PANACEA JOURNAL OF MEDICAL SCIENCES最新文献_第4页

Impact of case-based learning approach in clinical microbiology on second-year students: A prospective observational study 临床微生物学案例式学习法对二年级学生的影响：前瞻性观察研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.003

Lakshmi Jyothi T, M. Wajid, Saranya M, Shazia Naaz, Vivek Hada, Usha Rani, S. Suravaram, Ariyanachi K

引用次数: 0

Comparison of quality of life in hemodialysis and pre dialysis patients: A cross sectional study 血液透析患者与透析前患者生活质量的比较：横断面研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.043

Ashok Bhat

引用次数: 0

A retrospective study of clinical profile of para-phenylenediamene poisoning (hair dye poisoning) in cases admitted in medical college 医学院收治的对苯二胺中毒（染发剂中毒）病例临床概况回顾性研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.031

Neha Ahuja, Kanwal Kamboj, Amrita Sinha, Nilam Nigam

引用次数: 0

FNAC as preoperative diagnostic tool for neoplastic and non-neoplastic breast lesions with special reference to IAC standardised reporting in Coastal population - A teaching hospital experience 将 FNAC 作为肿瘤性和非肿瘤性乳腺病变的术前诊断工具，并特别参考沿海人口中的 IAC 标准化报告 - 一家教学医院的经验

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.004

Supriya P Savant, Vinay Naik, Jyothi B. Lingegowda

{"title":"FNAC as preoperative diagnostic tool for neoplastic and non-neoplastic breast lesions with special reference to IAC standardised reporting in Coastal population - A teaching hospital experience","authors":"Supriya P Savant, Vinay Naik, Jyothi B. Lingegowda","doi":"10.18231/j.pjms.2024.004","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.004","url":null,"abstract":"Breast cancer is steadily increasing worldwide. This study is based on application of recently proposed International Academy of cytology (IAC) Yokohama categorisation system of Breast cytology from C1 to C5. (C1-Insufficient material, C2-Benign, C3- Atypical, C4-Suspicious & C5-Malignant). We aim to categorize the breast lesions based on the above-mentioned categorization scheme (IAC, Yokohama 2016) along with histopathological correlation (wherever possible). This was a retrospective observational study conducted from January 2018 to December 2021 in the Department of Pathology of a tertiary care hospital involving coastal population. Ethical clearance was taken from institutional reviw committee. All patients with palpable breast lumps who had undergone FNAC were included in the study. Patient details and data were collected from the case records maintained in Department of Pathology. All quantitative parameters were described through descriptive statistics. Total scores were computed for all the risk factors. Sensitivity, specificity, Positive Predictive Value, Negative Predictive Value calculated. Risk of malignancy(ROM) was calculated for each category. A total 200 patients, with age group ranging from 17 - 67 years with breast lesions were included in the study. C1 lesions were found in 5 cases, C2 in 152 cases, C3 in 11 cases, C4 in 4 cases, and C5 in 28 cases. Cytohistological correlation obtained in 94 cases with concordance noted in 89 cases and discordance in 5 cases. Breast FNAC cytology categorization according to IAC Yokohama system increases accuracy of diagnosis and helps clinician in appropriate patient management.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"96 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study evaluating and comparing the effectiveness of combination therapy – Duloxetine with darifenacin versus darifenacin as monotherapy on perception of symptoms, quality and standard of life in patients suffering with overactive bladder (OAB) 一项研究，评估和比较杜洛西汀联合达非那新与达非那新作为单一疗法对膀胱过度活动症（OAB）患者的症状感知、生活质量和标准的效果

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.015

Nidhi Goel, Ved Prakash, K. R. Giri, Amol Dehade

{"title":"A study evaluating and comparing the effectiveness of combination therapy – Duloxetine with darifenacin versus darifenacin as monotherapy on perception of symptoms, quality and standard of life in patients suffering with overactive bladder (OAB)","authors":"Nidhi Goel, Ved Prakash, K. R. Giri, Amol Dehade","doi":"10.18231/j.pjms.2024.015","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.015","url":null,"abstract":": Overactive bladder is chronic debilitating condition, with physical, psychological, and economical consequences. Urinary vesicle tissue contains muscarinic receptors, M3 is principal mediator of detrusor contraction. Muscarinic receptor antagonists, comprises traditional pharmacological treatment. But due to non-selective inhibition, these agents, probably been related with safety and tolerability concerns. Drugs particular inhibiting sM3 receptor (Darifenacin) have potential to present effective relief while reducing side effects concerned with blockade of M1, M2 and M5 receptors. Duloxetine is Serotonin and nor-epinephrine reuptake inhibitor, leading increased concentration of 5-HT and NE in synaptic cleft, increases stimulation of pudendal motor neurons, thus increasing resting tone and contraction of urethral sphincter.: In present prospective, randomized, parallel group, comparative open label study with 60 OAB patients the combination therapy of Duloxetine with Darifenacin was equated with monotherapy using Darifenacin. The outcome thus analyzed using three different OAB-questionnaires and was statistically compared. : We demonstrated that addition of Duloxetine has shown better result outcome in symptoms as well as quality of life, though the difference of OAB-V8, OABss mean score was non-significant, but for OAB-qSF the reduction (percentage change) in mean score was more in treatment group II as compare to group I (w6:13.82±3.17% vs 12.13±3.24% & W12 29.99±5.40% Vs 25.56±5.17%) , and was statistically significant.(p<0.05).: Duloxetine has synergistic effect to Darifenacin, its ability to increase bladder capacity may be the reason for the improvement OAB symptoms, promising in controlling and treating symptoms either alone or in combination with anti-cholinergic drugs.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"22 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Isosorbide dinitrate and Hydralazine combination in non ischemic dilated cardiomyopathy in a tribal based population at a tertiary care hospital 二硝酸异山梨酯和氢氯吡嗪联合疗法对一家三级医院中以部落为基础的非缺血性扩张型心肌病的疗效

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.053

Saikat Sau, Lina Mukherjee, Sourav Sau

{"title":"Efficacy of Isosorbide dinitrate and Hydralazine combination in non ischemic dilated cardiomyopathy in a tribal based population at a tertiary care hospital","authors":"Saikat Sau, Lina Mukherjee, Sourav Sau","doi":"10.18231/j.pjms.2024.053","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.053","url":null,"abstract":"Non ischemic dilated cardiomyopathy is an important cause of heart failure and cardiovascular mortality. Numerous pharmacologic therapies have been applied from the ancient era for treatment. Some of them have shown improve morbidity. From various literatures it was concluded that combination therapy with H-ISDN in addition to conventional medicines are very effective in black population group. In our study we have tried to establish the efficacy of fixed dose drug combination (Hydralazine + Isosorbide dinitrate) to alleviation of heart failure symptoms and mortality benefit if any. : Patient in NYHA 3 or ambulatory class 4 were included in study. Total two hundred populations were included in the prospective study. One hundred patients were treated by conventional optimum medications for heart failure including ACE inhibitors, ARBs. One hundred patients were given ISDN+Hydralazine (fixed dose) in addition to conventional medicines.: Mean age of study and controlled group was 62.5 years and 61.4 years respectively. Base line mean ejection fraction in control group was 33% and study group was 33%. After a mean one and half year follow up 61% of patient population achieved NYHA 2 in case group and 53% in control group. We assess the NT pro BNP level in both group of population at baseline and every six month interval. There is significant reduction in BNP level in study patients. 72% achieved below baseline cut off value for the age in control. In control population 51% achieved the estimated BNP value cut off for age. : Significant scope remains to improve the outcome for these patients through research related to use of H-ISDN in heart failure patients.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"11 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of serological tests in the diagnosis of scrub typhus 评估诊断恙虫病的血清学试验

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.042

Mvnl Ram Mohan, Shiva Prasad Jamakayala, Subhada K, Talasila Sudha, Teja V.D, U. Pamidimukkala

{"title":"Evaluation of serological tests in the diagnosis of scrub typhus","authors":"Mvnl Ram Mohan, Shiva Prasad Jamakayala, Subhada K, Talasila Sudha, Teja V.D, U. Pamidimukkala","doi":"10.18231/j.pjms.2024.042","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.042","url":null,"abstract":"Scrub typhus is a leading cause of acute undifferentiated febrile illness in India. Overlapping clinical presentation and very low incidence of characteristic eschar makes serology the main stay of diagnosis. IgM ELISA is the most common test performed in tertiary care centres along with rapid diagnostic tests (RDT) and Weil Felix with varying sensitivity and specificityThe present study was conducted to compare the RDT’s and Weil Felix with IgM ELISA and analyse the demographic and clinical profile of scrub positive patientsSerum samples from clinically suspected scrub typhus patients admitted in a tertiary care hospital were tested by Weil Felix, RDT and IgM ELISA. Scrub typhus was confirmed in 38 of the 100 clinically suspected patients by IgM ELISA. Fever was the most common presenting symptom with significant proportion of patients being exposed to vegetation (p=0.0001).Sensitivity of Weil Felix and RDT was 42.1% and 84.2% respectively. Acute Kidney injury was the most common complication and mortality rate was 7.9%.Weil Felix is not a reliable test for scrub typhus diagnosis due to low sensitivity. Results of positive RDT’s can used for early initiation of specific treatment and IgM ELISA can be used as a confirmatory test in highly suspected cases.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"69 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective study of CNS tumors in a tertiary care centre in Western Odisha - A 4 year study 西奥迪沙邦一家三级医疗中心中枢神经系统肿瘤的回顾性研究--一项为期四年的研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.012

Jyotirmayee Mishra, Sobhagini Nayak, K. Mohapatra, H. Singh

{"title":"Retrospective study of CNS tumors in a tertiary care centre in Western Odisha - A 4 year study","authors":"Jyotirmayee Mishra, Sobhagini Nayak, K. Mohapatra, H. Singh","doi":"10.18231/j.pjms.2024.012","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.012","url":null,"abstract":"Central nervous system (CNS) tumors comprise nearly 3% of all malignancies world-wide whereas in India it accounts for about 2%. In recent years there has been an increase in CNS tumors with new potential risk factors being observed. The aim of the present study is to highlight the histopathological spectrum of brain tumors in a single tertiary care centre in Western Odisha.This retrospective histopathological analysis of CNS tumors was conducted in the Department of Pathology, VIMSAR, Burla, Odisha, India from October 2016 to September 2020. In the span of 4 years, a total of 94 neurosurgical biopsies were studied. Histopathological examination of routinely processed tissue and hematoxylin and eosin (H&E) stained sections of corresponding cases were thoroughly examined. Immunohistochemistry (IHC) was done whenever required. Thereafter an approach was made to diagnose the cases, based on WHO classification system of 2016.A wide range of histopathological spectrum of CNS tumors was observed and was classified according to the WHO classification system of 2016. The primary CNS tumors were graded from Grade I to Grade IV. The most common CNS tumor in our study we found to be Astrocytic tumors (21 cases, 22.34%) followed by Schwannoma (19 cases, 20.21%) and meningiomas (18 cases, 19.14%). The incidence was more among males (59.51%) as compared to females (40.4%). This study provides an information regarding the prevalence of disease in Western Odisha. Use of modern imaging technique helps to a major extent in making a provisional.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"10 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of USG and MRI to detect the rotator cuff injury and to compare the efficacy of both USG 和 MRI 在检测肩袖损伤方面的作用以及两者功效的比较

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.019

Lohith K, Vinaya Manohara Gowda, Pradeep Kumar C N, Sriviruthi B S

{"title":"Role of USG and MRI to detect the rotator cuff injury and to compare the efficacy of both","authors":"Lohith K, Vinaya Manohara Gowda, Pradeep Kumar C N, Sriviruthi B S","doi":"10.18231/j.pjms.2024.019","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.019","url":null,"abstract":"The objectives of this study were to detect the rotator cuff injury using high-resolution ultrasonography in clinically suspected patients, compute MRI findings and compare the effectiveness of ultrasound and MRI diagnostically in such patients. 30 patients who were suspected to be suffering from rotator cuff injury were referred to the Department of Radiodiagnosis, Medical Trust Hospital, Kochi, Kerala. MRI and high-resolution ultrasonography were used to evaluate them after taking their written consent. The present study was carried out from November 2018 to October 2019. In partial thickness tears, the specificity of ultrasound was 87.5% and sensitivity was 72% whereas it was 83.3 % and 95.8% respectively for full-thickness tears. MRI was more sensitive than USG in evaluating the capsular and labral pathologies. MRI was the most sensitive and specific modality in the evaluation of shoulder pain. A specificity of 94% and a sensitivity of 92.3% was seen in relation to MRI in case of partial thickness tears; whereas in full thickness tears a specificity of 95.8% and a sensitivity of 100.0% were seen. In calcific tendinitis, picking bursal fluid and impingement, MRI was better than USG and also highly sensitive for labral tears. In the evaluation of shoulder pain, MRI is the most appropriate evaluation modality and in case of labral tears it is highly sensitive. When compared to USG, MRI is better in picking bursal fluid, impingement as well as calcific tendinitis and also in evaluating labral and capsular pathologies.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"15 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HRCT chest: A valuable tool to differentiate other pneumonias from covid-19 pneumonia 胸部 HRCT：区分其他肺炎与柯维-19 肺炎的重要工具

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.017

A. Dhok, N. Shinde, Simran Rathi, Kajal Mitra

{"title":"HRCT chest: A valuable tool to differentiate other pneumonias from covid-19 pneumonia","authors":"A. Dhok, N. Shinde, Simran Rathi, Kajal Mitra","doi":"10.18231/j.pjms.2024.017","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.017","url":null,"abstract":"To assess how COVID-19 pneumonia differs from other pneumonias in terms of the chest computed tomography features.In this study we included 170 clinically diagnosed cases pneumonia referred to department of radio diagnosis subjected to HRCT thorax which include out patients and in patients out of which 127 patients tested RT-PCR positive for Covid 19 pneumonia for a total duration of 1 year. (March 2020 to March 2021). The parenchymal abnormalities including Ground glass opacities (GGO), ground glass opacities with interlobular septal thickening (crazy paving), GGO with consolidation, consolidation, pulmonary nodules, tree in bud appearances, bronchiolar wall thickening, interlobular septal thickening , halo sign, reverse halo sign, cavitation and pleural effusion and were observed and categorized along with determination of pattern of distribution on chest CT.127 patients who tested positive for COVID 19 and 43 patients with other pneumonia (such as community-acquired pneumonia) were visited, and CT scans were analysed to determine the presence and distribution of the disease pattern.Patients with COVID 19 pneumonia primarily have peripheral-based lesions (90%), whereas patients with other pneumonias primarily have mixed patterns (70%)—a difference that is statistically different (p 0.05).Statistics show that COVID 19 had higher bilateral involvement than other pneumonia (p<0.05). In COVID-19 pneumonia, GGOs, GGOs with interlobular septal thickening (crazy paving), and GGOs with consolidation with peripheral and basal predominance in bilateral lung parenchyma are the most common imaging patterns and findings. These findings will help us distinguish COVID-19 pneumonia from other causes of pneumonia. There is less evidence of tree in bud, pure consolidation, cavitation, and bronchiolar wall thickening.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"65 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0