013.13
G. Clemenson, F. Gage, C. Stark
{"title":"Environmental Enrichment and Neuronal Plasticity","authors":"G. Clemenson, F. Gage, C. Stark","doi":"10.1093/OXFORDHB/9780190635374.013.13","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190635374.013.13","url":null,"abstract":"This chapter reviews the literature on environmental enrichment and specifically discusses its influence on the hippocampus of the brain. In animal models, the term “environmental enrichment” is used to describe a well-defined manipulation in which animals are exposed to a larger and more stimulating environment. This experience has been shown to have a powerful and positive impact on hippocampal cognition and neuroplasticity in animals. In humans, however, the translation of environmental enrichment is less clear. Despite the fact that humans live considerably more enriching lives compared to laboratory animals, studies have shown that training and expertise (such as exercise and spatial exploration) can lead to both functional and structural changes in the human brain. This chapter is a comprehensive review of environmental enrichment, drawing parallels between animal models and humans to present a more complete understanding of environmental enrichment.","PeriodicalId":309448,"journal":{"name":"The Oxford Handbook of Developmental Neural Plasticity","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133221483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Regulation of CNS Plasticity Through the Extracellular Matrix 细胞外基质对中枢神经系统可塑性的调控
The Oxford Handbook of Developmental Neural Plasticity Pub Date : 2017-05-10 DOI: 10.1093/OXFORDHB/9780190635374.013.11
P. Warren, Stuart Dickens, S. Gigout, J. Fawcett, Jessica C. F. Kwok
{"title":"Regulation of CNS Plasticity Through the Extracellular Matrix","authors":"P. Warren, Stuart Dickens, S. Gigout, J. Fawcett, Jessica C. F. Kwok","doi":"10.1093/OXFORDHB/9780190635374.013.11","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190635374.013.11","url":null,"abstract":"Contrary to established dogma, the central nervous system (CNS) has a capacity for regeneration and is moderately plastic. Traditionally, such changes have been recognized through development, but more recently, this has been documented in adults through learning and memory or during the advent of trauma and disease. One of the causes of such plasticity has been related to changes in the extracellular matrix (ECM). This complex scaffold of sugars and proteins in the extracellular space alters functionality of the surrounding tissue through moderation of synaptic connections, neurotransmission, ion diffusion, and modification to the cytoskeleton. This chapter discusses the role of the ECM in CNS plasticity in development and the adult. Further, it determines how the ECM affects normal neuronal functioning in critical processes such as memory. Finally, the chapter assesses how the ECM contributes to adverse CNS changes in injury and disease, concentrating on how this matrix may be targeted for therapeutic intervention.","PeriodicalId":309448,"journal":{"name":"The Oxford Handbook of Developmental Neural Plasticity","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126618117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Pharmacological Manipulation of Critical Period Plasticity 关键时期可塑性的药理学操作
The Oxford Handbook of Developmental Neural Plasticity Pub Date : 2017-05-10 DOI: 10.1093/OXFORDHB/9780190635374.013.10
R. Guirado, E. Castrén
{"title":"Pharmacological Manipulation of Critical Period Plasticity","authors":"R. Guirado, E. Castrén","doi":"10.1093/OXFORDHB/9780190635374.013.10","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190635374.013.10","url":null,"abstract":"Neuronal networks are refined through an activity-dependent competition during critical periods of early postnatal development. Recent studies have shown that critical period plasticity is influenced by a number of environmental factors, including drugs that are widely used for the treatment of brain disorders. These findings suggest a new paradigm, where pharmacological treatments can be used to open critical period–like plasticity in the adult brain. The plastic networks can then be modified through rehabilitation or psychotherapy to rewire those abnormally wired during development. This kind of combination of pharmacotherapy with physical or psychological rehabilitation may open a new opportunity for a more efficient recovery of a number of neurological and neuropsychiatric disorders.","PeriodicalId":309448,"journal":{"name":"The Oxford Handbook of Developmental Neural Plasticity","volume":"15 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122478410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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