Case Reports in Transplantation最新文献

Distal Allograft Pancreatectomy After Pancreas Transplantation: A Case Report and Review of Literature. 胰腺移植后远端同种异体胰腺切除术1例报告及文献复习。

Case Reports in Transplantation Pub Date : 2026-05-04 eCollection Date: 2026-01-01 DOI: 10.1155/crit/6655739

Eriselda Keshi, Brigitta Globke, Charlie Alexander Hamm, Andreas Kahl, Johann Pratschke, Robert Öllinger, Nathanael Raschzok

引用次数: 0

EBV-Negative Post-Lung Transplant Lymphoma Diagnosed via Paracentesis: A Case Report and Literature Review. 肺泡穿刺诊断ebv阴性肺移植后淋巴瘤1例报告及文献复习。

Case Reports in Transplantation Pub Date : 2026-04-09 eCollection Date: 2026-01-01 DOI: 10.1155/crit/3950122

Pooja Suchday, Rutvik Raval, Aneeket Marwaah, Deepa Jagadeesh, Atul C Mehta

{"title":"EBV-Negative Post-Lung Transplant Lymphoma Diagnosed via Paracentesis: A Case Report and Literature Review.","authors":"Pooja Suchday, Rutvik Raval, Aneeket Marwaah, Deepa Jagadeesh, Atul C Mehta","doi":"10.1155/crit/3950122","DOIUrl":"https://doi.org/10.1155/crit/3950122","url":null,"abstract":"Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation. While usually Epstein-Barr virus (EBV)-positive PTLD, EBV-negative PTLD is a distinct, typically late-onset, and aggressive entity. A 66-year-old man developed progressive abdominal distension and anemia 11 years after bilateral lung transplantation for idiopathic pulmonary fibrosis. Paracentesis with flow cytometry of ascitic fluid revealed a monoclonal B-cell population (CD10, CD19, and CD20 positive). EBV PCR and EBER chromogenic in situ hybridization confirmed EBV negativity, establishing EBV-negative PTLD. Mycophenolate mofetil was discontinued, and tacrolimus levels were maintained at 6-8 ng/mL. Five additional EBV-negative PTLD cases after lung transplantation were identified in the literature; most occurred beyond 1 year, were diagnosed by biopsy, and had high mortality. EBV-negative PTLD is rare and often fatal. Ascitic fluid cytology can facilitate early, minimally invasive diagnosis, warranting high clinical suspicion in transplant recipients with unexplained ascites.","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2026 ","pages":"3950122"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Kidney Transplantation Outcomes Through Robotic-Assisted Paired Kidney Exchange: A Case Report. 通过机器人辅助配对肾脏交换提高肾脏移植效果：一例报告。

Case Reports in Transplantation Pub Date : 2026-03-08 eCollection Date: 2026-01-01 DOI: 10.1155/crit/9302274

Vitor Turra, Sarah Rombach, Joao Manzi, Simone Zaragoza, Giselle Guerra, Rodrigo Vianna, Phillipe Abreu

{"title":"Enhancing Kidney Transplantation Outcomes Through Robotic-Assisted Paired Kidney Exchange: A Case Report.","authors":"Vitor Turra, Sarah Rombach, Joao Manzi, Simone Zaragoza, Giselle Guerra, Rodrigo Vianna, Phillipe Abreu","doi":"10.1155/crit/9302274","DOIUrl":"https://doi.org/10.1155/crit/9302274","url":null,"abstract":"Chronic kidney disease (CKD) is a significant global health challenge with a rising prevalence, primarily affecting adults with underlying diabetes and hypertension. End-stage renal disease (ESRD), the most severe form of CKD, necessitates renal replacement therapy, such as dialysis or kidney transplantation, to sustain life. Although kidney transplantation offers superior survival and quality of life outcomes, the demand for donor kidneys far exceeds supply, leading to long waiting times and high mortality rates. Living donor kidney transplants demonstrate better outcomes, yet incompatibilities, such as blood type or human leukocyte antigen (HLA) sensitization, limit donor-recipient matches. Paired kidney exchange (PKE) is an innovative strategy that facilitates transplants between HLA-incompatible or ABO-incompatible donor-recipient pairs, increasing the donor pool and improving compatibility. This case report presents a PKE performed robotically at the Miami Transplant Institute, involving two incompatible pairs. Both donor and recipient surgeries were conducted using robotic-assisted techniques, optimizing surgical precision and patient recovery. The robotic approach minimized complications, expedited recovery, and improved postoperative outcomes. This case underscores the potential of combining robotic surgery with PKE to address challenges in kidney transplantation, enhancing compatibility, and patient outcomes while reducing invasiveness and recovery time. Despite its promise, the widespread adoption of robotic-assisted PKE is limited by cost, accessibility, and the need for robust support and educational systems to encourage donor participation.","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2026 ","pages":"9302274"},"PeriodicalIF":0.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cold Case: Cold Agglutinin Disease Complicating Stem Cell Transplant. 一个冷病例：冷凝集素病并发干细胞移植。

Case Reports in Transplantation Pub Date : 2026-02-24 eCollection Date: 2026-01-01 DOI: 10.1155/crit/6270387

Majed W Al-Nazer, Sara Alsammerai, Hemalatha G Rangarajan, Rolla F Abu-Arja

{"title":"A Cold Case: Cold Agglutinin Disease Complicating Stem Cell Transplant.","authors":"Majed W Al-Nazer, Sara Alsammerai, Hemalatha G Rangarajan, Rolla F Abu-Arja","doi":"10.1155/crit/6270387","DOIUrl":"https://doi.org/10.1155/crit/6270387","url":null,"abstract":"Allogeneic hematopoietic cell transplants (HCTs) offer a curative option for patients with life-threatening hematologic diseases. While stem cell infusion reactions are common, they are generally not severe and typically do not affect engraftment. We present a rare case of isolated secondary cold agglutinin syndrome (CAS) in a donor, complicating the graft infusion and causing poor graft function (PGF) in a recipient. The 27-year-old recipient, diagnosed with refractory T-cell acute lymphoblastic leukemia (ALL), underwent a 9/10 HLA-mismatched unrelated peripheral blood stem cell transplant. The donor developed an upper respiratory infection 1 week before the donation, and cold agglutinin antibodies were detected in the donor's stem cell product. During infusion, the patient developed fever, tachycardia, and hypertension. Despite initial neutrophil engraftment and full donor chimerism, the patient remained transfusion-dependent, indicating PGF. A subsequent CD34-selected stem cell boost from the same donor on Day +108 posttransplant, confirmed to be CAS-negative, resulted in successful platelet engraftment and recovery. This case highlights the potential complications of CAS in donors, emphasizing the need for comprehensive donor evaluation and management strategies to mitigate adverse effects on recipients.","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2026 ","pages":"6270387"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Diagnosing and Managing Hepatitis E in Transplant Recipients: A Case Report. 移植受者诊断和管理戊型肝炎的挑战：一个病例报告。

Case Reports in Transplantation Pub Date : 2026-02-12 eCollection Date: 2026-01-01 DOI: 10.1155/crit/3747751

Ana Cristina Martins, Gonçalo Pimenta, André Mascarenhas, Rita Veríssimo, Sara Querido, André Weigert

{"title":"Challenges in Diagnosing and Managing Hepatitis E in Transplant Recipients: A Case Report.","authors":"Ana Cristina Martins, Gonçalo Pimenta, André Mascarenhas, Rita Veríssimo, Sara Querido, André Weigert","doi":"10.1155/crit/3747751","DOIUrl":"10.1155/crit/3747751","url":null,"abstract":"Hepatitis E virus (HEV) is a common but often underdiagnosed cause of hepatitis in both the general population and transplant patients. Diagnosis is usually made by detecting IgM anti-HEV antibodies, with immunosuppressed individuals being at higher risk for chronic infection. We present the case of a 56-year-old man who developed asymptomatic liver cytolysis 4 months after a kidney transplant, with no significant physical findings or relevant epidemiological history. Abdominal ultrasound revealed hepatic steatosis. Drug-induced liver injury was suspected, prompting the discontinuation of potential causative agents. However, liver enzymes worsened asymptomatically after 2 weeks, prompting further medication adjustments. Testing for Hepatitis B and C, as well as IgM for Toxoplasma, was negative. Serologies for herpes simplex and varicella zoster were positive for IgG and negative for IgM, and CMV viral load was undetectable. HEV serologies were negative for IgG and IgM. A liver biopsy revealed nonspecific acute hepatitis without fibrosis. The positive HEV plasma viral load was suggestive of Hepatitis E. As the patient was asymptomatic with no further analytical worsening, targeted treatment was not initiated. The patient achieved spontaneous viral clearance in less than 12 weeks, despite his immunocompromised condition. This case report highlights the diagnostic challenges of HEV hepatitis in immunosuppressed patients, as detection may rely solely on viral load testing due to potential serological negativity. This case also highlights that despite the patient's immunosuppressed condition, viral clearance is possible without the need for targeted antiviral therapy.","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2026 ","pages":"3747751"},"PeriodicalIF":0.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robot-Assisted Cystoprostatectomy for Muscle-Invasive Bladder Cancer in a Patient With a Prior Simultaneous Pancreas-Kidney Transplantation. 机器人辅助膀胱前列腺切除术治疗同时行胰肾移植的肌肉浸润性膀胱癌患者。

Case Reports in Transplantation Pub Date : 2026-02-06 eCollection Date: 2026-01-01 DOI: 10.1155/crit/9534770

Laetitia Lonca, Peter Beniac, Andrei Necsulescu, David Teixeira-Guerra, Bastien Parier, Jacques Irani, Sophie Ferlicot, Thomas Bessede, Renaud Snanoudj, Cedric Lebacle

{"title":"Robot-Assisted Cystoprostatectomy for Muscle-Invasive Bladder Cancer in a Patient With a Prior Simultaneous Pancreas-Kidney Transplantation.","authors":"Laetitia Lonca, Peter Beniac, Andrei Necsulescu, David Teixeira-Guerra, Bastien Parier, Jacques Irani, Sophie Ferlicot, Thomas Bessede, Renaud Snanoudj, Cedric Lebacle","doi":"10.1155/crit/9534770","DOIUrl":"10.1155/crit/9534770","url":null,"abstract":"Introduction: Kidney transplant recipients are at increased risk of malignancy due to chronic immunosuppression. Although rare (≈0.3%), bladder cancer in this population tends to be aggressive and may present with atypical symptoms. We report a case of muscle-invasive bladder cancer in a patient with prior simultaneous pancreas-kidney transplantation, successfully managed by fully intracorporeal robot-assisted radical cystoprostatectomy and urinary diversion.Presentation: A 46-year-old male with a history of a simultaneous pancreas and kidney transplantation presented with persistent storage lower urinary tract symptoms. Cystoscopy revealed a necrotic, atypical lesion with associated inflammatory changes. Preoperative CT urography showed thickening of the bladder dome, with peripheral enhancement and a calcified component. The patient underwent robot-assisted radical cystoprostatectomy with intracorporeal ileal conduit involving the transplanted kidney.Clinical discussion: This rare case highlights the importance of thorough urological evaluation in transplant recipients presenting with atypical urinary symptoms.Conclusion: This case demonstrates the feasibility and safety of fully intracorporeal robot-assisted cystoprostatectomy with urinary diversion in a patient with a simultaneous pancreas-kidney transplant.","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2026 ","pages":"9534770"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12877718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Disappearing Act: A Case of Emphysematous Pyelonephritis and a Vanishing Kidney Allograft. 消失的行为：一例肺气性肾盂肾炎和消失的异体肾移植。

Case Reports in Transplantation Pub Date : 2026-02-04 eCollection Date: 2026-01-01 DOI: 10.1155/crit/3760606

Laura Imarhiagbe, Manish Talwar, Barry M Wall, Vasanthi Balaraman, Zeina Khairy, Aimen Liaqat

引用次数: 0

Can Paracorporeal Bi-VAD Improve the Outcome of a Patient Candidate for Heart Transplant? 副躯体双vad能改善心脏移植患者的预后吗？

Case Reports in Transplantation Pub Date : 2025-12-04 eCollection Date: 2025-01-01 DOI: 10.1155/crit/5080204

Giuseppe Fischetti, Lorenzo Giovannico, Federica Mazzone, Nicola Di Bari, Domenico Parigino, Massimo Padalino, Tomaso Bottio

引用次数: 0

Novel Hybrid Approach to Portal Vein Thrombectomy Immediately Prior to Orthotopic Liver Transplantation. 原位肝移植前立即门静脉取栓的新型混合入路。

Case Reports in Transplantation Pub Date : 2025-11-29 eCollection Date: 2025-01-01 DOI: 10.1155/crit/8882747

Jonathan Jou, Brandon Pearson, Zachary Haber, Samer Ebaid

{"title":"Novel Hybrid Approach to Portal Vein Thrombectomy Immediately Prior to Orthotopic Liver Transplantation.","authors":"Jonathan Jou, Brandon Pearson, Zachary Haber, Samer Ebaid","doi":"10.1155/crit/8882747","DOIUrl":"10.1155/crit/8882747","url":null,"abstract":"Portal vein thrombosis (PVT) is common among liver transplant candidates, affecting up to 26% of patients awaiting liver transplant. Despite the suspected negative impact of PVT on liver transplant outcomes, consensus recommendations remain lacking. Thrombus circumvention is most commonly achieved with eversion portal thromboendovenectomy or venous jump graft. We present a novel hybrid approach addressing PVT in a patient with acute hepatic decompensation and worsening clot burden extending to the superior mesenteric and splenic veins. This patient underwent a transjugular intrahepatic portosystemic shunt (TIPS) placement and endovascular thrombectomy of the splanchnic veins less than 24 h prior to undergoing an orthotopic liver transplant with the graft maintained on normothermic machine perfusion. Three-month postoperative scans demonstrated a patent portal venous system with trace residual clot burden. This is the first reported case utilizing a hybrid approach for a portal vein thrombus extending into the superior mesenteric and splenic veins with subsequent orthotopic liver transplant.","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2025 ","pages":"8882747"},"PeriodicalIF":0.0,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12681409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fecal Impaction: An Unusual Cause of Acute Kidney Injury in a Kidney Transplant Recipient. 粪便嵌塞：肾移植受者急性肾损伤的不寻常原因。

Case Reports in Transplantation Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI: 10.1155/crit/5726025

Hafsa Tariq, Madhuri Ramakrishnan, Pablo Portocarrero, Mallika Gupta, Nicholas Herrera, Jeffrey Klein, Aditi Gupta, Diane Cibrik

{"title":"Fecal Impaction: An Unusual Cause of Acute Kidney Injury in a Kidney Transplant Recipient.","authors":"Hafsa Tariq, Madhuri Ramakrishnan, Pablo Portocarrero, Mallika Gupta, Nicholas Herrera, Jeffrey Klein, Aditi Gupta, Diane Cibrik","doi":"10.1155/crit/5726025","DOIUrl":"10.1155/crit/5726025","url":null,"abstract":"Acute kidney injury (AKI) is common in kidney transplant recipients, and the etiology varies depending on the time since transplantation. We present an uncommon case of AKI from obstructive uropathy 7 years posttransplant in a 47-year-old Caucasian male with moderate intellectual disability and end-stage kidney disease secondary to glomerulonephritis who received a deceased donor kidney transplant. He presented with abdominal pain, lethargy, hypercalcemia, and AKI. However, though his serum calcium level improved with intravenous fluid resuscitation, the AKI did not improve. Kidney transplant ultrasound showed hydronephrosis of the transplant ureter, and a noncontrast abdominal and pelvic computed tomography scan showed fecal impaction as the cause of obstruction of the transplanted ureter. The patient underwent fecal disimpaction resulting in the resolution of his hydronephrosis and return of his kidney function to baseline. Although a few case reports have been published of fecal impaction causing AKI due to obstruction of native ureters, to our knowledge, this is the first case describing AKI from fecal impaction in an adult kidney transplant recipient.","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2025 ","pages":"5726025"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0