Association of Genetic Polymorphisms of IFNGR1 with the Risk of Pulmonary Tuberculosis in Zahedan, Southeast Iran

Tuberculosis Research and Treatment Pub Date : 2015-11-15 DOI:10.1155/2015/292505

M. Naderi, M. Hashemi, M. Rezaei, A. Safdari

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引用次数: 14

Abstract

Aim. The present study was undertaken to find out the possible association between interferon-gamma (IFN-γ) receptor 1 (IFNGR1) gene polymorphisms and risk of pulmonary tuberculosis (PTB) in a sample of Iranian population. Methods. Polymorphisms of IFNGR1 rs1327474 (−611 A/G), rs11914 (+189 T/G), rs7749390 (+95 C/T), and rs137854905 (27-bp ins/del) were determined in 173 PTB patients and 164 healthy subjects. Results. Our findings showed that rs11914 TG genotypes decreased the risk of PTB in comparison with TT (OR = 0.36, 95% CI = 0.21–0.62, and p = 0.0002). The rs11914 G allele decreased the risk of PTB compared with T allele (OR = 0.41, 95% CI = 0.25–0.68, and p = 0.0006). IFNGR1 rs7749390 CT genotype decreased the risk of PTB in comparison with CC genotype (OR = 0.55, 95% CI = 0.32–0.95, and p = 0.038). No significant association was found between IFNGR1 rs1327474 A/G polymorphism and risk/protective of PTB. The rs137854905 (27-bp I/D) variant was not polymorphic in our population. Conclusion. Our findings showed that IFNGR1 rs11914 and rs7749390 variants decreased the risk of PTB susceptibility in our population.

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伊朗东南部扎黑丹地区IFNGR1基因多态性与肺结核发病风险的关系

的目标。本研究旨在发现干扰素-γ (IFN-γ)受体1 (IFNGR1)基因多态性与伊朗人群中肺结核(PTB)风险之间可能存在的关联。方法。在173例肺结核患者和164名健康受试者中检测到IFNGR1 rs1327474 (- 611 A/G)、rs11914 (+189 T/G)、rs7749390 (+95 C/T)和rs137854905 (27 bp ins/del)多态性。结果。我们的研究结果显示，与TT相比，rs11914 TG基因型降低了PTB的风险(OR = 0.36, 95% CI = 0.21-0.62, p = 0.0002)。与T等位基因相比，rs11914 G等位基因降低了PTB的风险(OR = 0.41, 95% CI = 0.25-0.68, p = 0.0006)。与CC基因型相比，IFNGR1 rs7749390 CT基因型降低了PTB的风险(OR = 0.55, 95% CI = 0.32-0.95, p = 0.038)。IFNGR1 rs1327474 A/G多态性与PTB发病风险/保护性无显著相关性。rs137854905 (27-bp I/D)在人群中不存在多态性。结论。我们的研究结果表明，IFNGR1 rs11914和rs7749390变异降低了我们人群中PTB易感性的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tuberculosis Research and Treatment

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审稿时长

17 weeks