Transbaikalian Medical Bulletin最新文献

{"title":"ROLE OF INTERCELLULAR ADHESION MOLECULES (ICAM-1), VASCULAR CELL ADHESION (VCAM-1) AND CALPROTECTIN (MRP8/14) IN PATHOGENESIS OF DIABETIC RETINOPATHY","authors":"O. A. Saklakova, M. V. Maksimenya, E. V. Fefelova, T. Karavaeva, P. Tereshkov, A. A. Perelomova, N. Kotsyurzhinskaya","doi":"10.52485/19986173_2024_2_52","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_52","url":null,"abstract":"Aim of the research. The aim is to study the content of intercellular adhesion molecules (ICAM-1), vascular cell adhesion molecule (VCAM-1) and calprotectin in the blood serum of patients with type 2 diabetes mellitus and various stages of diabetic retinopathy. The aim is also to evaluate the role of these molecules in the pathogenesis of the disease. Materials and methods. Four groups of people were formed: first group (control group) included 21 healthy individuals; second group included 21 patients with prediabetes, third group 21 patients with type 2 diabetes. The fourth group included 63 patients with diabetic retinopathy, and this group was further divided into 3 groups of 21 people each: with non-proliferative stage of DR, with preproliferative stage, with proliferative stage.. The concentrations of ICAM-1, VCAM-1 and calprotectin (MRP8/14) in blood serum were determined using Human Vascular Inflammation Panel 1 multiplex analysis kits from Biolegend (USA). The results were assessed using CytoFlex flow cytometer (USA). The results were calculated using Jamovi version 2.3. Results. In individuals with prediabetes, the content of MRP8/14 was increased by 111,7% (p < 0,001) relative to the control group. In type 2 diabetes without retinopathy, the values of MRP8/14 protein exceed the control group values by 2,7 times (p < 0,001) and those in individuals with prediabetes by 29,2% (p = 0,049). In the group of patients who had non-proliferative stage of DR, the levels of ICAM-1, VCAM-1 and MRP8/14 are higher than control group values in the groups of people with prediabetes and patients with diabetes without complications. During the preproliferative stage, the number of adhesion molecules increases even more; during the proliferative stage, the concentrations of VCAM-1 and calprotectin remain high, and the level of ICAM-1 increases relative to the previous stages. Conclusion. Increasing of MRP8/14 level in diabetes and increasing of ICAM-1 and VCAM-1 concentrations in the initial stage of DR demonstrate the role of these molecules in the initiation of DR in type 2 diabetes. Researching the relationship between these markers and the development of DR can provide additional information to develop strategies for prevention and treatment of DR as well as predicting its complications.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"120 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMBINED CRITICAL ILLNESS–RELATED CORTICOSTEROID AND THYROID INSUFFICIENCY DURING TARGETED TEMPERATURE MANAGEMENT: A PROSPECTIVE COHORT STUDY","authors":"M. B. Kutcyi, N. Altshuler, O. Parinov, K. A. Popugaev","doi":"10.52485/19986173_2024_2_20","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_20","url":null,"abstract":"Objective. To study the effect of therapy for adrenal and thyroid dysfunction on the course and outcomes of critical care. Materials and methods. 51 patients requiring targeted temperature management (ТТМ) were included in a single-center prospective cohort study. Results. Group I (with adrenal and thyroid dysfunction) included 39 (76,5%) patients on TTM, group II (without adrenal and thyroid dysfunction ) included 12 (23,5%) patients without endocrinopathies. In patients on TTM, adrenal dysfunction developed on day (D) 0 and manifested only clinically in the form of vascular insufficiency. When evaluating clinical and laboratory data in patients at TTM, thyroid dysfunction was diagnosed at D1, D2, and D3. The manifestation of adrenal and thyroid dysfunction in patients at is primarily due to central nervous system injury rather than sepsis. Treatment of adrenal and thyroid dysfunction was performed with hydrocortisone and levothyroxine. Conclusion. Formation of combination of adrenal and thyroid dysfunction at TTM leads to the development of multiple organ dysfunction not associated with the development of septic complications. Timely diagnosis and adequate correction of adrenal and thyroid dysfunction in patients undergoing critical illness and requiring TTM allows to reliably reduce mortality.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"95 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE SIGNIFICANCE OF GENE POLYMORPHISM OF SOME PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH SEVERE ULCERATIVE COLITIS","authors":"I. V. Zhilin, E. Chashkova, А. А. Zhilina, V. V. Gorbunov","doi":"10.52485/19986173_2024_2_1","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_1","url":null,"abstract":"The objective of the study was too study the polymorphism of TNFa(rs1800629), IL10(1800871, 1800896) ITGA4(rs1143674, rs1449263), ITGB7(rs11574532) genes in patients with severe ulcerative colitis (UC) Materials and methods. The study included 70 people with UC who lived in the Irkutsk region, the Republic of Buryatia and the Zabaikalsky krai. Patients were divided into two groups: patients receiving genetically engineered biological therapy (GIBT; n = 22) and patients receiving basic therapy (n=48). The control consisted of 115 healthy volunteers. The genotypes were studied by real-time PCR. For statistical processing, we used the criterion χ2, the odds ratio (OR), binary logistic regression analysis with the calculation of 95% confidence interval (CI) using the program \"IBM SPSS Statistics Version 25.0\". Results. Homozygotes of ITGA4(rs1449263)GG had 2.5 times higher chances of developing the disease than carriers of other polymorphic variants (OR = 2,580; 95% CI: 1,129-5,898; χ2 = 5,266; p = 0,022). Patients with extracellular manifestations (ECM) were 3 times more likely to receive GIBT (OR = 3,000; 95% CI: 0,982-9,167; χ2 = 3,878; p = 0,049). IL10 media(1800896)AA prevailed in the group of patients receiving basic therapy (OR = 0,282; 95% CI: 0,089-0,890; χ2 = 5,473; p = 0,020). Subjects with the homozygous variant of ITGA4(rs1143674)CC were 3.5 times more likely to have indications for the administration of GIBT (OR = 3,536; 95% CI: 1,077-11,603; χ2 = 4,576; p = 0,033). The results of binary logistic regression demonstrated that the homozygous genotype of ITGA4(rs1143674)CC and extraintestinal manifestations of the disease were predictors for an unfavorable prognosis of UC accompanied by the GIBT administration. Conclusion. The association of the debut of the disease, smoking, polymorphic variants TNFa(rs1800629), IL10(1800871), ITGB7(rs11574532) with the UC development and clinical manifestations was not revealed. The disease developed 2,5 times faster in homozygote ITGA4(rs1449263)GG than in other genotype carriers. Subjects with polymorphic variant IL10(1800896)AA prevailed in the group of patients with basic therapy. In addition to the previously known extraintestinal manifestations of the disease, the ITGA4 genotype (rs1143674) CC can act as a risk factor for the development of severe UC, requiring the GIBT administration.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"90 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACUTE KIDNEY INJURI OF PATIENTS WITH ACUTE MIOCARD INFARCTION","authors":"A. Korostelev, A. P. Potapov, A. A. Ivanova, К. А. Hudaynazarova, A. Bulatov, N. N. Silina, P. I. Zakharov, T. V. Ievleva","doi":"10.52485/19986173_2024_2_11","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_11","url":null,"abstract":"Aim of research – the comparative analysis of the frequency and the identification of factors for the development of acute kidney injury (AKI) in patients with myocardial infarction (MI) with and without the formation of pathologic Q-tooth. Material and methods. The total of 134 patients were studied and divided into 2 groups: Group 1 – patients with coronary heart disease (CHD) MI with pathologic Q tooth formation (n = 29); Group 2 – CHD MI patients without Q tooth formation (n = 105). Inclusion criteria are first-ever MI, age older than 18 years, increase in serum creatinine level above 26.5 μmol/l within 48 hours and decrease in diuresis less than 0,5 ml/ kg/h, informed voluntary consent for participation in the study. Exclusion criteria are terminal chronic renal failure, age under 18 years, chronic heart failure with left ventricular ejection fraction (LVEF) below 40%, MI anamnesis, refusal to participate in the study. Results. Among 134 patients with MI, signs of AKI were detected in 40 (29,9%) patients. In group 1, the mean value of glomerular filtration rate (GFR) was 41,0 ± 8,2, in group 2 it was 73,2 ± 13,9 ml/min/1,73m2. Signs of AKI in group 1 were observed in 20 (69,0%) patients, in group 2 in 20 (19,0%) patients. The comparative analysis of the study groups revealed that group 1 patients, compared to group 2 patients, had higher body mass index (BMI)(p < 0,001), more often concomitant chronic kidney disease (CKD) was observed (p < 0,001), lower hemoglobin level was typical (p < 0,001), and arterial hypotension was noted at prehospital stage (p = 0,034). In addition, group 1 patients were more likely to develop complications such as bleeding at the site of arterial puncture during percutaneous coronary intervention (PCI) (p < 0,046), pulmonary edema (p < 0,001) and cardiogenic shock (CS) (p < 0,001). The length of stay of group 1 patients in the Intensive Therapy and Resuscitation Department was 11,5 ± 3,6 bed days, group 2 was 9,6 ± 3,9 bed days (p < 0,019), and 8 (27,6%) patients and 1 (1,1%) died, respectively (p < 0,001). Conclusion. Early signs of AKI were detected in 29,9% of patients with MI; this condition was more frequent in the group of patients with MI who had a formed pathologic Q wave (69%). High BMI (p = 0,02), increased blood levels of HDL (p < 0,006) and total cholesterol (p < 0,001), decreased blood hemoglobin (p = 0,001), arterial hypotension (p = 0,013) and initial CKD (p < 0,001) were the factors contributing to the development of AKI.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"87 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROGNOSTIC FACTORS FOR THE DEVELOPMENT OF SEPSIS IN POSTPARTUM WOMEN WHO HAVE SUFFERED CRITICAL OBSTETRICAL CONDITIONS","authors":"O. V. Lazareva, E. M. Shifman, S. V. Barinov, L. L. Shkabatnya, A. B. Tolkach, Y. Tirskaya, T. V. Kadtsyna, A. Pukha, J. I. Chulovskij","doi":"10.52485/19986173_2024_2_32","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_32","url":null,"abstract":"The aim of the research. To identify prognostic factors for the development of sepsis in postpartum women who have suffered critical obstetric conditions (CAC). Materials and methods. We retrospectively examined 39 postpartum women after CAC, who were divided into groups: A – main group, with advanced sepsis (n = 18), B – control group without sepsis (n = 21). An analysis of clinical data upon admission was carried out. The results were processed using Statistica 12.0, Microsoft Excel and in the R environment. Results. Statistically significantly more often, patients in the main group gave birth before the 34th week of pregnancy, p = 0.04. About 50% of the subjects gave birth in first-level maternity facility. Preeclampsia and obstetric hemorrhage were the main causes of CAC development. Hemorrhagic shock occurred in 84,6% of subjects. All women underwent total hysterectomy. Sepsis developed on day 9 (4; 9) after delivery. It was shown that the chance of developing obstetric sepsis is 28 times more often in the case of artifical ventilation and at AVPU, 10 times – in case of adult respiratory distress syndrom, 7 times – in case of developed kidney failure, 6 times – in case of cerebral edema. When assessing the condition of postpartum women using the integral scales APACHE II, APACHE III, SOFA, NEWS2, a statistically significant OR in the development of sepsis remains only for the NEWS2 index; with a score of 4 points, the resulting model predicts the development of sepsis. The risk of developing obstetric sepsis is associated with MNO ≥ 1,13, CVP ≥ 6 and ASAT ≥ 45; in the presence of at least one of these factors, it increases by 7-8 times in terms of odds ratio (OR). Conclusion. The risk of developing obstetric sepsis in critical obstetric conditions is associated with the presence of mechanical ventilation and AVPU, adult RDS, renal failure, cerebral edema, a NEWS2 score of 4 or more points, MNO ≥ 1,13, CVP ≥ 6 and ASAT ≥ 45. The effectiveness of the developed prognostic model is: sensitivity – 94,5%, specificity – 90,5%.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"49 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARACTERISTICS OF THE RESULTS OF ELECTRICAL EXPOSURE WHEN INDUCING OSTEOMYELITIS IN RATS BY DIFFERENT TYPES OF PATIENTS","authors":"E. Ovchinnikov, N. Kubrak, O. Diuriagina, E. A. Kireeva, N. V. Tushina, B. G. Yushkov","doi":"10.52485/19986173_2024_2_44","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_44","url":null,"abstract":"The aim of the research. To study the features of the course of osteomyelitis in rats during the induction of an infectious and inflammatory process by various pathogens under conditions of early and delayed local exposure to direct electric current. Materials and methods. The study was carried out on 53 Wistar rats, divided into 3 series. In each series, osteomyelitis of the femur was modeled by direct inoculation into the femoral canal of a monobacterial culture (Staphylococcus aureus; MSSA, museum strain, or Pseudomonas aeruginosa, museum strain, or Escherichia coli, museum strain) at a concentration of 1 × 108 CFU and placing an intramedullary metal implant. The animals of each series were divided into 3 groups. In group 1, no additional manipulations were performed with the animals; in groups 2 and 3, the source of infection was exposed to a direct electric current (150 mAm, 1 minute) on days 0, 2, 4 and 6, or on days 7, 9, 11 and 13. The duration of the experiment was 21 days. Results. All animals had a clinical picture characteristic of osteomyelitis, but the nature, severity and frequency of occurrence of signs of the infectious-inflammatory process in the groups were different. Conclusion. Exposure to electric current early after infection had the most pronounced antimicrobial effect against P. aeruginosa when exposure began on day 7 after infection. A less pronounced effect of electrical exposure was noted in relation to S.aureus and E.coli when exposure began on the first day after infection.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"106 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN PEDIATRIC PRACTICE","authors":"Е. Р. Bataeva, О. G. Maksimova, I. I. Petrukhina, А. N. Kazantseva, Т. S. Molchanova, М. А. Chesnokova, Е. I. Dyukova","doi":"10.52485/19986173_2024_1_179","DOIUrl":"https://doi.org/10.52485/19986173_2024_1_179","url":null,"abstract":"The article presents a review of literature sources highlighting the issues of clinical and laboratory diagnosis of hemophagocytic lymphohistiocytosis in children. The authors of various observations have repeatedly emphasized hemophagocytic lymphohistiocytosis continues to be a life-threatening disease despite modern implementations in diagnosis and treatment. At the same time, the prognosis and outcome are largely determined by the timeliness of diagnosis and the right tactic. The review is illustrated by a clinical example of a fatally ended case of an infant, he was diagnosed posthumously based on the results of a molecular genetic tests.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"111 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIOVASCULAR SYSTEM DAMAGE DURING POST-COVID SYNDROME","authors":"К. А. Matafonova, Е. N. Romanova, Е. М. Romanova, D. V. Malko","doi":"10.52485/19986173_2024_1_154","DOIUrl":"https://doi.org/10.52485/19986173_2024_1_154","url":null,"abstract":"The epidemic of a new coronavirus infection provoked a second pandemic, “post-Covid”, among convalescents with a long-lasting clinical condition. Most patients who have had COVID-19 recover completely after two weeks from the onset of the disease. At the same time, every tenth person faces long-term manifestations from a number of body systems. Symptoms of post-Covid syndrome are numerous, heterogeneous and difficult to interpret. The review examines the development mechanisms and main manifestations of long-term COVID-19. Particular attention is paid to the causes and clinical variants of damage to the cardiovascular system, including endothelial dysfunction.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"105 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOLL-LIKE RECEPTORS AND BRONCHIAL ASTHMA: PART 1","authors":"А. А. Mineeva, L. V. Makarova, О. V. Antonov","doi":"10.52485/19986173_2024_1_163","DOIUrl":"https://doi.org/10.52485/19986173_2024_1_163","url":null,"abstract":"Bronchial asthma is a chronic disease of the respiratory tract, which is formed by the action of endogenous factors and environmental influences. At the same time, T-helpers of the second type play a major role in the development of bronchial asthma, causing hyperreactivity and inflammation of the respiratory tract. However, the data that bronchial asthma in most cases is an allergic, eosinophilic, T-helper-mediated disease of the second type is insufficient to establish complete control over the course of disease. This is probably due to the fact that endogenous factors play an important role in the pathogenesis of asthma, knowledge of which is currently limited. Toll-like receptors are an established element of the development of bronchial asthma. Their insufficient function or, conversely, the launch of an excessive immune response is associated with the initiation of the disease or its exacerbations. Expanding the understanding of Toll-like receptors leads not only to a more detailed understanding of the pathogenesis of bronchial asthma, but also to the application of this knowledge in practice.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"103 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STRESS RESISTANCE IN THE PROFESSIONAL ACTIVITY OF ANAESTHESIOLOGIST AND INTENSIVE CARE PHYSICHIAN","authors":"V. Е. Ironosov, К. V. Pshenisnov, Y. Aleksandrovich","doi":"10.52485/19986173_2024_1_198","DOIUrl":"https://doi.org/10.52485/19986173_2024_1_198","url":null,"abstract":"The aim of the research is to assess stress levels and stress resistance in anesthesiologists and intensive care physicians.Materials and methods. The study includes 149 anesthesiologists and intensive care physicians working in the Russian Federation. The average age of respondents was 37,2 ± 12,1 years. Depending on age, all participants were divided into groups III: group I (under 29 years old) – 45 (30,2%) people, group II (30- 49 years old) – 77 (51,7%) and group III (over 50 years old) – 27 (18,1%) people, the sex distribution was approximately the same: 77 women and 72 men, among them 82 doctors had a family and 67 people were single. The average work experience in the specialty was 11,2 ± 11,0 years. The average diploma score of the university was 4,21 ± 0,39.Study results. It was revealed that 35% of respondents are introverts and 58% showed themselves as emotionally stable extroverts. When analyzing the results of testing according to Lusher, it was found that the majority of respondents at the first presentation of eight cards chose blue as the main color, which indicates the need for calm and peace. The maximum level of neuropsychiatric tension was characteristic of doctors working for days: 42,5 ± 9,3 points, with a minimum score of 30 points and a maximum score of 71 points. Women were characterized by higher rates, but this was not statistically significant. There was a strong statistically significant negative correlation between the level of NSP and age r = - 0,80, p < 0,05) and a direct correlation with health status (r = 0,83, p < 0,05). There was also a statistically significant direct correlation between neuropsychiatric tension level and stress resistance (r = 0,36, p < 0,05).Conclusion. The majority of anesthesiologists and intensive care physicians are characterized by extraversion, a high level of internality and sensitivity, the need for calm and peace, while the main priority in the practical activities of anesthesiologists-resuscitators is situational orientation.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"115 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}