The Journal of ExtraCorporeal Technology最新文献_第5页

Cardiac and vascular anesthesia: The requisites in anesthesiology 心脏和血管麻醉:麻醉学的必要条件

The Journal of ExtraCorporeal Technology Pub Date : 2004-09-01 DOI: 10.1051/ject/2004363284

引用次数: 0

Selected Abstracts for the Australasian Society of Cardio-Vascular Perfusionists Inc. 澳大利亚心血管灌注医师协会精选摘要。

The Journal of ExtraCorporeal Technology Pub Date : 2004-09-01 DOI: 10.1051/ject/2004363294

H. Dando, N. Casey, A. Vuylsteke, T. Burns

{"title":"Selected Abstracts for the Australasian Society of Cardio-Vascular Perfusionists Inc.","authors":"H. Dando, N. Casey, A. Vuylsteke, T. Burns","doi":"10.1051/ject/2004363294","DOIUrl":"https://doi.org/10.1051/ject/2004363294","url":null,"abstract":"Objective: Reports evaluating the efficacy of heparin-bonded circuits (HBC) to blunt inflammation, platelet dysfunction and thrombin generation in response to cardiopulmonary bypass (CPB) have varied. We hypothesized that this variability may, in part, be related to the use of cardiotomy suction (CS), which has been demonstrated to reintroduce pro-coagulant and pro-inflammatory factors into the systemic circulation during CPB. A prospective, randomized study was undertaken to evaluate the specific effects of CS. Methods: Thirty-six patients undergoing first-time, non-emergent, coronary artery bypass graft surgery with CPB were randomized to one of three treatment groups: I) non-heparin bonded circuits with the use of CS (n = 12), II) Duraflo-II HBC with CS (n = 12), or III) Duraflo-II HBC without CS (n = 12). Thrombin generation (PF1.2), neutrophil activation (PMN elastase, PMN-E), platelet activation ( (cid:1) -thromboglobulin, (cid:1) -TG) and neuronal injury (neuron-specific enolase, NSE) were analyzed by ELISA assays post CPB and compared to pre bypass levels. Results are presented as mean ± SEM. Results: Pre bypass levels of all markers were similar amongst treatment groups.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122856107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plateletworks™ Platelet Function Test Compared to the Thromboelastograph™ for Prediction of Postoperative Outcomes Plateletworks™血小板功能试验与Thromboelastograph™预测术后预后的比较

The Journal of ExtraCorporeal Technology Pub Date : 2004-06-01 DOI: 10.1051/ject/2004362149

J. Ostrowsky, Jennifer Foes, M. Warchol, Gary Tsarovsky, J. Blay

{"title":"Plateletworks™ Platelet Function Test Compared to the Thromboelastograph™ for Prediction of Postoperative Outcomes","authors":"J. Ostrowsky, Jennifer Foes, M. Warchol, Gary Tsarovsky, J. Blay","doi":"10.1051/ject/2004362149","DOIUrl":"https://doi.org/10.1051/ject/2004362149","url":null,"abstract":"Approximately 3.5 million units of platelets are transfused in the United States each year to patients undergoing open-heart surgery with cardiopulmonary bypass (CPB). CPB is a known contributor to platelet loss and platelet dysfunction leading to disruption of hemostasis. Impaired hemostasis results in excess bleeding in 5–25% of all patients undergoing CPB. For this reason, it may be beneficial to measure platelet number and function in these patients. The purpose of this study was to compare the Plateletworks™ platelet function analyzer to the thromboelastograph (TEG) in predicting postoperatiave hemostatic outcomes as measured by blood product use and chest tube (CT) drainage. This study consisted of 35 adult patients undergoing cardiac surgery with cardiopulmonary bypass at Rush-Presbyterian-Saint Luke’s Medical Center (RPSLMC). The Plateletworks™ and TEG tests were performed preoperatively, after protamine was given, and 24 hours postoperatively on all patients. Plateletworks™ demonstrated a statistically significant change in platelet function as shown by the adenosine diphosphate (ADP) reagent tube from the preoperative period to the removal of the aortic cross clamp (p = .011). The TEG did not demonstrate a significant change in the k-time and maximum amplitude (MA), but did show a significant change in the alpha-angle from the pre-operative to postoperatiave sample (p = .035). A correlation was found between Plateletworks™ collagen reagent tubes preoperatively and CT drainage (p = .048, r −0.324). No statistical correlation was established between TEG parameters and CT drainage at any time interval. TEG preoperative MA showed a correlation to receipt of blood products (p = .016). When comparing the Plateletworks™ to the TEG in this study, the Plateletworks™ system was a more useful predictor of blood product use and chest tube drainage.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124497554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

TGF-β1 Overexpression: A Mechanism of Diastolic Filling Dysfunction in the Aged Population TGF-β1过表达:老年人舒张充盈功能障碍的一种机制

The Journal of ExtraCorporeal Technology Pub Date : 2004-03-01 DOI: 10.1051/ject/200436169

D. Larson, R. Ingham, Cory M. Alwardt, Bo Yang

{"title":"TGF-β1 Overexpression: A Mechanism of Diastolic Filling Dysfunction in the Aged Population","authors":"D. Larson, R. Ingham, Cory M. Alwardt, Bo Yang","doi":"10.1051/ject/200436169","DOIUrl":"https://doi.org/10.1051/ject/200436169","url":null,"abstract":"The prevalence of cardiovascular disease in the United States dramatically increases with age. A hallmark feature of the aged myocardium is increased fibrosis resulting in diastolic dysfunction. Moreover, the survival of patients subsequent to a myocardial infarction is inversely related to age because of a certain extent to maladaptive remodeling mediated by cardiac fibroblasts. Our hypothesis is that cardiac fibroblast (CF) dysfunction results in overexpressed TGF-β1 leading to increased cardiac collagen content in the aged population. TGF-β1 stimulates the synthesis of the extracellular matrix proteins, including collagen in the cardiac tissues. The RT–PCR analysis of mRNA expression of TGF-β1 of the CF was increased by 43% in the aged mice as compared to the younger. The stiffness of the left ventricle is expressed with the slope of the end-diastolic pressure-volume relationship parameter, (mmHg/L). In a mouse model, we demonstrated that was 0.30 ± 0.05 in the young as compared to 0.52 ± 0.10 in the aged (p < .05). The ventricular stiffness was associated with the myocardial collagen content; namely, young versus the aged was 9.5 ± 4.0 as compared to 16.4 ± 2.3% of total protein, respectively (p < .05). In conclusion, the gene structure–function relationships support our hypothesis that cardiac fibroblast disregulation contributes to diastolic filling dysfunction in elderly persons. These data provide a potential contributory mechanism for diastolic dysfunction that may be vital in caring for the aged open-heart surgical patient.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126152460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

American Society of Extra-Corporeal Technology 42nd International Conference 美国超物质技术学会第42届国际会议

The Journal of ExtraCorporeal Technology Pub Date : 2004-03-01 DOI: 10.1051/ject/200436191

引用次数: 8

The Rheological Effects of X-Coating™ with Albumin and Hetastarch on Blood during Cardiopulmonary Bypass X-Coating™与白蛋白和Hetastarch对体外循环血液流变学的影响

The Journal of ExtraCorporeal Technology Pub Date : 2004-03-01 DOI: 10.1051/ject/200436136

Bernadette T Nutter, A. Stammers, Ryan G Schmer, R. Ahlgren, Tunisia A Ellis, Chen Gao, Hunter B Holcomb, L. Hock, Tab Burkeman

{"title":"The Rheological Effects of X-Coating™ with Albumin and Hetastarch on Blood during Cardiopulmonary Bypass","authors":"Bernadette T Nutter, A. Stammers, Ryan G Schmer, R. Ahlgren, Tunisia A Ellis, Chen Gao, Hunter B Holcomb, L. Hock, Tab Burkeman","doi":"10.1051/ject/200436136","DOIUrl":"https://doi.org/10.1051/ject/200436136","url":null,"abstract":"Cardiopulmonary bypass (CPB) exposes blood to artificial surfaces, resulting in mechanical damage to the formed elements of the blood. The purpose of this study was to examine the effect of poly(2-methoxyethylacrylate) coating (PMEA, X-Coating™) on coagulation and inflammation under various prime conditions. An in vitro analysis was conducted utilizing fresh whole human blood (2 units) and a CPB circuit (n 18) consisting of a venous reservoir, oxygenator, and arterial filter. Nine nontreated circuits were used in a control group (CTR) and an equal number of tip-to-tip PMEA circuits for treatment (TRT). Each group was divided into three subgroups based upon prime: crystalloid, hetastarch (6%), and albumin (5%). CPB was conducted with a hematocrit 30% ± 2, temperature 37°C ± 1, and a flow of 4L/min. Samples were collected at 0, 60, 120, and 240 minute intervals. Endpoint measurements included thromboelastograph index (TI), and markers of inflammation and coagulation. The TI was significantly depressed in both groups when hetastarch was used in the prime. The TRT had significantly higher TI levels in both the crystalloid (0.3 ± 0.1 vs. −3.3±[1.2, P < .05) and albumin (0.6 ± 0.2 vs−3.9± −1.1. P < .03) subgroups compared to CTR groups. Platelet count was significantly higher in TRT as compared to CTR groups, except for both hetastarch groups. SEM demonstrated significant fibrin deposition on nontreated circuitry but little to no detection in the TRT group. In conclusion, both surface coating and prime components significantly effect coagulation, with PMEA circuits resulting in more favorable preservation of function.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132855603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

From the Editor Extracorporeal Circulation: A Half-Century of Accomplishment 体外循环:半个世纪的成就

The Journal of ExtraCorporeal Technology Pub Date : 2003-03-01 DOI: 10.1051/ject/20033512

A. Stammers

引用次数: 0

Trillium™-Coated Oxygenators in Adult Open-Heart Surgery: A Prospective Randomized Trial Trillium™涂层氧合器用于成人心内直视手术:一项前瞻性随机试验

The Journal of ExtraCorporeal Technology Pub Date : 2002-12-01 DOI: 10.1051/ject/2002344248

MS Timothy Dickinson, PhD C. B. Mahoney, MS Ccp Mark Simmons, MS Ccp Angela Marison, BS Ccp Paul Polanski, 60154-5701. E-mail

{"title":"Trillium™-Coated Oxygenators in Adult Open-Heart Surgery: A Prospective Randomized Trial","authors":"MS Timothy Dickinson, PhD C. B. Mahoney, MS Ccp Mark Simmons, MS Ccp Angela Marison, BS Ccp Paul Polanski, 60154-5701. E-mail","doi":"10.1051/ject/2002344248","DOIUrl":"https://doi.org/10.1051/ject/2002344248","url":null,"abstract":"This randomized, prospective clinical trial examines the impact of the use of Trillium™ biopassive surface coating on clinical outcomes after cardiopulmonary bypass (CPB) that may be induced by contact of blood elements with foreign surfaces. The study consisted of 98 consecutive patients randomly assigned to either a CPB circuit that consisted of a Trillium-coated Affinity open reservoir oxygenator or a CPB circuit with an uncoated Affinity open reservoir oxygenator. The operative procedure performed on all 98 patients consisted of either coronary artery bypass graft (CABG), valve, or a combination of the two. Exclusion criteria consisted of patients who presented to the operating room in circulatory arrest. Trillium biopassive surface coating resulted in improved clinical outcomes and fewer adverse events when compared to the control group. Significantly, fewer patients required no blood products (18.3% in the control group vs. 32.7% in the treatment group), even though the control group had a significantly higher pre-bypass hematocrit. Postoperative atrial fibrillation (24.5% vs. 16.3%) and reoperation for bleeding (10.2% vs. 4.1%) showed a much lower incidence in the Trillium group. Significance was not reached because of the small sample size resulting in low power. Trillium circuits result in improved patient outcomes in the treatment group when compared to the control circuit group.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132436093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Man to be Remembered Bennett A. Mitchell (1923–2002) 贝内特·A·米切尔(1923-2002)

The Journal of ExtraCorporeal Technology Pub Date : 2002-09-01 DOI: 10.1051/ject/2002343168

P. R. Cappola

引用次数: 0

Abstracts for Oral and Poster Presentations for the American Society of Extra-Corporeal Technology 40th International Conference 美国超物质技术学会第40届国际会议口头和海报报告摘要

The Journal of ExtraCorporeal Technology Pub Date : 2002-03-01 DOI: 10.1051/ject/200234141

引用次数: 0