Discover Social Science and Health最新文献_第5页

An integrative framework and recommendations for the study of DNA methylation in the context of race and ethnicity. 从种族和民族角度研究 DNA 甲基化的综合框架和建议。

Discover Social Science and Health Pub Date : 2023-01-01 Epub Date: 2023-04-20 DOI: 10.1007/s44155-023-00039-z

Meingold Hiu-Ming Chan, Sarah M Merrill, Chaini Konwar, Michael S Kobor

{"title":"An integrative framework and recommendations for the study of DNA methylation in the context of race and ethnicity.","authors":"Meingold Hiu-Ming Chan, Sarah M Merrill, Chaini Konwar, Michael S Kobor","doi":"10.1007/s44155-023-00039-z","DOIUrl":"10.1007/s44155-023-00039-z","url":null,"abstract":"Human social epigenomics research is critical to elucidate the intersection of social and genetic influences underlying racial and ethnic differences in health and development. However, this field faces major challenges in both methodology and interpretation with regard to disentangling confounded social and biological aspects of race and ethnicity. To address these challenges, we discuss how these constructs have been approached in the past and how to move forward in studying DNA methylation (DNAm), one of the best-characterized epigenetic marks in humans, in a responsible and appropriately nuanced manner. We highlight self-reported racial and ethnic identity as the primary measure in this field, and discuss its implications in DNAm research. Racial and ethnic identity reflects the biological embedding of an individual's sociocultural experience and environmental exposures in combination with the underlying genetic architecture of the human population (i.e., genetic ancestry). Our integrative framework demonstrates how to examine DNAm in the context of race and ethnicity, while considering both intrinsic factors-including genetic ancestry-and extrinsic factors-including structural and sociocultural environment and developmental niches-when focusing on early-life experience. We reviewed DNAm research in relation to health disparities given its relevance to race and ethnicity as social constructs. Here, we provide recommendations for the study of DNAm addressing racial and ethnic differences, such as explicitly acknowledging the self-reported nature of racial and ethnic identity, empirically examining the effects of genetic variants and accounting for genetic ancestry, and investigating race-related and culturally regulated environmental exposures and experiences.Supplementary information: The online version contains supplementary material available at 10.1007/s44155-023-00039-z.","PeriodicalId":29972,"journal":{"name":"Discover Social Science and Health","volume":"3 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9384988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agency and Subjective Health from Early Adulthood to Mid-Life: Evidence from the Prospective Youth Development Study. 从成年早期到中年期的代理与主观健康：来自前瞻性青年发展研究的证据。

Discover Social Science and Health Pub Date : 2022-12-01 Epub Date: 2022-02-25 DOI: 10.1007/s44155-022-00006-0

Jeylan T Mortimer, Jeremy Staff

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引用次数: 0

Examining correlates of life satisfaction among Indian older adults using household fixed-effect approach 使用家庭固定效应方法研究印度老年人生活满意度的相关性

Discover Social Science and Health Pub Date : 2022-12-01 DOI: 10.1007/s44155-022-00028-8

Akif Mustafa

引用次数: 1

Discover Social Science and Health Pub Date : 2022-11-24 DOI: 10.1007/s44155-022-00026-w

Michiyo Mizuno, Noriko Munezawa, Mami Onizuka, Saori Kashiwa, Y. Inoue, Jun Kataoka, Ai Taniguchi, Thomas Mayers

引用次数: 0

Sexual and gender-based violence victims’ satisfaction of the support services through the holistic model of care in the Democratic Republic of Congo 在刚果民主共和国，性暴力和基于性别的暴力受害者对通过整体护理模式获得的支持服务的满意度

Discover Social Science and Health Pub Date : 2022-11-22 DOI: 10.1007/s44155-022-00025-x

G. M. Mugisho, RAHA Maroyi, Solange Nabami, A. Kasherwa, Ali Bitenga, D. Mukwege

引用次数: 1

Using a realist approach in understanding youth offending service delivery requirements for young people who offend with speech, language and communication needs in England 用现实主义的方法来理解青少年犯罪的服务提供要求，以满足英国青少年在言语、语言和沟通方面的需求

Discover Social Science and Health Pub Date : 2022-11-01 DOI: 10.1007/s44155-022-00024-y

S. Redgate, W. Dyer, M. A. Smith

引用次数: 0

Income, education, and hospitalization in Canada: results from linked census and administrative data 加拿大的收入、教育和住院:来自相关人口普查和行政数据的结果

Discover Social Science and Health Pub Date : 2022-11-01 DOI: 10.1007/s44155-022-00023-z

J. Godley, K. Tang

引用次数: 0

Factors associated with poor quality of life of transgender people 与变性人生活质量差相关的因素

Discover Social Science and Health Pub Date : 2022-10-03 DOI: 10.1007/s44155-022-00020-2

K. H. C. Coswosck, J. Moreira, J. H. N. Navarro, V. Guandalini, J. Marques-Rocha

引用次数: 1

Engaging caregivers to use an evidence-based intervention for medicaid beneficiaries with Alzheimer’s disease: a pilot study 让护理人员为阿尔茨海默病的医疗补助受益人使用循证干预：一项试点研究

Discover Social Science and Health Pub Date : 2022-09-26 DOI: 10.1007/s44155-022-00018-w

S. Spoelstra, A. Sikorskii, Monica Schueller, Viktoria Basso, Autumn Baldwin

引用次数: 0

Burden of care among primary caregivers’ of spinal cord injury patients attending a tertiary care center in Eastern Nepal 尼泊尔东部三级医疗中心脊髓损伤患者初级护理人员的护理负担

Discover Social Science and Health Pub Date : 2022-07-28 DOI: 10.1007/s44155-022-00016-y

P. Sinha, R. Mehta, P. Parajuli, Pashupati Chaudhary, R. P. Kushwaha

引用次数: 1