Transbaikalian Medical Bulletin最新文献

ASSESSMENT OF THE LEVEL OF CONSCIOUSNESS IN REAL CLINICAL PRACTICE USING THE GLASGOW COMA SCALE AND THE FOUR SCALE 在实际临床实践中使用格拉斯哥昏迷量表和四级量表评估意识水平

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_73

V. I. Vechorko, A. A. Zimin, E. V. Obuhova

引用次数: 0

INTENSIVE TREATMENT OF SEPTIC SHOCK IN PEDIATRIC PRACTICE 儿科脓毒性休克的强化治疗

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_61

Y. Bykov, A. N. Obedin, O. V. Zinchenko, A. А. Muravyeva, I. Yatsuk, E. V. Volkov, V. V. Fischer

{"title":"INTENSIVE TREATMENT OF SEPTIC SHOCK IN PEDIATRIC PRACTICE","authors":"Y. Bykov, A. N. Obedin, O. V. Zinchenko, A. А. Muravyeva, I. Yatsuk, E. V. Volkov, V. V. Fischer","doi":"10.52485/19986173_2024_2_61","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_61","url":null,"abstract":"In pediatric practice, septic shock (SS) is a serious, urgent condition with a high incidence and increased risk of death. Intensive therapy in this condition is based on provision of volume-expansion fluid management, prescription of antibiotic medications, and vasopressor support. Urgent care for children is provided in an intensive care unit and includes mandatory determination of the aetiology of SS (by inoculation of blood samples for sterility), provision of venous access and continuous monitoring of vital signs with measurement of lactate levels. The intensity of respiratory support changes according to the following stepwise logic: oxygen therapy – non-invasive ventilation – mechanical ventilation. When providing fluid management to a patient with SS, preference is given to crystalloid solutions. Antibacterial therapy is devised empirically and must be administered within the first hour of ICU admission. If fluid management proves insufficient to ensure stable hemodynamic parameters, vasopressor support is provided by administering inotropic agents, vasodilators and inodilators (norepinephrine, epinephrine, dopamine and dobutamine). Evidence on the effectiveness of corticosteroids in children and adolescents with SS is lacking. Knowledge of the latest algorithms of intensive treatment of SS in pediatric practice will enhance the quality of care and improve the therapeutic prognosis in this category of patients.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"87 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DIFFERENTIATED VULVAR INTRAEPITHELIAL NEOPLASIA: A CLINICAL EXAMPLE OF INTERDISCIPLINARY PATIENT MANAGEMENT 分化型外阴上皮内瘤变：跨学科患者管理的临床范例

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_144

E. Kayukova, V. A. Dudarev, T. М. Barkan, A. A. Zajkina

引用次数: 0

ASCHERMAN SYNDROME: FROM ETIOLOGY TO PREVENTION 阿彻曼综合征：从病因到预防

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_122

O. V. Remneva, O. A. Belnickaya, M. B. Igitova, N. I. Fadeeva, S. F. Garanin

{"title":"ASCHERMAN SYNDROME: FROM ETIOLOGY TO PREVENTION","authors":"O. V. Remneva, O. A. Belnickaya, M. B. Igitova, N. I. Fadeeva, S. F. Garanin","doi":"10.52485/19986173_2024_2_122","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_122","url":null,"abstract":"Asherman's syndrome is a mysterious, multifaceted disease characterized by the formation ofintrauterine synechiae, up to complete obliteration of the uterine cavity. This is a very controversial topicbecause of its pronounced effect on both the reproductive prognosis (infertility, habitual miscarriage) andgynecological symptoms (menstrual dysfunction of the type of oligo-amenorrhea). Although the syndromehas been extensively studied, there is no clear evidence of both its prevention and effective treatment. Themain reason for the formation of intrauterine adhesions is recognized by most authors as endometrial injury.Understanding the pathogenesis of their formation is necessary to prevent the development of endometrialfibrosis and sclerosis. The review article presents in detail the causes of the disease, risk factors, clinicalmanifestations, and methods for diagnosing this syndrome. Therapeutic measures are presented in step-bystep low-traumatic ways to eliminate intrauterine adhesions with subsequent restoration of menstrual andreproductive functions. Particular attention is paid to anti-relapse prevention through the prescription ofintrauterine anti-adhesion gels.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"58 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE ROLE OF GLYCOCALYX IN THE PATHOGENESIS OF DIABETES MELLITUS COMPLICATIONS 糖萼在糖尿病并发症发病机制中的作用

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_80

A. P. Vorobyova, Y. Bykov, V. Baturin, V. V. Massorov

{"title":"THE ROLE OF GLYCOCALYX IN THE PATHOGENESIS OF DIABETES MELLITUS COMPLICATIONS","authors":"A. P. Vorobyova, Y. Bykov, V. Baturin, V. V. Massorov","doi":"10.52485/19986173_2024_2_80","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_80","url":null,"abstract":"Glycocalyx (GC) is represented by protein-polysaccharide compounds lining the inner surface of endothelial cells in the form of a gel. GC plays an important role in the regulation of vascular homeostasis, controls vascular wall permeability and microvascular tone, prevents microvascular thrombosis and participates in the regulation of leukocyte adhesion. Damage of endothelial HA is a part and initial link of pathophysiological processes underlying the development of complications of diabetes mellitus (DM). In most cases of DM is accompanied by degradation of HA caused by hyperglycemia, which leads to impaired microcirculatory perfusion and organ dysfunction. Further study of HA, determination of its contribution to the development of diabetes complications is a very promising area of research. In this review, we analyze the main mechanisms of destruction and the role of HA in the pathophysiological mechanisms of the development of DM complications. Although numerous studies indicate a significant role of HA dysfunction in the development of micro- and macroangiopathies in the outcome of diabetes, many aspects of pathophysiological processes are still unexplored and require further research.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"63 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOLOGICAL AND PROGNOSTIC IMPORTANCE OF CYTOKINES IN ORAL CANCER 细胞因子在口腔癌中的生物学和预后重要性

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_102

E. Y. Komarova, E. Zlatnik, E. F. Komarova, I. A. Novikova, A. B. Sagakyants, M. A. Engibaryan, O. G. Ishonina, E. Dzhenkova, V. V. Pozdnyakova, E. V. Shalashnaya

{"title":"BIOLOGICAL AND PROGNOSTIC IMPORTANCE OF CYTOKINES IN ORAL CANCER","authors":"E. Y. Komarova, E. Zlatnik, E. F. Komarova, I. A. Novikova, A. B. Sagakyants, M. A. Engibaryan, O. G. Ishonina, E. Dzhenkova, V. V. Pozdnyakova, E. V. Shalashnaya","doi":"10.52485/19986173_2024_2_102","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_102","url":null,"abstract":"Epidemiological data indicate high rates of morbidity and mortality of oral mucosal cancer worldwide. At the same time, even visual accessibility does not allow detecting oral cancer in the early stages. The purpose of the study. Assessment of the involvement of cytokines in the development and progression of oral cancer. Materials and methods. The search for publications was carried out in the databases of the RSCI, PubMed, Scopus 2019-2023 years for the following queries: cancer of the oral mucosa; potentially malignant diseases of the oral cavity; precancerous diseases of the oral cavity, inflammation and cancer, cytokines, saliva cytokines, serum cytokines. Results. It is now recognized that under the influence of inflammation, neoplastic and stromal cells interact and control tumor evolution by producing cytokines. Modern studies demonstrate the important role of cytokines such as TNF-α, IL-8, IL-6, IL-1β in the development and progression of oral cancer. A review of the conducted studies indicates that cytokines released by tumor cells of oral cancer, as well as the tumor microenvironment, contribute to cell proliferation, survival, and migration of tumor cells of this localization, although they activate immune cells, contributing to the modulation of the antitumor immune response. Hyperproduction of cytokines, registered at the local and systemic levels, appears to be a consequence of dysregulation of proliferative processes and at the same time one of the causes of tumor spread. Conclusion. Modern research demonstrates the important role of various cytokines in the development and progression of cancer of the oral mucosa. In this regard, therapeutic approaches that limit their growthstimulating activity should be considered.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"65 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141808207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PATHOGENESIS, DIAGNOSIS AND TREATMENT OF ACUTE RENAL INJURY IN PATIENTS WITH CORONAVIRUS INFECTION COVID-19 冠状病毒-19 感染者急性肾损伤的发病机制、诊断和治疗

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_90

A. V. Dats, L. S. Dats

引用次数: 0

HYPERAMMONEMIA IN NEONATOLOGY: DIAGNOSTIC DIFFICULTIES, MANAGEMENT FEATURES 新生儿高氨血症：诊断困难、管理特点

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_152

N. G. Popova, V. Kocherova, M. V. Konteeva

引用次数: 0

TOLL-LIKE RECEPTORS AND BRONCHIAL ASTHMA: PART 2 类毒素受体与支气管哮喘：第二部分

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_112

A. A. Mineeva, L. V. Makarova, O. V. Antonov

{"title":"TOLL-LIKE RECEPTORS AND BRONCHIAL ASTHMA: PART 2","authors":"A. A. Mineeva, L. V. Makarova, O. V. Antonov","doi":"10.52485/19986173_2024_2_112","DOIUrl":"https://doi.org/10.52485/19986173_2024_2_112","url":null,"abstract":"For the last decade, the attention of researchers has been attracted by Toll-like receptors that provide recognition of pathogens and trigger an immune response to them. As participants in acute infectious processes, with inadequate stimulation associated with mutation of genes regulating expression of the receptors, they cause the initiation or exacerbation of asthma in predisposed individuals. At the same time, the reduced function of the receptors leads to an insufficient immune response in respiratory infectious diseases, which also leads to an exacerbation of bronchial asthma. In addition, Toll-like receptors are direct elements of the pathogenesis of bronchial asthma, supporting or reducing inflammation. Thus, Toll-like receptors can not only aggravate the course of asthma, but also prevent exacerbations of the disease. Knowledge of the role of these receptors in the pathophysiology of bronchial asthma is necessary to improve diagnostic methods and timely detection of the disease. Using data on the effects realized by the receptors, medicines are being developed that are antagonists or agonists of a Toll-like receptors. The use of medicines acting on receptors in the treatment and prevention of asthma in the future may lead to increased control over the course of the disease.","PeriodicalId":305035,"journal":{"name":"Transbaikalian Medical Bulletin","volume":"53 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HEREDITARY CONGENITAL NEPHROTIC SYNDROME IN CHILDREN: FEATURES OF THE COURSE, MODERN PROSPECTS FOR LIFE AND HEALTH 儿童遗传性先天性肾病综合征：病程特点、现代生活和健康展望

Transbaikalian Medical Bulletin Pub Date : 2024-07-24 DOI: 10.52485/19986173_2024_2_135

E. Bataeva, L. R. Kalinina, T. V. Pomuleva, N. P. Ivanova, R. A. Sushchenko, E. V. Plyaskina

引用次数: 0