Lancet Regional Health-Americas最新文献

{"title":"Clarifying methods and interpretations in law enforcement mortality surveillance: response to Kamal","authors":"Peter T. Tanksley , J.C. Barnes , J. Pete Blair , M. Hunter Martaindale","doi":"10.1016/j.lana.2025.101330","DOIUrl":"10.1016/j.lana.2025.101330","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101330"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal effect of repetition and practice on the accuracy of lay anal examinations for detecting perianal and anal canal abnormalities: a prospective study","authors":"Alan G. Nyitray ,&nbsp;Timothy L. McAuliffe ,&nbsp;Jenna Nitkowski ,&nbsp;Cameron Liebert ,&nbsp;Michael D. Swartz ,&nbsp;Ashish A. Deshmukh ,&nbsp;Jared Kerman ,&nbsp;Ellen Almirol ,&nbsp;John A. Schneider ,&nbsp;J. Michael Wilkerson ,&nbsp;Lu-Yu Hwang ,&nbsp;Derek Smith ,&nbsp;Duo Yu ,&nbsp;Aniruddha Hazra ,&nbsp;Elizabeth Y. Chiao ,&nbsp;Prevent Anal Cancer Palpation Study Team","doi":"10.1016/j.lana.2025.101317","DOIUrl":"10.1016/j.lana.2025.101317","url":null,"abstract":"<div><h3>Background</h3><div>While anal cancer screening is now recommended in several countries for high-incidence populations, barriers impede screening uptake. It is well known that patient recognition of symptoms increases cancer screening uptake, and we previously demonstrated that patients can detect small masses at the perianus and in the anal canal. In this current analysis, we aimed to longitudinally assess the effect of repetition and practice on patient self-recognition of small masses.</div></div><div><h3>Methods</h3><div>Individuals and couples of sexual minority men and transgender women were taught to conduct an anal self-examination or anal companion examination (ASE/ACE) at visit 1 and then randomized to a practice or control condition. Six months later, at visit 2, the effect of practice and repetition of the ASE/ACE on detection of abnormalities was assessed by comparing the lay exam results to those of a clinician. Concordance, <em>κ,</em> and area under the receiver operating characteristic curves (AUC) was used to quantify the comparison.</div></div><div><h3>Findings</h3><div>Concordance between lay exam and clinician exam increased from visit 1 (73%, 524/714) to visit 2 (95%, 535/561) (<em>κ</em> = 0.87, 95% CI 0.82–0.92). Overall AUC at visit 2 was 0.93 (95% CI 0.90–0.96). Although there was no difference in concordance between the practice (95%, 267/281) and control arms (96%, 268/280) (p = 0.69), concordance increased with ASE/ACE repetition (p_trend &lt; 0.001) and was 98% (354/363) for individuals performing the ASE/ACE ≥2 times between visits. For individuals with incident abnormalities at visit 2, concordance was 100% (27/27). Results did not differ by age or HIV status. False positive and false negative results by the ASE/ACE were 2% (10/561) and 3% (16/561), respectively.</div></div><div><h3>Interpretation</h3><div>Because lay individuals can detect anal abnormalities, clinicians conducting an anal examination may suggest that the patient's own lay exams may detect early invasive anal cancer.</div></div><div><h3>Funding</h3><div><span>National Cancer Institute</span>.</div></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101317"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between optimized bismuth quadruple therapy and standard clarithromycin-based triple therapy for first-line Helicobacter pylori eradication: a double-blind randomized controlled trial","authors":"Patricio Andrés Medel-Jara ,&nbsp;Gonzalo Latorre ,&nbsp;Eduardo Fuentes-Lopez ,&nbsp;Margarita Pizarro ,&nbsp;Paola Viviani ,&nbsp;Javier Chahuán ,&nbsp;Sara Maquilón ,&nbsp;Oscar Corsi ,&nbsp;Diego Reyes ,&nbsp;Alberto Espino ,&nbsp;Jose Ignacio Vargas ,&nbsp;Ignacio A. Wichmann ,&nbsp;Paul Harris ,&nbsp;Carolina Serrano ,&nbsp;Isabella Buruato ,&nbsp;Christopher Sandoval ,&nbsp;Nelson M. Varela ,&nbsp;Leslie Cerpa ,&nbsp;Luis Quiñones ,&nbsp;Francis Megraud ,&nbsp;Arnoldo Riquelme Perez","doi":"10.1016/j.lana.2025.101312","DOIUrl":"10.1016/j.lana.2025.101312","url":null,"abstract":"<div><h3>Background</h3><div><em>Helicobacter pylori</em> eradication reduces the risk of peptic ulcer disease and gastric cancer. In Chile, the effectiveness of standard triple therapy has dropped below 80%. We compared <em>optimized bismuth quadruple therapy</em>: esomeprazole 40 mg three times a day, amoxicillin 1 gr three times a day, metronidazole 500 mg three times a day, and bismuth subsalicylate 369 mg three times a day for 14 days, and standard triple therapy omeprazole 20 mg twice a day, amoxicillin 1 gr twice a day, and clarithromycin 500 mg twice a day for 14 days in a Chilean population.</div></div><div><h3>Methods</h3><div>Randomized double-blind clinical trial. 127 treatment-naïve individuals with confirmed active <em>H. pylori</em> were recruited. The primary outcome was successful <em>H. pylori</em> eradication, at least 4 weeks post-treatment. We assessed <em>H. pylori</em> resistance to clarithromycin and participants’ <em>CYP2C19</em> genotype/phenotype. We compared eradication success between the groups using intention-to-treat and per-protocol analyses. The trial adhered to CONSORT guidelines. NTC-Number: <span><span>NCT05664685</span><svg><path></path></svg></span> (trial completed).</div></div><div><h3>Findings</h3><div>127 participants were recruited and randomized (64 standard triple therapy, 63 optimized bismuth quadruple therapy). Men were 44% (56/127), and the mean age was 48 (standard deviation: 14.2) in the sample. Baseline characteristics between the two groups were similar. In intention-to-treat analysis, optimized bismuth quadruple therapy had a significantly higher eradication rate versus standard triple therapy: 95% (60/63) [95% CI 86%–99%] vs. 81% (52/64) [70%–89%], p = 0.033. Adverse events were comparable: optimized bismuth quadruple therapy 67% (42/63) [54%–77%] vs. standard triple therapy 66% (42/64) [53%–76%], p = 1.00. There was no difference in baseline clarithromycin resistance or <em>CYP2C19</em> polymorphisms.</div></div><div><h3>Interpretation</h3><div>Optimized bismuth quadruple therapy eradication is higher than standard triple therapy in treatment-naïve individuals with active <em>H. pylori</em>, without difference in adverse events or adherence. Optimized bismuth quadruple therapy is a reliable and safe empiric eradication therapy, especially in areas with high clarithromycin resistance.</div></div><div><h3>Funding</h3><div><span>FONDECYT</span> (1230504 AR); <span>ANID-FONDAP</span> (152220002 AR); <span>Horizon 2020 program of European Union</span> (825832 AR); <span>ANID-FONDAP</span> (15130011).</div></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101312"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised, double-blind, sham-controlled, 2×2 factorial trial of aerobic vs. non-aerobic exercise and motor cortex transcranial direct current stimulation in fibromyalgia: effects on clinical outcomes and descending pain modulation","authors":"Felipe Fregni ,&nbsp;Luis Castelo-Branco ,&nbsp;Alejandra Cardenas-Rojas ,&nbsp;Marianna Daibes ,&nbsp;Fernanda MQ. Silva ,&nbsp;Kevin Pacheco-Barrios ,&nbsp;Guilherme J.M. Lacerda ,&nbsp;Lucas Camargo ,&nbsp;Anna Carolyna Gianlorenco ,&nbsp;Wolnei Caumo","doi":"10.1016/j.lana.2025.101314","DOIUrl":"10.1016/j.lana.2025.101314","url":null,"abstract":"<div><h3>Background</h3><div>Exercise is first-line therapy for fibromyalgia, but the superiority of aerobic vs. non-aerobic modalities is uncertain. Motor-cortex transcranial direct current stimulation (tDCS) may enhance descending pain inhibition. We tested the effects of exercise modality and tDCS on conditioned pain modulation (CPM) and clinical outcomes.</div></div><div><h3>Methods</h3><div>Double-blind, randomised 2 × 2 factorial trial in Boston, USA (2019–2024; allocation 1:1:1:1). Adults with fibromyalgia were assigned to aerobic + active tDCS, aerobic + sham, non-aerobic + active, or non-aerobic + sham. Participants completed 16 in-person sessions over 4 weeks, combining concurrent tDCS and exercise. The non-aerobic condition involved light treadmill walking matched for duration but below aerobic threshold (&lt;40% HRmax). Primary outcomes were changes in CPM and temporal summation of pain (TSP) at week 6; secondary outcomes were pain, fatigue, sleep, quality of life, and depressive symptoms.</div></div><div><h3>Findings</h3><div>Of 116 participants (mean age 47.1 ± 11.9 years), 88.8% were female. Active tDCS improved CPM vs. sham (Cohen's d = 0.66; p = 0.015), independent of exercise modality, and showed a small, nonsignificant improvement in TSP (mean change −0.19 [95% CI –0.90, 0.51]). All groups showed moderate-to-large improvements in pain, fatigue, and quality of life (Cohen's d 0.60–0.92), with no added benefit from tDCS. Non-aerobic and aerobic exercise produced comparable symptom improvements. Greater age and lower body mass index (BMI) were associated with enhanced response. Changes in pain modulation were not mediated by short-term clinical changes.</div></div><div><h3>Interpretation</h3><div>Supervised aerobic and non-aerobic exercise produced meaningful short-term clinical improvements. Motor-cortex tDCS enhanced descending pain inhibition but did not add clinical benefit beyond exercise over 6 weeks.</div></div><div><h3>Funding</h3><div>National Institutes of health (R01 1R01AT009491-01A1).</div></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101314"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEARTS quality: a policy framework to strengthen hypertension and cardiovascular risk management in primary healthcare—insights from HEARTS in the Americas","authors":"Esteban Londoño ,&nbsp;Reena Gupta ,&nbsp;Patrick Van der Stuyft ,&nbsp;Martin Heine ,&nbsp;Gloria Giraldo ,&nbsp;Grace Marie Ku ,&nbsp;Jeffrey Brettler ,&nbsp;Andrés Rosende ,&nbsp;Vilma Irazola ,&nbsp;Jerry Toelsie ,&nbsp;Carolina Neira ,&nbsp;Teresa Aumala ,&nbsp;Yamilé Valdés ,&nbsp;Eric Zúñiga ,&nbsp;Libardo Rodríguez ,&nbsp;Matías Villatoro ,&nbsp;María Cristina Escobar ,&nbsp;Vivian Pérez ,&nbsp;Alied Bencomo ,&nbsp;Michael Pereira ,&nbsp;Pedro Ordunez","doi":"10.1016/j.lana.2025.101311","DOIUrl":"10.1016/j.lana.2025.101311","url":null,"abstract":"<div><div>HEARTS in the Americas is the largest-scale implementation of the WHO's global initiative, with 33 countries participating, 28 having adopted standardized clinical pathways, and about 10,000 primary healthcare facilities engaged. Despite progress, fragmented care, limited availability of validated blood pressure devices, restricted access to essential medicines, and weak quality assurance systems continue to hinder hypertension control and cardiovascular risk management. In response, PAHO and participating countries co-developed the HEARTS Quality Framework. Grounded in regional implementation, this model synthesizes global evidence and lessons from Latin America and the Caribbean. Co-designed by Ministries of Health, care providers, and international experts, it translates HEARTS strategies into actionable system-level objectives. Clearly defined outcome indicators and implementation targets promote institutionalization, quality improvement, and primary healthcare strengthening—supporting HEARTS scale-up and equitable outcomes. With appropriate contextualization, the HEARTS Quality Framework provides a practical roadmap for countries beyond the Region to advance primary healthcare-based chronic disease care.</div></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101311"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and neck cancer mortality by gender, region and ethnicity: a population-based study in Brazil","authors":"Matheus de Abreu ,&nbsp;Maria do Rosario Dias de Oliveira Latorre ,&nbsp;Maria Paula Curado","doi":"10.1016/j.lana.2025.101306","DOIUrl":"10.1016/j.lana.2025.101306","url":null,"abstract":"<div><h3>Background</h3><div>Brazil exhibits the highest mortality rates for oral cavity (OCC), oropharyngeal (OPC), and laryngeal (LC) cancers in South-America. This study aims to analyze mortality trends in head and neck cancers (HNC) across the Brazilian population over 44-year period.</div></div><div><h3>Methods</h3><div>A time-series ecological study was conducted using OCC, OPC, LC mortality data. Age-period-cohort (APC) effects and the average annual percent change (AAPC) were estimated for each cancer subsite by gender, regions, ethnicity.</div></div><div><h3>Findings</h3><div>From 1980 to 2023, 303,882 HNC deaths were recorded among adults ≥40 years. LC predominated (45.4%), followed by OCC (30.5%), OPC (24.1%). Mortality rates were higher in men, LC showing the highest. After 2000, mortality declines for LC (RR: 0.98 [0.98–1.00 CI 95%]) in men, while women increasing mortality for OPC (RR: 1.12 [1.04–1.21]), OCC (RR: 1.08 [1.02–1.15]). Men born after-1955 showed reduced RR for all subsites, women exhibited for LC. The Northeast region showed an increasing trend across all age groups and cancer subsites. OPC presented an increase in mortality in all regions, in contrast to LC and OCC, which declined in the South and Southeast. White men had a decreasing trend for LC (AAPC −1.62 [−1.99 to −1.26]), OCC (AAPC −1.01 [−1.31 to −0.71]), OPC (AAPC −0.60 [−0.98 to −0.24]), whereas Brown showed an increasing for both genders in all subsites.</div></div><div><h3>Interpretation</h3><div>Gender, ethnicity, and geographic location are associated with HNC mortality in Brazil. White men and developed regions showed the most substantial improvements in mortality, while brown, women, and people in the North/Northeast exhibited concerning increases. OPC, although with the lowest rates, shows a growing mortality trend nationwide.</div></div><div><h3>Funding</h3><div>CAPES-Brazil.</div></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101306"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategic approaches to reducing the substance use-related burden of disease in Canada","authors":"Benedikt Fischer ,&nbsp;Wayne Hall ,&nbsp;Bernard Le Foll ,&nbsp;Patricia Conrod","doi":"10.1016/j.lana.2025.101289","DOIUrl":"10.1016/j.lana.2025.101289","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101289"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145420415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new era for RSV: the end in sight?","authors":"The Lancet Regional Health – Americas","doi":"10.1016/j.lana.2025.101364","DOIUrl":"10.1016/j.lana.2025.101364","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101364"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond F508del: equity as the next frontier in cystic fibrosis","authors":"Renata Wrobel Folescu Cohen ,&nbsp;Patrícia Fernandes Barreto Machado Costa ,&nbsp;Katty Anne Carvalho Marins ,&nbsp;Monica Muller Taulois ,&nbsp;Natalia Dias Barboza ,&nbsp;Célia Chaves ,&nbsp;Zilton Vasconcelos ,&nbsp;Tania Wrobel Folescu","doi":"10.1016/j.lana.2025.101328","DOIUrl":"10.1016/j.lana.2025.101328","url":null,"abstract":"","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101328"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wealth-based inequalities in family planning and perinatal coverage among adolescent and young women: analyses of national surveys from Latin America and the Caribbean","authors":"Antonio Sanhueza ,&nbsp;Sonja Caffe ,&nbsp;Emmanuel Gonzalez-Bautista ,&nbsp;Liliana Carvajal Velez ,&nbsp;Oscar J. Mujica ,&nbsp;Luis Paulo Vidaletti ,&nbsp;Cesar G. Victora ,&nbsp;Aluisio J.D. Barros","doi":"10.1016/j.lana.2025.101318","DOIUrl":"10.1016/j.lana.2025.101318","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to describe the coverage of key family planning (FP) and perinatal health indicators and to measure the associated social inequalities among adolescent and young women in the Latin American and Caribbean (LAC) region.</div></div><div><h3>Methods</h3><div>Nationally representative data from 20 LAC countries were analyzed using Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS) conducted between 2011 and 2016. Data were disaggregated by age group (15–19 and 20–24 years). Coverage was estimated for six key indicators, including FP, antenatal care (ANC), skilled birth attendance (SBA), and postnatal care (PNC). Socioeconomic inequalities in coverage were assessed using the Slope Index of Inequality (SII) and the Concentration Index (CIX).</div></div><div><h3>Findings</h3><div>Around 2015, median national coverage exceeded 90% for most ANC and PNC indicators, except for ANC with four or more visits and FP. Among adolescents, ANC coverage ranged from 44.6% in Uruguay (95% CI: 13.6–80.4) to 99.2% in Cuba (97.9–99.7); FP coverage was lowest in Guyana (16.7%, 11.7–23.3) and Haiti (28.7%, 22.7–35.6). Significant pro-rich inequalities were observed. The widest inequalities were observed, for ANC in Panama (SII = 46.5) and Haiti (SII = 48.8); for ANC quality in Guatemala (SII = 61.1); for SBA in Panama (SII = 90.0), and for FP inequalities in Guatemala (SII = 33.0).</div></div><div><h3>Interpretation</h3><div>Adolescents and young women in LAC face persistent and unequal coverage of FP and perinatal services. These baseline findings underscore the urgent need for youth-friendly, equity-focused interventions to meet SDG targets.</div></div><div><h3>Funding</h3><div>No direct funding was received.</div></div>","PeriodicalId":29783,"journal":{"name":"Lancet Regional Health-Americas","volume":"53 ","pages":"Article 101318"},"PeriodicalIF":7.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}