Tuberculosis Research and Treatment最新文献_第10页

Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin. 贝宁肺结核再治疗患者的特点及治疗效果。

Tuberculosis Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-03-24 DOI: 10.1155/2016/1468631

Serge Ade, Omer Adjibodé, Prudence Wachinou, Narcisse Toundoh, Bérénice Awanou, Gildas Agodokpessi, Dissou Affolabi, Gabriel Adè, Anthony D Harries, Séverin Anagonou

{"title":"Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin.","authors":"Serge Ade, Omer Adjibodé, Prudence Wachinou, Narcisse Toundoh, Bérénice Awanou, Gildas Agodokpessi, Dissou Affolabi, Gabriel Adè, Anthony D Harries, Séverin Anagonou","doi":"10.1155/2016/1468631","DOIUrl":"https://doi.org/10.1155/2016/1468631","url":null,"abstract":"Objective. To determine among retreatment tuberculosis patients in Benin baseline characteristics, culture, and drug sensitivity testing (DST) results and treatment outcomes. Materials and Methods. A retrospective national cohort study of all retreatment tuberculosis patients in Benin in 2013 using registers and treatment cards. Results. Of 3957 patients with tuberculosis, 241 (6%) were retreatment cases. Compared to new pulmonary bacteriologically confirmed tuberculosis (NPBCT) patients, there were significantly higher numbers of males (P = 0.04), patients from \"Atlantique-Littoral\" (P = 0.006), patients aged 45-64 years (P = 0.007), and HIV-positive patients (P = 0.04) among those retreated. Overall, 171 (71%) patients submitted sputum for DST, of whom (163) 95% were positive for Mycobacterium tuberculosis on Xpert MTB/RIF and/or culture and 17 (10%) were rifampicin resistant (9 with MDR-TB and 8 monoresistant to rifampicin). For those without MDR-TB (n = 224), treatment success was 93%. Worse outcomes occurred in those with unknown HIV status (RR: 0.27; 0.05-1.45; P < 0.01) while better outcomes occurred in those who relapsed (RR: 1.06, 95 CI: 1.02-1.10, P = 0.04). Conclusion. In 2013, a high proportion of retreatment patients received DST. Treatment success was good although more needs to be done to systematically increase the final follow-up smear examination. Reasons of high losses to follow-up from \"Oueme-Plateau\" should be investigated. ","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2016 ","pages":"1468631"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1468631","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34429117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Qualitative Assessment of Challenges in Tuberculosis Control in West Gojjam Zone, Northwest Ethiopia: Health Workers' and Tuberculosis Control Program Coordinators' Perspectives. 埃塞俄比亚西北部西Gojjam地区结核病控制挑战的定性评估:卫生工作者和结核病控制项目协调员的观点。

Tuberculosis Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-03-15 DOI: 10.1155/2016/2036234

Senedu B Gebreegziabher, Solomon A Yimer, Gunnar A Bjune

{"title":"Qualitative Assessment of Challenges in Tuberculosis Control in West Gojjam Zone, Northwest Ethiopia: Health Workers' and Tuberculosis Control Program Coordinators' Perspectives.","authors":"Senedu B Gebreegziabher, Solomon A Yimer, Gunnar A Bjune","doi":"10.1155/2016/2036234","DOIUrl":"https://doi.org/10.1155/2016/2036234","url":null,"abstract":"Background. Weak health systems pose many barriers to effective tuberculosis (TB) control. This study aimed at exploring health worker's and TB control program coordinator's perspectives on health systems challenges facing TB control in West Gojjam Zone, Amhara Region, Ethiopia. Methods. This was a qualitative descriptive study. Eight in-depth interviews with TB control program coordinators and two focus group discussions among 16 health workers were conducted. Purposive sampling was used to recruit study participants. Thematic analysis was used to identify and analyse main themes. Results. We found that intermittent interruptions of laboratory reagents and anti-TB drugs supplies, absence of trained and motivated health workers, poor TB data documentation, lack of adherence to TB treatment guideline, and lack of access to TB diagnostic tools at peripheral health institutions were challenges facing the TB control program performance in the study zone. Conclusions. Ensuring uninterrupted supply of anti-TB drugs and laboratory reagents to all health institutions is essential. Continuous refresher training of health workers on standard TB care and data handling and developing and implementing a sound retention strategy to attract and motivate health professionals to work in rural areas are necessary interventions to improve the TB control program performance in the study zone. ","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2016 ","pages":"2036234"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2036234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34392912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

The Use of Xpert MTB/Rif for Active Case Finding among TB Contacts in North West Province, South Africa. 使用专家MTB/Rif在南非西北省结核接触者中主动发现病例

Tuberculosis Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-07-14 DOI: 10.1155/2016/4282313

Limakatso Lebina, Nigel Fuller, Tolu Osoba, Lesley Scott, Katlego Motlhaoleng, Modiehi Rakgokong, Pattamukkil Abraham, Ebrahim Variava, Neil Alexander Martinson

{"title":"The Use of Xpert MTB/Rif for Active Case Finding among TB Contacts in North West Province, South Africa.","authors":"Limakatso Lebina, Nigel Fuller, Tolu Osoba, Lesley Scott, Katlego Motlhaoleng, Modiehi Rakgokong, Pattamukkil Abraham, Ebrahim Variava, Neil Alexander Martinson","doi":"10.1155/2016/4282313","DOIUrl":"https://doi.org/10.1155/2016/4282313","url":null,"abstract":"Introduction. Tuberculosis is a major cause of morbidity and mortality especially in high HIV burden settings. Active case finding is one strategy to potentially reduce TB disease burden. Xpert MTB/Rif has recently been recommended for diagnosis of TB. Methods. Pragmatic randomized trial to compare diagnosis rate and turnaround time for laboratory testing for Xpert MTB/Rif with TB microscopy and culture in household contacts of patients recently diagnosed with TB. Results. 2464 household contacts enrolled into the study from 768 active TB index cases. 1068 (44%) were unable to give sputum, but 24 of these were already on TB treatment. 863 (53%) participants sputum samples were tested with smear and culture and 2.7% (23/863; CI: 1.62-3.78) were diagnosed with active TB. Xpert MTB/Rif was used in 515 (21%) participants; active TB was diagnosed in 1.6% (8/515; CI: 0.52-2.68). Discussion and Conclusions. Additional 31 cases were diagnosed with contact tracing of household members. When Xpert MTB/Rif is compared with culture, there is no significant difference in diagnostic yield. ","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2016 ","pages":"4282313"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4282313","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34734481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Characteristics and Treatment Outcomes of "Transfer-Out" Pulmonary Tuberculosis Patients in Gondar, Ethiopia. 埃塞俄比亚贡达尔“转出”肺结核患者的特点和治疗结果

Tuberculosis Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-05-30 DOI: 10.1155/2016/1294876

Tadesse Belayneh, Afework Kassu, Desalgne Tigabu, Gashaw Asmare, Sofanit Tilaye, Eveline Klinkenberg

{"title":"Characteristics and Treatment Outcomes of \"Transfer-Out\" Pulmonary Tuberculosis Patients in Gondar, Ethiopia.","authors":"Tadesse Belayneh, Afework Kassu, Desalgne Tigabu, Gashaw Asmare, Sofanit Tilaye, Eveline Klinkenberg","doi":"10.1155/2016/1294876","DOIUrl":"https://doi.org/10.1155/2016/1294876","url":null,"abstract":"Background. During tuberculosis treatment, patients may transfer to continue treatment at another health facility. To ensure adherence until treatment completion, keeping track of patients is paramount. This study aimed to investigate treatment outcomes of patients who transferred out from the University of Gondar Hospital. Methods. This was a retrospective cohort evaluation of patients registered from 2009 to 2013. Treatment outcomes were collected from the TB registers of receiving units using a standardized data capture format. Results. During the study period 3,707 patients initiated treatment and 47.5% (1,760) transferred out. The study evaluated the outcome of 26% (457/1,760) patients, of whom 403 (88%) arrived in the receiving units. Overall, 79% were successfully treated and 13.8% transferred out for a second time. For all transferred-out cases, treatment outcomes were not reported to the referring unit. Conclusion and Recommendation. About half of the patients were transferred out to complete treatment elsewhere. Although successful treatment outcome was obtained in 79% of patients, these results were not fed back to the referring unit. Implementing a clear mechanism to communicate the arrival of and treatment outcome for transfer-out patients and appropriate patient education on treatment unit selection before treatment and during transfer-out are recommended. ","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2016 ","pages":"1294876"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1294876","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34585622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Endobronchial Tuberculosis Mimicking Asthma 支气管内结核模拟哮喘

Tuberculosis Research and Treatment Pub Date : 2015-12-20 DOI: 10.1155/2015/781842

Serap Argun Barış, T. Onyilmaz, I. Basyigit, H. Boyacı

引用次数: 11

Performance of LED Fluorescence Microscopy for the Diagnosis of Pulmonary Tuberculosis in HIV Positive Individuals in Addis Ababa, Ethiopia LED荧光显微镜在埃塞俄比亚亚的斯亚贝巴HIV阳性个体中诊断肺结核的性能

Tuberculosis Research and Treatment Pub Date : 2015-11-24 DOI: 10.1155/2015/794064

Konjit Getachew, T. Abebe, A. Kebede, A. Mihret, Getachew Melkamu

{"title":"Performance of LED Fluorescence Microscopy for the Diagnosis of Pulmonary Tuberculosis in HIV Positive Individuals in Addis Ababa, Ethiopia","authors":"Konjit Getachew, T. Abebe, A. Kebede, A. Mihret, Getachew Melkamu","doi":"10.1155/2015/794064","DOIUrl":"https://doi.org/10.1155/2015/794064","url":null,"abstract":"Background. Despite its lower sensitivity, smear microscopy remains the main diagnostic method for pulmonary tuberculosis (PTB) in resource-limited countries as TB culturing methods like LJ (Lowenstein-Jensen) are expensive to use as a routine base. This study aimed to evaluate the performance of LED-FM for the diagnosis of PTB in HIV positive individuals. Methods. Cross-sectional study was conducted in Zewditu Memorial Hospital and Teklehaimanot Health Center HIV/ART clinics in Addis Ababa, Ethiopia. Each sample was stained with ZN and Auramine O staining and examined with bright-field microscope and LED-FM microscope, respectively. LJ culture was used as a reference. Results. Out of 178 study participants, twenty-four (13.5%) patients were confirmed as positive for MTB with LJ culture. The yield of ZN microscopy and LED-FM in direct and concentrated sample was 3.9%, 8.4%, 6.2%, and 8.4%, respectively. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of direct ZN microscopy were 29.2%, 100%, 100%, and 90.1%, respectively, and of LED-FM microscopy in direct sputum sample were 62.5%, 100%, 100%, and 94.5%, respectively. Conclusion. LED-FM has better sensitivity for the diagnosis of PTB in HIV positive individuals as compared to conventional ZN microscopy. LED-FM can be used as an alternative to conventional ZN microscopy.","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/794064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65151038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Association of Genetic Polymorphisms of IFNGR1 with the Risk of Pulmonary Tuberculosis in Zahedan, Southeast Iran 伊朗东南部扎黑丹地区IFNGR1基因多态性与肺结核发病风险的关系

Tuberculosis Research and Treatment Pub Date : 2015-11-15 DOI: 10.1155/2015/292505

M. Naderi, M. Hashemi, M. Rezaei, A. Safdari

{"title":"Association of Genetic Polymorphisms of IFNGR1 with the Risk of Pulmonary Tuberculosis in Zahedan, Southeast Iran","authors":"M. Naderi, M. Hashemi, M. Rezaei, A. Safdari","doi":"10.1155/2015/292505","DOIUrl":"https://doi.org/10.1155/2015/292505","url":null,"abstract":"Aim. The present study was undertaken to find out the possible association between interferon-gamma (IFN-γ) receptor 1 (IFNGR1) gene polymorphisms and risk of pulmonary tuberculosis (PTB) in a sample of Iranian population. Methods. Polymorphisms of IFNGR1 rs1327474 (−611 A/G), rs11914 (+189 T/G), rs7749390 (+95 C/T), and rs137854905 (27-bp ins/del) were determined in 173 PTB patients and 164 healthy subjects. Results. Our findings showed that rs11914 TG genotypes decreased the risk of PTB in comparison with TT (OR = 0.36, 95% CI = 0.21–0.62, and p = 0.0002). The rs11914 G allele decreased the risk of PTB compared with T allele (OR = 0.41, 95% CI = 0.25–0.68, and p = 0.0006). IFNGR1 rs7749390 CT genotype decreased the risk of PTB in comparison with CC genotype (OR = 0.55, 95% CI = 0.32–0.95, and p = 0.038). No significant association was found between IFNGR1 rs1327474 A/G polymorphism and risk/protective of PTB. The rs137854905 (27-bp I/D) variant was not polymorphic in our population. Conclusion. Our findings showed that IFNGR1 rs11914 and rs7749390 variants decreased the risk of PTB susceptibility in our population.","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/292505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64887559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Five-year assessment of time of sputum smears conversion and outcome and risk factors of tuberculosis patients in central iran. 伊朗中部地区结核病患者痰涂片转化时间及预后和危险因素的五年评估。

Tuberculosis Research and Treatment Pub Date : 2015-01-01 Epub Date: 2015-01-14 DOI: 10.1155/2015/609083

Fatemah Behnaz, Mahmoud Mohammadzadeh, Golnaz Mohammadzade

{"title":"Five-year assessment of time of sputum smears conversion and outcome and risk factors of tuberculosis patients in central iran.","authors":"Fatemah Behnaz, Mahmoud Mohammadzadeh, Golnaz Mohammadzade","doi":"10.1155/2015/609083","DOIUrl":"https://doi.org/10.1155/2015/609083","url":null,"abstract":"Objective. To evaluate risk factors which influence sputum smear conversion, outcome, and trends of conversion of sputum smear during 5 years and compare outcomes in patients with different regimens. Methods. In a retrospective cohort study, all patients with sputum smear positive tuberculosis were evaluated for comorbidities and demographic, microbiological, and therapeutic data and outcome. Smear examinations were performed at the beginning, at 2 months for CAT I, at 3 months for CAT II, at the end of second month of maintenance phase, and at the end of treatment. Results. This study enrolled 211 sputum smear positive patients, but 189 patients who completed the intensive phase of treatment were evaluated. Sputum smear of 158 patients converted at the end of intensive phase (83.6). Univariate analysis indicated that the risk of a persistent positive smear at the end of intensive phase was greater in diabetic patients ((odds 4.038, 95% CI 1.123-14.516) P = 0.033), and also a 3+bacillary load had risk of 2.933-fold ((95% CI 1.278-6.732) P = 0.011). Overall rate of unfavorable outcome was 20.9%. Factors associated with unfavorable outcome were age (P value 0.000), male gender (P value 0.027), diabetes (P value 0.000), and delayed conversion of sputum at the end of intensive phase (P value 0.000). Outcome for different regimens was not different significantly. Two specimens were isoniazid resistant. Conclusions. We suggest supervised treatment and care for diabetic patients and those with higher bacillary load. Paying attention to early diagnosis of tuberculosis in the elderly to reduce poor outcome and further measures to prevent transfer-out could improve the success rate. ","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2015 ","pages":"609083"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/609083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33030109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. 坦桑尼亚结核性淋巴结炎患者抗炎、促炎血清细胞因子及趋化因子与性别、年龄相关的多重分析

Tuberculosis Research and Treatment Pub Date : 2015-01-01 Epub Date: 2015-04-28 DOI: 10.1155/2015/561490

Tehmina Mustafa, Karl Albert Brokstad, Sayoki G Mfinanga, Harald G Wiker

{"title":"Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients.","authors":"Tehmina Mustafa, Karl Albert Brokstad, Sayoki G Mfinanga, Harald G Wiker","doi":"10.1155/2015/561490","DOIUrl":"https://doi.org/10.1155/2015/561490","url":null,"abstract":"Objectives. Tuberculous lymphadenitis is the most common form of extrapulmonary tuberculosis (TB) with a female and paediatric preponderance, postulated to be due to differences in the immune response. The aim of this study was to analyze the differences in the serum cytokine levels of tuberculous lymphadenitis patients with respect to age and gender. Methods. A multiplex bead-based enzyme-linked immunosorbent assay was used to measure IFN-γ, TNF-α, GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-15, and IL-17 levels in sera of patients (n = 86) and healthy controls (n = 23). Results. Levels of IFN-γ, TNF-α, GM-CSF, IL-1β, IL-2, IL-4, and IL-6 were higher in adult patients than in controls, while those of IL-12 were lower (P < 0.05). Children had lower levels of TNF-α, GM-CSF, and IL-5 and higher levels of IL-2 compared with adult patients (P < 0.05). The male adult patients had higher levels of IL-17 and lower levels of IL-12 compared with female adult patients (P < 0.05). Conclusion. There were significant differences in the levels of circulating cytokines with respect to gender and age. Children had generally lower levels of cytokines as compared to adults, which could make them more susceptible. Findings do not support that female preponderance is due to differences in immune response. ","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2015 ","pages":"561490"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/561490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33376559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Evaluation of a u.s. Public health laboratory service for the molecular detection of drug resistant tuberculosis. 美国公共卫生实验室服务对耐药结核病分子检测的评价。

Tuberculosis Research and Treatment Pub Date : 2015-01-01 Epub Date: 2015-02-22 DOI: 10.1155/2015/701786

Mitchell A Yakrus, Beverly Metchock, Angela M Starks

{"title":"Evaluation of a u.s. Public health laboratory service for the molecular detection of drug resistant tuberculosis.","authors":"Mitchell A Yakrus, Beverly Metchock, Angela M Starks","doi":"10.1155/2015/701786","DOIUrl":"https://doi.org/10.1155/2015/701786","url":null,"abstract":"Crucial to interrupting the spread of tuberculosis (TB) is prompt implementation of effective treatment regimens. We evaluated satisfaction, comfort with interpretation, and use of molecular results from a public health service provided by the Centers for Disease Control and Prevention (CDC) for the molecular detection of drug resistant Mycobacterium tuberculosis complex (MTBC). An electronic survey instrument was used to collect information anonymously from U.S. Public Health Laboratories (PHL) that submitted at least one isolate of MTBC to CDC from September 2009 through February 2011. Over 97% of those responding expressed satisfaction with the turnaround time for receiving results. Twenty-six PHL (74%) reported molecular results to healthcare providers in less than two business days. When comparing the molecular results from CDC with their own phenotypic drug susceptibility testing, 50% of PHL observed discordance. No respondents found the molecular results difficult to interpret and 82% were comfortably discussing them with TB program officials and healthcare providers. Survey results indicate PHL were satisfied with CDC's ability to rapidly provide interpretable molecular results for isolates of MTBC submitted for determination of drug resistance. To develop educational materials and strategies for service improvement, reasons for discordant results and areas of confusion need to be identified. ","PeriodicalId":30261,"journal":{"name":"Tuberculosis Research and Treatment","volume":"2015 ","pages":"701786"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/701786","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6