经手术治疗的肺型肺腺癌具有存活期长的特点

Derya Kızılgöz, Pınar Akın Kabalak, Suna Kavurgacı, Tuba İNAL CENGİZ, F. Demirağ, L. Acar, Şebnem Yücel, Özlem Özmen, Ülkü Yılmaz
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引用次数: 0

摘要

目的:气胸型肺腺癌的定义是涉及肺部某一区域的肺炎样浸润或合并区域。这类癌症适合采用根治性治疗方案,早期发现的患者生存期较长,但由于其放射学外观和临床表现可能与感染性或炎症性肺部疾病相似,可能导致诊断延误或困难,从而使适合采用根治性治疗方案的患者病情恶化。 研究方法2011-2020年间接受手术治疗并经病理诊断为肺型腺癌的患者共41例。此外,还评估了专利的TTF-1、手术类型、病理分期、总生存期/无进展生存期,以及根据手术类型和放射学表现得出的总生存期/无进展生存期。 结果研究共纳入 41 例患者。虽然总生存时间较长,但楔形切除术组和肺叶切除术组的总生存时间在统计学上没有显著差异。虽然无进展生存期较长,但楔形切除术组与肺叶切除术组在无进展生存期方面的差异无统计学意义。根据放射学表现,实性组和合并组的总生存率和无进展生存率差异无统计学意义。TTF-1阳性组和阴性组在总生存率方面的差异无统计学意义。 结论肺泡型肺腺癌在早期诊断时可接受根治性治疗。可手术患者的最佳治疗方法是手术,这与延长生存期有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surgically treated pneumonic-type lung adenocarcinoma with long survival characteristics
Aims: Pneumonic-type lung adenocarcinoma is defined as a pneumonia-like area of infiltration or consolidation involving a region of the lung. These carcinomas, which are suitable for curative treatment options and have a long survival when detected at an early stage, may resemble infectious or inflammatory lung diseases due to their radiological appearance and clinical findings, may lead to potential delays or difficulties in diagnosis, and this may cause progression in patients who are suitable for curative treatment options. Methods: A total of 41 patients which were surgically treated between 2011-2020 and diagnosed pathologically with pneumonic-type adenocarcinoma. The patents’ TTF-1, type of operation, pathological stages, overall/progression-free survival, as well as overall/progression-free survival according to the type of operation and radiological appearance, were also evaluated. Results: The study included 41 patients. Although overall survival times were long, there was no statistically significant defference between wedge resection and lobectomy group in overall survival by operation type. Although progression-free survival times were long, there was no statistically significant defference between wedge resection and lobectomy group in progression-free survival by operation type. There was no statistically significant difference between solid and consolidated groups in terms of overall survival and progression-free survival according to radiological appearances. There was no statistically significant difference between TTF-1 positive and negative groups in overall survival. Conclusion: Pneumonic-type lung adenocarcinomas respond to curative treatments when diagnosed at an early stage. The optimal treatment method for operable patients is surgery, which is associated with prolonged survival.
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