Case Reports in Hepatology最新文献_第4页

Postliver Transplantation Rhino-Orbital Mucormycosis, an Unexpected Cause of a Downhill Course 肝移植后鼻-眶毛霉菌病，一个意想不到的下坡过程的原因

Case Reports in Hepatology Pub Date : 2022-05-28 DOI: 10.1155/2022/5413315

Swapnali Sabhapandit, Mithun Sharma, A. Sekaran, B. Menon, A. Kulkarni, Soumya Tr, P. Nagaraja Rao, D. Nageshwar Reddy

引用次数: 1

A Rare Cause of Haemorrhagic Shock: Rupture of Gastric Wall Seeding of Hepatocellular Carcinoma. 出血性休克的罕见病因:肝细胞癌胃壁破裂。

Case Reports in Hepatology Pub Date : 2022-03-12 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6560834

Naoki Ishimaru, Hirohisa Fujikawa, Kazuya Niwa, Yoshifumi Kobayashi

引用次数: 0

Treatment-Resistant Hepatitis C Viral Infection: A Case Report and Literature Review. 难治性丙型肝炎病毒感染1例报告及文献复习。

Case Reports in Hepatology Pub Date : 2022-03-11 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3556780

Victoria Green, Marina Roytman

{"title":"Treatment-Resistant Hepatitis C Viral Infection: A Case Report and Literature Review.","authors":"Victoria Green, Marina Roytman","doi":"10.1155/2022/3556780","DOIUrl":"https://doi.org/10.1155/2022/3556780","url":null,"abstract":"Hepatitis C virus (HCV) is an ongoing global public health threat affecting millions worldwide. Increasing recognition of its impact and recent advances towards HCV prevention and cure have provided incentive for the World Health Organization to call for global elimination by 2030. The goal of therapy is to achieve a sustained virologic response (SVR-12), defined as undetectable HCV-RNA within 12 weeks after treatment completion. In 2011, approval was given for the first direct-acting antiviral agents (DAAs). More recently, in 2013, more effective DAAs, with pan-genomic properties, have been introduced, and these regimens boast increasing rates of SVR. The ultimate goal is that the history of HCV ends with the pan-genotypic efficacy of multiple, easy-to-use and tolerate, combination regimens. These regimens have already demonstrated the ability to cure previously challenging patient groups. However, limitations exist in the current portfolio of agents, with suboptimal outcomes for patients with HCV genotype 3. In addition to this, access to DAAs remains an obstacle for many patients. We present this case of a 61-year-old male with HCV genotype 3 who has had several treatment failures with standard HCV therapy who was eventually approved for compassionate use of a 16-week course of glecaprevir (GLE)/pibrentasvir (PIB), sofosbuvir (SOF), and ribavirin (RBV) which ultimately led to SVR-12.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":" ","pages":"3556780"},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40308782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Possible Paternal Hepatitis B Virus Infection with Different Clinical Courses between Siblings: A Report of Two Cases 兄弟姐妹之间可能存在的不同临床病程的父亲乙型肝炎病毒感染:两例报告

Case Reports in Hepatology Pub Date : 2022-03-07 DOI: 10.1155/2022/5812135

Y. Sasaki, H. Kajino

引用次数: 1

Plasmapheresis for Pembrolizumab-Induced Hepatitis in a Patient with Squamous Cell Carcinoma and Prior Orthotopic Liver Transplantation. 血浆置换治疗鳞状细胞癌和既往原位肝移植患者的肝炎。

Case Reports in Hepatology Pub Date : 2022-01-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5908411

Sanaa Al-Nattah, Kusum Lata Sharma, Matthew Caldis, Erin Spengler, William Nicholas Rose

{"title":"Plasmapheresis for Pembrolizumab-Induced Hepatitis in a Patient with Squamous Cell Carcinoma and Prior Orthotopic Liver Transplantation.","authors":"Sanaa Al-Nattah, Kusum Lata Sharma, Matthew Caldis, Erin Spengler, William Nicholas Rose","doi":"10.1155/2022/5908411","DOIUrl":"https://doi.org/10.1155/2022/5908411","url":null,"abstract":"Checkpoint inhibitor therapy with monoclonal antibodies against programmed cell death protein 1 (PD1) has been implemented in the treatment of numerous malignancies. Pembrolizumab is one such medication. While severe toxicities are very rare, mild immune-mediated reactions with a variety of end organ injuries are among the most commonly encountered adverse events attributed to these medications. Acute liver injury manifesting as biochemical abnormalities with or without synthetic dysfunction is one such potential adverse reaction. Rarely, a relatively severe hepatitis can occur. While such severe adverse events are often successfully managed with systemic corticosteroids and drug discontinuation, our patient was refractory to standard management. We present a case of pembrolizumab-induced hepatitis in a patient with squamous cell carcinoma and prior orthotopic liver transplantation. Through a combination of serial plasmapheresis and intravenous immunoglobulin(IVIG) infusion, the patient's hepatitis resolved as evidenced by virtual normalization of his liver indices. This illustrates the effectiveness of a relatively novel treatment strategy for this rare side effect of checkpoint inhibitor antineoplastic therapy.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":" ","pages":"5908411"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39872123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation. 肝移植后顽固性癫痫发作升级至巴比妥酸盐诱导昏迷。

Case Reports in Hepatology Pub Date : 2022-01-10 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9311922

Brittany Miles, Muhammad Mujtaba, Shehzad Merwat, Rupak Kulkarni, Jeffrey Fair, Michael Kueht

引用次数: 0

De Novo Autoimmune Hepatitis after COVID-19 Infection in an Unvaccinated Patient. 未接种疫苗患者COVID-19感染后自身免疫性肝炎的发生

Case Reports in Hepatology Pub Date : 2022-01-01 DOI: 10.1155/2022/8409269

Francisco A Durazo, Kelly Kristbaum, James Miller, Kia Saeian, Motaz Selim, Johnny C Hong

引用次数: 5

Cytomegalovirus Cholangiopathy in an Immunocompetent Patient: A Case Report and Literature Review. 免疫功能正常患者巨细胞病毒胆管病1例报告及文献复习。

Case Reports in Hepatology Pub Date : 2021-11-10 eCollection Date: 2021-01-01 DOI: 10.1155/2021/2420668

Ervin Alibegovic, Admir Kurtcehajic, Boris Ilic, Ahmed Hujdurovic, Edinka Smajic, Amar Habibovic, Darja Perkunic

{"title":"Cytomegalovirus Cholangiopathy in an Immunocompetent Patient: A Case Report and Literature Review.","authors":"Ervin Alibegovic, Admir Kurtcehajic, Boris Ilic, Ahmed Hujdurovic, Edinka Smajic, Amar Habibovic, Darja Perkunic","doi":"10.1155/2021/2420668","DOIUrl":"https://doi.org/10.1155/2021/2420668","url":null,"abstract":"A 37-year-old man presented with jaundice, upper right quadrant pain, and intermittent fever with chills. Laboratory assessment showed biliary stasis, with total bilirubin of 203 µmol/L (2-20), conjugated bilirubin of 105 µmol/L, and alkaline phosphatase of 556 U/L (30-120). Markers for hepatitis A-E viruses were negative. Serology assessment for rubeola, herpes simplex virus, Epstein-Barr virus, and Toxoplasma gondii showed negative IgM antibodies. HIV serology status was negative. For cytomegalovirus, both types of antibodies (IgM and IgG) were positive, with an IgM level >300 U/mL. pp65 antigen was also detected as well as CMV DNA. Diagnostic imaging of the abdomen except the dilated common bile duct showed a normal appearance of the gallbladder, liver, pancreas, spleen, and both kidneys. To our knowledge, cytomegalovirus cholangiopathy in the absence of any other underlying disease has not been reported. Therefore, the presence of cholangiopathy in our patient is interesting from an imaging, laboratory, and clinical point of view.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2021 ","pages":"2420668"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39897528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Veillonella Bacteremia in Alcoholic Hepatitis. 酒精性肝炎中的细络菌菌血症。

Case Reports in Hepatology Pub Date : 2021-10-13 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9947213

Patrick Lee, Brandon K K Fields, Tom Liang, Michael P Dubé, Seth Politano

引用次数: 5

A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia. 丙型肝炎致混合性冷球蛋白血症1例。

Case Reports in Hepatology Pub Date : 2021-10-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8244432

Sameeha Khalid, Dhuha Alhankawi, Kamalmeet Kaur, Ali Ali, Anna Kazaryan, Marina Roytman

引用次数: 1