Revista Amazônica de Ciências Farmacêuticas最新文献

{"title":"O AUMENTO DO RISCO DE OSTEOPOROSE ASSOCIADA AO USO CRÔNICO DOS INIBIDORES DA BOMBA DE PRÓTONS: UMA REVISÃO BIBLIOGRÁFICA INTEGRATIVA","authors":"Isabel Cristina de Moura Carvalho, Marcio Tiago Cavalheiro Oliveira Junior, C. P. B. Silveira, José Raul Rocha de Araújo Júnior","doi":"10.17648/2675-5572.racf.v3n1.2","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v3n1.2","url":null,"abstract":"Introduction: Proton Pump Inhibitors (PPI) emerged in the 1980s, becoming one of the most prescribed drug classes for the prevention and treatment of gastric diseases. PPIs have high therapeutic safety and few adverse effects, but their long-term use, whether through indiscriminate use through self-medication or recurrence of medical prescriptions, can lead to potential adverse effects such as calcium malabsorption due to suppression of gastric acid secretion, calcium absorption being dependent on the acidic pH of the stomach which can lead to the onset of osteoporosis. Objective: To assess the increased risk of osteoporosis associated ___________________________________________________________________________ Revista Amazônica de Ciências Farmacêuticas. 2022; 3(1): 9-20. 10 with the chronic use of proton pump inhibitors. Methods: An integrative and basic literature review was carried out, from 2010 to 2021, in the Google Academic, PubMed and SciELO databases. Results and discussion: Eleven works that addressed this topic were analyzed. According to the analysis, continued use of PPIs can lead to impaired calcium absorption, interference with osteoclastic pumps, and hyperparathyroidism, leading to loss of bone mineral density, which can increase the risk of osteoporosis. Conclusions: It is essential to reinforce the dangers of excessive use of PPIs on bone mineral density and to emphasize the need for studies that better clarify their adverse effects, in order to preserve the population's quality of life.","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126669806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A IMPORTÂNCIA DA EXPANSÃO DA MODELAGEM MOLECULAR COMO TÉCNICA PARA PESQUISAS DE NOVOS FARMACOS","authors":"Murillo Tembra Valente, Leliane Pinheiro Silva, Antônio José Cerasi Junior","doi":"10.17648/2675-5572.racf.v3n1.1","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v3n1.1","url":null,"abstract":"One of the most important advances in the creation of new drugs has been the use of molecular modeling, as it is an essential tool in the process of discovering new bioactive molecules, and also in the improvement of an existing prototype. Molecular variation is the chemical change of a heterogeneous, in order to improve its purpose as a drug, increasing its effectiveness, improving its percentage and extent of absorption, decreasing toxicity and modifying physicochemical characteristics such as solubility. Objectives: to highlight the importance of expanding molecular modeling as a technique for researching new therapeutic agents. ___________________________________________________________________________ Revista Amazônica de Ciências Farmacêuticas. 2022; 3(1): 1-8. 2 Methodology: This is a work through a bibliographic research of the last 10 years, using as a research instrument: books, periodicals, magazines, scientific articles, and national and international databases, such as PubMed and Scielo, using up as a molecular modeling descriptor. Results and discussion: Computational techniques allowed intermediate structures of reactions or hypothetical transition states to be modeled and their properties measured, enabling the study of conformations and properties of a molecule. Conclusions: A great variety of computer programs and methods have been developed to visualize the three-dimensional geometry (3D) and calculate the physical properties of drugs, aiming at the creation of new bioactive molecules, whose purpose is to develop safer medicines, with better results. specificity, increased drug-receptor selectivity, with the purpose of decreasing and/or eliminating adverse effects and toxicity of a drug.","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133471854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A IMPORTÂNCIA DA ATUAÇÃO DO FARMACÊUTICO NA FARMACOVIGILÂNCIA HOSPITALAR NO BRASIL: UMA REVISÃO DE LITERATURA","authors":"Cristiane Mancio Sauma, Ely de Nazaré Oliveira Drago, Karla Suanny Navarro, M. C. D. Almeida, Carla de Castro Sant’ Anna","doi":"10.17648/2675-5572.racf.v2n2.2","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n2.2","url":null,"abstract":"Introdução: Farmacovigilância é a ciência que estuda as atividades relacionadas a detecção, avaliação, compreensão e prevenção dos efeitos adversos a medicamentos. Investigando e notificando as queixas técnicas com base nas RAM's (Reações Adversas a Medicamentos), o farmacêutico é o profissional mais preparado e qualificado para reduzir os riscos relativos à utilização desses medicamentos, por meio do acompanhamento sistemático de ocorrências desses eventos. Objetivo: Demonstrar a importância da atuação do farmacêutico no âmbito da farmacovigilância hospitalar no Brasil. Método: Revisão de literatura, a partir de artigos encontrados nas bases de dados SciELO, LILACS, MedLine e Google Acadêmico, indexados no período de 2011 a 2021, por meio dos descritores: Farmacovigilância hospitalar; Atuação do Farmacêutico; Reações Adversas a Medicamentos (RAMs). As referências foram analisadas conforme ano, idioma, país de publicação e tipo de estudo e classificadas de acordo com seu foco em relação às atividades relacionadas a detecção, avaliação, compreensão e prevenção dos efeitos adversos a medicamentos (RAM’s) e a atuação do Farmacêutico na Farmacovigilância Hospitalar. Resultados: A partir da leitura analítico-reflexiva de cerca de 1690 artigos indexados nas bases de dados, conforme os critérios de inclusão e exclusão, optou-se pela escolha daqueles que respondem à questão norteadora, restando 08 estudos. Utilizou-se duas categorias de investigação, ou seja, atividades relacionadas a detecção, avaliação, compreensão e prevenção dos efeitos adversos a medicamentos e atuação do Farmacêutico na Farmacovigilância Hospitalar. Conclusão: As publicações enfatizaram a discussão sobre a Farmacovigilância hospitalar e a atuação do farmacêutico direcionada à investigação e notificação de queixas com base nas RAM’s, apresentando um impacto positivo dessa atuação em relação à assistência à saúde, como segurança do paciente. Tais estudos podem fundamentar o processo de tomada de decisão e a formulação de estratégias que visem ampliar a capacidade de gestão e a qualidade do serviço prestado.","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133877441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANÁLISE DE ESTUDOS COMPUTACIONAIS DE FÁRMACOS PROMISSORES ANTI SARS-COV-2: UMA REVISÃO INTEGRATIVA","authors":"A. R. Silva, A. N. D. Santos, Agnaldo S. Carneiro","doi":"10.17648/2675-5572.racf.v2n2.1","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n2.1","url":null,"abstract":"","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"47 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126003065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MECANISMO DE AÇÃO, BENEFÍCIOS E INTERCORRÊNCIAS NO TRATAMENTO FACIAL COM ÁCIDO HIALURÔNICO – UMA REVISÃO DA LITERATURA","authors":"Evilla Nazaré Machado Corrêa, Dianne Brabo Fernandes, Daniella Paternostro de Araújo Grisólia","doi":"10.17648/2675-5572.racf.v2n2.5","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n2.5","url":null,"abstract":"","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124003700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANÁLISE SOBRE O CONHECIMENTO DE DESENVOLVIMENTO E APLICAÇÃO DE VACINAS DOS ESTUDANTES DE ENSINO SUPERIOR: UM OLHAR SOBRE A COVID-19","authors":"Leonan Cordeiro de Oliveira, T. Alves","doi":"10.17648/2675-5572.racf.v2n2.3","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n2.3","url":null,"abstract":"","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121475372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DESCRIÇÃO DA FARMACOTERAPIA DA CROMOBLASTOMICOSE: REVISÃO DA LITERATURA","authors":"Maria de Fátima Barrozo da Costa, Lidiane Rodrigues Monteiro, A. B. D. M. Moura, Daniella Paternostro de Araújo Grisólia","doi":"10.17648/2675-5572.racf.v2n2.4","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n2.4","url":null,"abstract":"","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"96 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127993931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USO IRRACIONAL DE ANTIBIÓTICOS, QUAIS OS FATORES ENVOLVIDOS?","authors":"L. S. Costa, L. Lima, Eliene Costa, Alan Barroso Araújo Grisólia, Daniella Paternostro de Araújo Grisólia","doi":"10.17648/2675-5572.racf.v2n1.9","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n1.9","url":null,"abstract":"Introduction: antibiotics are medicines used to fight high-risk infectious diseases caused by bacteria. According to the World Health Organization, Brazil is the country that most indiscriminately consumes this class of medication. Aims: the aim of this study was to identify, based on an analysis in the literature, the main cause of the irrational use of antibiotics, to point out the main aggravating factor of the misuse of this class and to emphasize the importance of the role of the pharmacist in this scenario. Methods: The research was conducted from an integrative review, with electronic search for articles in the BVS, SCIELO, PUBMED, CINHHL databases, using descriptors: \"Irrational use of antibiotics\", \"factors of antibiotic self-medication\", \"consequences of irrational use of antibiotics\" and \"importance of the pharmacist\" in the period 2010 to 2020. Results and discussion: Based on the data survey, the main factors that led to self-medication of antimicrobials were the use of old prescriptions, rapid relief of symptoms, difficulty in accessing public health service and prior knowledge of the pathology. Conclusion: the main problem related to the irrational use of antimicrobials was bacterial resistance and it was also possible to observe that the authors recognize the importance of the role of the pharmacist in promoting the rationalization of the use of this drug.","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131003846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RELATO DE EXPERIÊNCIA SOBRE CUIDADOS FARMACÊUTICOS EM SAÚDE NAS COMUNIDADES ATENDIDAS PELO PROJETO ADOTE UM SORRISO EM BELÉM DO PARÁ","authors":"Kamila Leal Correa, Camilla Eduarda Lima Rolim, Marcus Vinícius Ribeiro","doi":"10.17648/2675-5572.racf.v2n1.11","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n1.11","url":null,"abstract":"","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124507046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propriedade Cicatrizante da Espécie Arrabidaea chica (HUMB. BONPL.) B. VERLT.: Uma Revisão Integrativa.","authors":"Maria Fernanda Carvalho Stegg da Silva, Jaqueline Salim Brabo, Lucas Roberto Castro de Lima, Mauro Sérgio Marques Alves","doi":"10.17648/2675-5572.racf.v2n1.7","DOIUrl":"https://doi.org/10.17648/2675-5572.racf.v2n1.7","url":null,"abstract":"","PeriodicalId":305381,"journal":{"name":"Revista Amazônica de Ciências Farmacêuticas","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125016247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}