Troia Medical Journal最新文献

{"title":"Investigation of DNA affinity levels of pesticides: docking analysis results","authors":"Merve Aras, Ö. Yayintaş, Sibel Oymak Yalcin","doi":"10.55665/troiamedj.1137673","DOIUrl":"https://doi.org/10.55665/troiamedj.1137673","url":null,"abstract":"Objective: According to studies conducted in recent years, pesticides can lead to the development of cancer, Parkinson's disease, Alzheimer's disease, reproductive system disorders, and birth defects. The aim of this study is to examine the DNA affinity levels of Alpha-cypermethrin, Malathion, Quinclorac, and Roundup (Glyphosate) plant protection products and to discuss them in the light of the literature. Methods: Docking results between ligand and receptor were detected using Hex 8.0.0 software. Preparation of the receptor and ligand for docking was done with UCSF Chimera 1.15 software. Docking visualizations were made with BIOVIA Discovery Studio and PyMol software. While the interaction images of pesticides with DNA were detected with BIOVIA Discovery Studio software, DNA binding images were detected with PyMol software. Results: In our study, the affinity levels of the plant protection products frequently used in the Çanakkale region were determined as Alpha Cypermethrin>Malathion>Quinclorac>Roundup /Glyphosate, respectively, according to the results of the docking analysis. The pesticide with the highest interaction with DNA was Alpha Cypermethrin (-248.24 KJ mol-1) and the lowest binding energy was Roundup (-161.54 KJ mol-1). Conclusion: In line with the literature, alpha-cypermethrin is the molecule with the highest toxicity and gene damage potential. Considering the variety of products, it is necessary to pay attention to the use of both single and multiple plant protection products. During the use of this molecule, plant protection products with lower DNA affinity and toxicity can be preferred as an alternative.","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122081332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudomotor disfonksiyonu olan diyabetik hastalarda ayak bakım eğitimi etkinliğinin değerlendirilmesi","authors":"Emine SEVİNÇ POSTACI, Şule ALPAR ECEVİT","doi":"10.55665/troiamedj.1160760","DOIUrl":"https://doi.org/10.55665/troiamedj.1160760","url":null,"abstract":"Amaç: Araştırmada, ayak nem ölçümüyle sudomotor disfonksiyonu belirlenen diyabetik hastalarda verilen ayak bakım eğitiminin ayak sağlığı üzerine etkilerinin hastaların diyabet yönetimine ilişkin öz-etkililikleri ve diyabet hastalarında ayak bakım alışkanlıklarına etkisinin değerlendirilmesi amaçlanmıştır. Yöntem: Araştırmada, Çanakkale Onsekiz Mart Üniversitesi tıp fakültesi hastanesi endokrinoloji polikliniğine temmuz 2012- mart 2013 tarihlerinde başvuran 597 diyabet hastasından, amaçlı örneklem doğrultusunda vaka seçim kriterlerine uyan ve araştırmaya katılımda gönüllü olan 112 hasta değerlendirildi. Çalışma örneklemini oluşturan hastaların 59’una (deney grubu) eğitim verilirken, 53 kişiye (kontrol grubu) eğitim verilmedi. Deney grubundaki hastalara araştırmacı tarafından ayak bakım eğitimi verildi. Araştırma verileri için hasta bilgi formu, metabolik değişkenler formu, ayak değerlendirme formu, diyabet yönetimine ilişkin öz-etkililik ölçeği, diyabet hastalarında ayak bakım alışkanlığı formu kullanıldı. Veriler SPSS 16.0 paket programı kullanılarak karşılaştırma testleri ve tanımlayıcı istatistiksel yöntemlerle analiz edildi. Bulgular: Öz-etkililik ölçeği puan ortalamaları açısından araştırmanın başlangıcında ve sonundaki fark deney grubunda istatistiksel olarak anlamlı bulundu (p","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133983158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Şeker hastalığı üzerinde quercetin, gallik asit, oleanolik asit ve ursolik asitin in siliko analizi","authors":"Merve Aras, Özlem Yayintaş","doi":"10.55665/troiamedj.1163784","DOIUrl":"https://doi.org/10.55665/troiamedj.1163784","url":null,"abstract":"Objective: Diabetes is a disease that occurs due to pancreatic β cells failing to produce enough insulin or the inability to use the produced insulin effectively in the body. According to the data of the IDF diabetes atlas, it has been reported that there are 537 million diabetic patients aged 20-79 worldwide in 2021 and this number is expected to reach 643 million in 2030 and 783 million in 2045. To control diabetes at such a severe level, scientists are trying to find various treatment methods. One of them is natural treatments. In this study, the affinity values of quercetin, gallic acid, oleanolic acid and ursolic acid, which have antidiabetic properties, to diabetes-related renin, cathepsin-d, T-PA, leptin, MASP-2, FABP4 proteins were investigated. Methods: For molecular docking analysis, unwanted residues and chains were deleted from the proteins with UCSF Chimera 1.15 software and prepared for docking by adding polar hydrogen atoms. Next, quercetin, gallic acid, oleanolic acid and ursolic acid used as ligands were brought to minimum energy conformation. Protein and ligands prepared for molecular docking were analyzed with Autodock Tools 1.5.6 software. Molecular docking results were viewed with BIOVIA Discovery Studio and protein plus software. Moreover, pkCSM software was used for ADME analysis. Conclusion: As a result, quercetin was found to be more effective than the other three flavonoids.","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125839081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eisenmenger sendromlu bir hastada 11 yıllık dönemde bosentan monoterapisinin seri değerlendirmesi: Olgu takip raporu","authors":"Gökay Taylan, Yekta Gürlertop, Kenan Yalta","doi":"10.55665/troiamedj.1139311","DOIUrl":"https://doi.org/10.55665/troiamedj.1139311","url":null,"abstract":"Eisenmenger syndrome is a rare disease primarily characterized by severe degrees of irreversible pulmonary arterial hypertension in the setting of congenital heart disease. In this report, we aim to report, on a yearly basis, the clinical, hemodynamic and echocardiographic parameters of a female patient with Eisenmenger syndrome who had been under bosentan treatment during an 11-year follow-up.","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"39 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123286683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Belirgin kardiyovasküler hastalığı olmayan hastalarda COVID-19 mRNA aşısının elektrokar-diyografik parametreler üzerinde herhangi bir etkisi var mı?","authors":"Ayhan Küp, Mehmet Çelik, Abdulkadir Uslu, Şeyhmus Külahçıoğlu, Elif TÜKENMEZ TİGEN, Serdar Demi̇r, Kamil Gülşen, Servet İzci, Yeşim UYGUN KIZMAZ, Alper Kepez","doi":"10.55665/troiamedj.1151301","DOIUrl":"https://doi.org/10.55665/troiamedj.1151301","url":null,"abstract":"Objective: Electrocardiographic alterations were investigated following the second dosage of COVID-19 mRNA vaccination. Methods: A total of 260 individuals after two doses of COVID-19 vaccine with Pfizer-BioNTech were included in the study. The electrocardiographic parameters recorded at baseline and approximately one week later after two doses of Pfizer-BioNTech vaccine were compared for all patients. Results: PR interval was increased and QTc maximum interval was decreased significantly after second dose COVID-19 mRNA vaccination. Baseline and post-second dose vaccination states regarding P wave dispersion and QT dispersion/Tp-e interval which have been recognized to imply inhomogeneous atrial conduction and heterogeneity in ventricular repolarization were similar between groups. Conclusion: Our findings suggest that there should be no concern related to asymptomatic involvement of the myocardium subsequent the second dose of COVID-19 mRNA vaccination.","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130264566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kalp yetmezliği hastalarında ödem miktarı ve fonksiyonel kapasite ile annexin V ve ICAM 1 arasındaki ilişki","authors":"Ali Duygu, Hilal Şehi̇toğlu, Hakkı Kaya, Mehmet Arslan, Ercan Akşit","doi":"10.55665/troiamedj.1119916","DOIUrl":"https://doi.org/10.55665/troiamedj.1119916","url":null,"abstract":"Amaç: Konjestif kalp yetmezliğinin yaygın bulgularından biri olan ödem pretibial, skrotal ya da pulmoner ödem şeklinde görülebilmekte ve hastaların yaşam standartlarını daima olumsuz yönde etkilemektedir. Bazı sitokin ve inflamasyon markerlarının kalp yetmezliği ile korelasyonu daha önce kimi çalışmalarda gösterilmiştir. Amacımız; kalp yetmezliği hastalarında fonksiyonel kapasite ve ödem miktarı ile ICAM 1 ve annexin V arasında ilişkiyi incelemektir. Yöntem: Çalışmaya kalp yetmezliği tanısı almış 20 ve kontrol grubu olarak belirlenmiş 20 olmak üzere toplam 40 kişi alındı. Ödem dereceleri ve fonksiyonel kapasiteleri skorlanarak not edildi. Tüm hastalara transtorasik ekokardiografi yapıldı. Hasta ve kontrol grubu arasında ICAM 1 ve annexin V düzeyleri karşılaştırıldı. Ödem derecesi ve fonksiyonel kapasite ile ICAM 1 ve annexin V düzeyleri arasındaki korelasyona bakıldı. Kesim noktasının belirlenmesi için ROC Curve analizi kullanıldı. Bulgular: Hem ICAM 1 hem de annexin V düzeylerinde hasta grupta kontrol grubuna kıyasla anlamlı fark oluştu (ICAM 1 58.14±25.65 ng/mL, 36.04±14.14 ng/mL, p","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133875264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there any relationship between serum leptin and tryptophan levels and depression and anxiety in obese patients?","authors":"Z. Velioglu, D. Yıldırım, Mehmet Eryilmaz","doi":"10.55665/troiamedj.1118052","DOIUrl":"https://doi.org/10.55665/troiamedj.1118052","url":null,"abstract":"Objectives: Depression and anxiety are common conditions in obese patients. Leptin plays a role in obesity, the role of tryptophan in obesity has been investigated frequently in current studies. The aim of this study is to evaluate whether serum leptin and triptophan levels are related to depression and anxiety in obesity patients. Methods: This is a descriptive and cross-sectional study in which the data of 88 patients aged 18 years and over, BMI 25 kg/m2 and above, who applied to the Family Medicine outpatient clinic between 01.07.2019 and 31.12.2019, were examined. Sociodemographic data form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) were completed by all patients included in the study. Results: There was no significant relationship between BMI and leptin, BMI and tryptophan levels. A positive correlation was found between tryptophan and weight, waist circumference and systolic blood pressure (SBP). Tryptophan was also significantly higher in smokers and those with a history of psychiatric treatment. Tryptophan levels in men were found to be significantly higher than in women. Serum tryptophan concentration of the patients was positively correlated with weight, waist circumference and SBP. Tryptophan level was found significantly higher in men than in women. Tryptophan was also significantly higher in smokers and those with a history of psychiatric treatment. There was no significant relationship between BDI, BAI and leptin and tryptophan levels. Conclusion: The significant relationships between serum tryptophan level and weight, waist circumference and SBP may be useful in the management, follow-up and treatment of obese patients.","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131263560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the predictability of prognoses of COVID-19 patients hospitalized in the pandemic service by hospitalization blood values: A retrospective study","authors":"M. Kızmaz, Funda Gökgöz Durmaz","doi":"10.55665/troiamedj.1120090","DOIUrl":"https://doi.org/10.55665/troiamedj.1120090","url":null,"abstract":"Objectives: Prognostic predictors are important for the rapid response and optimal use of the health system during the ongoing COVID-19 pandemic. It has been reported that many hematological parameters may deteriorate starting from the early stages in COVID-19 patients. The aim of the present study was to determine the relationship between hematological and biochemical parameters of patients followed in the service, intensive care hospitalization, and mortality. Methods: The present study is a retrospective study. Participants consist of patients hospitalized in the pandemic service between 1.09.2021 and 15.12.2021. All 366 patients hospitalized in the relevant date range were evaluated, and after exclusion criteria, the study was conducted on 242 patients. Polymerase chain reaction tests of all patients were positive. The hematological and biochemical parameters of the patients on the first day of hospitalization, their age, height, weight, gender, chronic diseases, and steroid treatments were recorded. According to service exits, patients were categorized into three groups: transfer to intensive care (discharged after intensive care treatment), resulting in death (transferred from the ward to intensive care unit and died without discharge), and discharged home (discharged home from the ward without intensive care admission). Results: Of the 242 patients included in the study, 135 (55.8%) were female and 107 (44.2%) were male. Of the patients, 213 (88%) were discharged home from the ward, 8 (3.3%) were transferred to the intensive care unit, and 21 (8.7%) died. The mean age of the patients who died (69.6±13.14 years) was significantly higher than of those transferred to the intensive care unit (61.25±15.75) and discharged home from the service (68.91±12.97). When the patients were divided into two groups as survived and dead; age, lymphocyte, blood urea nitrogen, glomerular filtration rate, aspartate aminotransferase, albumin, C reactive protein, procalcitonin, D-dimer, platelet lymphocyte ratio (TLO) and neutrophil lymphocyte Ratio (NLO) values were significantly different between the two groups. According to the regression model created with significant values, age, high NLO and D-dimer, and low TLO were found to be independent risk factors for mortality. Conclusion: In the present study, age, D-dimer, TLO and NLO measured on the day of hospitalization were found to be independent prognostic markers for mortality in COVID-19 patients.","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129726690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could the change of anorexigenic function of nesfatin-1 during the day be associated with circadian rhythm?","authors":"Zafer Şahi̇n","doi":"10.55665/troiamedj.1108125","DOIUrl":"https://doi.org/10.55665/troiamedj.1108125","url":null,"abstract":"Nutrition is a body function exhibited to provide the metabolic needs of the organism. The regulation of feeding behavior is provided by homeostatic mechanisms. Food consumption of individuals is time-dependently coordinated by the brain throughout the approximately 24-hour circadian cycle. The biological clocks in the body set the daily intervals in which food consumption can occur in the circadian rhythm. These time zones are usually in the active period phase. The biological clocks that provide circadian control of food intake are a light-entrained master clock in the suprachiasmatic nucleus of the hypothalamus and numerous secondary oscillators in the brain and other tissues of the body. Nesfatin-1 is a hormone derived from the precursor protein of nucleobindin 2 and has strong effects on appetite. The anorexigenic effect of Nesfatin-1 is more pronounced, especially in the dark period of the day. This raises the question of whether the hormone in question has a circadian rhythm. In our review, the findings obtained from the studies on the subject are discussed cross-sectionally, and the possible relationship between the regulation of feeding behavior and the effects of nesfatin-1 with the circadian rhythm is evaluated.","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122155800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kronik sigara içiciliğinin EKG parametrelerine etkileri","authors":"Muhammet Kızmaz, Funda GÖKGÖZ DURMAZ, M. Ay, Burcu KUMTEPE KURT, Ezgi Döner","doi":"10.55665/troiamedj.1100226","DOIUrl":"https://doi.org/10.55665/troiamedj.1100226","url":null,"abstract":"","PeriodicalId":301488,"journal":{"name":"Troia Medical Journal","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128019167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}