Virus Reviews Research最新文献_第5页

INFLUENZA A (H1N1) AND THE RESISTANCE TO OSELTAMIVIR 甲型h1n1流感和对奥司他韦的耐药性

Virus Reviews Research Pub Date : 2012-12-17 DOI: 10.17525/VRRJOURNAL.V17I1-2.56

C. Gomes, Eugênio Rodrigo Zimmer Neves

{"title":"INFLUENZA A (H1N1) AND THE RESISTANCE TO OSELTAMIVIR","authors":"C. Gomes, Eugênio Rodrigo Zimmer Neves","doi":"10.17525/VRRJOURNAL.V17I1-2.56","DOIUrl":"https://doi.org/10.17525/VRRJOURNAL.V17I1-2.56","url":null,"abstract":"Influenza is an acute infection of the respiratory system usually self-limiting, evolving towards complete cure due to the immunological response of the infected organism, but that can have serious complications, such as pneumonia and death. It is a disease widely distributed around the world, associated with several pandemics for over a century. The most recent pandemic occurred in 2009, when a new strain of influenza A (H1N1) virus caused an outbreak in Veracruz, Mexico, and rapidly spread though all the continents, causing over 12 thousand deaths in less than a year. Considering that this new strain of the virus is only sensitive to neuraminidase inhibitors (oseltamivir and zanamivir) and that the protocol of the World Health Organization recommends the use of oseltamivir as a single drug therapy, this study was performed with the intention of collecting and compiling data about the occurrence of resistance to this medication, in particular due to a H274Y substitution. In addition to mapping the occurrence of resistant virus, data was also collect about the person-to-person transmission of the virus with the mutation H274Y, as well as about the association of the appearance of resistance with the use of the drug. DOI: http://dx.doi.org/10.17525/vrrjournal.v17i1-2.56","PeriodicalId":30621,"journal":{"name":"Virus Reviews Research","volume":"17 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2012-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67516927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of 40 patients with HIV in São Bernardo do Campo with previous antiviral drug resistance, enfuvirtide antiretroviral treatment and treatment failure <s:1> o Bernardo do Campo县40例既往抗病毒药物耐药、恩福韦肽抗逆转录病毒治疗失败的HIV患者报告

Virus Reviews Research Pub Date : 2012-12-17 DOI: 10.17525/VRR.V17I1-2.58

Iara Cruz, J. Frazão, A. Condino-Neto, P. Errante

{"title":"A case report of 40 patients with HIV in São Bernardo do Campo with previous antiviral drug resistance, enfuvirtide antiretroviral treatment and treatment failure","authors":"Iara Cruz, J. Frazão, A. Condino-Neto, P. Errante","doi":"10.17525/VRR.V17I1-2.58","DOIUrl":"https://doi.org/10.17525/VRR.V17I1-2.58","url":null,"abstract":"Human immunodeficiency virus (HIV) infection leads to T CD4+ cell depletion with progressive immune dysfunction, and despite benefits of antiretroviral therapy, if not judiciously used, it leads to the emergence of drug resistance. In this study, we evaluated 40 patients with HIV that enrolled the Unique Health System-SUS and pharmacy of Medical Specialties Clinic of Sao Bernardo do Campo, Sao Paulo, Brazil. The enrolled patients were treated with enfuvirtide after treatment failure for HIV by the use of reverse transcriptase inhibitors (NRTIs), non-nucleoside inhibitors of transcriptase reverse (TTRNN) and protease inhibitors (PI). The effectiveness of enfuvirtide treatment was evaluated through viral RNA quantification, T CD4+ cell count and patient’s clinical manifestations. Our results show that all patients presented viral load reduction after treatment and the reduction seen during enfuvirtide treatment occurred under the first 6 months of treatment. All patients reported to be satisfied with enfuvirtide therapy, however discontinuation of enfuvirtide treatment once and more than once in the previous week was observed due to adverse reactions involving cutaneous signs and digestive symptoms, suggesting, in this case, the presence of a favorable situation towards the development of drug resistance. DOI: http://dx.doi.org/10.17525/vrr.v17i1-2.58","PeriodicalId":30621,"journal":{"name":"Virus Reviews Research","volume":"17 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2012-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67515577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NO ASSOCIATION BETWEEN VIRAL CYTOPATHIC EFFECT IN MCCOY CELLS AND MTT COLORIMETRIC ASSAY FOR THE IN VITRO ANTI-RABIES EVALUATION. McCoy细胞的病毒病变效应与MTT比色法体外抗狂犬病评价无相关性。

Virus Reviews Research Pub Date : 2012-12-17 DOI: 10.17525/VRR.V17I1-2.57

J. H. Chávez, J. Yokosawa, T. Oliveira, C. Simões, C. R. Zanetti

{"title":"NO ASSOCIATION BETWEEN VIRAL CYTOPATHIC EFFECT IN MCCOY CELLS AND MTT COLORIMETRIC ASSAY FOR THE IN VITRO ANTI-RABIES EVALUATION.","authors":"J. H. Chávez, J. Yokosawa, T. Oliveira, C. Simões, C. R. Zanetti","doi":"10.17525/VRR.V17I1-2.57","DOIUrl":"https://doi.org/10.17525/VRR.V17I1-2.57","url":null,"abstract":"Rabies is an important viral disease with a great impact on public health due to its extensively fatal outcome. In endemic areas, rabies may be responsible for over 50,000 human fatalities per year, which is a high number, since a well-established prophylaxis by immunization is available. Despite experimental protocols, no antiviral drugs are currently effective against rabies virus infection. For this reason, antivirals directed to treat human rabies need to be developed. In order to standardize in vitro antiviral screening for rabies virus, we evaluated two methods: the inhibition of cytopathic effect (CPE) and the MTT assay. Anti-rabies activity was only measurable by CPE, while the MTT assay failed to detect antiviral activity in rabies infected McCoy cells. In addition, no significant correlation was observed when comparing both assays. The correlation between the inhibition of CPE and MTT assay was shown when Vero cells were infected with herpes simplex virus type 1 and Hep-2 cells were infected with adenovirus type 5, reinforcing that despite the reliable CPE, McCoy cells infected with rabies cannot be assessed by MTT. In conclusion, these results have shown that the inhibition of CPE should be used for anti-rabies screening in McCoy cells, while the MTT assay was unsuitable in this in vitro system. DOI: http://dx.doi.org/10.17525/vrr.v17i1-2.57","PeriodicalId":30621,"journal":{"name":"Virus Reviews Research","volume":"17 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2012-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67515564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

HUMAN PAPILOMAVIRUS INFECTION AND P16 INK4A HYPERMETHYLATION IN A CASE OF ESOPHAGEAL PAPILLOMATOSIS 食管乳头状瘤病1例人乳头瘤病毒感染及p16 ink4a高甲基化

Virus Reviews Research Pub Date : 2012-11-11 DOI: 10.17525/VRR.V17I1-2.61

L. Afonso, L. F. Pesca, F. N. Carestiato, S. Cavalcanti

引用次数: 0

Posters Plant and Invertebrates Virology 植物和无脊椎动物病毒学

Virus Reviews Research Pub Date : 2012-10-03 DOI: 10.17525/VRR.V17I2.77

Sociedade Brasileira de Virologia

引用次数: 0

Detection of a novel norovirus recombinant strain in an African-descendant community from the Amazon region, Brazil, 2008 2008年巴西亚马逊地区非洲人后裔社区新型诺如病毒重组株的检测

Virus Reviews Research Pub Date : 2012-10-03 DOI: 10.17525/VRR.V17I2.75

T. Fumian, G. C. Aragão, J. Mascarenhas, J. Kaiano, J. A. M. Siqueira, L. Soares, A. Linhares, Yvone M Gabbay