Anatolian Current Medical Journal最新文献

{"title":"Surgically treated pneumonic-type lung adenocarcinoma with long survival characteristics","authors":"Derya Kızılgöz, Pınar Akın Kabalak, Suna Kavurgacı, Tuba İNAL CENGİZ, F. Demirağ, L. Acar, Şebnem Yücel, Özlem Özmen, Ülkü Yılmaz","doi":"10.38053/acmj.1340516","DOIUrl":"https://doi.org/10.38053/acmj.1340516","url":null,"abstract":"Aims: Pneumonic-type lung adenocarcinoma is defined as a pneumonia-like area of infiltration or consolidation involving a region of the lung. These carcinomas, which are suitable for curative treatment options and have a long survival when detected at an early stage, may resemble infectious or inflammatory lung diseases due to their radiological appearance and clinical findings, may lead to potential delays or difficulties in diagnosis, and this may cause progression in patients who are suitable for curative treatment options. Methods: A total of 41 patients which were surgically treated between 2011-2020 and diagnosed pathologically with pneumonic-type adenocarcinoma. The patents’ TTF-1, type of operation, pathological stages, overall/progression-free survival, as well as overall/progression-free survival according to the type of operation and radiological appearance, were also evaluated. Results: The study included 41 patients. Although overall survival times were long, there was no statistically significant defference between wedge resection and lobectomy group in overall survival by operation type. Although progression-free survival times were long, there was no statistically significant defference between wedge resection and lobectomy group in progression-free survival by operation type. There was no statistically significant difference between solid and consolidated groups in terms of overall survival and progression-free survival according to radiological appearances. There was no statistically significant difference between TTF-1 positive and negative groups in overall survival. Conclusion: Pneumonic-type lung adenocarcinomas respond to curative treatments when diagnosed at an early stage. The optimal treatment method for operable patients is surgery, which is associated with prolonged survival.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of hormonal status, morphological subtypes and proliferative marker Ki-67 labeling index on long-term outcomes in patients with acromegaly: a single tertiary center’s experience","authors":"Ç. Keskin, Mustafa Şahi̇n, S. Kiremitci, Esra Erden, A. Gökçay Canpolat, Ş. Canlar, M. Ci̇nel, Özge Baş Aksu, Ö. Demir, R. Emral, S. Güllü, D. Çorapçıoğlu","doi":"10.38053/acmj.1343934","DOIUrl":"https://doi.org/10.38053/acmj.1343934","url":null,"abstract":"Aims: Acromegaly is a rare disorder resulting from benign growth hormone secreting pituitary adenomas. Many factors affect long-term outcomes in acromegaly. In this study we aimed to investigate effects of hormonal status, morphological subtypes, immunohistochemical expression of pituitary hormones and Ki-67 labeling index on long-term outcomes in patients with acromegaly. Methods:. We collected the medical and pathological records of sixty-four patients who underwent surgery for growth hormone (GH) secreting somatotroph tumors between 2005-2017. Results: The remission rate after surgery was 48% (31/64) in all patients (33% for macroadenomas, 94% for microadenomas; p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between oral and dental health and appendicitis","authors":"Semih Sağlık, Enver Ay, Veysel Bakir, N. Nas","doi":"10.38053/acmj.1318825","DOIUrl":"https://doi.org/10.38053/acmj.1318825","url":null,"abstract":"Aims: In this study, we aimed to evaluate the relationship between the scores of the “Simplified Oral Hygiene Index” (OHI-S) indicating poor oral hygiene and the “Decayed, Missing and Filled Teeth” (DMFT) index indicating oral health impairment, and acute appendicitis (AA). Methods: Eighty four patients who were operated on with the diagnosis of acute appendicitis between April 2022 and May 2023 were included. The control group included 32 individuals without a history of appendectomy. In our study, oral health was evaluated using the DMFT and OHI-S indices. The DMFT index is one of the indices quantifying dental health status based on the number of cavities. OHI-S is an index used to evaluate oral hygiene. Results: The OHI-S index scores of the patients with AA were significantly higher than those of the control group (3.53±1.43, 2.56±1.24, p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of variants in maturity onset of diabetes young related genes in Balıkesir region","authors":"Hamide Betül Gerik Çelebi, M. Demiral","doi":"10.38053/acmj.1338092","DOIUrl":"https://doi.org/10.38053/acmj.1338092","url":null,"abstract":"Aims: Maturity-onset diabetes of the young (MODY) is an early-onset, monogenic diabetes with an autosomal dominant inheritance pattern. Single gene mutations that cause dysfunction in pancreatic beta cells are responsible for MODY etiology. In this study, we investigated the genetic variants involved in the etiopathogenesis of MODY in our region. Methods: Between May 2018 and April 2023, 40 pediatric patients (n=25 females, n=15 males) with a clinical diagnosis of MODY were evaluated by targeted genome sequencing. Results: Among the 40 pediatric patients included in this study, variants in MODY-associated genes were detected in 21 patients (52.5%), eight (38.09%), of which were pathogenic (38.09%), five (23.8%) were probable pathogenic, and eight (38.09%), were of uncertain significance. Conclusion: In this study, genetic diagnostic yield (including pathogenic and likely pathogenic variants) was detected in 32.5% (13/40) patients with MODY using targeted genome sequencing analysis. This rate is consistent with other studies. However, unlike other similar studies, the MODY12 subtype was the second most frequent in our study. In addition, nine novel variants were reported, including ABCC8 (n=3), CEL (n=2), KLF11 (n=1), GCK (n=1), HNF1A (n=1), and HNF1B (n=1) genes. We have presented clinical findings to improve genotype-phenotype correlation in the literature for novel variants.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of direct-acting antivirals (DAA) on confirmed noninvasive fibrous parameters in chronic hepatitis C patients","authors":"D. Bulut, M. S. Sayar, Ali Acar","doi":"10.38053/acmj.1343277","DOIUrl":"https://doi.org/10.38053/acmj.1343277","url":null,"abstract":"Aims: Chronic hepatitis C (CHC) is an important public health problem in terms of the number of people it affects worldwide and the diseases it causes. The high sustained virological response (SVR) rates achieved by the use of direct-acting antiviral (DAA) drugs in the recent period have shown that a new era has begun in this disease. It was aimed to evaluate the effect of DAAs on confirmed noninvasive fibrous parameters together with their effectiveness. Methods: 75 patients who were started on DAA treatment for CHC were included in the study. In addition, laboratory parameters values at the beginning of the treatment, 12 and 24 weeks after the end of the treatment, hepatitis C virus ribonucleic acid (HCV RNA) results and Aminotransferase-to-Platelet Ratio Index (APRI), Fibrosis-4 (FIB-4) scores were compared. Results: The most common comorbidity in patients is hypertension (HT), and the most common source of transmission is surgical operations. Genotype 1b was the dominant genotype. The SVR rates of all patients 12 and 24 weeks after the end of treatment were 100%. The APRI and FIB-4 scores of the patients decreased significantly at the 12th and 24th weeks at the end of the treatment compared to the beginning of the treatment. Conclusion: The confirmed noninvasive fibrous parameters used in the treatment of CHC are useful in evaluating the results of the treatments applied.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farklı çay markalarının akışkan rezin kompozitin renk değişimine etkisi","authors":"Merve YENİÇERİ ÖZATA, E. Bakir, Sami Ünal, Gamze Polat, Ebru Akleyi̇n","doi":"10.38053/acmj.1298243","DOIUrl":"https://doi.org/10.38053/acmj.1298243","url":null,"abstract":"Aims: This study aimed to evaluate the color change of a low-viscosity fluid resin composite (FRC) aged in 2 different brands of black tea and a Ceylon tea for three different periods (24 hours, 7 days, and 28 days). Methods: Twenty-eight Filtek Ultimate FRC samples with a diameter of 10 mm and a thickness of 2 mm were prepared and polymerized using polytetrafluoroethylene molds. All samples were numbered and polished, and initial color measurements were made. Samples were divided into three experimental groups and a control group (Distilled water) (n=7). All samples were kept in solutions for 24 hours, 7 days, and 28 days, and at the end of these periods, color measurements were made with a spectrophotometer. Data were recorded according to the CIE Lab system. ΔE was calculated by dividing the sum of squares of the difference of the last and first color measurement values by two. One-way ANOVA and Tukey test were used in the analysis of the data. Results: The Yellow Label black tea group caused significantly more color change in 24 hours than the Ceylon tea (p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between digital game addiction, cyberloafing, and psychological well-being in primary school students","authors":"Serkan Zi̇nci̇r, Fatma Sapmaz, N. Hamutoğlu, Murat Topal","doi":"10.38053/acmj.1361982","DOIUrl":"https://doi.org/10.38053/acmj.1361982","url":null,"abstract":"Aims: Today, with the advances in technology, the use of devices such as computers, digital game consoles, phones, and tablets has also increased. However, with the widespread use of internet access, digital platforms have started to be used frequently in interpersonal interaction and relations. The use of digital games and the internet, where the user age is in a wide range, has decreased to very young ages, and the time spent by individuals in games and on the internet has gradually increased. In this context, the duration of stay in the digital environment can be seen as an important criterion in terms of addiction. Spending excessive time in the digital environment can cause individuals to be adversely affected by psychosocial aspects. The purpose of our study is to reveal the reasons for the complex and multifaceted relationship between cyberloafing, digital game addiction, and well-being, and to discuss potential solutions. Methods: This study was designed as a cross-sectional study. The study group was formed of 1330 students in the second stage of primary education in grades, 5, 6, 7, and 8, in state schools. The sample Group consisted of 614 females and 716 males in almost the same age group. The game addiction scale, perceived cyberloafing scale, and psychological well-being scale were applied to students. The necessary permission to conduct the study was obtained from, then the data were collected in face-to-face interviews on a voluntary basis. The data obtained in this study were analyzed statistically using SPSS vn. 23 and AMOS 23 software. Results: The Gaming Addiction Scale score was determined to be mean 42.09 for the whole group, 36.96 for females, and 46.96 for males. The Cyberloafing Scale score was determined to be a mean of 24.01 for the whole group, 21.94 for females, and 25.79 for males. The Psychological Well-Being Scale score was found to be a mean of 30.60 for the whole group, 32.02 for females and, 29.39 for males. A positive correlation was observed between gaming addiction and, cyberloafing, (p=0.00) and both of these conditions were determined to be negatively correlated with psychological well-being. (p=0.00) Conclusion: Activities to support students’ psychological well-being can help prevent vicious cycles between cyberloafing, game addiction, and psychological well-being by contributing to controlling cyberloafing and game addiction tendencies.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the role of sensitization in carpal tunnel syndrome where pain impacts functional capacity?","authors":"Emel Güler, Musa Polat, Gülay Soykök, Tuğçe YAVUZ MOLLAVELİOĞLU","doi":"10.38053/acmj.1322933","DOIUrl":"https://doi.org/10.38053/acmj.1322933","url":null,"abstract":"Aims: Expression of carpal tunnel syndrome (CTS) caused by the entrapped median nerve includes pain, paraesthesia and numbness. Extra median spread of pain can furthermore be seen as a clinical requirement defined by neuro inflammation. Central sensitization (CS) constructs a similar mechanism. This study aims to evaluate sensitization in patients diagnosed with CTS. Methods: A total number of 152 patients diagnosed with CTS were evaluated, prospectively. Patients data such as gender, age, body mass index (BMI), disease duration, pain severity (NRS), painDETECT questionnaire, Boston CTS symptom severity scale (SSS) and functional status scale (FSS), CS scale, electroneuromyography results have been collected by the author and then the patients are divided into three groups. Results: Regarding the age, BMI and CS rate, there was no statistical difference between the three patient groups (p>0.05). However, a statistically significant difference was found between these groups in disease duration, day-time and night-time NRS, Boston SSS, FSS, and pain DETECT scores (p0.05). Yet, statistically significant differences were found in a comparison of the patients with and without CS, in disease duration, NRS night scores, and painDETECT scores (p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of chronic obstructive pulmonary disease stage on muscle oxygenation during exercise","authors":"Gülhan YILMAZ GÖKMEN, Canan Demi̇r","doi":"10.38053/acmj.1366947","DOIUrl":"https://doi.org/10.38053/acmj.1366947","url":null,"abstract":"Aims: The aim of this study was to investigate peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD) at rest, during submaximal exercise, and during recovery, and to determine the effects of disease stage on peripheral muscle oxygenation. Methods: Of the 35 stable COPD patients (62.49±8.45 years), 18 patients in GOLD 1 and 2 were assigned to Group 1 and 17 patients in GOLD 3 and 4 were assigned to Group 2. Dyspnea perception of the patients was evaluated with the Modified Medical Research Council (mMRC) Dyspnea Scale, severity of the disease affecting daily life was evaluated with the COPD Assessment Test (CAT-COPD Assessment Test), respiratory function was evaluated with the Pulmonary Function Test, and quadriceps muscle strength was evaluated with a manual muscle testing device. Muscle oxygenation of the patients was measured with Near-infrared spectroscopy (NIRS) for 5 minutes at rest, 6 minutes during the 6-Minute Walk Test (6-MWT), and 5 minutes during recovery after the end of the test. The results of the two groups were compared. Results: Intragroup comparisons of muscle oxygenation at rest, during 6-MWT and during recovery; in Group 1, there was a statistically significant decrease between resting SmO2 mean and test SmO2 mean (p=0.001), a increase between test SmO2 mean and recovery SmO2 mean (p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The initial symptoms in multiple sclerosis: clinical and demographic data of Çorum province","authors":"Sinan Eliaçık, Serdar Aykaç","doi":"10.38053/acmj.1323204","DOIUrl":"https://doi.org/10.38053/acmj.1323204","url":null,"abstract":"Aims: Multiple sclerosis, which has individual and societal effects such as being observed in young and middle-aged people and its long and expensive treatment process, has become an important public health issue. Methods: Between January 2022 and January 2023, 103 patients with MS were evaluated using anamnesis, neurological examinations, and neuroimaging results. The patients’ initial findings upon their MS diagnosis, the duration of diagnosis, their neurological observations in the past month, and their clinical categorization were examined. Results: Out of the 103 patients, 70 (67.96%) were female, and 33 (32.04%) were male, which was detected as a female-to-male ratio of 2.12/1. The average age of the patients was 34.41±8.4 years, and the average disease duration was 8±5.8 years. The initial findings in females were as follows; 25 patients (35.7%) had sensory, 13 patients (18.6%) had motor (pyramidal), 17 patients (24.3%) had brain stem-cerebellar, 10 patients (14.3%) had a visual impairment, and 5 patients (7.1%) had other findings. The distributions of the initial symptoms in males were as follows; 12 patients (36.4%) were motor (pyramidal), 10 patients (30.3%) were sensory, 5 patients (15.1%) were brain stem-cerebellar, 5 patients (15.1%) had visual impairment, and 1 patient (.3.1%) had other findings. The mean Expanded Disability Status Scale (EDSS) at the time of initial diagnosis was 2.5± 1.5. Among the 60 patients with RRMS who were first diagnosed, the duration elapsed between initial symptom onset and diagnosis was 12.8± 5.7 months. Conclusion: Demographic information of the MS patients followed up in our clinic, their initial complaints, frequency of clinical subtypes, differences between clinical subtypes, their clinical status in the last month, and their EDDS at their initial diagnosis and last follow-up are presented. As this represents the first data on the epidemiology of MS in our city, we believe it will contribute to the national data of Turkey and help raise MS awareness among clinicians.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}