IEEE Ultrasonics Symposium, 2005.最新文献

{"title":"Improved spatiotemporal voxel space interpolation for 3D echocardiography with irregular sampling and multibeat fusion","authors":"J. Bosch, M. van Stralen, M. Voormolen, B. Krenning, C. Lancée, J. Reiber, A. V. D. van der Steen, N. de Jong","doi":"10.1109/ULTSYM.2005.1603074","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1603074","url":null,"abstract":"We developed a novel multi-beat image fusion technique using a special spatiotemporal interpolation for sparse, irregularly sampled data (ISI). It is applied to irregularly distributed 3D cardiac ultrasound data acquired with the fast rotating ultrasound (FRU) transducer developed in our laboratory, a phased array rotating mechanically at very high speed (240-480rpm). High-quality 2D images are acquired at ~100 frames/s over 5-10 seconds. ISI was compared quantitatively to spatiotemporal nearest neighbor interpolation (STNI) on synthetic data and compared qualitatively to classical trilinear voxel interpolation on 10 in-vivo cardiac image sets. ISI showed considerably lower absolute distance errors than STNI. For in-vivo images, ISI voxel sets showed reduced motion artifacts, suppression of noise and interpolation artifacts and better delineation of endocardium. In conclusion, ISI improves the quality of 3D+T images acquired with a fast rotating transducer in simulated and in-vivo data.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121260516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ultrasonic intensity on the amyloid induced apoptosis of pc-12 cells","authors":"June-Yi Chiu, Shyh-Hau Wang, Show-Hui Chen, Wen-Tyng Li","doi":"10.1109/ULTSYM.2005.1603203","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1603203","url":null,"abstract":"Previous studies have shown that the effect of Amyloid-β (Aβ) on the induction of apoptosis could lead neuronal loss to the Alzheimer's disease. The stimulation by physical energy, such as optics, was found able to greatly diminish Aβ induced apoptosis. This study is to further explore the effect of different ultrasonic energies on the neuronal cells. The experiments were carried out using such precursor neuronal cells as PC-12 which was added with Aβ of a 20 µM concentration during pre-cultured preparation. These cells were subsequently stimulated by a 20% duty cycle ultrasound of different energies ranged from 50 to 150 mW(SATA) for three minutes. The cellular response under ultrasound exposure was assessed, 7 times within 48 hours after those cells were stimulated, using the microscopic morphology, cell death measured by the typical MTT assay, and DNA fragmentation assay. Results showed that stimulations by ultrasound intensities of lower and higher than 100 mW/cm 2 may respectively diminish and increase Aβ induced apoptosis compared to those control groups. Morphological results indicated that those cells stimulated by higher intensity ultrasounds tended to activate more differentiations in PC-12 discerned by morphological changes. This study demonstrated that the proliferation to diminish apoptosis and differentiation of neuronal cells could be regulated with the insonation of an appropriate ultrasonic intensity.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130321926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative relations between acoustic inertial cavitation and gene transfection rate/cell viability","authors":"Chun-Yen Lai, Chia-Hsuan Wu, C. Chen, Pai-Chi Li","doi":"10.1109/ULTSYM.2005.1603197","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1603197","url":null,"abstract":"Ultrasound has been utilized to assist gene transfection. In combination with ultrasound, microbubble-based contrast agents have also been used to enhance the transfection efficiency by inducing acoustic inertial cavitation. However, the relations between inertial cavitation and gene transfection rate/cell viability are still unknown. It is the primary purpose of this study to examine the relations experimentally and quantitatively. A commercial contrast agent Levovist ® was used, and","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123242054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustical investigation of freely moving single microbubbles","authors":"H. Vos, F. Guidi, E. Boni, P. Tortoli","doi":"10.1109/ULTSYM.2005.1602961","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1602961","url":null,"abstract":"A new approach to characterize full populations of contrast agents suspended in a water tank is presented. In particular, the movements of single bubbles due to ultrasound (US) radiation force are observed. The backscattered signal and bubble displacement measured in various experimental conditions are compared to predictions of a non-linear model describing both radial and translational bubble motion. Two different types of experiments have been performed to estimate viscoelastic properties and radial dimensions of thermoplastic shelled microballoons and BR14. First, maximum bubble velocities experienced by a full population insonified at frequencies ranging from 2 to 8 MHz have been measured. Such velocities have then been compared to those predicted by the model for resonant bubbles. The modeled shell properties have finally been updated to obtain a good fit over all frequencies. The diameters have been estimated by exploiting the non-linear behavior of single bubbles. In this case, the bubbles have been insonified by a 20 cycle 2 MHz burst with 490 kPa rarefactional pressure. The received relative second harmonic signal level and the bubble velocity are compared to values predicted by simulation for incrementing bubble radii, until a unique radius can be read.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127805908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly non-linear contrast agent oscillations: the compression-only behavior","authors":"S. van der Meer, P. Marmottant, S. Hilgenfeldt, M. Versluis, D. Lohse, C. Chin, A. Bouakaz, F. Mastik, M. Emmer, N. de Jong","doi":"10.1109/ULTSYM.2005.1603012","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1603012","url":null,"abstract":"Here we report the observation of a highly non-linear bubble response of phospholipid coated contrast agents, termed 'compression-only behavior' where the microbubbles only compress, yet hardly expand. The occurrence of this phenomenon has been studied retrospectively and it was found that 33% of the examined cases show this behavior. The compression-only behavior is described by a newly developed shell model for phospholipid coated bubbles. The model extends previous elastic models with shell compressibility, a buckling radius and a break-up tension. It also predicts large amplitude oscillations, and bubble break-up.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133901633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear imaging of targeted microbubbles with intravascular ultrasound","authors":"D. Goertz, A. van Wamel, M. Frijlink, N. de Jong, A. V. D. van der Steen","doi":"10.1109/ULTSYM.2005.1603270","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1603270","url":null,"abstract":"The nonlinear detection of targeted microbubbles at high ultrasound frequencies was investigated. A prototype nonlinear intravascular ultrasound (IVUS) system was employed using a 20 MHz fundamental frequency (F20) to examine 40 MHz second harmonic (H40) signals and a 40 MHz fundamental frequency (F40) to examine 20 MHz subharmonic (SH20) signals. An experimental biotinated micron to submicron lipid encapsulated agent was targeted to avidin coated agar-based tissue mimicking phantoms. An examination of bound bubble acoustic signatures demonstrated the feasibility of initiating H40 and SH20 signals. Imaging experiments showed improvements in contrast-to-tissue ratios (CTR) using both H40 and SH20 relative to fundamental frequency imaging. These results indicate the potential of high frequency nonlinear imaging as a means of improving the detection of targeted microbubbles.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116276848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double passive cavitation detection of Optison shell rupture","authors":"A. Ammi, R. Cleveland, Jonathan Mamou, G.I. Wang, S. Bridal, W. O’Brien","doi":"10.1109/ULTSYM.2005.1602982","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1602982","url":null,"abstract":"An improved understanding of ultrasound contrast agent (UCA) shell rupture is required to optimize therapeutic and diagnostic use. This experimental and theoretical study aims to explore the mechanism of UCA shell rupture by determining thresholds as a function of ultrasonic excitation parameters (driving frequency, pulse duration, and peak rarefactional pressure). The experimental setup is based on a passive cavitation detection system described in previous work. However, this system has been modified to allow simultaneous acquisition of the signals received with the 13-MHz passive receiver and the signals incident upon the lower frequency (0.9, 2.8 and 4.6 MHz) transmitting transducer functioning in the pulse-echo mode. Post-excitation signals were used to detect rupture thresholds. By allowing acquisition of the signals received by the insonifying transducer (pulse-echo during the excitation and passively at post-excitation) additional information is obtained within a frequency range and a transmission/reception configuration typical of ultrasonic diagnostic imaging. Data are analyzed to estimates the incident peak rarefactional pressure leading to 50% destruction. Comparison of experimental results with microbubble dynamics predicted using the Modified Herring equation was used to explore microbubble rupture indices based on radial expansion and peak velocity.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130753452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating antibubbles with ultrasound","authors":"M. Postema, N. de Jong, G. Schmitz, A. van Wamel","doi":"10.1109/ULTSYM.2005.1603013","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1603013","url":null,"abstract":"Ultrasound contrast agents have been investigated for their potential applications in local drug and gene delivery. A microbubble might act as the vehicle to carry a drug or gene load to a perfused region of interest. The load has to be released with the assistance of ultrasound. We investigate the suitability of antibubbles for ultrasound-assisted local delivery. As opposed to bubbles, antibubbles consist of a liquid core surrounded by a gas encapsulation. Incorporating a liquid drop containing drugs or genes inside an ultrasound contrast agent microbubble, however, is technically challenging. An ultrasound-insonified microbubble generates a pressure field that is inversely proportional to the distance from the mi- crobubble. Therefore, an oscillating contrast agent microbubble may create a surface instability with a relatively big bubble at a short distance. For big enough instabilities, a drop may be formed inside the big bubble. Three different contrast agents were subjected to 0.5 MHz ultrasound, with mechanical indices >0.6. The contrast agents were inserted through an artificial capillary which led through the acoustic focus of the transducer. High-speed photographs were captured at a speed of 3 million frames per second and higher. We observed that ultrasound contrast microbubbles below resonance size may create visible surface instabilities with bubbles above resonance size. With an albumin-shelled contrast agent, we induced a surface instability that was big enough to create an antibubble inside a free (unencapsulated) gas bubble with an 8 micron diameter. The surface instability has been attributed to the presence of a contrast microbubble with a 3 micron diameter. This instability has the form of a re-entrant jet protruding into the gas bubble. The inward protrusion grew and subsequently drained, leaving a droplet with a five micron diameter inside the bubble. In a subsequent recording after 100 ms, only the gas bubble could be detected. Thus, the life- time of the antibubble was less then 100 ms. The presence of a surfactant on the interfaces might lead to an improved stability of an antibubble.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115597838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue microscopy using optical generation and detection of ultrasound","authors":"S. Ashkenazi, R. Witte, K. Kim, Y. Hou, M. O’Donnell","doi":"10.1109/ULTSYM.2005.1602847","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1602847","url":null,"abstract":"Optical detection of ultrasound provides a unique and appealing way of forming detector arrays (1D or 2D). Etalon based optical techniques are of particular interest, due to their relatively high sensitivity resulting from multiple optical reflections within the resonance structure. Detector arrays formed by etalon based techniques are characterized by high element density and small element active area, which enables high resolution imaging at high ultrasonic frequencies (typically 10-50 MHz). Laser generated ultrasound using the photoacoustic effect has been demonstrated in recent years as a powerful imaging modality for medical and biological applications. A short laser pulse illuminates a tissue creating rapid thermal expansion and acoustic emission. Detection of the resulting acoustic field by a detector array enables the imaging of the tissue optical absorption using ultrasonic imaging methods. One of the most appealing features of photoacoustic imaging is that it provides access to tissue composition at the molecular level using multiple wavelength illumination. elements are easily accomplished by optical focusing. These techniques are typically characterized by a flat bandwidth. Laser generation of ultrasound was studied and demonstrated for several decades but gained renewed interest since the late nineties for applications in medical imaging (7-10). The method is based on illuminating tissue with a short laser pulse. The optical pulse is absorbed by the tissue causing it to heat rapidly. The temperature rise is followed by thermal expansion producing acoustic emission. Detection of the resulting acoustic field allows reconstructing the initial distribution of heat deposition and therefore the distribution of optical absorption in the tissue. The most appealing feature of this method is that image contrast is based on the optical properties of tissue. This makes it possible for ultrasonic imaging to probe tissue composition at the molecular level and facilitates the interaction with optical based contrast agents for functional imaging (11, 12).","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131658033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deformable bezier curves for young's modulus reconstruction and delineation of vulnerable atherosclerotic plaque components","authors":"R. Baldewsing, F. Mastik, J. Schaar, A. V. D. Steen","doi":"10.1109/ULTSYM.2005.1602842","DOIUrl":"https://doi.org/10.1109/ULTSYM.2005.1602842","url":null,"abstract":"To allow modulus-based tissue characterization of arterial plaques, we have developed an iterative plaque-model- based reconstruction method that reconstructs a Young's modulus (YM) image from a measured radial strain image of a plaque. In comparison with our previous 'Circular plaque model', which consisted of circles, our newly developed 'Bezier plaque model' uses (i) the real vessel wall boundaries and (ii) deformable Bezier curves to allow more accurate delineation of complex plaque components. To illustrate the delineation improvement we used both plaque models to reconstruct a plaque from a radial strain elastogram that was (i) simulated using a histology-traced thin-cap fibroatheroma plaque and (ii) measured with IntraVascular UltraSound (IVUS) elastography from a vessel phantom having a soft plaque.","PeriodicalId":302030,"journal":{"name":"IEEE Ultrasonics Symposium, 2005.","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124004972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}