Geriatric Care最新文献

{"title":"Serum interleukin-6 levels are higher in old age subjects with Alzheimer’s dementia","authors":"V. Boccardi, M. Baroni, R. Cecchetti, M. Scamosci, P. Bastiani, P. Mecocci","doi":"10.4081/GC.2021.9423","DOIUrl":"https://doi.org/10.4081/GC.2021.9423","url":null,"abstract":"Elevated interleukin-6 (IL-6) levels have been found positively associated with markers of physical frailty as well as identified as a potential biomarker of Alzheimer’s disease (AD). Thus, we explored the levels of plasma IL-6 at baseline in a cohort of older subjects with or without cognitive impairment, which results may have also implications for coronavirus disease 2019 (COVID-19) clinical management. This is a retrospective study including a cohort of over 60 years old-age subjects, 72 healthy controls, 95 mild cognitive impairment, and 73 AD were included in the study. Plasma IL-6 was measured in all subjects. The sample population included 240 subjects, mostly women with a mean age of 78.61±6.30 (range: 60-93) years. Age significantly correlated with IL-6 plasma levels (r=0.204, P=0.002) even after controlling by gender. No difference was found in body mass index (BMI), nutritional status (assessed by mini nutritional assessment), and comorbidity indices (cumulative illness rating scaleseverity and comorbidity index) among groups. Instead, IL-6 significantly differed, having patients affected by AD higher levels compared to the other groups. Final linear regression analysis showed that independently of age, gender, BMI, nutritional status, number of clinically relevant concomitant diseases, the diagnosis of AD was associated with higher IL-6 plasma levels. These data indicate that serum IL-6 is more elevated in AD, supporting that IL-6 may have also a potential role in response to COVID-19 in old age subjects with cognitive impairment.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42027933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMEPA (COVID-19 Medicina Policlinico Palermo): a study in hospitalized patients.","authors":"Ligia Juliana Dominguez Rodriguez, P. Mansueto, M. Soresi, N. Veronese, A. Licata, L. Giannitrapani, R. Citarrella, M. Barbagallo","doi":"10.4081/GC.2021.9895","DOIUrl":"https://doi.org/10.4081/GC.2021.9895","url":null,"abstract":"","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":"1 1","pages":"9895-9897"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70165120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-research in geriatric medicine: a survey of the Italian Society of Hospital and Community Geriatrics (SIGOT)","authors":"N. Veronese, J. Demurtas, S. Maggi, A. Cherubini, V. Solfrizzi, A. Cella, F. Fimognari, A. Ferrari, A. Pilotto","doi":"10.4081/gc.2020.9339","DOIUrl":"https://doi.org/10.4081/gc.2020.9339","url":null,"abstract":"The need for major information in meta-research (i.e. the part of medicine interested in systematic reviews [SRs] and meta-analyses [MAs]) is increasing. In the last years we are observing an exponential rate of publications as SRs/MAs in geriatric medicine. In order to better assess the interest in meta-research, we proposed a survey to know the knowledge and the needs in meta-research in geriatrics. A short survey (about 5 minutes) was freely available in the Italian Society of Hospital and Community Geriatrics (SIGOT) website and diffused in social networks. The survey was available during the entire 2019. The survey regards demographic information, previous research activities and the knowledge of the participant on meta-research. Altogether, 148 participants mainly men (=65.5%) and mainly aged 36 to 44 years and working in hospital from all Italian regions completed the survey. Responders read more than 20 articles in the previous year (=58.1%), including 10-20 SRs/MAs (25%). Many respondents (41.9%) had published >20 articles during their life. At the same time, a consistent part of the respondents recognized the importance of metaresearch for clinical practice and almost all the participants recognized that metaresearch has changed their daily clinical approach to the patient. Almost all the participants would like to have more training in meta-research suggesting that SIGOT should organize training courses for metaresearch in geriatric medicine. In conclusion, our survey showed that the interest in SRs/MAs is high, whilst the knowledge is still limited suggesting that education is needed to fill the gap in this field.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42482112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between chronic diseases and diet in older persons in nursing homes","authors":"Melahat Kizil, K. Turhan, R. Kızıl, Nursun Üstünkarli","doi":"10.4081/gc.2020.8920","DOIUrl":"https://doi.org/10.4081/gc.2020.8920","url":null,"abstract":"This study aimed to determine the relationship between chronic diseases and nutrition in the older adults in a nursing home. In 2014 and 2019, we investigated older people aged 60 years and over living in a nursing home in Izmir and who agreed to participate and could perform self-care. A 26-item questionnaire that focuses on sociodemographic, socioeconomic and chronic disease characteristics, and the Turkish version of Mini Nutritional Assessment Test-Short Form were applied using the face-to-face method. In 2014, 68.9% of the older had no malnutrition risk, 23% had malnutrition risk, and 8.1% had malnutrition. The women had a higher malnutrition risk and actual malnutrition than men (P<0.05). Malnutrition was most common in 75-84 years of age. In 2019, 41.6% of the older had malnutrition risk, whereas 7.8% had actual malnutrition. No difference was found between malnutrition and malnutrition risk, between women and men and between age and sex (P>0.05). At both times, malnutrition risk increased in those with chronic disease (P<0.05). At least one chronic disease (high blood pressure, heart disease, diabetes, etc.) was found in 67.6% of the older. Meanwhile, 70.1% had been previously hospitalized for some reason. Malnutrition risk increases with old age. An adequate and well-balanced diet is important for protecting health and increasing longevity and quality of life in old age. Older people and nursing home employees need to be trained on the relationship and risks of chronic disease and malnutrition.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44464969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BrainProtect® - A cognitive training program with nutritional and physical counseling components: a retrospective analysis of its effects in healthy individuals","authors":"J. Falkenreck, M. Roheger, Hannah Weigert, A. Friese, Petra Jahr, I. Becker, G. Nelles, E. Kalbe, M. Polidori","doi":"10.4081/gc.2020.9328","DOIUrl":"https://doi.org/10.4081/gc.2020.9328","url":null,"abstract":"Cognitive integrity has a multifactorial basis and is essential for quality of life and wellbeing. Several lifestyle programs including those using cognitive training have been developed in the past recent years to preserve cognitive health, but there is still debate about the most effective strategy to be used. We retrospectively analyzed data from 289 healthy participants of the BrainProtect® cognitive training program, developed by the German Association for Memory Training (Bundesverband Gedächtnistraining e.V.). Eight weekly 90minute sessions of cognitive exercises were holistically structured to include physical exercises and nutrition counseling basing upon social interaction. The large majority (79.9%) of the participants showed improved cognitive scores after the intervention with respect to the baseline, with more than 10/69 points gained. Almost 60% felt their cognitive efficiency increased and an average increase in all cognitive domain explored could be observed. This retrospective analysis of preliminary data suggests that BrainProtect® might improve mental fitness after 8 weeks of multidomain cognition-centered training. These encouraging results need to be confirmed in further randomized studies.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47985832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-care with Ou MC decrescendo phenomenon may possibly prevent mild COVID-19 disease developing into severe or critical stage","authors":"M. Ou, D. Ou, Chung-Chu Pang","doi":"10.4081/gc.2020.9171","DOIUrl":"https://doi.org/10.4081/gc.2020.9171","url":null,"abstract":"Ou MC decrescendo phenomenon treatment (OuDPt) is a self-administered practice in which the interactions of the anatomical axes result in a physiological response and produce a zone under the contralateral hand with decreased pain or inflammation. OuDPt has shown an effect to alleviate cough, rhinorrhea, headache, acute edematous swellings, dysmenorrhea, endometriosis and joint pain that are related to inflammatory reaction. Most symptoms with coronavirus infection disease 2019 (COVID-19) as fever, cough, myalgia or diarrhea are also associated with inflammation. If the inflammation by severe acute respiratory syndrome coronavirus 2 is suppressed, mild COVID-19 disease may not develop into severe or critical stage. Further investigations are warranted.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/gc.2020.9171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49483520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readmissions in elderly patients with heart failure. A retrospective study","authors":"R. Alves, M. Fernandes, I. Figueiredo, D. Borges, Filipa Louenço","doi":"10.4081/GC.2020.9106","DOIUrl":"https://doi.org/10.4081/GC.2020.9106","url":null,"abstract":"Heart failure is a major cause of morbidity and mortality worldwide. The prevalence increases with age and usually progresses, leading to repeated hospital admissions and significant symptom burden for patients. The correct management of these patients may decrease readmissions and increase quality of life. Our aim is to compare elderly patients with and without 1-year readmissions in an internal medicine ward, particularly in terms of mortality. Retrospective study, consulting patient’s clinical records, with a diagnosis of heart failure. The patients were characterized and divided in groups: with (wR) and without readmission (woR) within 1 year. Mortality was the primary outcome. Eighty-nine patients were included; 60 woR and 29 wR. There was no gender difference between groups, the wR group had older patients. The most frequent comorbidities included atrial fibrillation, hypertension and chronic renal failure stage 3 or higher. The most frequent cause of hospitalization was heart failure due to insufficient therapy or natural progression of the disease. The etiology of heart failure was mainly hypertensive and ischemic. The wR group had more patients classified as NYHA >III . In relation to the primary outcome; mortality at 12 months was higher in the group with repeated admissions . The characterization of this population allows us to highlight the causes of decompensation and to review medication in order to increase the quality of life. Introduction and objectives Heart failure is defined as a clinical syndrome comprised of typical symptoms including breathlessness, fatigue and peripheral edema, among others, many related to congestion and fluid overload resulting from structural or functional cardiac abnormality.15 Heart failure is currently divided in three subgroups; heart failure with decreased ejection fraction (EF) (EF<40%), heart failure with intermediate EF (EF 40-49%) which currently has no clinical implications but is a target for research, and finally heart failure with preserved EF (EF>50%).5 Heart failure severity is classified according to symptom severity and exercise tolerance using the New York Heart Academy functional classification. Heart failure is a major cause of morbidity and mortality worldwide; it affects about 2% of the adult population, and the lifetime risk of developing heart failure is one in five.1-3 The prevalence increases with age and it is associated with highly prevalent comorbidities such as hypertension, coronary artery disease, cardiomyopathies and valve disease. As a result of ageing of the population the prevalence of heart failure is projected to increase by 25% in the next 20 years.1,3 Mortality remains high despite improvements, with a rate of 6-7% in chronic heart failure and 25% in patients with acute decompensations and hospital admission.1,3,69 According to European guidelines,5 heart failure with reduced EF treatment is based on neuro-hormonal antagonists and devices to block the remodeling o","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/GC.2020.9106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47648963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honorary authorship in Geriatric Literature: do authors adhere to the ICMJE-guidelines?","authors":"A. Verhemel, Y. Dahi, Selay Kakar, P. Gadjradj","doi":"10.4081/GC.2020.9227","DOIUrl":"https://doi.org/10.4081/GC.2020.9227","url":null,"abstract":"To protect appropriate authorship, the International Committee of Medical Journal Editors (ICMJE) formulated a guideline on authorship. Researchers not fulfilling these criteria and still enlisted as author are seen as honorary authors (HA). The objective of this study is to assess authorship decision making and the proportion of HA in journals in the field of geriatrics and gerontology. Corresponding authors of six highimpact journals in geriatrics and gerontology were sent a survey. The survey consisted of three parts: i) demographics of the respondent; ii) awareness of authorship guidelines; and iii) authorship decisions made for the paper they are authors of. Respondents were also asked if one of their coauthors does not deserve authorship. This is defined as self-perceived HA. Furthermore, respondents were asked if any of their co-authors only performed tasks from a list of non-authorship tasks. This is defined as ICMJE-defined HA. Of the 1592 contacted authors, 528 filled in a survey (response rate 33.2%). 84.4% was aware of the ICMJE-guidelines, but 44.2% was unaware of the issue of HA. The proportion of self-perceived HA was 12.7%. Independent factors associated with more self-perceived HA were having a senior member automatically enlisted as coauthor [odds ratio (OR) 3.4, 95%confidence interval (CI) 1.8 to 6.4] and have gotten the suggestion to include an HA (OR 11.1, 95% CI 4.4 to 27.9). The proportion of ICMJEdefined HA was 39.3%. The journal surveyed (OR 1.2, 1.0 to 1.3) was associated with more, and awareness of the ICMJE (OR 0.5, 95% CI 0.3 to 0.9) was associated with less ICMJE-defined HA respectively. Having a senior member automatically enlisted as co-author (OR 2.1 95% CI 1.3 to 3.4) and having anyone suggest to include an HA (OR 4.8 95% CI 1.8 to 12.8) were also associated with more ICMJE-defined HA. More than one out of ten of the corresponding authors thinks that based on the ICMJE-guidelines, one or more of their coauthors did not deserve authorship. A stricter journal policy and more awareness of the ICMJE-guidelines could help reduce the proportion of HA.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/GC.2020.9227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47198894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine and QTc: beyond COVID-19","authors":"A. Castagna, F. Vetta, G. Attisani, Raffaele Costa, Carmen Ruberto, Viviana Vespertini, L. Cosco, G. Ruotolo","doi":"10.4081/GC.2020.9064","DOIUrl":"https://doi.org/10.4081/GC.2020.9064","url":null,"abstract":"Hydroxychloroquine is an antimalarial drug also known for its anti-inflammatory and antiviral effects, which have raised the interest of many researchers for its potential use in COVID-19 patients. It is known that this drug, being able to influence the cardiac repolarization phase with QTc interval prolongation, can be potentially harmful, chiefly in elderly subjects with frailty syndrome, several comorbidities and polypharmacotherapy. Therefore, although electrocardiogram monitoring of QTc prolongation is the focal point for reducing the arrhythmic risk of these patients, in order to identify the most exposed patients, the traditional Comprehensive Geriatric Assessment should be combined with a multiparametric risk score for QTc prolongation.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/GC.2020.9064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46875431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract Book of the 34° Congresso Nazionale SIGOT - Live streaming, 22-23 settembre 2020","authors":"Alberto Pilotto","doi":"10.4081/GC.2020.9363","DOIUrl":"https://doi.org/10.4081/GC.2020.9363","url":null,"abstract":"Abstract Book of the 34° Congresso Nazionale SIGOT - Live streaming, 22-23 settembre 2020.","PeriodicalId":30930,"journal":{"name":"Geriatric Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47850991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}