Highlights on Medicine and Medical Science Vol. 9最新文献

Electrical Storm and ICD Therapy: An Overview Update 电风暴和ICD治疗:综述更新

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2460F

A. M. Júnior, Ana Luisa Adorno de Lima, Roberta Gomes da Mata, Dayanne Cardoso Teixeira

{"title":"Electrical Storm and ICD Therapy: An Overview Update","authors":"A. M. Júnior, Ana Luisa Adorno de Lima, Roberta Gomes da Mata, Dayanne Cardoso Teixeira","doi":"10.9734/BPI/HMMS/V9/2460F","DOIUrl":"https://doi.org/10.9734/BPI/HMMS/V9/2460F","url":null,"abstract":"An electrical storm (ES) is a ventricular arrhythmia (VA) consisting of the occurrence of three or more ventricular tachycardias (VT) per day, separated by five-minute intervals, or the presence of unceasing VT, even with the optimization of antiarrhythmic drug therapy. The objective of this chapter is to promote an overview update of electrical storm in patients with ICD Therapy. Data revealed that 84 out of 1274 patients with an implantable cardioverter-defibrillator (ICD) developed ES during follow-up. The incidence of ES in patients with ICD can reach 20% during the first 134 days after implantation. The pathophysiological mechanism is not well understood, because ES can be caused by several clinical conditions and through several different mechanisms, including VT and ventricular fibrillation (VF), global acute ischemia, and myocardial dysfunction. Patients with ES have a threefold greater risk of sudden cardiac death (SCD). The treatment is multimodal and consists primarily of emergency sedation, ventilation, neuraxial modulation, drug therapy (beta-blockers, amiodarone, sotalol, class I anti-arrhythmic drugs), and catheter ablation (CA). CA is a rescue procedure performed when there is little or no response to drug therapy. This approach is performed by first mapping the local and then choosing between approaches (endocardial or epicardial) and the different CA methods, which mainly include radiofrequency ablation, irrigated radiofrequency ablation, pulsed radiofrequency ablation, alcohol ablation, and cryoablation.","PeriodicalId":299825,"journal":{"name":"Highlights on Medicine and Medical Science Vol. 9","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127202918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Eruptive Fevers in the Infectious Diseases Department of Ouagadougou CHU-YO, Burkina Faso from 2005 to 2019 2005 - 2019年布基纳法索瓦加杜古CHU-YO市传染病科暴发性发热检测

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2833F

Savadogo Mamoudou, Diallo Ismael, S. Apoline

{"title":"Determination of Eruptive Fevers in the Infectious Diseases Department of Ouagadougou CHU-YO, Burkina Faso from 2005 to 2019","authors":"Savadogo Mamoudou, Diallo Ismael, S. Apoline","doi":"10.9734/BPI/HMMS/V9/2833F","DOIUrl":"https://doi.org/10.9734/BPI/HMMS/V9/2833F","url":null,"abstract":"Infectious pathologies of cutaneous expression constitute a major problem of public health in tropical environment. \u0000Objective: Describe the epidemiological, clinical, therapeutic and evolutionary aspects of eruptive fevers in the Infectious Diseases Department of CHU YO. \u0000Patients and Methods: The study took place in the Department of Infectious and Tropical Diseases at the Yalgado Ouedraogo University Hospital Center. This was a descriptive retrospective study of cases of eruptive fever, hospitalized in the department from January 1, 2005 to December 31, 2019. \u0000Results: During the study period, the prevalence of eruptive pathologies was 5%. The average age of patients was 16 years with extremes of 01 and 73 years. The most represented age group was 01-14 years old (53.1%) with a sex ratio of 1.4. Only 27.2% of patients were up-to-date with measles vaccine. The association fever and cough was the most frequently found syndrome (26.2%). The most common elemental lesions were maculopapular (46.2%), followed by vesicular lesions (10%). The pathologies involved were dominated by measles (50.8%), herpes (19.2%), chickenpox (14.6%), HIV infection (6.3%), meningitis (6.1%). \u0000The average duration of hospitalization was 7.5 days with extremes of 01 and 26 days. The lethality was 4.6%. \u0000Conclusion: Measles and chickenpox are still responsible for outbreaks in communities in Burkina Faso. It is important to increase awareness about vaccination against these febrile eruptive diseases.","PeriodicalId":299825,"journal":{"name":"Highlights on Medicine and Medical Science Vol. 9","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126417523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Mucosal Immunology of Human Head 人头部粘膜免疫学研究进展

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2821F

Ibrahim M. S. Shnawa

引用次数: 0

Evaluation of Vitamin D Status, Selenium & CRP Level in Psoriasis 银屑病患者维生素D、硒和CRP水平的评价

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2962F

S. Sumathi, S. Babu, K. Karthikeyan

{"title":"Evaluation of Vitamin D Status, Selenium & CRP Level in Psoriasis","authors":"S. Sumathi, S. Babu, K. Karthikeyan","doi":"10.9734/BPI/HMMS/V9/2962F","DOIUrl":"https://doi.org/10.9734/BPI/HMMS/V9/2962F","url":null,"abstract":"Background: Psoriasis is an inflammatory skin disease that is associated to a number of clinical conditions. It results from a combination of genetic predisposition and environmental factors, which together provoke sensitization of the immune system. We aim to explore the status of serum vitamin D, selenium and CRP levels in patients with psoriasis and their association with the severity of the disease. \u0000Materials and Methods: There were 50 psoriasis cases and 47 healthy people in this hospital-based case-control research. The levels of serum VD, selenium, and CRP were measured, as well as the general demographic data. \u0000Results: VD levels are considerably lower in psoriasis (p< 0.005) according to statistical analyses. Obesity was found to be more common among psoriasis patients than controls in the demographic factors.The levels of selenium and CRP in the serum did not differ significantly between the two groups. \u0000Conclusion: We conclude that vitamin D deficiency is strongly associated with psoriasis. Vitamin D supplementation can help with psoriasis management as well as obesity reduction. Serum selenium and CRP levels have shown very little significance in our study.","PeriodicalId":299825,"journal":{"name":"Highlights on Medicine and Medical Science Vol. 9","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117166127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Diagnosis of Focal Hepatic Lesions Using Ultrasound Confirmed with Histopathology: Recent Advancement 肝局灶性病变的超声鉴别诊断与病理组织学:最新进展

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/10190D

R. Ahmed, S. Alkathiri, Waad Altalhi, Hatun Eid, Manar Alshalawi, Sara Alotaibi

{"title":"Differential Diagnosis of Focal Hepatic Lesions Using Ultrasound Confirmed with Histopathology: Recent Advancement","authors":"R. Ahmed, S. Alkathiri, Waad Altalhi, Hatun Eid, Manar Alshalawi, Sara Alotaibi","doi":"10.9734/BPI/HMMS/V9/10190D","DOIUrl":"https://doi.org/10.9734/BPI/HMMS/V9/10190D","url":null,"abstract":"Advances in imaging technology over the past decades have contributed to better characterization of hepatic lesions. This study aims to differentiate focal hepatic lesions from their ultrasound (U/S) features and compared the obtained results with histopathology. A descriptive retrospective study of 100 patients who had focal hepatic lesions were reviewed during the period from 2012 to 2019 at King Abdul-Aziz Specialist Hospital, Taif, KSA. The inclusion criteria were Adults Saudi patients, ages 18 and above. LG-9 and Philips ultrasound machines with 3.5 MHz transducers were used in this study. Age group (55 to 80 years) represented 44%, mean age was 49 years, 92% were married. Regarding shape of the lesions during U/S scan, 47% of irregular outline were malignant (p=0.00), 93% of the rounded lesions were benign (p=0.00),86% of well-defined lesions margins were benign in histopathology, 61% ill-defined margin lesions were malignant and 73% of hyperechoic lesions were hemangioma (p=0.02). Regarding nature of hepatic lesions during U/S, 87% of solid lesions were malignant (p=0.03), while 89% of cystic lesions were benign. 61% of hypoechoic lesions were malignant. 80% from vascular lesions under color Doppler were benign. U/S sensitivity and specificity were 93.5 and 98%, respectively. U/S is a useful tool in differentiation cystic hepatic lesions from solid (p=0.03). Comparable studies with large samples must be done in Taif region to provide data base for hepatic lesions. Most of selected hepatic lesions with suspicious features were confirmed as malignant in histopathology with high degree of sensitivity and specificity.","PeriodicalId":299825,"journal":{"name":"Highlights on Medicine and Medical Science Vol. 9","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130498950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Factors and Postoperative Survival in Clear Cell Renal Carcinomas. A Histopathological Diagnosis 透明细胞肾癌的预后因素和术后生存率。A组织病理学诊断

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2691F

P. Colaci, A. Errecalde, A. Inda, Marcela N. Garcia

{"title":"Prognostic Factors and Postoperative Survival in Clear Cell Renal Carcinomas. A Histopathological Diagnosis","authors":"P. Colaci, A. Errecalde, A. Inda, Marcela N. Garcia","doi":"10.9734/BPI/HMMS/V9/2691F","DOIUrl":"https://doi.org/10.9734/BPI/HMMS/V9/2691F","url":null,"abstract":"Introduction: Clear cell Renal Cell Carcinoma (ccRCC) is the most common type of Renal Cell Carcinoma that occurs in adults and it has the worst prognosis among the common epithelial tumors of these organs. This neoplasm is characterized by a high blood supply. With this in mind, we have used the CD34, an endothelial antigen that has been used to highlight the microvessel density (MVD), as a direct marker of neoangiogenesis degree. \u0000Objective: To establish the correlation between CD34 and other prognostic factors like Fuhrman nuclear degree and tumoral size. \u0000Material and Methods: Tumour samples from 17 patients with histopathology diagnosis of ccRCC were examined by immunohistochemical staining for CD34. The CD34 expression was analyzed by Anova and Student Newman Multiple Comparison Test and Tuckey as a post-test, and finally, we used a Spearman Correlation to compare with the other prognostic factors analyzed and Kaplan Meier survival analysis for the disease-free survival of the patients. \u0000Results and Conclusion: There is a negative correlation between the MVD and the Fuhrman nuclear grade, whereas R = -0,46; and p < 0,05 and there is a positive correlation between the MVD and the maximum tumour diameter, whereas R = 0,47 and p < 0,05. In conclusion, we found that a high MVD is related to a low Fuhrman nuclear grade and a high tumour size. The possible significance of this study can be that in fact, we need more than one parameter to predict the biological behavior of the ccCCR.","PeriodicalId":299825,"journal":{"name":"Highlights on Medicine and Medical Science Vol. 9","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117192265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Importance of Liver Fatty Acid-Binding Protein Downregulation in Hepatocellular Carcinoma 肝脂肪酸结合蛋白下调在肝细胞癌中的重要性

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2717F

Masafumi Inoue, Yoshihisa Takahashi, T. Fujii, M. Kitagawa, T. Fukusato

引用次数: 0

Evaluating the Drug Utilization in Ophthalmology Outpatients at a Tertiary Care Teaching Hospital 某三级教学医院眼科门诊患者用药情况评价

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2850F

C. H. Janakidevi

引用次数: 0

Overview of Pediatric Nonalcoholic Fatty Liver Disease with a Focus on Histology 以组织学为重点的儿童非酒精性脂肪肝概述

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/2758F

Yoshihisa Takahashi, T. Fukusato

{"title":"Overview of Pediatric Nonalcoholic Fatty Liver Disease with a Focus on Histology","authors":"Yoshihisa Takahashi, T. Fukusato","doi":"10.9734/BPI/HMMS/V9/2758F","DOIUrl":"https://doi.org/10.9734/BPI/HMMS/V9/2758F","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is a condition in which excessive fat builds up in the liver of a person who has never drank excessive alcohol. This disease includes simple steatosis and nonalcoholic steatohepatitis (NASH). The hepatic manifestation of the metabolic syndrome is known as NAFLD/NASH. Pediatric NAFLD has risen in recent years, along with an increase in the frequency of childhood obesity. The frequency of pediatric NAFLD is believed to be between 2.6 and 9.6 percent, and it is linked to sex, age, and ethnicity. The \"two-hit\" concept is largely recognised when it comes to the aetiology of NAFLD, and oxidative stress is assumed to play a key role in the second hit. Despite the importance of clinical symptoms, laboratory data, and imaging results, liver biopsy remains the gold standard for diagnosing NAFLD/NASH. In addition, liver biopsy is essential for assessing the degree of necro-inflammatory change and fibrosis in NASH. There are two forms of steatohepatitis (type 1 and type 2 NASH), with type 2 NASH being present in up to 51% of juvenile NAFLD patients. We and others have seen, however, that type 1 and 2 patterns frequently overlap. Despite the fact that medication has been investigated in clinical trials, diet and exercise remain the foundation of NAFLD/NASH treatment.","PeriodicalId":299825,"journal":{"name":"Highlights on Medicine and Medical Science Vol. 9","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129274367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hematological Involvement in Pediatric Systemic Lupus Erythematosus 小儿系统性红斑狼疮的血液学损害

Highlights on Medicine and Medical Science Vol. 9 Pub Date : 2021-07-09 DOI: 10.9734/BPI/HMMS/V9/10709D

M. Ayala, X. Norambuena, Alfonso Loosli, A. Quezada

{"title":"Hematological Involvement in Pediatric Systemic Lupus Erythematosus","authors":"M. Ayala, X. Norambuena, Alfonso Loosli, A. Quezada","doi":"10.9734/BPI/HMMS/V9/10709D","DOIUrl":"https://doi.org/10.9734/BPI/HMMS/V9/10709D","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multisystemic involvement with a variable clinical course. Hematological involvement is frequent and both morbidity and mortality, as well as the increased risk of infection and decreased survival rates have been significantly related with such compromise. The objective of this study was to describe the hematologic alterations in pediatric patients with SLE at the time of diagnosis. \u0000Methods. A retrospective descriptive study of patients with SLE controlled in the Immunorheumatology outpatients centre of Exequiel Gonzalez Cortes Children´s Hospital, Santiago, Chile was conducted. Thirty-three clinical files were reviewed, and demographic and clinical data were obtained. \u0000Results. Thirty patients met the inclusion criteria, 22 females, mean age 11.6 years (range 5 to 14). The prevalence of hematological compromise was 60% (n = 18). The most frequent hematological alteration was lymphopenia in 14 patients, followed by autoimmune hemolytic anemia (HA) in 11, leukopenia in 10, and thrombocytopenia in 3 patients. The association between different hematological alterations showed lymphopenia with leukopenia in 50% of the patients (n = 9) and HA with lymphopenia in 8 patients. The most frequent extra-hematological manifestations in patients with hematological alterations was skin involvement in 26/30 patients, followed by kidney involvement in 25, articular in 22, and serositis in 17. \u0000Conclusions. Hematological involvement in this series of pediatric SLE was frequent and this is included in traditional and current diagnostic criteria. In a group of patients, it can be the first manifestation, and this requires a differential diagnosis and careful monitoring. In other cases, it may be a manifestation of severe SLE that requires vigorous treatment.","PeriodicalId":299825,"journal":{"name":"Highlights on Medicine and Medical Science Vol. 9","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122964656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0