Journal of Purdue Undergraduate Research最新文献_第7页

Iron Homeostasis and Manganese Exposure Occupational Cross-Sectional Study of a Welder Population 焊工人群的铁稳态和锰暴露职业横断面研究

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1486

M. Robbins

{"title":"Iron Homeostasis and Manganese Exposure Occupational Cross-Sectional Study of a Welder Population","authors":"M. Robbins","doi":"10.7771/2158-4052.1486","DOIUrl":"https://doi.org/10.7771/2158-4052.1486","url":null,"abstract":"Manganese exposure is a serious occupational health hazard for many welders, smelters, and miners. Manganese exposure may result in Parkinson-like symptoms. It has been hypothesized that altered iron concentrations in the brain could also lead to neurological symptoms similar to what appears in those with chronic exposer to manganese. Th erefore, the goal of this project is to explore the relationship between manganese and hepcidin as an indicator of altered iron homeostasis. Population demographics were collected from semi-trailer factory workers in a cross-sectional study via a questionnaire. Demographic information includes age, race, and weight. Toenail clippings and questionnaires were collected on the same day; blood and air concentrations were sampled on a diff erent day within a short time period. Statistical analyses include descriptive statistics and regression analyses. Multiple linear regressions were run that utilized hepcidin and transferrin as dependent variables, with air, toenail, and blood manganese and welder status as independent variables. Mean air concentrations for the metals were below recommended exposure limits. Manganese toenail concentrations were 5.23 μg/g (standard deviation [SD] = 2.53 μg/g) while iron toenail concentrations were 183.93 μg/g (SD = 124.06 μg/g). Results showed a statistically signifi cant association between natural log (ln)(hepcidin) and welding status (p = 0.042); no statistically signifi cant relationship was found between ln(hepcidin) with air manganese (p = 0.313) or toenail manganese (p = 0.672). Th ere was no association found between transferrin and air manganese, toenail manganese, or welder status. Continued research is needed to investigate these relationships further.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75640439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identity Development in Informal Learning Spaces: A Case Study of the Girls Excelling in Math and Science Club 非正式学习空间中的身份发展:以数理俱乐部女生为例

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1510

Michael A. Rice

{"title":"Identity Development in Informal Learning Spaces: A Case Study of the Girls Excelling in Math and Science Club","authors":"Michael A. Rice","doi":"10.7771/2158-4052.1510","DOIUrl":"https://doi.org/10.7771/2158-4052.1510","url":null,"abstract":"How do we present ourselves to others, especially in communities where we do not feel we belong? Despite national strides toward equality, women are still vastly unrepresented in STEM-based fields—and not for lack of merit. Lisa Darragh (“Identity research in mathematics education.” Educational Studies in Mathematics, 2016, doi.org/10.1007/s10649-016-9696-5) defines identity as the performance and recognition of one’s self and the individual’s larger role in society and social contexts. In 1994 Laura Jones was disheartened to hear her daughter describe herself as “not good at math,” despite overwhelming evidence to the contrary. Laura started an afterschool club, Girls Excelling in Math and Science (GEMS), to bolster confidence in young women who were self-selecting out of STEM classes. Survey responses, focus group interviews, and individual interviews were conducted with the original members of the first GEMS club. I considered responses from an original member, Amanda, using thematic analysis to identify and categorize references to herself and to her role in society. Given this, we were able to study how Amanda’s identity changed before, during, and after her participation in GEMS. When reflecting on her time prior to her involvement in GEMS, Amanda was self-critical, choosing to note that “I struggled a lot with science when I was in high school—I remember that very clearly. I was not very good.” However, a shift was identified when she described herself in the present, where she notes that “I manage people . . . like the boss, basically.” Given our findings from Amanda’s data, GEMS seems to be a context where girls develop their identity.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82635421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience Doesn't Matter, but the Direction Does 经验不重要，方向重要

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1503

Hailey Blythe

{"title":"Experience Doesn't Matter, but the Direction Does","authors":"Hailey Blythe","doi":"10.7771/2158-4052.1503","DOIUrl":"https://doi.org/10.7771/2158-4052.1503","url":null,"abstract":"There is disconnect between students’ intuitive expectations for object motion and normative scientific concepts that define such motion. As people gain intuition and understanding of physics through observing and interacting with their surroundings, one might expect that this disconnect would disappear. However, many students have extensive experiences where they behave correctly yet continue to construct incorrect explanations. In this study, 53 non-STEM undergraduate students enrolled in a physics course that had yet to cover the topic of relative motion were given a survey of common relative motion physics problems. The problems differed in the direction an object is thrown—either vertically or horizontally—and the frame of reference in which the reader is placed. The questions then involved subjects who were either stationary or moving, such as being on a skateboard or a bus. We found that the direction of the throw relative to the motion of the person (i.e., vertical or horizontal) and the reference frame in which the reader is placed affected the accuracy of student responses. This may be due to participants using different embodied experiences when imagining throwing a ball vertically to oneself than when throwing an object horizontally to another person, meaning that reenacting physical scenarios might provide a small benefit for more embodied tasks such as tossing a ball in a moving bus. Considering these results, future research should investigate students’ reasoning when completing relative motion problems that differ in direction and reference frame to fully understand the nature of the disconnect.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75291493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participatory Action Research: Undergraduate Researchers Engaging Secondary Students in Social Justice Mathematics 参与行动研究:大学生参与社会正义数学研究

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1508

Isabella Miller, Alexis Grimes, Camryn Adkison

引用次数: 0

Automated Data Processing: Making Community Indicators Possible for Lafayette, Indiana 自动化数据处理:使印第安纳州拉斐特社区指标成为可能

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1500

Jace T Newell, Eli Coltin, Eric Flaningam

引用次数: 0

Breaking Down the Impact of Resilience on Mental Health: An Analysis Utilizing the Resilience Scale for Adults 分解心理弹性对心理健康的影响:利用成人心理弹性量表的分析

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1516

S. Cook

{"title":"Breaking Down the Impact of Resilience on Mental Health: An Analysis Utilizing the Resilience Scale for Adults","authors":"S. Cook","doi":"10.7771/2158-4052.1516","DOIUrl":"https://doi.org/10.7771/2158-4052.1516","url":null,"abstract":"Resilience is the capacity to recover quickly from diffi culties, and previous studies have determined that resilience has a relationship with mental health. However, the association of each aspect of resilience on mental health, depression, and adverse childhood events (ACEs) have not been closely examined. Discerning which aspects of resilience are associated with mental health issues, depression, and ACEs can help psychiatric nurses determine eff ective treatments and interventions for at-risk patients. One hundred ninety-fi ve community-dwelling participants (ages 18 to 89) were invited to Purdue University in Indiana and Scripps College in California for the study. Participants completed the Resilience Scale for Adults (RSA), which examines six aspects of resilience: perception of self, planned future, social competence, structured style, family cohesion, and social resources. Additionally, the SF-12® Health Survey, the Center for Epidemiologic Studies Depression (CES-D) scale, and an ACE survey were completed. Using the six aspects of resilience as predictors, three hierarchical regression models were built with SF-12®, CES-D, and ACE as dependent variables. Findings showed that negative perception of self and impaired sense of planned future were associated with mental health issues; additionally, a lack of social resources was associated with depression, and weakened family cohesion was associated with ACEs. Psychiatric nurses can utilize the RSA during initial assessments to determine the most problematic areas for patients and fi nd ways to target their treatment and interventions. Pediatric nurses can also assess ACEs present in a child’s life and encourage family therapy sessions to promote family cohesion.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90931272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Good Data for Good Decisions about Resident Retention Analysis on Resident Retention 关于居民留存的良好决策的良好数据分析

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1531

Eli Coltin

{"title":"Good Data for Good Decisions about Resident Retention Analysis on Resident Retention","authors":"Eli Coltin","doi":"10.7771/2158-4052.1531","DOIUrl":"https://doi.org/10.7771/2158-4052.1531","url":null,"abstract":"Th e northern neighborhoods of Lafayette, Indiana, are plagued by high resident turnover, but the city strives to build a community where residents will want to live for an extended period. Th rough revitalization of these neighborhoods, the well-being of the community and the livability of the area for residents could be increased. Th e purpose of this study was to identify geographical and quantitative trends associated with these transient residents. In partnership with the City of Lafayette, the study analyzed geographical and numerical data about local households to understand these trends and aid in the city’s eff ort to increase resident retention in the northern neighborhoods by identifying areas to focus retention eff orts on. Th e study focused on analyzing household data to identify locations with patterns of households at high risk of low retention. Th e method used to identify these locations was plotting each household on a map of the studied neighborhoods and fi ltering households by diff erent factors determined to signifi cantly aff ect retention to derive geographical trends. Analyzing these trends showed that young low-income home renters were more likely to live in their home for shorter amounts of time. Geographical visualizations were produced focusing on these home renters and the northern neighborhood’s likely transient residents, and geographical areas of these potentially transient home renters were identifi ed. With these specifi c areas identifi ed, it was recommended that the community partner, the City of Lafayette, focus resources on eff orts of retention and revitalization in these specifi c areas of the northern neighborhoods of Lafayette.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91162668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visualizing Bacteriophage Evolution Through Sequence and Structural Phylogeny of Lysin A and Terminase Proteins: An Analysis of Protein Structure Across Phage Clusters 通过溶酶A和终止酶蛋白的序列和结构系统发育可视化噬菌体进化:噬菌体簇间蛋白质结构的分析

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1492

Maansi Asthana, Alyssa Easton, Julia Mollenhauer, Sean Renwick, Anita Golpalrathnam

{"title":"Visualizing Bacteriophage Evolution Through Sequence and Structural Phylogeny of Lysin A and Terminase Proteins: An Analysis of Protein Structure Across Phage Clusters","authors":"Maansi Asthana, Alyssa Easton, Julia Mollenhauer, Sean Renwick, Anita Golpalrathnam","doi":"10.7771/2158-4052.1492","DOIUrl":"https://doi.org/10.7771/2158-4052.1492","url":null,"abstract":"Understanding how genes evolve and persist is a critical part of viral genomics. Bacteriophages can provide unique insight about viral evolution because of their abundance and largely unexplored history. Traditionally, phylogenetic trees have used DNA sequence comparison to visualize evolutionary paths between organisms. However, DNA sequence similarity does not refl ect key alterations to protein structure and therefore how the protein performs its function. Phylogenetic trees based on predicted protein structure could provide an alternative lens through which to view evolutionary paths. From each of the 10 largest clusters included in the Actinobacteriophage Database, three mycobacteriophage genomes were selected. Lysin A and terminase proteins are encoded by all of the mycobacteriophage genomes and were therefore selected for analysis. Protein structural predictions were generated from amino acid sequences using Phyre2 and compared with the PyMol Molecular Graphics System, Version 2.0. Structural alignment scores from PyMol were used to quantify the structural homology of lysin A and terminase across diff erent clusters. Five phylogenetic trees were constructed: one was based on structural homology of lysin A, one was based on structural homology of terminase, two were based on amino acid sequence of these individual proteins, and one was based on overall genomic sequence alignment. Phylogenetic trees were compared to evaluate diff erences between amino acid sequence and structural homology. Visualizing the predicted relationships from amino acid sequences and structural analysis of phage proteins will provide a new perspective on the evolution of the virosphere.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72595305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Novel Innovations: Iron and Manganese Nanoparticles Produced Using a Spark Discharge System 应用新颖的创新:铁和锰纳米颗粒生产使用火花放电系统

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1522

Kaushal Prasad

引用次数: 0

Continuous Liquid-Liquid Extraction of Lomustine Synthesis 连续液-液萃取法合成洛莫司汀

Journal of Purdue Undergraduate Research Pub Date : 2021-10-27 DOI: 10.7771/2158-4052.1514

Devna Grover

{"title":"Continuous Liquid-Liquid Extraction of Lomustine Synthesis","authors":"Devna Grover","doi":"10.7771/2158-4052.1514","DOIUrl":"https://doi.org/10.7771/2158-4052.1514","url":null,"abstract":"Lomustine, which is a chemotherapy drug that treats Hodgkin’s lymphoma and brain tumors, had a price increase of 1,400% in 2014. The increased price raised concerns that the potentially lifesaving drug may not be prescribed to patients. The objective of this project is to develop a new end-to-end manufacturing process that enables the in-house manufacturing of Lomustine. The poster aims to determine key process parameters for a liquid-liquid extraction unit operation. The hypothesis for the unit operation is that a minimum impurity profile can be achieved in the organic phase of continuous-flow liquid-liquid extraction by varying critical process parameters. This profile was determined by implementing solvent selection, designing a conducive design of experiments, and analyzing the experimental results with high-pressure liquid chromatography. The process was repeated and edited to accommodate learnings through the experiments conducted. Partition coefficient calculated experimentally showed the best value at 0.36. The percentage of extraction of impurities was also calculated at 82%, which showcased a clear decrease in the impurity of the main process stream. The researchers anticipate that with a purer product stream, the manufacturing process will have less byproduct formation.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":"89 sup1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81274078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0