Danae K. R. Bardaji, Nagela B. S. Silva, Renata R. Miranda, Carlos Henrique G. Martins, Michael A. Savka and André O. Hudson*,
{"title":"","authors":"Danae K. R. Bardaji, Nagela B. S. Silva, Renata R. Miranda, Carlos Henrique G. Martins, Michael A. Savka and André O. Hudson*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.5c00069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madhav V. Samudrala, Somanath Dandibhotla, Arjun Kaneriya and Sivanesan Dakshanamurthy*,
{"title":"","authors":"Madhav V. Samudrala, Somanath Dandibhotla, Arjun Kaneriya and Sivanesan Dakshanamurthy*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.5c00053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marc-Antoine Turcotte, and , Jean-Pierre Perreault*,
{"title":"","authors":"Marc-Antoine Turcotte, and , Jean-Pierre Perreault*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.5c00004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144355179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Bio & Med Chem AuPub Date : 2025-05-27DOI: 10.1021/acsbiomedchemau.4c0015210.1021/acsbiomedchemau.4c00152
Fatemeh S. Hosseini, Ho-Man Kan, Taraje Whitfield, Chrysoula Argyrou, Amir A. Abedini, Nicholas S. Allen and Cato T. Laurencin*,
{"title":"Graphene Oxide in Bone Regenerative Engineering: Current Challenges and Future Perspectives","authors":"Fatemeh S. Hosseini, Ho-Man Kan, Taraje Whitfield, Chrysoula Argyrou, Amir A. Abedini, Nicholas S. Allen and Cato T. Laurencin*, ","doi":"10.1021/acsbiomedchemau.4c0015210.1021/acsbiomedchemau.4c00152","DOIUrl":"https://doi.org/10.1021/acsbiomedchemau.4c00152https://doi.org/10.1021/acsbiomedchemau.4c00152","url":null,"abstract":"<p >Owing to its exceptional physicochemical and biological properties, graphene oxide (GO), the oxidized form of graphene, has attracted considerable interest in bone regenerative engineering. The oxygen-functional groups on the backbone of GO enable biomolecule adherence, protein adsorption, cell adhesion, proliferation, differentiation, calcium ion adsorption and bone matrix mineralization. These oxygen functional groups enhance GO’s interaction with biological fluids, facilitating its hydrolytic biodegradation. Recent preclinical studies have indicated that GO effectively improves mechanical strength, immunomodulation, and osteoinduction when utilized within diverse matrix structures including natural and synthetic polymers and ceramics to induce osteogenesis. Advanced bone regenerative applications of GO, such as implant coating and delivery of bioactive compounds, have demonstrated enhanced osseointegration, antibacterial efficacy, and pro-healing microenvironments. However, there are still challenges regarding the high-quality large-scale synthesis and long-term biocompatibility of GO. Additionally, the variability in the characteristics of GO resulting from different synthesis methods demonstrates further challenges for therapeutic translation. This study provides a comprehensive review of the recent preclinical research on the translational potential of GO, discussing the convergence of its exceptional properties for use in bone regenerative engineering along with its current challenges and future perspectives.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"350–364 350–364"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsbiomedchemau.4c00152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Bio & Med Chem AuPub Date : 2025-05-27eCollection Date: 2025-06-18DOI: 10.1021/acsbiomedchemau.4c00152
Fatemeh S Hosseini, Ho-Man Kan, Taraje Whitfield, Chrysoula Argyrou, Amir A Abedini, Nicholas S Allen, Cato T Laurencin
{"title":"Graphene Oxide in Bone Regenerative Engineering: Current Challenges and Future Perspectives.","authors":"Fatemeh S Hosseini, Ho-Man Kan, Taraje Whitfield, Chrysoula Argyrou, Amir A Abedini, Nicholas S Allen, Cato T Laurencin","doi":"10.1021/acsbiomedchemau.4c00152","DOIUrl":"https://doi.org/10.1021/acsbiomedchemau.4c00152","url":null,"abstract":"<p><p>Owing to its exceptional physicochemical and biological properties, graphene oxide (GO), the oxidized form of graphene, has attracted considerable interest in bone regenerative engineering. The oxygen-functional groups on the backbone of GO enable biomolecule adherence, protein adsorption, cell adhesion, proliferation, differentiation, calcium ion adsorption and bone matrix mineralization. These oxygen functional groups enhance GO's interaction with biological fluids, facilitating its hydrolytic biodegradation. Recent preclinical studies have indicated that GO effectively improves mechanical strength, immunomodulation, and osteoinduction when utilized within diverse matrix structures including natural and synthetic polymers and ceramics to induce osteogenesis. Advanced bone regenerative applications of GO, such as implant coating and delivery of bioactive compounds, have demonstrated enhanced osseointegration, antibacterial efficacy, and pro-healing microenvironments. However, there are still challenges regarding the high-quality large-scale synthesis and long-term biocompatibility of GO. Additionally, the variability in the characteristics of GO resulting from different synthesis methods demonstrates further challenges for therapeutic translation. This study provides a comprehensive review of the recent preclinical research on the translational potential of GO, discussing the convergence of its exceptional properties for use in bone regenerative engineering along with its current challenges and future perspectives.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"350-364"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Bio & Med Chem AuPub Date : 2025-05-20DOI: 10.1021/acsbiomedchemau.5c0006910.1021/acsbiomedchemau.5c00069
Danae K. R. Bardaji, Nagela B. S. Silva, Renata R. Miranda, Carlos Henrique G. Martins, Michael A. Savka and André O. Hudson*,
{"title":"Unlocking the Potential of Brazilian Plant Terpenes to Combat Antimicrobial Resistance","authors":"Danae K. R. Bardaji, Nagela B. S. Silva, Renata R. Miranda, Carlos Henrique G. Martins, Michael A. Savka and André O. Hudson*, ","doi":"10.1021/acsbiomedchemau.5c0006910.1021/acsbiomedchemau.5c00069","DOIUrl":"https://doi.org/10.1021/acsbiomedchemau.5c00069https://doi.org/10.1021/acsbiomedchemau.5c00069","url":null,"abstract":"<p >The group of bacteria known as ESKAPE: <i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> spp. are well recognized for their high virulence and pathogenicity, employing diverse modalities and mechanisms to resist multiple classes of clinically relevant antibiotics. Their capacity to evade treatment presents a major public health challenge, highlighting the urgent need for novel antibiotics to address the growing resistance crisis. The plant kingdom presents a promising avenue to this fight. Plants are naturally endowed with the genomic and proteomic machinery to synthesize a wide arsenal of secondary metabolites, including terpenes and terpenoids, which have demonstrated potent antimicrobial properties both as standalone agents and as synergists or enhancers of existing antibiotics. These plant-derived compounds often operate through mechanisms distinct from those of conventional antibiotics, offering a potentially effective solution against antibiotic-resistant bacteria. Brazil, home to some of the richest biodiversity on the planet, boasts 46,000 recorded plant species, with 250 new species identified annually. This review delves into the methods of preparing and isolating terpenes and terpenoids from plants, explores the techniques used to assess their antibacterial activity, and highlights ongoing research using Brazilian plants to target ESKAPE pathogens. This compilation of knowledge aims to establish a pipeline for evaluating the antibacterial potential of terpenes and terpenoids, contributing to efforts addressing the growing threat of antimicrobial resistance.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"365–378 365–378"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsbiomedchemau.5c00069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Bio & Med Chem AuPub Date : 2025-05-20eCollection Date: 2025-06-18DOI: 10.1021/acsbiomedchemau.5c00069
Danae K R Bardaji, Nagela B S Silva, Renata R Miranda, Carlos Henrique G Martins, Michael A Savka, André O Hudson
{"title":"Unlocking the Potential of Brazilian Plant Terpenes to Combat Antimicrobial Resistance.","authors":"Danae K R Bardaji, Nagela B S Silva, Renata R Miranda, Carlos Henrique G Martins, Michael A Savka, André O Hudson","doi":"10.1021/acsbiomedchemau.5c00069","DOIUrl":"https://doi.org/10.1021/acsbiomedchemau.5c00069","url":null,"abstract":"<p><p>The group of bacteria known as ESKAPE: <i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> spp. are well recognized for their high virulence and pathogenicity, employing diverse modalities and mechanisms to resist multiple classes of clinically relevant antibiotics. Their capacity to evade treatment presents a major public health challenge, highlighting the urgent need for novel antibiotics to address the growing resistance crisis. The plant kingdom presents a promising avenue to this fight. Plants are naturally endowed with the genomic and proteomic machinery to synthesize a wide arsenal of secondary metabolites, including terpenes and terpenoids, which have demonstrated potent antimicrobial properties both as standalone agents and as synergists or enhancers of existing antibiotics. These plant-derived compounds often operate through mechanisms distinct from those of conventional antibiotics, offering a potentially effective solution against antibiotic-resistant bacteria. Brazil, home to some of the richest biodiversity on the planet, boasts 46,000 recorded plant species, with 250 new species identified annually. This review delves into the methods of preparing and isolating terpenes and terpenoids from plants, explores the techniques used to assess their antibacterial activity, and highlights ongoing research using Brazilian plants to target ESKAPE pathogens. This compilation of knowledge aims to establish a pipeline for evaluating the antibacterial potential of terpenes and terpenoids, contributing to efforts addressing the growing threat of antimicrobial resistance.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"365-378"},"PeriodicalIF":3.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Bio & Med Chem AuPub Date : 2025-05-12DOI: 10.1021/acsbiomedchemau.5c0001110.1021/acsbiomedchemau.5c00011
Alexander J. Hughes, Julie A. Talbert and Steven D. Townsend*,
{"title":"Discovery of Iboga-Derived Ligands for the Sigma-2 Receptor","authors":"Alexander J. Hughes, Julie A. Talbert and Steven D. Townsend*, ","doi":"10.1021/acsbiomedchemau.5c0001110.1021/acsbiomedchemau.5c00011","DOIUrl":"https://doi.org/10.1021/acsbiomedchemau.5c00011https://doi.org/10.1021/acsbiomedchemau.5c00011","url":null,"abstract":"<p >Substance use disorder (SUD) is a mental condition that affects a person’s brain and behavior, leading to a lack of control with alcohol, drug, and medication use. The lack of efficacious and novel treatments for SUD is a growing concern. As such, we have synthesized a series of iboga alkaloid derivatives and evaluated their receptor binding profiles against a panel of CNS-based proteins, which were performed at the National Institute of Mental Health Psychoactive Drug Screening Program. These studies revealed two compounds that exhibit high affinity for the sigma-2 receptor and introduce the iboga alkaloid framework as a new scaffold for the development of sigma-2 ligands.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"379–386 379–386"},"PeriodicalIF":3.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsbiomedchemau.5c00011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Bio & Med Chem AuPub Date : 2025-05-12eCollection Date: 2025-06-18DOI: 10.1021/acsbiomedchemau.5c00011
Alexander J Hughes, Julie A Talbert, Steven D Townsend
{"title":"Discovery of Iboga-Derived Ligands for the Sigma‑2 Receptor.","authors":"Alexander J Hughes, Julie A Talbert, Steven D Townsend","doi":"10.1021/acsbiomedchemau.5c00011","DOIUrl":"https://doi.org/10.1021/acsbiomedchemau.5c00011","url":null,"abstract":"<p><p>Substance use disorder (SUD) is a mental condition that affects a person's brain and behavior, leading to a lack of control with alcohol, drug, and medication use. The lack of efficacious and novel treatments for SUD is a growing concern. As such, we have synthesized a series of iboga alkaloid derivatives and evaluated their receptor binding profiles against a panel of CNS-based proteins, which were performed at the National Institute of Mental Health Psychoactive Drug Screening Program. These studies revealed two compounds that exhibit high affinity for the sigma-2 receptor and introduce the iboga alkaloid framework as a new scaffold for the development of sigma-2 ligands.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 3","pages":"379-386"},"PeriodicalIF":3.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}