{"title":"S01.3 New insights into Gardnerella and other BV-associated bacteria","authors":"N. Cerca","doi":"10.1136/SEXTRANS-2021-STI.21","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.21","url":null,"abstract":"","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123016447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S08.3a How to realize implementation in HIV self-testing by distribution via the social network in China: A joined collaboration between stakeholders","authors":"W. Tang, Y. Zhou","doi":"10.1136/SEXTRANS-2021-STI.39","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.39","url":null,"abstract":"HIV self-testing (HIVST) had been widely used in China since 2012, but social network strategies were rarely used to improve HIVST coverage. This presentation reports a case of community-based social network distribution of HIVST among Chinese men who have sex with men (MSM). In 2016, UNC Project-China hosted an HIV testing intervention development designathon and invited eight teams from two provinces to contribute. The Zhuhai team designed an HIVST promotion proposal, which was a joint working plan between a community-based organization and the local CDC. They co-developed a social media platform for self-test kits application and results reporting, which successfully provided 600 kits to MSM in 2016. However, due to the lack of evidence-based intervention, the program failed to increase the testing coverage and lack of innovation. After that, the researchers in the UNC Project-China team brought in secondary distribution idea, which allows the index MSM to apply for multiple kits and distribute them to people in their social network. After the piloting, 373 index MSM successfully motivated 287 alters for testing, among whole 40% were new testers, and the HIV testing yield among alters was significantly higher than that among index MSM. In the following RCT, a monetary incentive and peer referral further improved the mean number of kits that were distributed by index MSM (MD=1·21, 95% CI: 0·77–1·65). The strategy strongly increased testing coverage and was further implemented at the provincial level. Opportunities Social-media platform provided an opportunity to reach a diverse index MSM Social-network distribution expanded the testing coverage A jointed collaboration increased the understanding of the needs of the community Challenges The proportion of index that willing to distribute kits is remaining low Did not involve in the alters for further distribution Did not take the key influencers into consideration","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122943952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Kpokiri, Weiming Tang, G. Marley, N. Fongwen, Dan Wu, S. Berendes, B. Ambil, S. Loveday, R. Sampath, Jennifer S. Walker, J. Matovu, C. Boehme, N. Pai, J. Tucker
{"title":"S08.1 Diagnostic Infectious diseases self-testing and self-sampling outside clinics: A global systematic review","authors":"E. Kpokiri, Weiming Tang, G. Marley, N. Fongwen, Dan Wu, S. Berendes, B. Ambil, S. Loveday, R. Sampath, Jennifer S. Walker, J. Matovu, C. Boehme, N. Pai, J. Tucker","doi":"10.1136/SEXTRANS-2021-STI.37","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.37","url":null,"abstract":"","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128307208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S05.1 Being ALHIV: Sexual and reproductive health of adolescents and young people living with HIV in sub-Saharan Africa","authors":"E. Toska, B. Banougnin","doi":"10.1136/sextrans-2021-sti.32","DOIUrl":"https://doi.org/10.1136/sextrans-2021-sti.32","url":null,"abstract":"Background Over three quarters of all new HIV infections among 15–24 year old adolescents and young people globally take place in sub-Saharan Africa. As this growing cohort becomes older, understanding and meeting their sexual and reproductive health (SRH) needs is critical, particularly in light of COVID-19 healthcare and social disruptions. However, few studies have documented these outcomes among adolescents in resource-limited settings, with none reporting data from longitudinal cohorts. Summary This talk summarises what we know about the sexual and reproductive health of adolescents living with HIV in sub-Saharan Africa, particularly experiences of pregnancy, motherhood and relationships. It draws from findings of a review of SRHR experiences of adolescents and young people living with HIV, complemented by analyses of two large community-traced cohort: the Mzantsi Wakho (‘Your South Africa’) and HEY BABY (Helping Empower Youth Brought up in Adversity with their Babies and Young children) studies in South Africa. The Mzantsi Wakho cohort conducted three waves of data collection with over 1,600 adolescents and young people living with HIV (93%-97% retained at each wave), 1,064 of whom were living with HIV since baseline. The HEY BABY study recruited over 1,000 adolescent and young women who had their first child","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122383248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S04.2 How should antimicrobial resistance in Neisseria gonorrhoeae influence PID treatment","authors":"J. Ross","doi":"10.1136/SEXTRANS-2021-STI.30","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.30","url":null,"abstract":"Rising levels of antibiotic resistance in uncomplicated N gonorrhoeae infection have led to changes in recommended treatment and suggestions for new management paradigms. It is, however, unclear how these new approaches to treatment should be reflected in managing gonococcal pelvic inflammatory disease (PID). Gonorrhoea remains an important but relatively uncommon cause of PID for which treatment is often commenced prior to identification of the causative organisms. Those at highest risk (severe symptoms, partner with gonorrhoea, gram negative diplococci on microscopy) should have therapy which includes cover for N gonorrhoeae. Newer agents, such as lefamulin, gepotidacin and zoliflodacin have not been evaluated in women with pelvic infections but frequently have a wide spectrum of activity covering not just gonorrhoea but many of the other bacteria associated with PID, and achieve good tissue levels in the upper genital tract. However, optimal dosing regimens for PID to achieve clearance of infection but minimise the risk of developing future resistance need to be determined.","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117084381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S08.3b Using Social Media and Social Network to Expand HIV Self-Testing in China","authors":"Y. Ni, Y. Lu, Yuejiao Zhou, W. Tang","doi":"10.1136/SEXTRANS-2021-STI.40","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.40","url":null,"abstract":"HIV self-testing (HIVST) is considered as an effective strategy to enhance HIV testing, especially among the marginalized populations such as men who have sex with men (MSM). We aimed to evaluate the effectiveness of social network-based secondary distribution model of HIVST among MSM in China. MSM participants (defined as ‘indexes’) who were were recruited through an online platform. Indexes could order up to 5 HIVST kits through the online platform. Refundable deposits of 15 USD were attached to each HIVST kits. Indexes were encouraged to distribute HIVST kits to members (defined as ‘alters’) within their social networks. All testers were required to upload photos of results to the platform, and indexes could get fully refunded after the results were verified. We firstly tested the feasibility of the model, and then conducted a three-arm RCT (Intervention 1: monetary incentives, Intervention 2: monetary incentives+online peer referral; Control: standard approach). Indexes could send personalized referral links to alters and receive 3 USD for each successfully distributed HIVST kit. Overall, a total of 640 eligible indexes ordered 1984 HIVST kits via our online platform. In summary, 1935 results (returning rate: 97.5%, 1935/1984) were returned, of which 648 results were from 625 alters. For the three-arm RCT implemented between September 2019 and June 2020, the mean number of unique tested alters motivated by each index was 0·57±0·96 in the standard of care group, compared with 0·98±1·38 in the intervention 1 group (mean difference [MD] 0·41, 95% CI: 0·08–0·74), and 1·78±2·05 in the intervention 2 group (MD=1·21, 95% CI: 0·77–1·65). We conclude that social network-based secondary distribution model of HIVST is acceptable and effective in expanding HIV testing among MSM. Using social network strategies can optimize the current HIV testing services among the marginalized populations and it is promising to be scaled up.","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115551207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S02.4 Concordance between genotypic and phenotypic resistance, and implications for surveillance of AMR","authors":"M. Cole","doi":"10.1136/SEXTRANS-2021-STI.25","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.25","url":null,"abstract":"The gonococcus is now presenting some serious public health and clinical challenges. Notably, antibiotic-resistant Neisseria gonorrhoeae strains continue to emerge and spread and now threaten key gonorrhoea treatments, including ceftriaxone. Alternate treatment strategies are needed. Individualized therapy, whereby a rapid resistance test is used to inform individual patient treatment, is one proposed strategy. The use of individualised therapy in now already embedded in treatment of antibiotic (azithromycin)-resistant Mycoplasma genitalium infection, but is still in its infancy for the gonococcus. Key challenges exist, including knowledge gaps relating resistance mechanisms, the fact that sequence targets may change over time. These hurdles are not insurmountable, and can potentially be overcome via enhanced international collaboration and sequence/data sharing.","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134040366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S09.4 Prevalence of molecular markers for azithromycin resistance found in Treponema pallidum in British Columbia, Canada","authors":"M. Morshed","doi":"10.1136/SEXTRANS-2021-STI.45","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.45","url":null,"abstract":"","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130886945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S03.1 Role of Mycoplasma genitalium in symptoms and syndromes in cisgender women","authors":"M. Trent","doi":"10.1136/SEXTRANS-2021-STI.26","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.26","url":null,"abstract":"","PeriodicalId":301606,"journal":{"name":"Symposium presentations","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126083876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}