Annals of Tropical Pathology最新文献_第10页

Otorhinolaryngological manifestations of pediatric patients with sickle cell disease in Nguru, Nigeria 尼日利亚恩古鲁镰状细胞病儿科患者的耳鼻喉科表现

Annals of Tropical Pathology Pub Date : 2018-07-01 DOI: 10.4103/atp.atp_27_18

A. Babadoko, A. Oluwatosin, M. Lawan, Idi Tikau, M. Umar

{"title":"Otorhinolaryngological manifestations of pediatric patients with sickle cell disease in Nguru, Nigeria","authors":"A. Babadoko, A. Oluwatosin, M. Lawan, Idi Tikau, M. Umar","doi":"10.4103/atp.atp_27_18","DOIUrl":"https://doi.org/10.4103/atp.atp_27_18","url":null,"abstract":"Background: Virtually no organ of the body is exempted from the effects of sickle cell disease (SCD) following repeated episodes of vaso-occlusion, infarction, and hemolysis leading to organ dysfunction. However, there is a dearth of data on the anatomic and functional changes of the ears, nose, and throat (ENT) in patients with SCD. Therefore, monitoring and evaluation of the effects of this disease on these organs will be defective due to the absence of baseline data necessary for institution of intervention programs and policy formulation. Aim: To review and determine the prevalence of the general anatomic changes and functional effects of SCD on the ENT in the pediatric age group. Materials and Methods: A cross-sectional prospective study of 52 children with SCD was carried out in 2018. Hematological parameters were determined while otolaryngoscopic examination and audiometric tests were conducted. Data were analyzed using SPSS version 19 software, and Pearson's linear correlation statistical method was also employed and level of significance was set at P ≤ 0.05. Results: The mean age of the children was 8.81 ± 4.58 years. Excessive snoring was present in 28.8% (15) of the participants, of which 60% (9) had >75% occlusion of the nasopharynx. Recurrent ear discharge was seen in 21.2% of the participants. Conductive hearing loss (HL) was 9.6% and 7.7% for the right and left ears, respectively, while sensorineural HL was 13.5% and 3.8% for the right and left ears, respectively. Recurrent sore throat was recorded in 17.3% of the participants, while 73.1% had Brodsky Grade 1 tonsillar enlargement. Conclusion: Ear infections, HL, and tonsillar enlargement are common among pediatric patients with SCD. This may not be unconnected to inadequate clinical care due to lack of good health education, ignorance, poverty, and prophylaxis from infections.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127565012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A 10-year review of thyroid lesions in a tertiary hospital in Abuja, Nigeria 尼日利亚阿布贾一家三级医院甲状腺病变10年回顾

Annals of Tropical Pathology Pub Date : 2018-07-01 DOI: 10.4103/atp.atp_21_18

S. Amin, Z. Jawa, Jibrin Paul Gowon, O. George, Yau A Gagarawa, Owoicho Ikwu Eiyeje

引用次数: 2

Gluteal malignant proliferating pilar tumor: An unusual presentation in an elderly male 臀恶性增殖性支柱瘤:一位老年男性的罕见表现

Annals of Tropical Pathology Pub Date : 2018-07-01 DOI: 10.4103/atp.atp_29_18

G. Waziri, D. Suleiman, Tahir Mohammed, M. Samaila

引用次数: 1

Management of essential thrombocythemia in a resource-limited country: A Nigerian case study 在资源有限的国家管理原发性血小板增多症:尼日利亚的案例研究

Annals of Tropical Pathology Pub Date : 2018-07-01 DOI: 10.4103/atp.atp_37_18

T. Akingbola, O. Adeoye, O. Akinwunmi

{"title":"Management of essential thrombocythemia in a resource-limited country: A Nigerian case study","authors":"T. Akingbola, O. Adeoye, O. Akinwunmi","doi":"10.4103/atp.atp_37_18","DOIUrl":"https://doi.org/10.4103/atp.atp_37_18","url":null,"abstract":"Essential thrombocythemia (ET) is one of the classical clonal myeloproliferative neoplasms (MPNs) that constitute a clinical entity distinct from the other MPNs such as polycythemia vera and primary myelofibrosis despite the similarities in their molecular basis. The genetic basis of ET has been associated with the detection of the mutation of three mutually exclusive driver mutations, namely, Janus kinase 2 (JAK2), calreticulin, and myeloproliferative leukemia genes, making them important biomarkers in the diagnosis of ET. This condition is clinically characterized by thrombohemorrhagic complications and progression to myelofibrosis and acute myeloid leukemia. The reduction of the thrombotic complication and/or the associated hemorrhage constitutes the primary goal of the therapeutic practice for the management of ET. We report here seven cases of ET referred to the University College Hospital within a 3-year period (2014–2016). This case series describes the management practices and the therapeutic outcomes in the patients (using the resolution of the clinical presentations and decrease in platelet count). The report also highlights some of the challenges encountered in the management of ET in a resource-limited country like Nigeria.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"113 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133171168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of epidemiology and management of multiple myeloma in a resource poor country 一个资源贫乏国家多发性骨髓瘤的流行病学和治疗综述

Annals of Tropical Pathology Pub Date : 2018-07-01 DOI: 10.4103/atp.atp_8_18

A. Dosunmu, A. Akinbami, E. Uche

{"title":"A review of epidemiology and management of multiple myeloma in a resource poor country","authors":"A. Dosunmu, A. Akinbami, E. Uche","doi":"10.4103/atp.atp_8_18","DOIUrl":"https://doi.org/10.4103/atp.atp_8_18","url":null,"abstract":"Multiple myeloma (MM) is a B-cell malignancy characterized by clonal proliferation of terminally differentiated B lymphocytes. Rational use of proteasome inhibitors, immunomodulators, anti CD38 or CD 138, and tandem autologous stem cell transplant have improved 5-year overall survival beyond 50% in advanced countries. However, the disease prevalence is probably highest in Sub-Saharan Africa where diagnostic and treatment facilities are lacking. The authors have reviewed published articles on epidemiology and outcomes of MM in Nigeria in the light of international recommendations with the aim of suggesting adaptable practices in a resource-poor environment. Publications from Nigeria were obtained from search engines such as Google Scholar and PubMed while recent guidelines were obtained from websites of the National Comprehensive Cancer Network and Medscape Oncology. The mean age at presentation ranged between 54 and 62 years, and there was a higher prevalence among males (ratio 1.1: 1–4.4: 1). A study in Nigeria found an increased incidence in oil-producing areas. In earlier publications between 2005 and 2007 years, about a quarter of patients could not afford treatment and most of the patients presented in advanced stages of the disease. During that period, the mean survival was 7 months and only 13.3% lived beyond 2 years. The treatment then was based on either melphalan ± prednisolone or combination of vincristine, adriamycin, and dexamethasone. By 2012/14, thalidomide, bortezomib, biphosphonates, radiotherapy, and renal dialysis were introduced with a mean survival of 4 years. Optimization of available facilities would, therefore, improve the disease-free survival.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"207 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116425877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A histopathologic review of cervical cancers in Jos University Teaching Hospital, Jos, Nigeria 乔斯大学教学医院宫颈癌的组织病理学回顾，乔斯，尼日利亚

Annals of Tropical Pathology Pub Date : 2018-07-01 DOI: 10.4103/atp.atp_26_18

O. Silas, D. Yakubu, O. Jegede, O. Ajetunmobi, O. Mosugu

{"title":"A histopathologic review of cervical cancers in Jos University Teaching Hospital, Jos, Nigeria","authors":"O. Silas, D. Yakubu, O. Jegede, O. Ajetunmobi, O. Mosugu","doi":"10.4103/atp.atp_26_18","DOIUrl":"https://doi.org/10.4103/atp.atp_26_18","url":null,"abstract":"Background: Cervical cancer is the most common gynecological malignancy globally, with a high prevalence in developing countries. We, therefore, undertook this review to document and evaluate its prevalence and histologic patterns seen at a tertiary hospital in Jos, Northcentral Nigeria. Materials and Methods: This is a 10-year (2006–2015) retrospective study of all cervical cancers diagnosed at the Pathology Department of Jos University Teaching Hospital, Jos Nigeria. Results: Three hundred and six cervical cancers accounting for 92.4% of all gynecologic malignancies were diagnosed during the 10-year study period. Patient's ages ranged from 18 to 85 years (mean 51.12 ± standard deviation 12.63 years), with peak occurrence in the fifth decade. Squamous cell carcinoma (SCC) was by far the most common histologic type (88.9%), the most common histologic grade was moderate differentiation (70%). Adenocarcinomas accounted for 4.3% and leiomyosarcoma accounted for only 0.03% of cases (1 case only). Only 0.65% (2) patients knew their HIV status and both had SCC. Conclusion: Our finding of the dismal proportion of cervical cancer is consistent with most published reports in Nigeria and Sub-Saharan Africa but somewhat at variance with that reported in the developed world where cervical cancer is much less common. A total reappraisal of our preventive efforts is therefore needed urgently.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127702883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Derivation of a list of priority antibodies from the analysis of a cohort of cases sent from Nigeria for external consultation 从尼日利亚送去外部咨询的一组病例分析中得出一份重点抗体清单

Annals of Tropical Pathology Pub Date : 2017-07-01 DOI: 10.4103/atp.atp_10_17

U. Igbokwe, D. Olusina, M. O. Odubanjo, C. Anunobi, O. Akinde, K. Badmos, F. Abdulkareem, A. Banjo

{"title":"Derivation of a list of priority antibodies from the analysis of a cohort of cases sent from Nigeria for external consultation","authors":"U. Igbokwe, D. Olusina, M. O. Odubanjo, C. Anunobi, O. Akinde, K. Badmos, F. Abdulkareem, A. Banjo","doi":"10.4103/atp.atp_10_17","DOIUrl":"https://doi.org/10.4103/atp.atp_10_17","url":null,"abstract":"Introduction: The major obstacle to developing sustainable services in a resource-limited setting, which hitherto has not had routine availability of diagnostic immunohistochemistry (IHC), is choosing from a large array of over 200 antibodies that are currently in use in the Western world. Materials and Methods: By critically analyzing the use of diagnostic IHC in a cohort of 360 cases sent for consultation from Nigeria to the UK between January 2014 and May 2016, we have derived a list of antibodies that could meet over 85% of current diagnostic IHC needs in Nigeria. Results: From our analysis, a starter list of only two antibodies could immediately meet over 30% of the IHC needs. Having mastered this starter list, the service could move to the next step by adding 23 other antibodies which could meet another 85% of diagnostic IHC needs. Conclusions: Testing with these 25 antibodies can be done at least twice weekly to address the 3 areas mentioned above and greatly increase the chances of success in establishing a sustainable service. We recommend this list to the various groups working with diagnostic IHC in Nigeria and look forward to reports of their efforts.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"105 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116521579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of squamous intraepithelial lesion among women in Kaduna State, Nigeria 尼日利亚卡杜纳州妇女鳞状上皮内病变的患病率

Annals of Tropical Pathology Pub Date : 2017-07-01 DOI: 10.4103/atp.atp_5_17

Sheba Joseph Magaji, M. Aminu, H. Inabo, A. Oguntayo, Saad A Ahmed, J. Yaro, D. Suleiman, Mudashiru Lawal

{"title":"Prevalence of squamous intraepithelial lesion among women in Kaduna State, Nigeria","authors":"Sheba Joseph Magaji, M. Aminu, H. Inabo, A. Oguntayo, Saad A Ahmed, J. Yaro, D. Suleiman, Mudashiru Lawal","doi":"10.4103/atp.atp_5_17","DOIUrl":"https://doi.org/10.4103/atp.atp_5_17","url":null,"abstract":"Background: Cervical cancer is one of the most common cancers in women. Human papillomavirus (HPV) infection is the primary cause of virtually all cervical cancers. Cervical cancer typically develops from precancerous changes, squamous intraepithelial lesion (SIL) over a period of 10–20 years, in about 5%–10% HPV-infected individuals. This study was carried out to determine the prevalence and risk factors of SIL among women in Kaduna State, Nigeria. Materials and Methods: This study was a hospital-based and cross-sectional study that combined the use of a structured questionnaire and analysis of cervical scrapings samples obtained from 276 consenting women in Kaduna State, Nigeria. The samples were analyzed for SIL using conventional Papanicolaou smear. Results: The prevalence rate of 6.2% for SIL was obtained with low-grade SIL being the most common type of cervical abnormality. Sociodemographic factors associated with the development of SIL in the study were marriage type, level of education, and occupation (P ≤ 0.05). The risk factors that were associated to the development of SIL in the study were multiple sexual partners and high parity (P ≤ 0.05). The symptoms associated with SIL were intermenstrual bleeding, dyspareunia, and postcoital bleeding. Conclusion: The prevalence of SIL obtained from this study is appreciable, and this calls for the institution of awareness programs for HPV-associated cervical cancer and the implementation of a routine cervical cancer screening program in Kaduna State, Nigeria.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116329415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A rare case of malignant thymoma with superior vena cava syndrome in a young man 一例罕见的恶性胸腺瘤合并上腔静脉综合征

Annals of Tropical Pathology Pub Date : 2017-07-01 DOI: 10.4103/atp.atp_32_17

J. Aiyekomogbon, D. Itanyi, Adamu Ibrahim Yaro

{"title":"A rare case of malignant thymoma with superior vena cava syndrome in a young man","authors":"J. Aiyekomogbon, D. Itanyi, Adamu Ibrahim Yaro","doi":"10.4103/atp.atp_32_17","DOIUrl":"https://doi.org/10.4103/atp.atp_32_17","url":null,"abstract":"AUJ was a 29-year-old male student who presented with a 4-month history of cough, vomiting, headache, distended neck veins, dysphagia to solid meals, and recurrent episodes of dyspnea. Physical examination revealed right supraclavicular soft-to-firm nontender mass with no palpable thrill. The superficial veins of the face, neck, and chest were dilated. Chest computed tomography (CT) scanogram showed widened mediastinum with a lobulated soft-tissue mass seen at that region, compressing the trachea, bronchi, and superior vena cava. The anterior mediastinal mass was lobulated and showed heterogeneous density with minimal contrast enhancement. It was complex mixed echogenic on ultrasound with no remarkable color signal changes on color Doppler interrogation. A diagnosis of anterior mediastinal mass, most likely thymoma with superior vena cava syndrome, was made. CT-guided biopsy confirmed the diagnosis of malignant thymoma. He was slated for debulking surgery, and this was to be followed by radiotherapy and/or chemotherapy. At the time of intubation during anesthetic procedure, however, he developed cardiac arrest and died on the 15th day of intensive care management.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124296994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunohistochemical expression of epstein–Barr virus Latent Membrane Protein-1 in nasopharyngeal carcinoma eb病毒潜伏膜蛋白-1在鼻咽癌组织中的免疫组织化学表达

Annals of Tropical Pathology Pub Date : 2017-07-01 DOI: 10.4103/atp.atp_30_17

S. Yates, Y. Iliyasu, Saad A Ahmed, A. Liman

{"title":"Immunohistochemical expression of epstein–Barr virus Latent Membrane Protein-1 in nasopharyngeal carcinoma","authors":"S. Yates, Y. Iliyasu, Saad A Ahmed, A. Liman","doi":"10.4103/atp.atp_30_17","DOIUrl":"https://doi.org/10.4103/atp.atp_30_17","url":null,"abstract":"Background: Epstein–Barr virus (EBV) has a consistent global association with nasopharyngeal carcinoma (NPC). The detection of EBV in NPC has been shown to have diagnostic and prognostic importance. Latent membrane protein-1 (LMP-1) immunochemical staining is a well-recognized, rapid, and effective method of EBV detection. This study aims to determine the EBV status of NPC seen over 22 years, from 1992 to 2013 in Ahmadu Bello University Teaching Hospital (ABUTH). Materials and Methods: It was a retrospective study of all NPCs diagnosed at the Department of Pathology, ABUTH from January 1, 1992 to December 31, 2013. The paraffin-embedded tissue blocks of all histologically diagnosed NPCs within the study period were retrieved and examined. Cases in which the tissue blocks were missing, badly damaged, or had insufficient tissue were excluded from the study. Histopathological diagnosis was in accordance to the 2005 World Health Organization classification. EBV detection was done using immunohistochemistry (IHC) for EBV LMP-1. Data were analyzed using SPSS 24. Fisher's exact test statistic value is 0.545, which is not significant at P < 0.05. Results: A total of 112 NPC cases were histologically diagnosed, 66 (58.9%) of these were available for EBV LMP-1 IHC and 46 (41.1%) were excluded. EBV LMP-I IHC was positive in 51 samples (77.3%), while 15 (22.7%) were negative. There were 63 (95.5%) cases of nonkeratinizing carcinoma (NKC) seen, of which 49 (77.8%) were EBV positive and 14 (22.2%) were negative. Keratinizing squamous cell carcinoma (KSCC) constituted 3 (4.5%) cases, 2 of which were EBV positive (66.7%) and 1 was negative (33.3%). No basaloid squamous cell carcinoma case was available for the study. Conclusions: There is a high prevalence of EBV in NPC. However, there is no statistical difference in the prevalence of EBV in NKC and KSCC. NPC showed an association with EBV irrespective of histological type. LMP-1 IHC has proved useful in detecting EBV in NPC in this study.","PeriodicalId":307224,"journal":{"name":"Annals of Tropical Pathology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127745661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3