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One for All and All for One: New Insights into Enhancers Driving MYC Dysregulation. 我为人人，人人为我：对MYC失调增强因子的新见解。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-05-05 DOI: 10.1158/2643-3230.BCD-25-0075
Roger Mulet-Lazaro, Ruud Delwel
{"title":"One for All and All for One: New Insights into Enhancers Driving MYC Dysregulation.","authors":"Roger Mulet-Lazaro, Ruud Delwel","doi":"10.1158/2643-3230.BCD-25-0075","DOIUrl":"https://doi.org/10.1158/2643-3230.BCD-25-0075","url":null,"abstract":"<p><p>The role of the proto-oncogene MYC as a driver of lymphoma has been known since the 1980s, but the mechanisms underlying its dysregulation are not completely understood. In this issue of Blood Cancer Discovery, Iyer and colleagues employ a CRISPR interference screen targeted at open chromatin regions to unveil enhancers critical for MYC overexpression in lymphoma, including a novel regulatory element in the MYC locus that controls germinal center reentry and is recurrently amplified in diffuse large B-cell lymphomas (germinal center B-cell diffuse large B-cell lymphoma). See related article by Iyer et al., p. 233.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":"6 3","pages":"149-152"},"PeriodicalIF":11.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma. myc -完整和myc -重排生发中心b细胞弥漫性大b细胞淋巴瘤的选择性增强子依赖性
IF 11.5
Blood Cancer Discovery Pub Date : 2025-05-05 DOI: 10.1158/2643-3230.BCD-24-0126
Ashwin R Iyer, Aishwarya Gurumurthy, Shih-Chun A Chu, Rohan Kodgule, Athalee R Aguilar, Travis Saari, Abdullah Ramzan, Jan Rosa, Juhi Gupta, Arvind Emmanuel, Cody N Hall, John S Runge, Anna B Owczarczyk, Jang W Cho, Matthew B Weiss, Rockwell Anyoha, Kristin Sikkink, Savanna Gemus, Charles P Fulco, Anamarija M Perry, Anthony D Schmitt, Jesse M Engreitz, Noah A Brown, Marcin P Cieslik, Russell J H Ryan
{"title":"Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma.","authors":"Ashwin R Iyer, Aishwarya Gurumurthy, Shih-Chun A Chu, Rohan Kodgule, Athalee R Aguilar, Travis Saari, Abdullah Ramzan, Jan Rosa, Juhi Gupta, Arvind Emmanuel, Cody N Hall, John S Runge, Anna B Owczarczyk, Jang W Cho, Matthew B Weiss, Rockwell Anyoha, Kristin Sikkink, Savanna Gemus, Charles P Fulco, Anamarija M Perry, Anthony D Schmitt, Jesse M Engreitz, Noah A Brown, Marcin P Cieslik, Russell J H Ryan","doi":"10.1158/2643-3230.BCD-24-0126","DOIUrl":"10.1158/2643-3230.BCD-24-0126","url":null,"abstract":"<p><strong>Significance: </strong>Aberrant MYC activity defines the most aggressive GCB-DLBCLs. We characterized a mechanism of MYC transcriptional activation via a native enhancer that is active in MYC-intact GCB-DLBCL, establishing fitness-sustaining cis- and trans-regulatory circuitry in GCB-DLBCL models that lack MYC enhancer-hijacking rearrangement. See related commentary by Mulet-Lazaro and Delwel, p. 149.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":" ","pages":"233-253"},"PeriodicalIF":11.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Model of Intratumor and Interpatient Heterogeneity Explains Clinical Trials of Curative Combination Therapy for Lymphoma. 肿瘤内和患者间异质性模型解释了淋巴瘤根治性联合疗法的临床试验。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-05-05 DOI: 10.1158/2643-3230.BCD-24-0230
Amy E Pomeroy, Adam C Palmer
{"title":"A Model of Intratumor and Interpatient Heterogeneity Explains Clinical Trials of Curative Combination Therapy for Lymphoma.","authors":"Amy E Pomeroy, Adam C Palmer","doi":"10.1158/2643-3230.BCD-24-0230","DOIUrl":"10.1158/2643-3230.BCD-24-0230","url":null,"abstract":"<p><strong>Significance: </strong>A new model of intratumor and interpatient heterogeneity in response to drug combinations explains and predicts the results of clinical trials of curative-intent treatments for DLBCL. This model can be used to understand and inform optimal design of curative drug combinations and clinical trials. See related commentary by Goldstein et al., p. 153.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":" ","pages":"254-269"},"PeriodicalIF":11.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Paradox of Acute Myeloid Leukemia Responsiveness to Adoptive T-cell Therapy. 急性髓系白血病对过继t细胞治疗反应性的悖论。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-05-05 DOI: 10.1158/2643-3230.BCD-25-0017
Terry J Fry
{"title":"The Paradox of Acute Myeloid Leukemia Responsiveness to Adoptive T-cell Therapy.","authors":"Terry J Fry","doi":"10.1158/2643-3230.BCD-25-0017","DOIUrl":"https://doi.org/10.1158/2643-3230.BCD-25-0017","url":null,"abstract":"<p><p>Since the recognition of the allogeneic graft-versus-leukemia effect, acute myeloid leukemia (AML) has been identified as a T cell-targetable malignancy, but success with modern forms of immunotherapy has been slower than anticipated. In this issue, we discuss the biological barriers to the treatment of AML with T-cell therapy revealed by recent reports, including mechanistic insights into AML resistance to T cell-mediated killing by Tin and colleagues. See related article by Tin et al., p. 217.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":"6 3","pages":"157-158"},"PeriodicalIF":11.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing CAR T-cell Therapies with Artificial Intelligence: Opportunities and Challenges. 利用人工智能推进CAR - t细胞疗法：机遇与挑战。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-05-05 DOI: 10.1158/2643-3230.BCD-23-0240
Fabio Luciani, Arman Safavi, Puneeth Guruprasad, Linhui Chen, Marco Ruella
{"title":"Advancing CAR T-cell Therapies with Artificial Intelligence: Opportunities and Challenges.","authors":"Fabio Luciani, Arman Safavi, Puneeth Guruprasad, Linhui Chen, Marco Ruella","doi":"10.1158/2643-3230.BCD-23-0240","DOIUrl":"10.1158/2643-3230.BCD-23-0240","url":null,"abstract":"<p><p>Artificial intelligence could enhance chimeric antigen receptor T-cell therapy outcomes through optimization of all steps, from target identification, vector design, and manufacturing to personalized data-driven clinical decisions. In this report, we highlight steps toward unlocking this potential, including the need for standardized, comprehensive data repositories as a way for addressing barriers to artificial intelligence learning, such as data heterogeneity and patient privacy.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":" ","pages":"159-162"},"PeriodicalIF":11.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity. SOCS1 可保护急性髓性白血病免受异体 T 细胞介导的细胞毒性的影响。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-05-05 DOI: 10.1158/2643-3230.BCD-24-0140
Enoch Tin, Sergio Rutella, Ismat Khatri, Yoosu Na, Yongran Yan, Neil MacLean, Jayakumar Vadakekolathu, Mark D Minden, Aaron D Schimmer, JongBok Lee, Li Zhang
{"title":"SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity.","authors":"Enoch Tin, Sergio Rutella, Ismat Khatri, Yoosu Na, Yongran Yan, Neil MacLean, Jayakumar Vadakekolathu, Mark D Minden, Aaron D Schimmer, JongBok Lee, Li Zhang","doi":"10.1158/2643-3230.BCD-24-0140","DOIUrl":"10.1158/2643-3230.BCD-24-0140","url":null,"abstract":"<p><strong>Significance: </strong>Our investigation of the SOCS1 pathway in AML and T-cell interactions provides insights into potential mechanisms of resistance of AML to allogeneic hematopoietic stem cell transplantation and demonstrates the potential of targeting SOCS1 and its downstream mediators to enhance antileukemic T-cell activity. See related commentary by Fry, p. 157.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":" ","pages":"217-232"},"PeriodicalIF":11.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of Mutant Hematopoietic Progenitor Cells Are Not Associated with Clinical Outcomes in Multiple Myeloma. 造血祖细胞突变的动态与多发性骨髓瘤的临床结果无关。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-05-05 DOI: 10.1158/2643-3230.BCD-24-0274
Camila Guerrero, Maria-Jose Larrayoz, Irache Erdozain, Noemi Puig, Maria-Teresa Cedena, Catarina Maia, Amagoia Mañu, Natalia Gordillo, Oihane Churruca, Diego Alignani, Sarai Sarvide, Iria Vazquez, Cristina Perez, Albert Oriol, Laura Rosinol, Rafael Ríos-Tamayo, Marta-Sonia Gonzalez-Perez, Ana-Pilar Gonzalez-Rodriguez, Felipe de Arriba, Jose M Moraleda, Jesus Martin, Luis Palomera, Valentin Cabañas, Maria-Jose Calasanz, Joaquin Martinez-Lopez, Maria-Victoria Mateos, Joan Bladé, Juan-Jose Lahuerta, Jesus F San-Miguel, Bruno Paiva
{"title":"Dynamics of Mutant Hematopoietic Progenitor Cells Are Not Associated with Clinical Outcomes in Multiple Myeloma.","authors":"Camila Guerrero, Maria-Jose Larrayoz, Irache Erdozain, Noemi Puig, Maria-Teresa Cedena, Catarina Maia, Amagoia Mañu, Natalia Gordillo, Oihane Churruca, Diego Alignani, Sarai Sarvide, Iria Vazquez, Cristina Perez, Albert Oriol, Laura Rosinol, Rafael Ríos-Tamayo, Marta-Sonia Gonzalez-Perez, Ana-Pilar Gonzalez-Rodriguez, Felipe de Arriba, Jose M Moraleda, Jesus Martin, Luis Palomera, Valentin Cabañas, Maria-Jose Calasanz, Joaquin Martinez-Lopez, Maria-Victoria Mateos, Joan Bladé, Juan-Jose Lahuerta, Jesus F San-Miguel, Bruno Paiva","doi":"10.1158/2643-3230.BCD-24-0274","DOIUrl":"https://doi.org/10.1158/2643-3230.BCD-24-0274","url":null,"abstract":"<p><strong>Significance: </strong>SPMs that develop in patients with multiple myeloma have a deleterious impact on survival. Patients with CH may be at risk of developing SPMs, which could potentially be avoided through individualized treatment. However, our results suggest that screening for CH at diagnosis has limited utility.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":"6 3","pages":"203-216"},"PeriodicalIF":11.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation. 人类造血单细胞转录图谱揭示了AML异常分化的遗传和基于层次的决定因素。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-04-28 DOI: 10.1158/2643-3230.BCD-24-0342
Andy G X Zeng, Ilaria Iacobucci, Sayyam Shah, Amanda Mitchell, Gordon Wong, Suraj Bansal, David Chen, Qingsong Gao, Hyerin Kim, James A Kennedy, Andrea Arruda, Mark D Minden, Torsten Haferlach, Charles G Mullighan, John E Dick
{"title":"Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation.","authors":"Andy G X Zeng, Ilaria Iacobucci, Sayyam Shah, Amanda Mitchell, Gordon Wong, Suraj Bansal, David Chen, Qingsong Gao, Hyerin Kim, James A Kennedy, Andrea Arruda, Mark D Minden, Torsten Haferlach, Charles G Mullighan, John E Dick","doi":"10.1158/2643-3230.BCD-24-0342","DOIUrl":"https://doi.org/10.1158/2643-3230.BCD-24-0342","url":null,"abstract":"<p><strong>Significance: </strong>We present a single-cell reference atlas of human hematopoiesis and a computational tool for rapid mapping and classification of healthy and leukemic cells. Applied to AML, this has enabled single-cell analysis at the scale of hundreds of patient samples, revealing the full breadth of derailment of differentiation in AML. See related commentary by Berger and Penter, p. XX.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":" ","pages":"OF1-OF18"},"PeriodicalIF":11.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Cell Resolved Oncogene Co-expression: From Principles to Clinical Impact. 单细胞溶解癌基因共表达：从原理到临床影响。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-04-28 DOI: 10.1158/2643-3230.BCD-25-0064
Shruti Sridhar, Allison S Y Chan, Anand D Jeyasekharan
{"title":"Single-Cell Resolved Oncogene Co-expression: From Principles to Clinical Impact.","authors":"Shruti Sridhar, Allison S Y Chan, Anand D Jeyasekharan","doi":"10.1158/2643-3230.BCD-25-0064","DOIUrl":"https://doi.org/10.1158/2643-3230.BCD-25-0064","url":null,"abstract":"<p><p>This commentary explores the concept and utility of studying oncogene co-expression at single-cell resolution and its clinical and biological implications. We emphasize the importance of scalable methods, mathematically driven quantification models, and artificial intelligence integration to enhance the clinical utility of this approach.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":" ","pages":"OF1-OF5"},"PeriodicalIF":11.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Putting AML Differentiation States on the BoneMarrowMap. 将AML分化状态放在BoneMarrowMap上。
IF 11.5
Blood Cancer Discovery Pub Date : 2025-04-28 DOI: 10.1158/2643-3230.BCD-25-0083
Jonas Berger, Livius Penter
{"title":"Putting AML Differentiation States on the BoneMarrowMap.","authors":"Jonas Berger, Livius Penter","doi":"10.1158/2643-3230.BCD-25-0083","DOIUrl":"https://doi.org/10.1158/2643-3230.BCD-25-0083","url":null,"abstract":"<p><p>This article presents a novel computational tool, \"BoneMarrowMap,\" that enables the mapping of leukemic single-cell RNA sequencing datasets to hematopoietic differentiation states. By utilizing BoneMarrowMap for a large-scale single-cell RNA sequencing reanalysis, the authors discover 12 recurrent acute myeloid leukemia differentiation patterns linked to prognosis and treatment and dissect leukemic clonal architectures within individual patients. See related article by Zeng and colleagues, p. XX.</p>","PeriodicalId":29944,"journal":{"name":"Blood Cancer Discovery","volume":" ","pages":"OF1-OF4"},"PeriodicalIF":11.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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