PANACEA JOURNAL OF MEDICAL SCIENCES最新文献_第4页

Impact of case-based learning approach in clinical microbiology on second-year students: A prospective observational study 临床微生物学案例式学习法对二年级学生的影响：前瞻性观察研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.003

Lakshmi Jyothi T, M. Wajid, Saranya M, Shazia Naaz, Vivek Hada, Usha Rani, S. Suravaram, Ariyanachi K

引用次数: 0

Comparison of quality of life in hemodialysis and pre dialysis patients: A cross sectional study 血液透析患者与透析前患者生活质量的比较：横断面研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.043

Ashok Bhat

引用次数: 0

A retrospective study of clinical profile of para-phenylenediamene poisoning (hair dye poisoning) in cases admitted in medical college 医学院收治的对苯二胺中毒（染发剂中毒）病例临床概况回顾性研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.031

Neha Ahuja, Kanwal Kamboj, Amrita Sinha, Nilam Nigam

引用次数: 0

FNAC as preoperative diagnostic tool for neoplastic and non-neoplastic breast lesions with special reference to IAC standardised reporting in Coastal population - A teaching hospital experience 将 FNAC 作为肿瘤性和非肿瘤性乳腺病变的术前诊断工具，并特别参考沿海人口中的 IAC 标准化报告 - 一家教学医院的经验

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.004

Supriya P Savant, Vinay Naik, Jyothi B. Lingegowda

{"title":"FNAC as preoperative diagnostic tool for neoplastic and non-neoplastic breast lesions with special reference to IAC standardised reporting in Coastal population - A teaching hospital experience","authors":"Supriya P Savant, Vinay Naik, Jyothi B. Lingegowda","doi":"10.18231/j.pjms.2024.004","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.004","url":null,"abstract":"Breast cancer is steadily increasing worldwide. This study is based on application of recently proposed International Academy of cytology (IAC) Yokohama categorisation system of Breast cytology from C1 to C5. (C1-Insufficient material, C2-Benign, C3- Atypical, C4-Suspicious & C5-Malignant). We aim to categorize the breast lesions based on the above-mentioned categorization scheme (IAC, Yokohama 2016) along with histopathological correlation (wherever possible). This was a retrospective observational study conducted from January 2018 to December 2021 in the Department of Pathology of a tertiary care hospital involving coastal population. Ethical clearance was taken from institutional reviw committee. All patients with palpable breast lumps who had undergone FNAC were included in the study. Patient details and data were collected from the case records maintained in Department of Pathology. All quantitative parameters were described through descriptive statistics. Total scores were computed for all the risk factors. Sensitivity, specificity, Positive Predictive Value, Negative Predictive Value calculated. Risk of malignancy(ROM) was calculated for each category. A total 200 patients, with age group ranging from 17 - 67 years with breast lesions were included in the study. C1 lesions were found in 5 cases, C2 in 152 cases, C3 in 11 cases, C4 in 4 cases, and C5 in 28 cases. Cytohistological correlation obtained in 94 cases with concordance noted in 89 cases and discordance in 5 cases. Breast FNAC cytology categorization according to IAC Yokohama system increases accuracy of diagnosis and helps clinician in appropriate patient management.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"96 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study evaluating and comparing the effectiveness of combination therapy – Duloxetine with darifenacin versus darifenacin as monotherapy on perception of symptoms, quality and standard of life in patients suffering with overactive bladder (OAB) 一项研究，评估和比较杜洛西汀联合达非那新与达非那新作为单一疗法对膀胱过度活动症（OAB）患者的症状感知、生活质量和标准的效果

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.015

Nidhi Goel, Ved Prakash, K. R. Giri, Amol Dehade

{"title":"A study evaluating and comparing the effectiveness of combination therapy – Duloxetine with darifenacin versus darifenacin as monotherapy on perception of symptoms, quality and standard of life in patients suffering with overactive bladder (OAB)","authors":"Nidhi Goel, Ved Prakash, K. R. Giri, Amol Dehade","doi":"10.18231/j.pjms.2024.015","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.015","url":null,"abstract":": Overactive bladder is chronic debilitating condition, with physical, psychological, and economical consequences. Urinary vesicle tissue contains muscarinic receptors, M3 is principal mediator of detrusor contraction. Muscarinic receptor antagonists, comprises traditional pharmacological treatment. But due to non-selective inhibition, these agents, probably been related with safety and tolerability concerns. Drugs particular inhibiting sM3 receptor (Darifenacin) have potential to present effective relief while reducing side effects concerned with blockade of M1, M2 and M5 receptors. Duloxetine is Serotonin and nor-epinephrine reuptake inhibitor, leading increased concentration of 5-HT and NE in synaptic cleft, increases stimulation of pudendal motor neurons, thus increasing resting tone and contraction of urethral sphincter.: In present prospective, randomized, parallel group, comparative open label study with 60 OAB patients the combination therapy of Duloxetine with Darifenacin was equated with monotherapy using Darifenacin. The outcome thus analyzed using three different OAB-questionnaires and was statistically compared. : We demonstrated that addition of Duloxetine has shown better result outcome in symptoms as well as quality of life, though the difference of OAB-V8, OABss mean score was non-significant, but for OAB-qSF the reduction (percentage change) in mean score was more in treatment group II as compare to group I (w6:13.82±3.17% vs 12.13±3.24% & W12 29.99±5.40% Vs 25.56±5.17%) , and was statistically significant.(p<0.05).: Duloxetine has synergistic effect to Darifenacin, its ability to increase bladder capacity may be the reason for the improvement OAB symptoms, promising in controlling and treating symptoms either alone or in combination with anti-cholinergic drugs.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"22 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Isosorbide dinitrate and Hydralazine combination in non ischemic dilated cardiomyopathy in a tribal based population at a tertiary care hospital 二硝酸异山梨酯和氢氯吡嗪联合疗法对一家三级医院中以部落为基础的非缺血性扩张型心肌病的疗效

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.053

Saikat Sau, Lina Mukherjee, Sourav Sau

{"title":"Efficacy of Isosorbide dinitrate and Hydralazine combination in non ischemic dilated cardiomyopathy in a tribal based population at a tertiary care hospital","authors":"Saikat Sau, Lina Mukherjee, Sourav Sau","doi":"10.18231/j.pjms.2024.053","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.053","url":null,"abstract":"Non ischemic dilated cardiomyopathy is an important cause of heart failure and cardiovascular mortality. Numerous pharmacologic therapies have been applied from the ancient era for treatment. Some of them have shown improve morbidity. From various literatures it was concluded that combination therapy with H-ISDN in addition to conventional medicines are very effective in black population group. In our study we have tried to establish the efficacy of fixed dose drug combination (Hydralazine + Isosorbide dinitrate) to alleviation of heart failure symptoms and mortality benefit if any. : Patient in NYHA 3 or ambulatory class 4 were included in study. Total two hundred populations were included in the prospective study. One hundred patients were treated by conventional optimum medications for heart failure including ACE inhibitors, ARBs. One hundred patients were given ISDN+Hydralazine (fixed dose) in addition to conventional medicines.: Mean age of study and controlled group was 62.5 years and 61.4 years respectively. Base line mean ejection fraction in control group was 33% and study group was 33%. After a mean one and half year follow up 61% of patient population achieved NYHA 2 in case group and 53% in control group. We assess the NT pro BNP level in both group of population at baseline and every six month interval. There is significant reduction in BNP level in study patients. 72% achieved below baseline cut off value for the age in control. In control population 51% achieved the estimated BNP value cut off for age. : Significant scope remains to improve the outcome for these patients through research related to use of H-ISDN in heart failure patients.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"11 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indian women should be encouraged to use combined contraceptive vaginal ring 应鼓励印度妇女使用复方阴道避孕环

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.001

Sourav Das, Tiasa Sinha

引用次数: 0

A study to see association between vitamin d level and obstructive sleep apnea 一项关于维生素 d 水平与阻塞性睡眠呼吸暂停之间关系的研究

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.040

Huma Firdaus, Shadan Sadaf, Rajendra Kumar Saini, Mohammad Shameem

{"title":"A study to see association between vitamin d level and obstructive sleep apnea","authors":"Huma Firdaus, Shadan Sadaf, Rajendra Kumar Saini, Mohammad Shameem","doi":"10.18231/j.pjms.2024.040","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.040","url":null,"abstract":"Obese patients have low levels of serum 25-hydroxy vitamin D due to feedback inhibition of hepatic synthesis of the metabolite by increased circulating 1,25(OH) vitamin D. Obese individuals have more physical activity which limits their exposure to sunlight resulting in lower levels of 25(OH)D. Sleep fragmentation in OSA leads to daytime drowsiness, fatigue and hence decreased outdoor activity contributing to the same. Hence, OSA aggravates obesity and obesity aggravates OSA creating a vicious cycle and together contribute to the depletion of serum vitamin D level.Patients attending the special clinic of sleep were included in the study and were screened using STOP-BANG scoring system for OSA Patients with score of >2 were included in the study and further underwent polysomnography test. Among the study population, cases had an apnea-hypopnea index (AHI) > 5 in polysomnography and controls had AHI <5. Controls were further matched for age, sex and BMI with cases. Vitamin D Level was tested in both cases and controls for comparison using arterial blood sample.Total ninety-three patients were included in the study, out of whom 59 were cases which formed the OSA group, had mean age of 48.02 ±8.435 years, mean body mass index (BMI) 33.73 ±7.48 kg/m2, mean neck circumference 37.8 cm ±5.08 Mean vitamin D level in the case and control was 21.02 ± 7.27 and 24.48 ± 6.92 respectively with a p value < 0.05, with a negative correlation of AHI with serum vitamin D level (p< 0.001, r = −0.286).Different mechanisms play a role in OSA patients affecting. This study shows inverse relationship between vitamin D level and AHI (apnea-hypopnea index) which was statistically significant and vitamin D level was higher in controls than cases. Thus it can be said that 25(OH)D levels and OSAS are related, but it is difficult to establish a direct causal association between them.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"65 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of serological tests in the diagnosis of scrub typhus 评估诊断恙虫病的血清学试验

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.042

Mvnl Ram Mohan, Shiva Prasad Jamakayala, Subhada K, Talasila Sudha, Teja V.D, U. Pamidimukkala

{"title":"Evaluation of serological tests in the diagnosis of scrub typhus","authors":"Mvnl Ram Mohan, Shiva Prasad Jamakayala, Subhada K, Talasila Sudha, Teja V.D, U. Pamidimukkala","doi":"10.18231/j.pjms.2024.042","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.042","url":null,"abstract":"Scrub typhus is a leading cause of acute undifferentiated febrile illness in India. Overlapping clinical presentation and very low incidence of characteristic eschar makes serology the main stay of diagnosis. IgM ELISA is the most common test performed in tertiary care centres along with rapid diagnostic tests (RDT) and Weil Felix with varying sensitivity and specificityThe present study was conducted to compare the RDT’s and Weil Felix with IgM ELISA and analyse the demographic and clinical profile of scrub positive patientsSerum samples from clinically suspected scrub typhus patients admitted in a tertiary care hospital were tested by Weil Felix, RDT and IgM ELISA. Scrub typhus was confirmed in 38 of the 100 clinically suspected patients by IgM ELISA. Fever was the most common presenting symptom with significant proportion of patients being exposed to vegetation (p=0.0001).Sensitivity of Weil Felix and RDT was 42.1% and 84.2% respectively. Acute Kidney injury was the most common complication and mortality rate was 7.9%.Weil Felix is not a reliable test for scrub typhus diagnosis due to low sensitivity. Results of positive RDT’s can used for early initiation of specific treatment and IgM ELISA can be used as a confirmatory test in highly suspected cases.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"69 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HRCT chest: A valuable tool to differentiate other pneumonias from covid-19 pneumonia 胸部 HRCT：区分其他肺炎与柯维-19 肺炎的重要工具

PANACEA JOURNAL OF MEDICAL SCIENCES Pub Date : 2024-03-15 DOI: 10.18231/j.pjms.2024.017

A. Dhok, N. Shinde, Simran Rathi, Kajal Mitra

{"title":"HRCT chest: A valuable tool to differentiate other pneumonias from covid-19 pneumonia","authors":"A. Dhok, N. Shinde, Simran Rathi, Kajal Mitra","doi":"10.18231/j.pjms.2024.017","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.017","url":null,"abstract":"To assess how COVID-19 pneumonia differs from other pneumonias in terms of the chest computed tomography features.In this study we included 170 clinically diagnosed cases pneumonia referred to department of radio diagnosis subjected to HRCT thorax which include out patients and in patients out of which 127 patients tested RT-PCR positive for Covid 19 pneumonia for a total duration of 1 year. (March 2020 to March 2021). The parenchymal abnormalities including Ground glass opacities (GGO), ground glass opacities with interlobular septal thickening (crazy paving), GGO with consolidation, consolidation, pulmonary nodules, tree in bud appearances, bronchiolar wall thickening, interlobular septal thickening , halo sign, reverse halo sign, cavitation and pleural effusion and were observed and categorized along with determination of pattern of distribution on chest CT.127 patients who tested positive for COVID 19 and 43 patients with other pneumonia (such as community-acquired pneumonia) were visited, and CT scans were analysed to determine the presence and distribution of the disease pattern.Patients with COVID 19 pneumonia primarily have peripheral-based lesions (90%), whereas patients with other pneumonias primarily have mixed patterns (70%)—a difference that is statistically different (p 0.05).Statistics show that COVID 19 had higher bilateral involvement than other pneumonia (p<0.05). In COVID-19 pneumonia, GGOs, GGOs with interlobular septal thickening (crazy paving), and GGOs with consolidation with peripheral and basal predominance in bilateral lung parenchyma are the most common imaging patterns and findings. These findings will help us distinguish COVID-19 pneumonia from other causes of pneumonia. There is less evidence of tree in bud, pure consolidation, cavitation, and bronchiolar wall thickening.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"65 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0