Lancet Regional Health-Americas最新文献

{"title":"Sociohistorical justice: a corrective framework to mend the modern harms of medical history","authors":"Carmen Black , Shavonne Temple , Amber Acquaye , Christopher Fields , Abigail Konopasky","doi":"10.1016/j.lana.2024.100874","DOIUrl":"10.1016/j.lana.2024.100874","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100874"},"PeriodicalIF":7.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24002011/pdfft?md5=050c9283fc3a018904d27e6e485396c9&pid=1-s2.0-S2667193X24002011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our environment, our health, our challenge: perspectives from a Southern Brazil tragedy","authors":"Rafael Dall’Alba , Marco André Germanò , Carine B. Ferreira Nied , Paula Emília Adamy , Cristianne Famer Rocha","doi":"10.1016/j.lana.2024.100878","DOIUrl":"10.1016/j.lana.2024.100878","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100878"},"PeriodicalIF":7.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24002059/pdfft?md5=aaad5d3cc59cfc1ab2061e5e34f58b0c&pid=1-s2.0-S2667193X24002059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of end-of-life discussions and palliative care: implications for neurological intensive care among Latinos in the U.S.","authors":"Monica M. Diaz ,&nbsp;Lesley A. Guareña ,&nbsp;Bettsie Garcia ,&nbsp;Christoper A. Alarcon-Ruiz ,&nbsp;Stella M. Seal ,&nbsp;Clio Rubinos ,&nbsp;Dulce M. Cruz-Oliver ,&nbsp;J. Ricardo Carhuapoma","doi":"10.1016/j.lana.2024.100873","DOIUrl":"10.1016/j.lana.2024.100873","url":null,"abstract":"<div><p>Goals of care (Goals-of-care) discussions and palliative care (PC) are crucial to providing comprehensive healthcare, particularly for acute neurological conditions requiring admission to a neurological intensive care unit. We identified gaps in the literature and describe insight for future research on end-of-life discussions and PC for U.S. Latinos with acute neurological conditions. We searched 10 databases including peer-reviewed abstracts and manuscripts of hospitalized U.S. Latinos with acute neurological and non-neurological conditions. We included 44 of 3231 publications and identified various themes: PC utilization, pre-established advanced directives in Goals-of-care discussions, Goals-of-care discussion outcomes, tracheostomy or percutaneous gastrostomy tube placement rates among hospitalized Latinos. Our review highlights that Latinos appear to have lower palliative care utilization compared with non-Latino Whites and may be less likely to have pre-established advanced directives, more likely to have gastrostomy or tracheostomy placement and less likely to have do-not-resuscitate status.</p></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100873"},"PeriodicalIF":7.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X2400200X/pdfft?md5=08f8d85c1d015dccfb682f58937c86f1&pid=1-s2.0-S2667193X2400200X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural racism: a fundamental cause of drug overdose disparities","authors":"David T. Zhu","doi":"10.1016/j.lana.2024.100875","DOIUrl":"10.1016/j.lana.2024.100875","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100875"},"PeriodicalIF":7.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24002023/pdfft?md5=21ebbf1f957e17fe8522cb33fe12e16b&pid=1-s2.0-S2667193X24002023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-guided identification of risk variants for adrenocortical tumours in TP53 p.R337H carrier children: a genetic association study","authors":"Bonald C. Figueiredo ,&nbsp;Florent Dupont ,&nbsp;Geoffrey Portelli ,&nbsp;Tatiana E.J. Costa ,&nbsp;Gislaine Custódio ,&nbsp;Mariana M. Paraizo ,&nbsp;Heloisa Komechen ,&nbsp;Hadrien Gascuel ,&nbsp;Maxime Bottau ,&nbsp;Elodie Callea ,&nbsp;Ana Paula Percicote ,&nbsp;Leila G. Telles ,&nbsp;Mehdi Jendoubi ,&nbsp;Enzo Lalli","doi":"10.1016/j.lana.2024.100863","DOIUrl":"10.1016/j.lana.2024.100863","url":null,"abstract":"<div><h3>Background</h3><p>Adrenocortical tumours (ACT) in children are part of the Li-Fraumeni cancer spectrum and are frequently associated with a germline <em>TP53</em> pathogenic variant. <em>TP53</em> p.R337H is highly prevalent in the south and southeast of Brazil and predisposes to ACT with low penetrance. Thus, we aimed to investigate whether genetic variants exist which are associated with an increased risk of developing ACT in <em>TP53</em> p.R337H carrier children.</p></div><div><h3>Methods</h3><p>A genetic association study was conducted in trios of children (14 girls, 7 boys) from southern Brazil carriers of <em>TP53</em> p.R337H with (<em>n</em> = 18) or without (<em>n</em> = 3) ACT and their parents, one of whom also carries this pathogenic variant (discovery cohort). Results were confirmed in a validation cohort of <em>TP53</em> p.R337H carriers with (<em>n</em> = 90; 68 girls, 22 boys) or without ACT (<em>n</em> = 302; 165 women, 137 men).</p></div><div><h3>Findings</h3><p>We analysed genomic data from whole exome sequencing of blood DNA from the trios. Using deep learning algorithms, according to a model where the affected child inherits from the non-carrier parent variant(s) increasing the risk of developing ACT, we found a significantly enriched representation of non-coding variants in genes involved in the cyclic AMP (cAMP) pathway known to be involved in adrenocortical tumorigenesis. One among those variants (rs2278986 in the <em>SCARB1</em> gene) was confirmed to be significantly enriched in the validation cohort of <em>TP53</em> p.R337H carriers with ACT compared to carriers without ACT (OR 1.858; 95% CI 1.146, 3.042, p = 0.01).</p></div><div><h3>Interpretation</h3><p>Profiling of the variant rs2278986 is a candidate for future confirmation and possible use as a tool for ACT risk stratification in <em>TP53</em> p.R337H carriers.</p></div><div><h3>Funding</h3><p><span>Centre National de la Recherche Scientifique</span> (CNRS), <span>Behring Foundation</span>, <span>Conselho Nacional de Desenvolvimento Científico e Tecnológico</span> (CNPq).</p></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100863"},"PeriodicalIF":7.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X2400190X/pdfft?md5=a1febed3f3ea3fb3dd7ea58e92302897&pid=1-s2.0-S2667193X2400190X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding reach, enhancing capacity: embracing the role of primary care in lung cancer screening and smoking cessation in the United States","authors":"Elochukwu Ezenwankwo ,&nbsp;Duong Thuy Nguyen ,&nbsp;Idorenyin Ubon Akpabio ,&nbsp;Jan M. Eberth","doi":"10.1016/j.lana.2024.100870","DOIUrl":"10.1016/j.lana.2024.100870","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100870"},"PeriodicalIF":7.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24001972/pdfft?md5=952021c25dcb44a245e42313714dc66f&pid=1-s2.0-S2667193X24001972-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery – a prospective cohort study","authors":"Carlos J. Pérez Rivera ,&nbsp;Nicolás Lozano-Suárez ,&nbsp;Alejandro Velandia-Sánchez ,&nbsp;Maria Paula Vargas-Cuellar ,&nbsp;Luisa Fernanda Rojas-Serrano ,&nbsp;Camilo A. Polanía-Sandoval ,&nbsp;Daniela Lara-Espinosa ,&nbsp;Laura García-Zambrano ,&nbsp;Maria Paz Bohórquez-Tarazona ,&nbsp;Silvia Valentina Agudelo-Mendoza ,&nbsp;Paulo A. Cabrera-Rivera ,&nbsp;Leonardo Briceno-Ayala","doi":"10.1016/j.lana.2024.100862","DOIUrl":"10.1016/j.lana.2024.100862","url":null,"abstract":"<div><h3>Background</h3><p>Surgical care holds significant importance in healthcare, especially in low and middle-income countries, as at least 50% of the 4.2 million deaths within the initial 30 days following surgery take place in these countries. The Lancet Commission on Global Surgery proposed six indicators to enhance surgical care. In Colombia, studies have been made using secondary data. However, strategies to reduce perioperative mortality have not been implemented. This study aims to describe the fourth indicator, perioperative mortality rate (POMR), with primary data in Colombia.</p></div><div><h3>Methods</h3><p>A multicentre prospective cohort study was conducted across 54 centres (hospitals) in Colombia. Each centre selected a 7-day recruitment period between 05/2022 and 01/2023. Inclusion criteria involved patients over 18 years of age undergoing surgical procedures in operating rooms. Data quality was ensured through a verification guideline and statistical analysis using mixed-effects multilevel modelling with a case mix analysis of mortality by procedure-related, patient-related, and hospital-related conditions.</p></div><div><h3>Findings</h3><p>3807 patients were included with a median age of 48 (IQR 32–64), 80.3% were classified as ASA I or II, and 27% of the procedures had a low-surgical complexity. Leading procedures were Orthopedics (19.2%) and Gynaecology/Obstetrics (17.7%). According to the Clavien–Dindo scale, postoperative complications were distributed in major complications (11.7%, 10.68–12.76) and any complication (31.6%, 30.09–33.07). POMR stood at 1.9% (1.48–2.37), with elective and emergency surgery mortalities at 0.7% (0.40–1.23) and 3% (2.3–3.89) respectively.</p></div><div><h3>Interpretation</h3><p>The POMR was higher than the ratio reported in previous national studies, even when patients had a low–risk profile and low-complexity procedures. The present research represents significant public health progress with valuable insights for national decision-makers to improve the quality of surgical care.</p></div><div><h3>Funding</h3><p>This work was supported by <span>Universidad del Rosario</span> and Fundación Cardioinfantil-Instituto de Cardiología grant number CTO-057-2021, project-ID IV-FGV017.</p></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100862"},"PeriodicalIF":7.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24001893/pdfft?md5=e610997e5ae9fb05500259165df6e8b9&pid=1-s2.0-S2667193X24001893-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pan-American data initiative for the analysis of population racial/ethnic health inequities: the Pan-DIASPORA project","authors":"Mabel Carabali ,&nbsp;Sharrelle Barber ,&nbsp;Andrea J.F. Ferreira ,&nbsp;Ana F. Ortigoza ,&nbsp;Dandara Ramos ,&nbsp;Emanuelle Goes ,&nbsp;Arjumand Siddiqi ,&nbsp;Diego I. Lucumi ,&nbsp;Dennis Perez-Chacon ,&nbsp;John W. Jackson ,&nbsp;Huda Bashir ,&nbsp;Yazmin Sanchez ,&nbsp;Yasmine M. Elmi ,&nbsp;Celine M. Goulart ,&nbsp;Claudia Y. Perea-Aragon ,&nbsp;Randy L. Grillo ,&nbsp;Diana Higuera-Mendieta ,&nbsp;Khardjatou Marianne Djigo ,&nbsp;Vanessa Melo-Ferreira ,&nbsp;Marelys Martinez","doi":"10.1016/j.lana.2024.100868","DOIUrl":"10.1016/j.lana.2024.100868","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"37 ","pages":"Article 100868"},"PeriodicalIF":7.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24001959/pdfft?md5=abe6832f4449390b9b998e403a30f2be&pid=1-s2.0-S2667193X24001959-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serving justice-involved persons and the opioid epidemic","authors":"Augustine Kang ,&nbsp;Rosemarie Martin","doi":"10.1016/j.lana.2024.100871","DOIUrl":"10.1016/j.lana.2024.100871","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100871"},"PeriodicalIF":7.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24001984/pdfft?md5=b9f2d51a820793431e1aaab53a2042d9&pid=1-s2.0-S2667193X24001984-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coccidioidomycosis seasonality in California: a longitudinal surveillance study of the climate determinants and spatiotemporal variability of seasonal dynamics, 2000–2021","authors":"Alexandra K. Heaney ,&nbsp;Simon K. Camponuri ,&nbsp;Jennifer R. Head ,&nbsp;Philip Collender ,&nbsp;Amanda Weaver ,&nbsp;Gail Sondermeyer Cooksey ,&nbsp;Alexander Yu ,&nbsp;Duc Vugia ,&nbsp;Seema Jain ,&nbsp;Abinash Bhattachan ,&nbsp;John Taylor ,&nbsp;Justin V. Remais","doi":"10.1016/j.lana.2024.100864","DOIUrl":"10.1016/j.lana.2024.100864","url":null,"abstract":"<div><h3>Background</h3><p>Coccidioidomycosis, an emerging fungal disease in the western USA, exhibits seasonal patterns that are poorly understood, including periods of strong cyclicity, aseasonal intervals, and variation in seasonal timing that have been minimally characterized, and unexplained as to their causal factors. Coccidioidomycosis incidence has increased markedly in recent years, and our limited understanding of intra- and inter-annual seasonality has hindered the identification of important drivers of disease transmission, including climate conditions. In this study, we aim to characterize coccidioidomycosis seasonality in endemic regions of California and to estimate the relationship between drought conditions and coccidioidomycosis seasonal periodicity and timing.</p></div><div><h3>Methods</h3><p>We analysed data on all reported incident cases of coccidioidomycosis in California from 2000 to 2021 to characterize seasonal patterns in incidence, and conducted wavelet analyses to assess the dominant periodicity, power, and timing of incidence for 17 counties with consistently high incidence rates. We assessed associations between seasonality parameters and measures of drought in California using a distributed lag nonlinear modelling framework.</p></div><div><h3>Findings</h3><p>All counties exhibited annual cyclicity in incidence (i.e., a dominant wavelet periodicity of 12 months), but there was considerable heterogeneity in seasonal strength and timing across regions and years. On average, 12-month periodicity was most pronounced in the Southern San Joaquin Valley and Central Coast. Further, the annual seasonal cycles in the Southern San Joaquin Valley and the Southern Inland regions occurred earlier than those in coastal and northern counties, yet the timing of annual cycles became more aligned among counties by the end of the study period. Drought conditions were associated with a strong attenuation of the annual seasonal cycle, and seasonal peaks became more pronounced in the 1–2 years after a drought ended.</p></div><div><h3>Interpretation</h3><p>We conclude that drought conditions do not increase the risk of coccidioidomycosis onset uniformly across the year, but instead promote increased risk concentrated within a specific calendar period (September to December). The findings have important implications for public health preparedness, and for how future shifts in seasonal climate patterns and extreme events may impact spatial and temporal coccidioidomycosis risk.</p></div><div><h3>Funding</h3><p>National Institutes of Health.</p></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"38 ","pages":"Article 100864"},"PeriodicalIF":7.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667193X24001911/pdfft?md5=219dfd1df370e40cc27baf0760b2ea95&pid=1-s2.0-S2667193X24001911-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}