O AUMENTO DO RISCO DE OSTEOPOROSE ASSOCIADA AO USO CRÔNICO DOS INIBIDORES DA BOMBA DE PRÓTONS: UMA REVISÃO BIBLIOGRÁFICA INTEGRATIVA

Abstract

Introduction: Proton Pump Inhibitors (PPI) emerged in the 1980s, becoming one of the most prescribed drug classes for the prevention and treatment of gastric diseases. PPIs have high therapeutic safety and few adverse effects, but their long-term use, whether through indiscriminate use through self-medication or recurrence of medical prescriptions, can lead to potential adverse effects such as calcium malabsorption due to suppression of gastric acid secretion, calcium absorption being dependent on the acidic pH of the stomach which can lead to the onset of osteoporosis. Objective: To assess the increased risk of osteoporosis associated ___________________________________________________________________________ Revista Amazônica de Ciências Farmacêuticas. 2022; 3(1): 9-20. 10 with the chronic use of proton pump inhibitors. Methods: An integrative and basic literature review was carried out, from 2010 to 2021, in the Google Academic, PubMed and SciELO databases. Results and discussion: Eleven works that addressed this topic were analyzed. According to the analysis, continued use of PPIs can lead to impaired calcium absorption, interference with osteoclastic pumps, and hyperparathyroidism, leading to loss of bone mineral density, which can increase the risk of osteoporosis. Conclusions: It is essential to reinforce the dangers of excessive use of PPIs on bone mineral density and to emphasize the need for studies that better clarify their adverse effects, in order to preserve the population's quality of life.